#cGASSTING
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egastroenterology.bsky.social
⭐ Latest Perspective in #eGastroenterology

🔬 Prof. Wen-Xing Ding and his team from the University of Kansas Medical Center, USA, explore the dual role of megamitochondria in ALD. #Hepatology #ALD #Mitochondria #LiverCancer #cGASSTING

📖 Read it here: doi.org/10.1136/egastro-2026-100408
July 13, 2026 at 7:07 AM
castltrastondrs.medsky.network
Phosphorylation of the transcriptional regulator IRF3 and the expression of IFNB, which encodes a type I IFN, were abrogated in cGAS-deficient fused cells. Moreover, infection with VSV-SARSCoV2 also induced cell fusion, DNA damage, and cGASSTING- dependent expression of IFNB.
May 25, 2026 at 4:55 AM
castltrastondrs.medsky.network
as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...
rdcu.be
February 21, 2024 at 12:14 PM
moloncology.bsky.social
🔦 Have you seen our latest Commentary?

TREX1, a predator for treating MSI-H tumors?

🔓 buff.ly/MAOG3pB

#cGASSTING #ImmuneEvasion #CancerResearch
December 16, 2025 at 9:30 AM
scholargoggler.bsky.social
A word cloud based on Samuel K Campos's Google Scholar profile. Popular topics: human, papillomavirus, infection.
Cloud of words in various colors and sizes on a black background, arranged in the shape of a circle. Some of the largest words include human papillomavirus infection protein entry targeting trafficking adenoviral biotinylated sars-cov-2 vector hpv16 metabolically purification capsid cell genome sorting type adenovirus nexin pathway adaptor cgassting effects facilitates keratinocytes membrane mitotic proteins
November 12, 2024 at 8:07 AM
linglingtian.bsky.social
⬇️ review unpacks how radiotherapy can trigger abscopal immunity: turning local DNA damage into systemic tumor control. Link: buff.ly/4lXAUWK
#Radiotherapy #AbscopalEffect #Immunotherapy #Oncology #cGASSTING #IO #CancerResearch
January 21, 2026 at 8:15 AM
cp-trendsbiochem.bsky.social
Online now - the Forum "The interplay of the cGAS–STING pathway with the lysosome" from Yinfeng Xu and Wei Wan.

#InnateImmunity #Lysosome #cGASSTING

Read it here: authors.elsevier.com/a/1lpuN_M0e4...
September 24, 2025 at 1:04 AM
icis-stephanie.bsky.social
Four. Major. Awards. In One Year. 🤯
Dr. James Chen out collecting Lasker Awards & other prestigious prizes like Pokemon. His cGAS-STING discovery solved a 100-year-old immunity mystery!
Catch his keynote Nov 4th at Cytokines 2025!
buff.ly/nT5nD6E
#LaskerAward #cGASSTING #AwardSweep #InnateImmunity
October 1, 2025 at 7:02 PM
alicefrolov.bsky.social
LINE-1 Retrotransposon Derepression in Aging Tissues: Publication Trend Analysis (2015–2024)

#LINE1Retrotransposons #TransposableElements #EpigeneticAging #HeterchromatinErosion #cGASSTING #CellularSenescence #RepetitiveElementBiology #GenomicInstability
LINE-1 Retrotransposon Derepression in Aging Tissues: Publication Trend Analysis (2015–2024) The PubMed bibliometric data for LINE-1 retrotransposon derepression in aging tissues reveals a field that has undergone a discernible but restrained growth trajectory over the past decade, with an apparent plateau emerging after approximately 2021. Beginning at a low baseline of 3 publications in 2015, output remained modest and inconsistent through 2018, consistent with a pre-paradigmatic phase in which mechanistic frameworks—particularly those connecting heterochromatin erosion, loss of DNMT1/3a-mediated CpG methylation at L1 5' UTR promoters, and downstream innate immune activation via cGAS-STING—were still being consolidated from disparate lines of evidence. The notable inflection between 2018 and 2021, peaking at 8 publications, temporally correlates with several convergent developments: the demonstration that age-associated H3K9me3 depletion at L1 loci facilitates ORF1p and ORF2p expression in somatic tissues, the characterization of L1-derived reverse transcription intermediates as cGAS ligands, and the mechanistic linking of L1 reactivation to the sterile inflammatory phenotype characteristic of cellular senescence and the senescence-associated secretory phenotype (SASP). The stabilization at 6–8 publications annually from 2021 onward is analytically informative and warrants careful interpretation rather than dismissal. It does not straightforwardly indicate decline or saturation of scientific interest. Rather, it may reflect a field entering a phase of methodological and conceptual consolidation, wherein the primary mechanistic axes—epigenetic derepression via loss of repressive chromatin marks, retrotransposition-competent versus retrotransposition-incompetent L1 element activity, nucleic acid sensing pathway engagement, and tissue-specific permissiveness to L1 expression during aging.
June 2, 2026 at 5:03 PM
genesndiseases.bsky.social
This review highlights how endo/exonucleases regulate #DNADamage repair, #genome stability, and #cGASSTING signaling, with controlled activity preventing #autoimmunity while excessive cleavage enhances #CancerImmunotherapy. #AutoimmuneDiseases

#OpenAccess: doi.org/10.1016/j.ge...
December 26, 2025 at 4:34 PM
natcellbio.nature.com
👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...
February 14, 2026 at 1:09 PM