This review highlights how VCP coordinates the cross-talk between the #Ubiquitin-#Proteasome system and #Autophagy in #Cancer, identifying it as a crucial regulatory axis and potential #TherapeuticTarget. @tulanemedicine.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 8, 2026 at 4:45 PM
This review highlights how VCP coordinates the cross-talk between the #Ubiquitin-#Proteasome system and #Autophagy in #Cancer, identifying it as a crucial regulatory axis and potential #TherapeuticTarget. @tulanemedicine.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 17, 2025 at 1:25 AM
ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Ninjurin-1 mediates cell lysis and PANoptosis-induced inflammation during #InfluenzaA virus infection, highlighting its potential as a #TherapeuticTarget & #Biomarker in #ViralPneumonia & #ViralSepsis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 26, 2025 at 11:00 PM
Ninjurin-1 mediates cell lysis and PANoptosis-induced inflammation during #InfluenzaA virus infection, highlighting its potential as a #TherapeuticTarget & #Biomarker in #ViralPneumonia & #ViralSepsis. @tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
March 9, 2026 at 6:01 PM
GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Scientists uncover nuclear droplets that link multiple #leukemias revealing new #therapeuticTarget.
@gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al
@cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...
@gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al
@cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...
Scientists uncover nuclear droplets that link multiple leukemias revealing new therapeutic target
A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow...
www.bcm.edu
November 4, 2025 at 4:48 PM
Scientists uncover nuclear droplets that link multiple #leukemias revealing new #therapeuticTarget.
@gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al
@cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...
@gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al
@cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...
The cryptic lncRNA-encoded microprotein TPM3P9 promotes #ccRCC tumorigenesis by driving #Oncogenic RNA splicing, revealing a novel regulatory mechanism and potential #TherapeuticTarget in #RenalCancer.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
April 23, 2026 at 7:00 AM
The cryptic lncRNA-encoded microprotein TPM3P9 promotes #ccRCC tumorigenesis by driving #Oncogenic RNA splicing, revealing a novel regulatory mechanism and potential #TherapeuticTarget in #RenalCancer.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Full-length #Transcriptome atlas of #GallbladderCancer reveals that ERBB2 alternative splicing mediates trastuzumab resistance in gallbladder cancer, highlighting alternative splicing as a key #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
May 10, 2026 at 3:30 PM
Full-length #Transcriptome atlas of #GallbladderCancer reveals that ERBB2 alternative splicing mediates trastuzumab resistance in gallbladder cancer, highlighting alternative splicing as a key #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This study reveals that #CREB1-induced #lncRNA LOC100270746 facilitates #GastricCancer progression through a DDX5/mTOR-dependent mechanism, establishing it as a promising #Biomarker and #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
February 10, 2026 at 7:00 AM
This study reveals that #CREB1-induced #lncRNA LOC100270746 facilitates #GastricCancer progression through a DDX5/mTOR-dependent mechanism, establishing it as a promising #Biomarker and #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This study shows that EBNA1 induces ADAR1-driven resistance to #Immunotherapy by suppressing dsRNA-mediated innate immune signaling, identifying a novel #TherapeuticTarget for EBV-positive malignancies.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
February 22, 2026 at 11:15 AM
This study shows that EBNA1 induces ADAR1-driven resistance to #Immunotherapy by suppressing dsRNA-mediated innate immune signaling, identifying a novel #TherapeuticTarget for EBV-positive malignancies.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Using #scRNAseq, researchers identified prolactin signaling as a key pathological driver and potent #TherapeuticTarget in #Adenomyosis, providing insights into disease-associated cellular and molecular alterations. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
June 1, 2026 at 5:37 AM
