In recent years, non-typhoidal Salmonella (NTS) infections have become a considerable threat to public health. This pathogen has increased in incidence and i...

In sub-Saharan Africa, typhoidal and non-typhoidal Salmonella (NTS) are leading causes of invasive disease among young children. Trivalent Salmonella conjugate vaccine (TSCV) consists of Vi capsule polysaccharide conjugated to tetanus toxoid and core-plus-O-polysaccharides from the two most prevalent invasive NTS serovars conjugated to flagellin subunits. We conducted a first-in-human, randomized, placebo-controlled, phase 1 trial evaluating the safety and immunogenicity of TSCV. A total of 22 healthy adults aged 18−45 years were randomly allocated to 6.25-µg TSCV (n = 8), 12.5-µg TSCV (n = 10) or placebo (n = 4). The primary objective was the assessment of safety. The co-primary immunogenicity objective was the serum IgG response against the three vaccine polysaccharides and two flagellin carrier proteins. Here we show that TSCV was safe and well tolerated, meeting the prespecified safety endpoints, with the most common solicited symptom being short-lived injection site pain. For each

In recent years, non-typhoidal Salmonella (NTS) infections have become a considerable threat to public health. This pathogen has increased in incidence and i...

Salmonella enterica is a widespread pathogen of major global health relevance, with over 2,500 serovars classified into non-typhoidal and typhoidal groups. Within the typhoidal group, S. enterica Para...

Salmonella is a significant public health pathogen responsible for a wide spectrum of diseases, ranging from gastroenteritis to invasive non-typhoidal salmonellosis (iNTS) and enteric fever. Although ...

The Trivalent Salmonella Conjugate Vaccine (TSCV), which simultaneously addresses typhoid fever and foodborne illness caused by non-typhoidal Salmonella enterica, elicited strong immune response in 10...

Non-typhoidal Salmonella serovars primarily cause gastrointestinal infections but can also lead to bacteremia through mechanisms that are not completely elucidated. Here we show that the outer membran...

In a randomized, placebo-controlled, stepwise dose-escalation phase 1 trial evaluating a conjugate vaccine against both typhoid and invasive non-typhoidal Salmonella infections, the vaccine was found to be safe and immunogenic in healthy adults.

AlertX verified 358 cases of non-typhoidal salmonellosis in Hungary over the last 90 days, with a steady trend across reporting countries.

Non-typhoidal Salmonella serovars, such as Salmonella enterica serovar Typhimurium (STm), are a leading cause of inflammatory diarrhea in otherwise healthy individuals. Among children, the elderly, an...

Salmonella is a significant public health pathogen responsible for a wide spectrum of diseases, ranging from gastroenteritis to invasive non-typhoidal salmonellosis and enteric fever. Although advance...

Evaluating temporal trends in foodborne outbreak and illness attribution to specific food types is important for understanding which foods may be emerging as sources of illness and whether prevention ...