Our review examines how epigenetic mechanisms shape vascular smooth muscle cell plasticity in atherosclerosis, injury, and aging, highlighting BRD4 as a potential therapeutic target and challenges for clinical translation
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 30, 2026 at 4:57 AM
Our review examines how epigenetic mechanisms shape vascular smooth muscle cell plasticity in atherosclerosis, injury, and aging, highlighting BRD4 as a potential therapeutic target and challenges for clinical translation
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Epigenetic regulation of vascular #SmoothMuscleCell plasticity in vascular injury, repair & aging
PRMT5, EZH2, LSD1, CBP/P300, heterochromatin, BRD4
Happy to contribute a bit (Mechano-epigenetics; Aneurysm) to this review by my PhD supervisor😁
#VasPharma 2026
www.sciencedirect.com/science/arti...
PRMT5, EZH2, LSD1, CBP/P300, heterochromatin, BRD4
Happy to contribute a bit (Mechano-epigenetics; Aneurysm) to this review by my PhD supervisor😁
#VasPharma 2026
www.sciencedirect.com/science/arti...
October 25, 2026 at 7:49 PM
Epigenetic regulation of vascular #SmoothMuscleCell plasticity in vascular injury, repair & aging
PRMT5, EZH2, LSD1, CBP/P300, heterochromatin, BRD4
Happy to contribute a bit (Mechano-epigenetics; Aneurysm) to this review by my PhD supervisor😁
#VasPharma 2026
www.sciencedirect.com/science/arti...
PRMT5, EZH2, LSD1, CBP/P300, heterochromatin, BRD4
Happy to contribute a bit (Mechano-epigenetics; Aneurysm) to this review by my PhD supervisor😁
#VasPharma 2026
www.sciencedirect.com/science/arti...
Targeting the ENL–USP7–BRD4 pathway offers a new way to disrupt hidden HIV reservoirs as part of a broader cure strategy. This research could help guide the development of future strategies aimed at eliminating HIV reservoirs that persist despite effective treatment,
October 26, 2026 at 6:40 AM
Targeting the ENL–USP7–BRD4 pathway offers a new way to disrupt hidden HIV reservoirs as part of a broader cure strategy. This research could help guide the development of future strategies aimed at eliminating HIV reservoirs that persist despite effective treatment,
I can see me doing same now.
This clip of Alan always makes me smile whenever it crops up as well.
m.youtube.com/watch?v=brd4...
This clip of Alan always makes me smile whenever it crops up as well.
m.youtube.com/watch?v=brd4...
Spitfire flies LOW over TV presenter
YouTube video by WingsTV Channel
m.youtube.com
October 25, 2026 at 3:48 PM
I can see me doing same now.
This clip of Alan always makes me smile whenever it crops up as well.
m.youtube.com/watch?v=brd4...
This clip of Alan always makes me smile whenever it crops up as well.
m.youtube.com/watch?v=brd4...
He does and I like the way he lets us hear the noise too. Skillful driving around narrow lanes of Bamford estate as well.
This one always deserves a repeat too
m.youtube.com/watch?v=brd4...
This one always deserves a repeat too
m.youtube.com/watch?v=brd4...
Spitfire flies LOW over TV presenter
YouTube video by WingsTV Channel
m.youtube.com
October 25, 2026 at 3:50 PM
He does and I like the way he lets us hear the noise too. Skillful driving around narrow lanes of Bamford estate as well.
This one always deserves a repeat too
m.youtube.com/watch?v=brd4...
This one always deserves a repeat too
m.youtube.com/watch?v=brd4...
Design and Biological Evaluation of a Potent Dual PARP and BRD4 Inhibitor for Tumor Therapy via Disrupting HRR and BRD4-cJUN-CCL2 Axis
pubs.acs.org/jmcmar/artic...
pubs.acs.org/jmcmar/artic...