Using #scRNAseq, researchers identified prolactin signaling as a key pathological driver and potent #TherapeuticTarget in #Adenomyosis, providing insights into disease-associated cellular and molecular alterations. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Research shows that adipocyte-specific TMEM41B deficiency enhances bone formation and attenuates osteoporosis via the YY1–calreticulin axis, highlighting TMEM41B as a potential #TherapeuticTarget for bone loss.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 8, 2026 at 1:06 PM
Research shows that adipocyte-specific TMEM41B deficiency enhances bone formation and attenuates osteoporosis via the YY1–calreticulin axis, highlighting TMEM41B as a potential #TherapeuticTarget for bone loss.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
An in vivo genome-wide #CRISPR screen identified that NBL1 drives #OvarianCancer #Metastasis by mediating Jak/Stat3 signaling crosstalk, highlighting the NBL1–Jak/Stat3 axis as a promising #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
May 31, 2026 at 5:30 PM
An in vivo genome-wide #CRISPR screen identified that NBL1 drives #OvarianCancer #Metastasis by mediating Jak/Stat3 signaling crosstalk, highlighting the NBL1–Jak/Stat3 axis as a promising #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
C1orf122 promotes #HepatoCellularCarcinoma cell growth, proliferation, & migration, and suppresses #apoptosis via the SRPK1-PI3K/AKT/GSK3β axis, highlighting its potential as a diagnostic or #TherapeuticTarget for HCC. #biomarker #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
June 27, 2025 at 10:56 AM
C1orf122 promotes #HepatoCellularCarcinoma cell growth, proliferation, & migration, and suppresses #apoptosis via the SRPK1-PI3K/AKT/GSK3β axis, highlighting its potential as a diagnostic or #TherapeuticTarget for HCC. #biomarker #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#OpenAccess:
www.sciencedirect.com/science/arti...
Excessive #Inflammation during #InfluenzaA infection causes severe tissue damage.
This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget.
@tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget.
@tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
July 12, 2026 at 6:30 AM
Excessive #Inflammation during #InfluenzaA infection causes severe tissue damage.
This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget.
@tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget.
@tsinghuauniversity.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Reviewing the epidemiology of high-risk HPV (hr-HPV)-related cancers, the lifecycle and the oncogenic signaling pathways of hr-HPV, with a discussion on its role as a #Biomarker and anti-cancer #TherapeuticTarget. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
October 26, 2025 at 2:00 AM
Reviewing the epidemiology of high-risk HPV (hr-HPV)-related cancers, the lifecycle and the oncogenic signaling pathways of hr-HPV, with a discussion on its role as a #Biomarker and anti-cancer #TherapeuticTarget. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
How does glycogen accumulation influence #LiverCancer?
This study shows that the AKAP1–YTHDF2–G6PC pathway drives glycogen metabolic rewiring and #Hepatocarcinogenesis, highlighting AKAP1 as a promising #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that the AKAP1–YTHDF2–G6PC pathway drives glycogen metabolic rewiring and #Hepatocarcinogenesis, highlighting AKAP1 as a promising #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
August 2, 2026 at 11:30 AM
How does glycogen accumulation influence #LiverCancer?
This study shows that the AKAP1–YTHDF2–G6PC pathway drives glycogen metabolic rewiring and #Hepatocarcinogenesis, highlighting AKAP1 as a promising #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that the AKAP1–YTHDF2–G6PC pathway drives glycogen metabolic rewiring and #Hepatocarcinogenesis, highlighting AKAP1 as a promising #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
ZNF554 functions as a #TumorSuppressor in UCEC, inhibiting its progression by regulating the RBM5/WNT/beta-catenin signaling pathway, thus highlighting it as both a prognostic #Biomarker and a #TherapeuticTarget for UCEC.
Read: doi.org/10.1007/s115...
Read: doi.org/10.1007/s115...
January 23, 2026 at 12:35 PM
ZNF554 functions as a #TumorSuppressor in UCEC, inhibiting its progression by regulating the RBM5/WNT/beta-catenin signaling pathway, thus highlighting it as both a prognostic #Biomarker and a #TherapeuticTarget for UCEC.
Read: doi.org/10.1007/s115...
Read: doi.org/10.1007/s115...
