🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
Redirecting
doi.org
May 20, 2025 at 8:07 AM
🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy
Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions
or difficult-to-replicate regions. This review delineates the pathways that generate,
stabilize, and process these i...
www.cell.com
March 22, 2026 at 3:39 AM
Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:39 PM
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social
SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression
Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in
doi.org
June 12, 2025 at 5:35 AM
New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social
as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...
rdcu.be
February 21, 2024 at 12:14 PM
as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
Just as the heart is essential for life, TopBP1 is crucial for cell survival.
Cells need nuclear actin to relocate harmful DNA damage to safe areas.
IGH - MPL France
#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch
Cells need nuclear actin to relocate harmful DNA damage to safe areas.
IGH - MPL France
#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch
February 14, 2025 at 2:52 PM
Just as the heart is essential for life, TopBP1 is crucial for cell survival.
Cells need nuclear actin to relocate harmful DNA damage to safe areas.
IGH - MPL France
#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch
Cells need nuclear actin to relocate harmful DNA damage to safe areas.
IGH - MPL France
#valentinesday #PhDstudent #cancer #dnadamage #dnarepair #replicationstress #nuclearactin #condensates #cancerresearch
FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
May 1, 2026 at 5:00 PM
FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
