Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
June 4, 2025 at 7:10 PM
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
instructions and assembles proteins needed for life. Interrupting this process stops the cell from functioning. Manikomycin binds tightly to the ribosome and blocks a critical step. It prevents an important molecule from exiting the structure, halting protein production entirely. Without proteins,
September 28, 2026 at 4:08 PM
instructions and assembles proteins needed for life. Interrupting this process stops the cell from functioning. Manikomycin binds tightly to the ribosome and blocks a critical step. It prevents an important molecule from exiting the structure, halting protein production entirely. Without proteins,
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
go.nature.com/4v7ZeTt
Substrate selectivity of the human RNA m5C methyltransferase NSUN2 - Nature
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
go.nature.com
May 29, 2026 at 9:16 AM
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
go.nature.com/4v7ZeTt
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
a small molecule that can stop SARS-CoV-2 from replicating in cells. #immunologySky #MedSky
www.nature.com/artic...
1/5
a small molecule that can stop SARS-CoV-2 from replicating in cells. #immunologySky #MedSky
www.nature.com/artic...
1/5
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
Nature - The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.
www.nature.com
December 20, 2024 at 2:28 PM
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
a small molecule that can stop SARS-CoV-2 from replicating in cells. #immunologySky #MedSky
www.nature.com/artic...
1/5
a small molecule that can stop SARS-CoV-2 from replicating in cells. #immunologySky #MedSky
www.nature.com/artic...
1/5
Sitting in during my hobbit's physical and the doctor mentions "CMOT" and I can't think of anything but "Cut-me-own-Throat Dibbler"
She was talking about Catechol-O-methyltransferase not Discworld
She was talking about Catechol-O-methyltransferase not Discworld
Catechol-O-methyltransferase - Wikipedia
en.wikipedia.org
April 30, 2024 at 10:00 PM
Sitting in during my hobbit's physical and the doctor mentions "CMOT" and I can't think of anything but "Cut-me-own-Throat Dibbler"
She was talking about Catechol-O-methyltransferase not Discworld
She was talking about Catechol-O-methyltransferase not Discworld
I’m very happy to share the published version of our paper on the role of MET1 in wheat 🌾 🧬
It’s been really exciting to discover more about DNA methylation in wheat and it’s huge polyploid genome
doi.org/10.1093/jxb/...
It’s been really exciting to discover more about DNA methylation in wheat and it’s huge polyploid genome
doi.org/10.1093/jxb/...
Partial redundancy buffers deleterious effects of mutating DNA methyltransferase 1-1 (MET1-1) in polyploid wheat
Varying gene dosage through mutating DNA methyltransferase 1-1 (MET1-1 ) in polyploid wheat generates quantitative changes to CG methylation without the le
doi.org
April 8, 2025 at 7:36 AM
I’m very happy to share the published version of our paper on the role of MET1 in wheat 🌾 🧬
It’s been really exciting to discover more about DNA methylation in wheat and it’s huge polyploid genome
doi.org/10.1093/jxb/...
It’s been really exciting to discover more about DNA methylation in wheat and it’s huge polyploid genome
doi.org/10.1093/jxb/...
SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain | Nucleic Acids Research
#epigenetics #chromatin
academic.oup.com/nar/advance-...
#epigenetics #chromatin
academic.oup.com/nar/advance-...
SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain
Abstract. SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a major protein lysine methyltransferase trimethylating lysine 9 on histone
academic.oup.com
November 17, 2024 at 10:01 PM
SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain | Nucleic Acids Research
#epigenetics #chromatin
academic.oup.com/nar/advance-...
#epigenetics #chromatin
academic.oup.com/nar/advance-...
DFG proposal on methyltransferase degraders together with Eric Metzger funded! @uni-freiburg.de @dfg.de #PROTACs
July 23, 2026 at 6:07 AM
DFG proposal on methyltransferase degraders together with Eric Metzger funded! @uni-freiburg.de @dfg.de #PROTACs
"Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase"
www.nature.com/articles/s41....
www.nature.com/articles/s41....
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase - Nature
The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.
www.nature.com
December 13, 2024 at 12:58 PM
"Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase"
www.nature.com/articles/s41....
www.nature.com/articles/s41....
Another case of a tRNA modification enzyme with a modification independent role, here in aminoacylation #rnasky www.cell.com/molecular-ce...
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
Ali et al. report that multiple 12q-amplified genes collaborate with AKT in sarcomagenesis,
including METTL1. This oncogenic function of METTL1 is independent of its methyltransferase
activity. METTL1...
www.cell.com
March 23, 2025 at 11:21 AM
Another case of a tRNA modification enzyme with a modification independent role, here in aminoacylation #rnasky www.cell.com/molecular-ce...
Discovery of SARS-CoV-2 Nsp10-16 Methyltransferase Enzyme Inhibitors Offers Hope for Antiviral Treatments
www.thailandmedical.news/news/discove...
www.thailandmedical.news/news/discove...
Discovery of SARS-CoV-2 Nsp10-16 Methyltransferase Enzyme Inhibitors Offers Hope for Antiviral Treatments - Thailand Medical News
www.thailandmedical.news
March 20, 2025 at 12:38 AM
Discovery of SARS-CoV-2 Nsp10-16 Methyltransferase Enzyme Inhibitors Offers Hope for Antiviral Treatments
www.thailandmedical.news/news/discove...
www.thailandmedical.news/news/discove...
