The clinical vignette and findings raise a differential diagnosis of paraprotein-related glomerulopathy, fibrillary glomerulopathy, and type I cryoglobulinemia among others. The immunoperoxidase stain shown is a DNAJB9 stain that is specific and sensitive for fibrillary glomerulopathy.
What is this immunoperoxidase stain? For bonus points, what was found on electron microscopy?
#renalpath #kidneypath #pathology #renal
#renalpath #kidneypath #pathology #renal
October 20, 2026 at 3:10 PM
The clinical vignette and findings raise a differential diagnosis of paraprotein-related glomerulopathy, fibrillary glomerulopathy, and type I cryoglobulinemia among others. The immunoperoxidase stain shown is a DNAJB9 stain that is specific and sensitive for fibrillary glomerulopathy.
Used to donate blood here in the UK, but since being diagnosed with a paraprotein 3yrs ago, my blood has been shunned 😆 I miss the free biccies and that feeling of doing something useful.
September 11, 2026 at 11:52 PM
Used to donate blood here in the UK, but since being diagnosed with a paraprotein 3yrs ago, my blood has been shunned 😆 I miss the free biccies and that feeling of doing something useful.
- immunofluorescence. Because of this and other masked lesions (such as some cryoglobulinemic GNs and paraprotein-related GNs) predilection for staining with C3 only by routine immunofluorescence, we suggest paraffin retrieved immunofluorescence be done on all C3 only staining cases before a -
September 1, 2026 at 1:24 PM
- immunofluorescence. Because of this and other masked lesions (such as some cryoglobulinemic GNs and paraprotein-related GNs) predilection for staining with C3 only by routine immunofluorescence, we suggest paraffin retrieved immunofluorescence be done on all C3 only staining cases before a -
Review: Monoclonal and monotypic immunoglobulin-related kidney diseases in young people: literature review including evolving entities #openaccess
buff.ly/p8Q8wMq
buff.ly/p8Q8wMq
Monoclonal and monotypic immunoglobulin-related kidney diseases in young people: literature review including evolving entities - Pediatric Nephrology
Monoclonal gammopathy, paraprotein secreted by a clonal B-lymphoproliferative or plasma cell disorder, is quite rare in children and adolescents and may be transient. Kidney injury related to…
link.springer.com
August 27, 2026 at 5:01 PM
Review: Monoclonal and monotypic immunoglobulin-related kidney diseases in young people: literature review including evolving entities #openaccess
buff.ly/p8Q8wMq
buff.ly/p8Q8wMq
11/n #ECNeph
@drsumanbehera.bsky.social
@myadla.bsky.social
@theisn.org
Though a mild increase in paraprotein ratio , should we label as paraproteinemia or is there any other DD ?
@drsumanbehera.bsky.social
@myadla.bsky.social
@theisn.org
Though a mild increase in paraprotein ratio , should we label as paraproteinemia or is there any other DD ?
March 28, 2025 at 4:22 PM
11/n #ECNeph
@drsumanbehera.bsky.social
@myadla.bsky.social
@theisn.org
Though a mild increase in paraprotein ratio , should we label as paraproteinemia or is there any other DD ?
@drsumanbehera.bsky.social
@myadla.bsky.social
@theisn.org
Though a mild increase in paraprotein ratio , should we label as paraproteinemia or is there any other DD ?
New page on Myeloma and Monoclonal Gammopathy of Undetermined Significance (MGUS).Please note that – unlike CRP – an ESR will be raised with a paraprotein so important to remember as a first line test. Please see referral criteria for Myeloma USC here: apps.nhslothian.scot/refhelp/myel...
Myeloma and MGUS - RefHelp
Myeloma and Monoclonal Gammopathy of Undetermined Significance (MGUS) Multiple myeloma generally presents in those aged 60 or more, with a higher incidence in people of black ethnicity. It can be a di...
apps.nhslothian.scot
May 5, 2026 at 9:05 AM
New page on Myeloma and Monoclonal Gammopathy of Undetermined Significance (MGUS).Please note that – unlike CRP – an ESR will be raised with a paraprotein so important to remember as a first line test. Please see referral criteria for Myeloma USC here: apps.nhslothian.scot/refhelp/myel...
Most monotypic fibrillary glomerulopathy is not a MGRS lesion and is being removed from the MGRS classification. An exception though is heavy chain fibrillary GN, which can be driven by a monoclonal paraprotein.
By Dr. Nasr at @glomcon.org
By Dr. Nasr at @glomcon.org
May 25, 2025 at 4:12 PM
Most monotypic fibrillary glomerulopathy is not a MGRS lesion and is being removed from the MGRS classification. An exception though is heavy chain fibrillary GN, which can be driven by a monoclonal paraprotein.
