Epigenetics Update - 4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development u.epigenome.us/UdF01QJG
Huiqing Jiang, Tingting Li, & Jia Wang in Nature Cell Biol
#Epigenetics #Cancer #LiverCancer #4Dnucleome
---
Gain deeper insight; epigenometech.com
Huiqing Jiang, Tingting Li, & Jia Wang in Nature Cell Biol
#Epigenetics #Cancer #LiverCancer #4Dnucleome
---
Gain deeper insight; epigenometech.com
4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development - Nature Cell Biology
Xie, Tan, Mo and colleagues show that a liver-specific bipartite structure of the active X chromosome is lost early in hepatocarcinogenesis in mice and humans, driving X-linked gene activation and premalignant transformation, particularly in males.
u.epigenome.us
September 16, 2026 at 11:57 AM
Epigenetics Update - 4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development u.epigenome.us/UdF01QJG
Huiqing Jiang, Tingting Li, & Jia Wang in Nature Cell Biol
#Epigenetics #Cancer #LiverCancer #4Dnucleome
---
Gain deeper insight; epigenometech.com
Huiqing Jiang, Tingting Li, & Jia Wang in Nature Cell Biol
#Epigenetics #Cancer #LiverCancer #4Dnucleome
---
Gain deeper insight; epigenometech.com
New Epigenome Technologies Blog post! bit.ly/4rMNtAH
"New Efforts from the 4D Nucleome Project Report More Details of the Dynamic 3D Genome Organization"
#EpigenomeTech #Blog #Epigenetics #4DNucleome
"New Efforts from the 4D Nucleome Project Report More Details of the Dynamic 3D Genome Organization"
#EpigenomeTech #Blog #Epigenetics #4DNucleome
February 26, 2026 at 8:30 PM
New Epigenome Technologies Blog post! bit.ly/4rMNtAH
"New Efforts from the 4D Nucleome Project Report More Details of the Dynamic 3D Genome Organization"
#EpigenomeTech #Blog #Epigenetics #4DNucleome
"New Efforts from the 4D Nucleome Project Report More Details of the Dynamic 3D Genome Organization"
#EpigenomeTech #Blog #Epigenetics #4DNucleome
New preprint 🧠🧬
Post-stroke gene activity follows a genome hierarchy:
• New TADs scaffold transcription
• Loops work only in permissive TADs
• Compartments guide noncoding RNAs
🔗 www.biorxiv.org/content/10.6...
#4DNucleome #Chromatin #Stroke #HiC #Neurogenomics
Post-stroke gene activity follows a genome hierarchy:
• New TADs scaffold transcription
• Loops work only in permissive TADs
• Compartments guide noncoding RNAs
🔗 www.biorxiv.org/content/10.6...
#4DNucleome #Chromatin #Stroke #HiC #Neurogenomics
https://www.biorxiv.org/content/10.64898/2026.01.28.702387v1�
February 17, 2026 at 5:20 PM
New preprint 🧠🧬
Post-stroke gene activity follows a genome hierarchy:
• New TADs scaffold transcription
• Loops work only in permissive TADs
• Compartments guide noncoding RNAs
🔗 www.biorxiv.org/content/10.6...
#4DNucleome #Chromatin #Stroke #HiC #Neurogenomics
Post-stroke gene activity follows a genome hierarchy:
• New TADs scaffold transcription
• Loops work only in permissive TADs
• Compartments guide noncoding RNAs
🔗 www.biorxiv.org/content/10.6...
#4DNucleome #Chromatin #Stroke #HiC #Neurogenomics
Epigenetics News - Scientists map the human genome in 4D bit.ly/49qF65S
"Study is a landmark effort to understand how DNA's physical structure influences human biology"
#Epigenetics #News #4DNucleome
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Discover the breakthrough at epigenometech.com
"Study is a landmark effort to understand how DNA's physical structure influences human biology"
#Epigenetics #News #4DNucleome
---
Discover the breakthrough at epigenometech.com
Scientists map the human genome in 4D
Study is a landmark effort to understand how DNA’s physical structure influences human biology
bit.ly
January 12, 2026 at 1:29 PM
Epigenetics News - Scientists map the human genome in 4D bit.ly/49qF65S
"Study is a landmark effort to understand how DNA's physical structure influences human biology"
#Epigenetics #News #4DNucleome
---
Discover the breakthrough at epigenometech.com
"Study is a landmark effort to understand how DNA's physical structure influences human biology"
#Epigenetics #News #4DNucleome
---
Discover the breakthrough at epigenometech.com
Epigenetics Update - An integrated view of the structure and function of the human 4D nucleome go.nature.com/4aniupc
#Epigenetics #Nucelome #4DNucleome #Chromatin #ChromatinConformation
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Gain deeper insights into gene regulation; epigenometech.com
#Epigenetics #Nucelome #4DNucleome #Chromatin #ChromatinConformation
---
Gain deeper insights into gene regulation; epigenometech.com
December 18, 2025 at 8:01 AM
Epigenetics Update - An integrated view of the structure and function of the human 4D nucleome go.nature.com/4aniupc
#Epigenetics #Nucelome #4DNucleome #Chromatin #ChromatinConformation
---
Gain deeper insights into gene regulation; epigenometech.com
#Epigenetics #Nucelome #4DNucleome #Chromatin #ChromatinConformation
---
Gain deeper insights into gene regulation; epigenometech.com
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
lacaixafoundation.org
November 26, 2025 at 8:56 AM
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Happy to share our recent publication on benchmarking peak calling methods for CUT&RUN.
academic.oup.com/bioinformati...
Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social
#Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome
academic.oup.com/bioinformati...
Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social
#Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome
July 16, 2025 at 6:14 PM
Happy to share our recent publication on benchmarking peak calling methods for CUT&RUN.
academic.oup.com/bioinformati...
Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social
#Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome
academic.oup.com/bioinformati...
Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social
#Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome
Aficionados of #3DGenomics / #4DNucleome, please share this piece with friends 🙏🏼
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Geometric Diagrams of Genomes: constructing a visual grammar for 3D genomics - Genome Biology
Advances in the field of three-dimensional (3D) genomics have revealed an ever-expanding array of architectural features that were unknown only a few years ago. Just as ribbon diagrams integrate spati...
genomebiology.biomedcentral.com
June 27, 2025 at 8:24 AM
Aficionados of #3DGenomics / #4DNucleome, please share this piece with friends 🙏🏼
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
This has been a great collaboration with many people and institutions. Many thanks to all specially Carla Molins and the team at #ELISAVA.
If you are interested in details, send us an email and we can talk. We would love to start seeing this in 3D genome browsers 👏🏼
#3DGenome #4DNucleome
If you are interested in details, send us an email and we can talk. We would love to start seeing this in 3D genome browsers 👏🏼
#3DGenome #4DNucleome
June 27, 2025 at 8:17 AM
This has been a great collaboration with many people and institutions. Many thanks to all specially Carla Molins and the team at #ELISAVA.
If you are interested in details, send us an email and we can talk. We would love to start seeing this in 3D genome browsers 👏🏼
#3DGenome #4DNucleome
If you are interested in details, send us an email and we can talk. We would love to start seeing this in 3D genome browsers 👏🏼
#3DGenome #4DNucleome
Thanks to the large consortia like ENCODE, FANTOM5, GTEx, 4DNucleome for generating key training data. And finally, thanks to numerous researchers developing inspiring DNA sequence-to-function models, informative evaluations, and interpretation tools.
June 25, 2025 at 2:29 PM
Thanks to the large consortia like ENCODE, FANTOM5, GTEx, 4DNucleome for generating key training data. And finally, thanks to numerous researchers developing inspiring DNA sequence-to-function models, informative evaluations, and interpretation tools.
Our agenda has been finalized for this week’s exciting 4DNucleome Virtual Day, held via Zoom Friday, May 9. Hear from a wide variety of academic & industry speakers during this deep dive into four dimensions of the epigenome. Register now! bit.ly/4DNsc4All
#4DNsc4All
#4DNsc4All
May 5, 2025 at 10:03 PM
Our agenda has been finalized for this week’s exciting 4DNucleome Virtual Day, held via Zoom Friday, May 9. Hear from a wide variety of academic & industry speakers during this deep dive into four dimensions of the epigenome. Register now! bit.ly/4DNsc4All
#4DNsc4All
#4DNsc4All
Thank you to the NIH and all of the 4DNucleome common fund staff for all they have done to support us, inspire us, and to bring us together.
We will need each other more than ever in the coming months as we stand for the future of basic science research.
We will need each other more than ever in the coming months as we stand for the future of basic science research.
December 14, 2024 at 5:04 PM
Thank you to the NIH and all of the 4DNucleome common fund staff for all they have done to support us, inspire us, and to bring us together.
We will need each other more than ever in the coming months as we stand for the future of basic science research.
We will need each other more than ever in the coming months as we stand for the future of basic science research.
Out here at the #4DNucleome meeting in San Diego with a poster on our recent preprint where we explore the impact of Pol 1 and Pol 2 transcriptional inhibition on mesoscale chromatin organization.
#3DGenome
December 13, 2024 at 2:41 PM
Out here at the #4DNucleome meeting in San Diego with a poster on our recent preprint where we explore the impact of Pol 1 and Pol 2 transcriptional inhibition on mesoscale chromatin organization.
#3DGenome
Finally, there is so much gratitude for support from
@NIMHgov, @NIH_NINDS, @cziscience, @4DNucleome, and our community in the 4DN that empowered me to do this work.(8/8)
@NIMHgov, @NIH_NINDS, @cziscience, @4DNucleome, and our community in the 4DN that empowered me to do this work.(8/8)
December 5, 2024 at 5:45 PM
Finally, there is so much gratitude for support from
@NIMHgov, @NIH_NINDS, @cziscience, @4DNucleome, and our community in the 4DN that empowered me to do this work.(8/8)
@NIMHgov, @NIH_NINDS, @cziscience, @4DNucleome, and our community in the 4DN that empowered me to do this work.(8/8)
#IntroWeek 5/7
Enough of papers 😅.