New research identifies SLC45A4 as a pain gene, encoding a neuronal polyamine transporter that shows genetic association with human pain. #therapeutictarget #paintreatment www.nature.com/articles/s41...
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
September 15, 2025 at 3:51 PM
New research identifies SLC45A4 as a pain gene, encoding a neuronal polyamine transporter that shows genetic association with human pain. #therapeutictarget #paintreatment www.nature.com/articles/s41...
BMP4-mediated OPC–microglia crosstalk enhances Smad1/5/8–TREM2-driven microglial #Neuroprotection and reduces amyloid pathology, offering a promising #TherapeuticTarget in #AlzheimersDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
April 4, 2026 at 1:59 PM
BMP4-mediated OPC–microglia crosstalk enhances Smad1/5/8–TREM2-driven microglial #Neuroprotection and reduces amyloid pathology, offering a promising #TherapeuticTarget in #AlzheimersDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
miR-378 exacerbates #Osteoporosis (OP) post-ovariectomy by enhancing NF-kB-mediated osteoclastogenesis and TGFβ-mediated #osteogenesis impairment, thus establishing it as prognostic & #TherapeuticTarget in OP treatment. #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
July 11, 2025 at 5:56 PM
miR-378 exacerbates #Osteoporosis (OP) post-ovariectomy by enhancing NF-kB-mediated osteoclastogenesis and TGFβ-mediated #osteogenesis impairment, thus establishing it as prognostic & #TherapeuticTarget in OP treatment. #medsky
#OpenAccess:
#OpenAccess:
Researchers discover that rapid transcriptional elongation and pause release induced by SEC-driven RNA pol II promote endothelial plasticity & plaque vulnerability, offering a #TherapeuticTarget for #Atherosclerosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 20, 2026 at 12:45 PM
Researchers discover that rapid transcriptional elongation and pause release induced by SEC-driven RNA pol II promote endothelial plasticity & plaque vulnerability, offering a #TherapeuticTarget for #Atherosclerosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
🚀🧠 Breakthrough: The #kynurenine pathway 🧬💡 could unlock #Therapies for #Brain energy loss ⚡🔋 in psychiatric & neuro disorders! 🩺🌍 #Innovation #TherapeuticTarget #Neuropsychiatry
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration
Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production...
doi.org
December 9, 2025 at 6:52 AM
🚀🧠 Breakthrough: The #kynurenine pathway 🧬💡 could unlock #Therapies for #Brain energy loss ⚡🔋 in psychiatric & neuro disorders! 🩺🌍 #Innovation #TherapeuticTarget #Neuropsychiatry
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
This review highlights new insights into GATA6 function in #Pancreas #Physiology and PDA pathogenesis, underscoring its potential as a biomarker and #TherapeuticTarget. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 10, 2025 at 7:33 AM
This review highlights new insights into GATA6 function in #Pancreas #Physiology and PDA pathogenesis, underscoring its potential as a biomarker and #TherapeuticTarget. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
m6A-modified circArhgap26 attenuates cardiac I/R injury by suppressing plakophilin-1 palmitoylation, maintaining desmosome integrity and #Cardiomyocyte survival, offering a novel #TherapeuticTarget in #MyocardialInjury.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
March 29, 2026 at 11:15 AM
m6A-modified circArhgap26 attenuates cardiac I/R injury by suppressing plakophilin-1 palmitoylation, maintaining desmosome integrity and #Cardiomyocyte survival, offering a novel #TherapeuticTarget in #MyocardialInjury.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
The UCHL5–HSPA5–MYC feedback loop promotes #ProstateCancer #Metastasis by suppressing #ERstress-mediated #Anoikis and activating Wnt/β-catenin signaling, highlighting a potential #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 2, 2026 at 5:10 PM
The UCHL5–HSPA5–MYC feedback loop promotes #ProstateCancer #Metastasis by suppressing #ERstress-mediated #Anoikis and activating Wnt/β-catenin signaling, highlighting a potential #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...