By Dr. Nasr at @glomcon.org
By Dr. Nasr at @glomcon.org
@kdjhaveri Held a #flippedclassroom session re: #paraprotein #diseases for Core Conference today. Huge success! https://www.knewton.com/infographics/flipped-classroom/
Attention Required! | Cloudflare
www.knewton.com
December 9, 2024 at 10:05 PM
@kdjhaveri Held a #flippedclassroom session re: #paraprotein #diseases for Core Conference today. Huge success! https://www.knewton.com/infographics/flipped-classroom/
December 9, 2024 at 3:16 PM
This large study revealed that nearly 10% of pts w/ MGUS have multiple paraproteins. Findings show that different paraproteins reflect relatively independent disease processes & progression risk may be similar for those with multiple & single paraproteins 👉https://bit.ly/3OAqQxy
#MGUS #paraprotein
#MGUS #paraprotein
December 5, 2024 at 8:36 AM
This large study revealed that nearly 10% of pts w/ MGUS have multiple paraproteins. Findings show that different paraproteins reflect relatively independent disease processes & progression risk may be similar for those with multiple & single paraproteins 👉https://bit.ly/3OAqQxy
#MGUS #paraprotein
#MGUS #paraprotein
BRIEF REPORT Paraprotein-Induced Spurious Hypercalcaemia: Diagnostic Pitfalls in Two Cases by Nathan Lorde et al
EJE Volume 193, Issue 2, August 2025
Full article 👉 doi.org/10.1093/ejen...
ESE Members free via 👉 my.ese-hormones.org
#endocrinology #hypercalcaemia
EJE Volume 193, Issue 2, August 2025
Full article 👉 doi.org/10.1093/ejen...
ESE Members free via 👉 my.ese-hormones.org
#endocrinology #hypercalcaemia
October 21, 2025 at 4:16 PM
BRIEF REPORT Paraprotein-Induced Spurious Hypercalcaemia: Diagnostic Pitfalls in Two Cases by Nathan Lorde et al
EJE Volume 193, Issue 2, August 2025
Full article 👉 doi.org/10.1093/ejen...
ESE Members free via 👉 my.ese-hormones.org
#endocrinology #hypercalcaemia
EJE Volume 193, Issue 2, August 2025
Full article 👉 doi.org/10.1093/ejen...
ESE Members free via 👉 my.ese-hormones.org
#endocrinology #hypercalcaemia
8/
⚡️Low HDL⚡️
It's not uncommon to see a low HDL. But the presence of newly low HDL should raise the concern for a paraprotein.
Particularly when the HDL is undetectable!
https://pubmed.ncbi.nlm.nih.gov/15896728/
⚡️Low HDL⚡️
It's not uncommon to see a low HDL. But the presence of newly low HDL should raise the concern for a paraprotein.
Particularly when the HDL is undetectable!
https://pubmed.ncbi.nlm.nih.gov/15896728/
November 17, 2024 at 11:55 AM
8/
⚡️Low HDL⚡️
It's not uncommon to see a low HDL. But the presence of newly low HDL should raise the concern for a paraprotein.
Particularly when the HDL is undetectable!
https://pubmed.ncbi.nlm.nih.gov/15896728/
⚡️Low HDL⚡️
It's not uncommon to see a low HDL. But the presence of newly low HDL should raise the concern for a paraprotein.
Particularly when the HDL is undetectable!
https://pubmed.ncbi.nlm.nih.gov/15896728/
5/x clearly that did not make sense. Of note, the patient had had a ⬆️kappa 2660 mg/dL 3 mo prior. That sounded like the “hook” effect, artifactual low level of paraprotein driven by antigen excess https://pubmed.ncbi.nlm.nih.gov/29066226/
Cast Nephropathy and Deceptively Low Absolute Serum Free ...
Cast Nephropathy and Deceptively Low Absolute Serum Free ...
pubmed.ncbi.nlm.nih.gov
December 16, 2024 at 10:27 AM
5/x clearly that did not make sense. Of note, the patient had had a ⬆️kappa 2660 mg/dL 3 mo prior. That sounded like the “hook” effect, artifactual low level of paraprotein driven by antigen excess https://pubmed.ncbi.nlm.nih.gov/29066226/
Monoclonal-related neuropathies: diagnosis, prognosis, and outcomes
Monoclonal-related neuropathies: diagnosis, prognosis, and outcomes - PubMed
Monoclonal gammopathy is observed in approximately 10% of patients with peripheral neuropathy, which is particularly common in those with the immunoglobulin M monoclonal component. The diagnostic challenge lies in determining whether the neuropathy is causally related to the paraprotein or merely co …
pubmed.ncbi.nlm.nih.gov
December 15, 2025 at 6:15 PM
Monoclonal-related neuropathies: diagnosis, prognosis, and outcomes
OK #askrenal, how do I explain this 👇
Isotonic hyponatremia - we use ion selective electrodes as the method for measurement. No mannitol, IVIG, etc. Even if we didn't use direct ion selective electrodes, no paraprotein, hyperlipidemia, jaundice....
Isotonic hyponatremia - we use ion selective electrodes as the method for measurement. No mannitol, IVIG, etc. Even if we didn't use direct ion selective electrodes, no paraprotein, hyperlipidemia, jaundice....
November 17, 2024 at 12:03 AM
OK #askrenal, how do I explain this 👇
Isotonic hyponatremia - we use ion selective electrodes as the method for measurement. No mannitol, IVIG, etc. Even if we didn't use direct ion selective electrodes, no paraprotein, hyperlipidemia, jaundice....
Isotonic hyponatremia - we use ion selective electrodes as the method for measurement. No mannitol, IVIG, etc. Even if we didn't use direct ion selective electrodes, no paraprotein, hyperlipidemia, jaundice....
MCV normal.
No paraprotein.
Two populations of cells there..
And what about those neutrophils?
No paraprotein.
Two populations of cells there..
And what about those neutrophils?
November 19, 2024 at 11:11 AM
MCV normal.
No paraprotein.
Two populations of cells there..
And what about those neutrophils?
No paraprotein.
Two populations of cells there..
And what about those neutrophils?
Patients with a prothrombotic clinical course often associated with thrombocytopenia may have a monoclonal paraprotein, even at low levels, that activates platelets by binding to platelet factor 4. Read the Brief Report: nej.md/4gKmrUs
#MedSky #Hematology
#MedSky #Hematology
VITT-like Monoclonal Gammopathy of Thrombotic Significance | NEJM
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is associated with antibodies
that target platelet factor 4 (PF4) and are heparin-independent. VITT antibodies are
implicated in acute,...
nej.md
February 12, 2025 at 10:02 PM
Patients with a prothrombotic clinical course often associated with thrombocytopenia may have a monoclonal paraprotein, even at low levels, that activates platelets by binding to platelet factor 4. Read the Brief Report: nej.md/4gKmrUs
#MedSky #Hematology
#MedSky #Hematology
One of my favorite incidental/normal EM findings: crystalline pro-renin granules in JGA cells. No to be confused with any sort of paraprotein related processes. #renalpath #nephsky #pathsky
June 3, 2025 at 7:17 PM
One of my favorite incidental/normal EM findings: crystalline pro-renin granules in JGA cells. No to be confused with any sort of paraprotein related processes. #renalpath #nephsky #pathsky
When one paraprotein associated lesion is not enough. Concurrence of focal light chain cast nephropathy, monoclonal immunoglobulin deposition disease, and microangiopathy in a patient with plasma cell dyscrasia (igg-kappa). #renalpath #pathsky #nephsky
May 26, 2025 at 5:57 PM
When one paraprotein associated lesion is not enough. Concurrence of focal light chain cast nephropathy, monoclonal immunoglobulin deposition disease, and microangiopathy in a patient with plasma cell dyscrasia (igg-kappa). #renalpath #pathsky #nephsky
#BCMA as #Biomarker in #MM | Breaking Study at latest @bloodjournal.bsky.social
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Soluble B-cell maturation antigen levels for disease monitoring in oligosecretory and nonsecretory relapsed multiple myeloma
Key PointssBCMA correlates with %BMPC, total diffusion volume, circulating tumor cell, paraprotein levels, and changes in disease status in MM.sBCMA is use
ashpublications.org
January 30, 2025 at 5:06 PM
#BCMA as #Biomarker in #MM | Breaking Study at latest @bloodjournal.bsky.social
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinin, disialosyl antibody); IgM antibodies+chronic demyelinating neuropathy. Sensory ataxia, areflexia, bulbar+oculomotor weakness. Dr Siddik @AANmember pearl @theneurolander ...
December 1, 2024 at 8:34 AM
CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinin, disialosyl antibody); IgM antibodies+chronic demyelinating neuropathy. Sensory ataxia, areflexia, bulbar+oculomotor weakness. Dr Siddik @AANmember pearl @theneurolander ...
Had some wifi trouble during the lupus session. It was spirited.
We are back with paraprotein mediated kidney disease
Starting off with pathology, Dr Venesa Bijol from Arkana #GlomCon
We are back with paraprotein mediated kidney disease
Starting off with pathology, Dr Venesa Bijol from Arkana #GlomCon
September 24, 2025 at 9:18 PM
Had some wifi trouble during the lupus session. It was spirited.
We are back with paraprotein mediated kidney disease
Starting off with pathology, Dr Venesa Bijol from Arkana #GlomCon
We are back with paraprotein mediated kidney disease
Starting off with pathology, Dr Venesa Bijol from Arkana #GlomCon
Paraprotein–Related Kidney Disease Moving Points http://bit.ly/2bhQO9d @onconephrology @CJASN @CKINnews #onconephrology
December 16, 2024 at 6:47 AM
Paraprotein–Related Kidney Disease Moving Points http://bit.ly/2bhQO9d @onconephrology @CJASN @CKINnews #onconephrology
Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein http://www.ajkd.org/article/S0272-6386(16)30251-7/fulltext #onconephrology @CKINnews
December 16, 2024 at 6:27 AM
Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein http://www.ajkd.org/article/S0272-6386(16)30251-7/fulltext #onconephrology @CKINnews