Chronic mucosal inflammation relies on an IFNAR1-dependent metabolic circuit that drives neutrophil damage. Researchers identify an IFNAR1–Mitoferrin-1 circuit that drives #NETosis, #OxidativeStress, and #TissueInjury, while its blockade preserves immunity.
#OpenAccess: doi.org/10.1038/s413...

Thrilled for the next 3 days hearing the current insights on @helloeacr.bsky.social #CancerNeuroscience from a great selection of speakers.
If around, come to poster 38 for #neuros on #pancreaticcancer and #TissueInjury.

Using #Multiomics data integration, this Current Medical Science study from @WHU_1893 identified seven #HubGenes that mechanistically connect #ImmuneDyshomeostasis to #TissueInjury in #Sepsis-induced ALI. #medsky
Read: doi.org/10.1007/s115...

JAK not needed? An investigation of the potential significance of JAK signaling for the inflammatory effects of #influenza and secondary #bacterial #infection in a mouse model, reports that JAK inhibition did not achieve improvement of pathogen clearance or limit #tissueinjury

This investigation of molecular pathways needed for inflammatory effects of secondary #bacterial #infection complications of #influenza finds that that JAK inhibition in a mouse model did not improve pathogen clearance or limit #tissueinjury,
https://buff.ly/3WUmypm
#CellSignaling