AbstractMotivation. The combination of long-read sequencing technologies like Oxford Nanopore with single-cell RNA sequencing (scRNAseq) assays enables the

Sequencing the entire transcriptome for every perturbation is too expensive. This workflow offers a solution. TAP-seq (Targeted Perturb-seq) focuses single-cell RNA-seq coverage on a gene panel you d...

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Credit: Nadya Tkach/Getty Images A high-tech upgrade is allowing scientists to peer into the genetics of millions of individual cells, while achieving significant reductions in cost compared to traditional...

Sepsis is a life-threatening syndrome associated with high morbidity and mortality, underscoring the urgent need for early diagnostic biomarkers and therapeutic targets. However, current diagnostic strategies remain insufficiently precise because of the complex immune dysregulation and immune microenvironment heterogeneity that characterize sepsis. This study aimed to identify reliable diagnostic biomarkers for sepsis and explore their immune regulatory mechanisms together with potential therapeutic relevance using multidimensional bioinformatic analyses.

Signal Transduction and Targeted Therapy - Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma