#planarcellpolarity
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rink-lab.bsky.social
Proud to announce our epos on the multi-scale coordination of #cellpolarity and #planarcellpolarity at Featuring the formidable first authors @Soor88 and @meo0205, @TheGeneMyers and Azimzadeh labs and #planaria, of course. And 6 years of hard work :)
August 14, 2026 at 4:01 PM
haoyin.bsky.social
#EndothelialCell #PlanarCellPolarity

Mutated in Colorectal Cancer BioID interactome in EC▶️
Centriolar proteins +ROBO1 KEAP1 p62

EC MCC KO🐭Retina
⏬Vascularity
⏬Engaged sprouting tip cells (cell body orientation perpendicular to migration front)

#Angiogenesis 2026
link.springer.com/article/10.1...
July 4, 2026 at 10:29 AM
haoyin.bsky.social
α-Synuclein preformed fibrils spread from EC to Pericyte, with #TunnelingNanotube as one cellular approach

α-Syn PFF does Not⏫EC TNT#, but⏫TNT cargo trafficking via⏫EC Myo1d

Myo1D is a regulator of left-right asymmetry & #PlanarCellPolarity

#iScience 2023
www.cell.com/iscience/ful...
October 18, 2024 at 12:20 PM
haoyin.bsky.social
A surprising role of Vangl1/2 in Mesenchyme (not Epithelia) during🐭Lung #BranchingMorphologenesis

An amazing role of Vangl1/2 in Airway #SmoothMuscleCell Wrapping

CELSR1 & core #PlanarCellPolarity machinery may not function in🫁mesenchyme

#Development 2024
journals.biologists.com/dev/article/...
October 8, 2024 at 10:42 PM
haoyin.bsky.social
Vangl2, #PlanarCellPolarity protein, in Kidney Morphogenesis

Vangl2 lp/lp🐭
👉⏬Ureteric Budding/#BranchingMorphogenesis e13.5
👉Lack bush border/epithelial microvilli in proximal tubule e18.5
👉Smaller Glomerular tufts; loss of capillary loops

#HumMolGenet 2010
academic.oup.com/hmg/article/...
October 8, 2024 at 12:10 PM
haoyin.bsky.social
Vangl2 #PlanarCellPolarity in Coronary vascularization🫀

Vangl2 lp/lp🐭
1⃣Ectopic, dilated, tortuous coronary vessels e13.5 ~18.5
2⃣⏬epicardial EMT/inward migration e14.5
3⃣Thinned #SmoothMuscleCell coverage of intramyocardial coronary arteries

#CircRes 2008
www.ahajournals.org/doi/10.1161/...
October 7, 2024 at 7:47 PM
plosbiology.org
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
Schematic of how Vangl2 regulates cellular organization in both local and distant compartments through a vinculin-dependent mechanism. Left: Wildtype. Right: Localized Vangl2 deletion. The deletion of Vangl2 in either the greater epithelial ridge (GER) or the organ of Corti results in defects in cellular organization, such as the misorientation of hair cells and GER cells. These defects occur in the local and distant compartments, the latter via a vinculin-dependent process termed “compartment coupling”.
September 11, 2025 at 5:39 PM
plosbiology.org
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
Schematic of how Vangl2 regulates cellular organization in both local and distant compartments through a vinculin-dependent mechanism. Left: Wildtype. Right: Localized Vangl2 deletion. The deletion of Vangl2 in either the greater epithelial ridge (GER) or the organ of Corti results in defects in cellular organization, such as the misorientation of hair cells and GER cells. These defects occur in the local and distant compartments, the latter via a vinculin-dependent process termed “compartment coupling”.
September 11, 2025 at 1:34 PM
plosbiology.org
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
Schematic of how Vangl2 regulates cellular organization in both local and distant compartments through a vinculin-dependent mechanism. Left: Wildtype. Right: Localized Vangl2 deletion. The deletion of Vangl2 in either the greater epithelial ridge (GER) or the organ of Corti results in defects in cellular organization, such as the misorientation of hair cells and GER cells. These defects occur in the local and distant compartments, the latter via a vinculin-dependent process termed “compartment coupling”.
September 11, 2025 at 8:31 AM