Design and Biological Evaluation of a Potent Dual PARP and BRD4 Inhibitor for Tumor Therapy via Disrupting HRR and BRD4-cJUN-CCL2 Axis
Abstract. Inducing homologous recombination repair (HRR) deficiency is an attractive strategy to expand the therapeutic scope of PARP inhibitors. Since BRD
pubs.acs.org
October 23, 2026 at 11:06 PM
Design and Biological Evaluation of a Potent Dual PARP and BRD4 Inhibitor for Tumor Therapy via Disrupting HRR and BRD4-cJUN-CCL2 Axis
pubs.acs.org/jmcmar/artic...
pubs.acs.org/jmcmar/artic...
A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
How diabetes promotes cancer progression remains poorly understood. Li et al. show that high blood glucose stabilizes a cancer-promoting protein, BRD4, through a molecular switch involving USP28 and SIRT1. This USP28-BRD4 axis links hyperglycemia to breast cancer progression and may offer therapeutic insights.
dlvr.it
October 23, 2026 at 11:23 PM
A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
Here you can see a crystal structure of human BRD4-BD1 in complex with cyclic peptide 4.1B (PDB code: 9MPD)
3D VIEW 3dproteinimaging.com/protein-imag...
Rendering by Francisco J. Enguita made with #ProteinImager
#molecularart #epigenetics #cyclic #peptide #brd4 #bd1 #complex #xray
3D VIEW 3dproteinimaging.com/protein-imag...
Rendering by Francisco J. Enguita made with #ProteinImager
#molecularart #epigenetics #cyclic #peptide #brd4 #bd1 #complex #xray
October 21, 2026 at 7:59 AM
Here you can see a crystal structure of human BRD4-BD1 in complex with cyclic peptide 4.1B (PDB code: 9MPD)
3D VIEW 3dproteinimaging.com/protein-imag...
Rendering by Francisco J. Enguita made with #ProteinImager
#molecularart #epigenetics #cyclic #peptide #brd4 #bd1 #complex #xray
3D VIEW 3dproteinimaging.com/protein-imag...
Rendering by Francisco J. Enguita made with #ProteinImager
#molecularart #epigenetics #cyclic #peptide #brd4 #bd1 #complex #xray
RRID:AB_2152167 from @proteintech.bsky.social was used by authors in their Cell Reports paper. Thanks for making your methods matter! #BetterScience #OpenScience #reproducibility
NONO mitigates transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation
Read the full paper: NONO mitigates transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation
doi.org
October 16, 2026 at 7:00 AM
RRID:AB_2152167 from @proteintech.bsky.social was used by authors in their Cell Reports paper. Thanks for making your methods matter! #BetterScience #OpenScience #reproducibility
Online now! Online now! Disrupting BRD4-BD1-p62 engagement restores protective autophagy #chembiol
Disrupting BRD4-BD1-p62 engagement restores protective autophagy
Autophagy is impaired in idiopathic pulmonary fibrosis. Zhang et al. identify a BRD4-BD1-selective inhibitor that disrupts BRD4-BD1–p62 engagement, restores protective autophagy, and attenuates pulmonary fibrosis, revealing a druggable mechanism linking epigenetic regulation to autophagy.
dlvr.it
October 12, 2026 at 3:30 PM
Online now! Online now! Disrupting BRD4-BD1-p62 engagement restores protective autophagy #chembiol
RRID:AB_2882554 from @proteintech.bsky.social was used by authors in their Cell Chemical Biology paper. RRIDs improve reproducibility in scientific research. #reproducibility #STMpublishing #accelerateopenscience
Disrupting BRD4-BD1-p62 engagement restores protective autophagy
Read the full paper: Disrupting BRD4-BD1-p62 engagement restores protective autophagy
doi.org
October 11, 2026 at 7:00 AM
RRID:AB_2882554 from @proteintech.bsky.social was used by authors in their Cell Chemical Biology paper. RRIDs improve reproducibility in scientific research. #reproducibility #STMpublishing #accelerateopenscience
An unexpected role for cyclin E-CDK2 in regulating responses to cancer immunotherapy
An unexpected role for cyclin E-CDK2 in regulating responses to cancer immunotherapy
In this issue of Molecular Cell, Chu et al.1 describe that cancers with increased cyclin E-CDK2 activity suppress responses to immunotherapy through phosphorylation of BRD4, resulting in downregulation of interferon-stimulated genes. Their findings suggest approaches to enhance immunotherapy responses.