Some keywords that describe the work we do at marciuslab.org
Mainly:
#nucleus
#4DNucleome, #4Dnucleomics
#3Dgenome, #3Dgenomics
#chromatin
#epigenetics,
#generegulation, #geneexpression, #transcription
but also:
#microbiome
#spatialmicrobiome
#biogeography
Enough of papers 😅.
Some keywords that describe the work we do at marciuslab.org
Mainly:
#nucleus
#4DNucleome, #4Dnucleomics
#3Dgenome, #3Dgenomics
#chromatin
#epigenetics,
#generegulation, #geneexpression, #transcription
but also:
#microbiome
#spatialmicrobiome
#biogeography
November 18, 2024 at 1:14 PM
#IntroWeek 5/7
Enough of papers 😅.
Some keywords that describe the work we do at marciuslab.org
Mainly:
#nucleus
#4DNucleome, #4Dnucleomics
#3Dgenome, #3Dgenomics
#chromatin
#epigenetics,
#generegulation, #geneexpression, #transcription
but also:
#microbiome
#spatialmicrobiome
#biogeography
Enough of papers 😅.
Some keywords that describe the work we do at marciuslab.org
Mainly:
#nucleus
#4DNucleome, #4Dnucleomics
#3Dgenome, #3Dgenomics
#chromatin
#epigenetics,
#generegulation, #geneexpression, #transcription
but also:
#microbiome
#spatialmicrobiome
#biogeography
#IntroWeek 3/7
As the scientific community builds in @bsky.app ... we continue introducing what we do at marciuslab.org
Some of our articles on imaging the genome #3DGenome #4DNucleome #Imaging
www.nature.com/articles/s41...
journals.plos.org/plosgenetics...
www.nature.com/articles/s41...
As the scientific community builds in @bsky.app ... we continue introducing what we do at marciuslab.org
Some of our articles on imaging the genome #3DGenome #4DNucleome #Imaging
www.nature.com/articles/s41...
journals.plos.org/plosgenetics...
www.nature.com/articles/s41...
November 16, 2024 at 12:25 PM
#IntroWeek 3/7
As the scientific community builds in @bsky.app ... we continue introducing what we do at marciuslab.org
Some of our articles on imaging the genome #3DGenome #4DNucleome #Imaging
www.nature.com/articles/s41...
journals.plos.org/plosgenetics...
www.nature.com/articles/s41...
As the scientific community builds in @bsky.app ... we continue introducing what we do at marciuslab.org
Some of our articles on imaging the genome #3DGenome #4DNucleome #Imaging
www.nature.com/articles/s41...
journals.plos.org/plosgenetics...
www.nature.com/articles/s41...
Let me introduce our work -> marciuslab.org
Some may know what we do, others may not. We contribute to #3DGenomics & #4DNucleome fields. More recently we also work on #SpatialMicrobiomics.
I will post this once a day over a week. Science is here now, I think it is worth 😀. Sorry for the SPAM 😉.
Some may know what we do, others may not. We contribute to #3DGenomics & #4DNucleome fields. More recently we also work on #SpatialMicrobiomics.
I will post this once a day over a week. Science is here now, I think it is worth 😀. Sorry for the SPAM 😉.
Structural Genomics @ CNAG/CRG [home]
Structural Genomics at CNAG · CRG
marciuslab.org
November 14, 2024 at 12:12 PM
Let me introduce our work -> marciuslab.org
Some may know what we do, others may not. We contribute to #3DGenomics & #4DNucleome fields. More recently we also work on #SpatialMicrobiomics.
I will post this once a day over a week. Science is here now, I think it is worth 😀. Sorry for the SPAM 😉.
Some may know what we do, others may not. We contribute to #3DGenomics & #4DNucleome fields. More recently we also work on #SpatialMicrobiomics.
I will post this once a day over a week. Science is here now, I think it is worth 😀. Sorry for the SPAM 😉.
In this nice preprint the authors studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools. 👇🏽👇🏽👇🏽👇🏽
@Taihei Fujimori @BintuLab @boettigerlab @greenleaflab @4DNucleome.
www.biorxiv.org/content/10.1...
@Taihei Fujimori @BintuLab @boettigerlab @greenleaflab @4DNucleome.
www.biorxiv.org/content/10.1...
October 19, 2023 at 6:24 AM
In this nice preprint the authors studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools. 👇🏽👇🏽👇🏽👇🏽
@Taihei Fujimori @BintuLab @boettigerlab @greenleaflab @4DNucleome.
www.biorxiv.org/content/10.1...
@Taihei Fujimori @BintuLab @boettigerlab @greenleaflab @4DNucleome.
www.biorxiv.org/content/10.1...