Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and ...

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Gut microbes are known to modulate stress responsivity and behavior. Tofani et al. demonstrate that such modulations occur via the circadian system. The oscillations in gut microbiota composition regu...

The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...

Certain gut bacteria help to extend the reproductive lifespan of female mice, experiments show.

Nature - Certain gut bacteria help to extend the reproductive lifespan of female mice, experiments show.

Strain richness of gut microbiota ecosystems is a key characteristic underpinning engraftment in faecal microbiota transplantation, and could improve the design of defined live biotherapeuti...

Strain richness of gut microbiota ecosystems is a key characteristic underpinning engraftment in faecal microbiota transplantation, and could improve the design of defined live biotherapeuti...

Decreased cardiac output in heart failure leads to intestinal ischemia and increased permeability. Substantial changes occur in the gut microbiota, ch…

A bacterium from frog gut microbiota eliminated tumors in mice by selectively colonizing tumors and triggering both direct cell killing and immune-driven anticancer responses.

Despite the fundamental role of bacterial strain variation in gut microbiota function1–6, the number of unique strains of a species that can stably colonize the human intestine is still unknown for almost all species. Here we determine the strain richness (SR) of common gut species using thousands of sequenced bacterial isolates with paired metagenomes. We show that SR varies across species, is transferable by faecal microbiota transplantation, and is uniquely low in the gut compared with soil and lake environments. Active therapeutic administration of supraphysiologic numbers of strains per species increases recipient SR, which then converges back to the population average after dosing is ceased. Stratifying engraftment outcomes by high or low SR shows that SR predicts microbial addition or replacement in faecal transplants. Together, these results indicate that properties of the gut ecosystem govern the number of strains of each species colonizing the gut and thereby influence strain

This Review provides an overview of the interplay between host diet and the gut microbiota, and how this affects brain function.

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Abstract. Despite the importance of gut commensal microbiota to human health, there is little knowledge about their evolutionary histories, including their

Abstract. The success of fecal microbiota transplantation and live biotherapeutic products in preventing recurrent Clostridioides difficile infection demon

Fecal microbiota transplantation (FMT) therapies hold promise but suffer from variable transplantation efficiencies. Here, we examine microbiome spatiotemporal dynamics post-FMT with a super-colonizin...

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...