dlvr.it
October 6, 2026 at 7:14 PM
An unexpected role for cyclin E-CDK2 in regulating responses to cancer immunotherapy
Structural basis for P-TEFb association with BRD4 pubmed.ncbi.nlm.nih.gov/42818227/ #cryoem
October 2, 2026 at 11:42 PM
Structural basis for P-TEFb association with BRD4 pubmed.ncbi.nlm.nih.gov/42818227/ #cryoem
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
Chu et al. show that cyclin E-CDK2 has a cell-cycle-independent role in transcriptional regulation by phosphorylating BRD4 and controlling its chromatin occupancy. Cyclin E overexpression represses the expression of interferon-stimulated genes in cancer cells through BRD4 and promotes immunotherapy resistance, while inhibition of CDK2 activity enhances responses to immune checkpoint blockade.
dlvr.it
October 1, 2026 at 10:57 PM
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
Corrigendum to "PCIF1-mediated m6Am modification activates USP5/BRD4 Axis to promote glycolysis-driven immunosuppression in multiple myeloma" [Int. Immunopharmacol. 186 (2026), 117062]
International immunopharmacology · Long et al.
doi.org/10.1016/j.intimp.2026.117449
#RNAsky #RNAmods
International immunopharmacology · Long et al.
doi.org/10.1016/j.intimp.2026.117449
#RNAsky #RNAmods
Corrigendum to "PCIF1-mediated m6Am modification activates USP5/BRD4 Axis to promote glycolysis-driven immunosuppression in multiple myeloma" [Int. Immunopharmacol. 186 (2026), 117062]
International immunopharmacology · Long S, Ding T, Zhou L, Gao W, Wang Q, Liu Y.
doi.org
September 30, 2026 at 9:07 PM
Corrigendum to "PCIF1-mediated m6Am modification activates USP5/BRD4 Axis to promote glycolysis-driven immunosuppression in multiple myeloma" [Int. Immunopharmacol. 186 (2026), 117062]
International immunopharmacology · Long et al.
doi.org/10.1016/j.intimp.2026.117449
#RNAsky #RNAmods
International immunopharmacology · Long et al.
doi.org/10.1016/j.intimp.2026.117449
#RNAsky #RNAmods
It's World Heart Day. Heart failure affects approximately 64 million people worldwide. At Gladstone, Michael Alexanian is asking: what if we could just switch it off?
He's found two genes, BRD4 & MEOX1, that may hold the answer.
He's found two genes, BRD4 & MEOX1, that may hold the answer.
Ask a Scientist: Can We Turn Off the Molecular Switches That Cause Heart Failure?
Michael Alexanian is studying two promising genetic avenues for addressing heart failure, a massive global health burden in need of innovative treatments.
gladstone.org
September 29, 2026 at 6:21 PM
It's World Heart Day. Heart failure affects approximately 64 million people worldwide. At Gladstone, Michael Alexanian is asking: what if we could just switch it off?
He's found two genes, BRD4 & MEOX1, that may hold the answer.
He's found two genes, BRD4 & MEOX1, that may hold the answer.
@proteintech.bsky.social's resource, RRID:AB_2272676, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch #RRID
A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
Read the full paper: A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia
doi.org
September 25, 2026 at 7:00 AM
@proteintech.bsky.social's resource, RRID:AB_2272676, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch #RRID
8/10 Using synthezisable design, we found de novo hits for BRD4 BD1 and SARS-CoV-2 Nsp3 Mac1, with binding confirmed by NMR and Xray.