#MedSky🧪 #IDSky #drugdevelopment #Pharmasky #SkyRx This study identified uncharged, #noncovalent inhibitors of #SARSCoV2 NSP14 MTase with picomolar affinity & slow dissociation kinetics that bind to the viral cap
rdcu.be/d3BkN
rdcu.be/d3BkN
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
Nature - The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.
rdcu.be
December 15, 2024 at 7:29 AM
#MedSky🧪 #IDSky #drugdevelopment #Pharmasky #SkyRx This study identified uncharged, #noncovalent inhibitors of #SARSCoV2 NSP14 MTase with picomolar affinity & slow dissociation kinetics that bind to the viral cap
rdcu.be/d3BkN
rdcu.be/d3BkN
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 6:07 PM
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RNA translation in #cancer!
Check out this fun story about amplification of 12q13-15 leading to a quirky new role for METTL1.
Led by Alejandro Gutierrez, Richard Gregory and teams, and it was a pleasure to contribute ourselves!
#RNAsky
#Ribosome
#CANsky
#genomics
🧪
🧬 💻
www.cell.com/molecular-ce...
Check out this fun story about amplification of 12q13-15 leading to a quirky new role for METTL1.
Led by Alejandro Gutierrez, Richard Gregory and teams, and it was a pleasure to contribute ourselves!
#RNAsky
#Ribosome
#CANsky
#genomics
🧪
🧬 💻
www.cell.com/molecular-ce...
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
Ali et al. report that multiple 12q-amplified genes collaborate with AKT in sarcomagenesis,
including METTL1. This oncogenic function of METTL1 is independent of its methyltransferase
activity. METTL1...
www.cell.com
February 4, 2025 at 3:05 AM
Cap 2′-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Cap 2′-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity
Abstract. Non-obstructive azoospermia represents one of the most intractable forms of male infertility, with its onset frequently associated with meiotic a
academic.oup.com
July 9, 2026 at 2:28 PM
Cap 2′-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Using a dCas9 fused to a histone methyltransferase, @eahellerphd.bsky.social lab can manipulate histone methylation at specific locations in the mouse genome #ACNP2024
December 10, 2024 at 5:10 PM
Using a dCas9 fused to a histone methyltransferase, @eahellerphd.bsky.social lab can manipulate histone methylation at specific locations in the mouse genome #ACNP2024
📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification!
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltr...
elifesciences.org
January 9, 2025 at 2:36 PM
📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification!
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
A NAC transcription factor represses nicotine biosynthesis. Strangely, its DNA methylation level and expression went up in a DNA methyltransferase mutant.
From: onlinelibrary.wiley.com/doi/full/10....
#PlantSciences #SecMet
From: onlinelibrary.wiley.com/doi/full/10....
#PlantSciences #SecMet
Transcriptional Activation of NaNAC72 Suppresses Nicotine Biosynthesis in DNA Methyltransferase NaDRM2‐like2 Mutants of Nicotiana attenuata
Click on the article title to read more.
onlinelibrary.wiley.com
November 22, 2025 at 3:24 PM
A NAC transcription factor represses nicotine biosynthesis. Strangely, its DNA methylation level and expression went up in a DNA methyltransferase mutant.
From: onlinelibrary.wiley.com/doi/full/10....
#PlantSciences #SecMet
From: onlinelibrary.wiley.com/doi/full/10....
#PlantSciences #SecMet
239- 3-demethylubiquinone-9 3-O-methyltransferase
June 12, 2026 at 12:32 AM
239- 3-demethylubiquinone-9 3-O-methyltransferase
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase - Nature
The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported.
www.nature.com
December 12, 2024 at 5:08 PM
Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader
Protein arginine methyltransferase 5 (PRMT5) plays crucial roles in the regulation of various biological processes through the mono- and symmetric dimethylation of protein substrates. PRMT5 is overexp...
pubs.acs.org
May 16, 2025 at 11:03 AM
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader
Statement of Retraction: N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner
Bioengineered
doi.org/10.1080/21655979.2026.2728941
#RNAsky #RNAmods
Bioengineered
doi.org/10.1080/21655979.2026.2728941
#RNAsky #RNAmods
Statement of Retraction: N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner
Bioengineered
doi.org
October 2, 2026 at 1:21 PM
Statement of Retraction: N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner
Bioengineered
doi.org/10.1080/21655979.2026.2728941
#RNAsky #RNAmods
Bioengineered
doi.org/10.1080/21655979.2026.2728941
#RNAsky #RNAmods
IN BRIEF: “Two scoops, please!”: Twin cryo-EM structures of an Arabidopsis thaliana DNA methyltransferase (Jan Wilhelm Hübbers) doi.org/10.1093/plce... #PlantScience @aspbofficial
“Two scoops, please!”: Twin cryo-EM structures of an Arabidopsis thaliana DNA methyltransferase
If transcriptional enzymes such as RNA polymerases are vehicles on DNA roads, cytosine methylation is like placing cones on certain lanes: it slows or rero
doi.org
February 25, 2026 at 1:21 PM
IN BRIEF: “Two scoops, please!”: Twin cryo-EM structures of an Arabidopsis thaliana DNA methyltransferase (Jan Wilhelm Hübbers) doi.org/10.1093/plce... #PlantScience @aspbofficial
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux
Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.
www.science.org
September 18, 2025 at 7:02 PM
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.