#Medsky🧪 #IDsky #immunosky #ICU Elevated #angiopoietin2 is associated with diverse inflammatory conditions, including #sepsis, a leading global cause of mortality.
A candidate marker and therapeutic target in sepsis!
@samirparikhmd.bsky.social & team show cathepsin K cleavage of angiopoietin-2 produces detrimental Tie2 antagonist fragments in sepsis and inhibition of cathepsin K with odanacatib improved survival in sepsis models: buff.ly/ma6E8Ei
@samirparikhmd.bsky.social & team show cathepsin K cleavage of angiopoietin-2 produces detrimental Tie2 antagonist fragments in sepsis and inhibition of cathepsin K with odanacatib improved survival in sepsis models: buff.ly/ma6E8Ei
April 21, 2025 at 1:30 PM
#Medsky🧪 #IDsky #immunosky #ICU Elevated #angiopoietin2 is associated with diverse inflammatory conditions, including #sepsis, a leading global cause of mortality.
#HutchinsonGilfordProgeriaSyndrome
HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)
#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)
#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
October 19, 2024 at 7:15 PM
#HutchinsonGilfordProgeriaSyndrome
HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)
#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)
#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
Congrats to Prof Lynn McKeown's group at @universityofleeds.bsky.social for sciencedirect.com/science/article/pii/S0143416025000776, showing that histamine induces local Ca²⁺ release, leading to Ang2 secretion from endothelial cells. Proud our a-Rab46 antibody and Ang2 ELISA kit helped discovery!
NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking
Angiopoietin2 (Ang2), a regulator of angiogenesis, is stored with other pro-inflammatory and pro-thrombotic mediators, in endothelial-specific vesicle…
sciencedirect.com
November 21, 2025 at 8:47 AM
Congrats to Prof Lynn McKeown's group at @universityofleeds.bsky.social for sciencedirect.com/science/article/pii/S0143416025000776, showing that histamine induces local Ca²⁺ release, leading to Ang2 secretion from endothelial cells. Proud our a-Rab46 antibody and Ang2 ELISA kit helped discovery!