September 20, 2026 at 11:46 AM
8/10 Using synthezisable design, we found de novo hits for BRD4 BD1 and SARS-CoV-2 Nsp3 Mac1, with binding confirmed by NMR and Xray.
BRD4 bound unmodified nucleosomes with nearly the same affinity as modified ones, challenging the idea that a histone chemical tag is required. Whether this also happens in cells remains unclear. doi.org/hcjh4z
Cancer-linked protein binds to chromosome in unexpected way, study finds
A new 3D structure of a cancer-linked protein bound to its cellular partner reveals details of how the protein binds to chromosomes and could offer insights for future disease treatments.
phys.org
September 14, 2026 at 6:40 PM
BRD4 bound unmodified nucleosomes with nearly the same affinity as modified ones, challenging the idea that a histone chemical tag is required. Whether this also happens in cells remains unclear. doi.org/hcjh4z
Lots of new research in A&R to read up on:
SICCA-NextGen study identifies two immunological subtypes of Sjögren’s disease
doi.org/10.1002/art....
BRD4 expression upregulated in renal endothelial cells in lupus
doi.org/10.1002/art....
SICCA-NextGen study identifies two immunological subtypes of Sjögren’s disease
doi.org/10.1002/art....
BRD4 expression upregulated in renal endothelial cells in lupus
doi.org/10.1002/art....
September 12, 2026 at 11:34 AM
Lots of new research in A&R to read up on:
SICCA-NextGen study identifies two immunological subtypes of Sjögren’s disease
doi.org/10.1002/art....
BRD4 expression upregulated in renal endothelial cells in lupus
doi.org/10.1002/art....
SICCA-NextGen study identifies two immunological subtypes of Sjögren’s disease
doi.org/10.1002/art....
BRD4 expression upregulated in renal endothelial cells in lupus
doi.org/10.1002/art....
New study demonstrated that BRD4 expression is upregulated in renal endothelial cells in lupus patients and mice.
Inhibition of endothelial BRD4 robustly ameliorated hallmark features of lupus nephritis in a lupus mouse model
Arthritis & Rheumatology
doi.org/10.1002/art....
Inhibition of endothelial BRD4 robustly ameliorated hallmark features of lupus nephritis in a lupus mouse model
Arthritis & Rheumatology
doi.org/10.1002/art....
September 9, 2026 at 4:10 PM
New study demonstrated that BRD4 expression is upregulated in renal endothelial cells in lupus patients and mice.
Inhibition of endothelial BRD4 robustly ameliorated hallmark features of lupus nephritis in a lupus mouse model
Arthritis & Rheumatology
doi.org/10.1002/art....
Inhibition of endothelial BRD4 robustly ameliorated hallmark features of lupus nephritis in a lupus mouse model
Arthritis & Rheumatology
doi.org/10.1002/art....
⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
September 8, 2026 at 5:25 PM
⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
RRID:AB_469457 from @thermofishersci.bsky.social was used by authors in their Molecular Cell paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #OpenResearch #STMpublishing
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
Read the full paper: Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
doi.org
September 9, 2026 at 7:00 AM
RRID:AB_469457 from @thermofishersci.bsky.social was used by authors in their Molecular Cell paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #OpenResearch #STMpublishing
New preprint: in the last bit of my graduate work in the @voslab.org, we describe the mechanism for how BRD4 engages with P-TEFb in the context of regulating early RNA Pol II elongation. Read more here: www.biorxiv.org/content/10.6...
Structural basis for P-TEFb association with BRD4
Cyclin-dependent kinases (CDK) dynamically regulate RNA Polymerase (Pol) II during each stage of transcription. Phosphorylation of RNA Pol II and associated transcription factors by CDKs enables stage...
www.biorxiv.org
September 8, 2026 at 12:15 PM
New preprint: in the last bit of my graduate work in the @voslab.org, we describe the mechanism for how BRD4 engages with P-TEFb in the context of regulating early RNA Pol II elongation. Read more here: www.biorxiv.org/content/10.6...