Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.

A new way to protect against dementia.

Researchers discovered that a healthy low-carb diet and time-restricted eating, combined with moderate calorie restriction, offer significant weight loss and gut health benefits for overweight adults,...

Cutting calories doesn’t just slim you down—it also reduces cysteine, an amino acid that flips fat cells from storage mode to fat-burning mode. Researchers found that lowering cysteine sparks the conv...

Long-term calorie restriction may help preserve brain cell function and slow molecular signs of aging.

Wearing a weighted vest during a 6-month calorie-restricted weight loss program helped older adults with obesity regain less weight over 24 months compared to those on diet alone. This benefit may be ...

Study finds that combining caloric restriction with psychological interventions significantly alters the gut microbiome and improves stress-related mental health in women.

Abstract. Caloric restriction (CR) improves metabolic health and reduces the risk of aging-related vascular diseases. However, the systematic metabolic rep

What if you could stop aging? Tech millionaire Bryan Johnson is spending millions a year on "Blueprint," a radical, data-driven longevity protocol to do just that. With a team of doctors, a massive daily supplement stack, and a hyper-strict vegan diet, his goal is simple: "Don't Die." But is this the next evolution for humanity, or the obsessive quest of one man trying to outrun the inevitable? This podcast goes beyond the headlines to give you the complete, unvarnished story of the Blueprint protocol. We’ll dive into Johnson's official documentation and his core philosophy of "Zeroism"—the quest to bridge our fragile human existence to a superintelligent future. We'll explore the science, the supplements, and the ambitious goal of achieving "species maximization." Then, we pull back the curtain on the controversy. We'll take you inside the explosive Reddit discussions where healthcare professionals and critics question the healthiness of his methods, from extreme caloric restriction to his low body fat. We'll also examine the tough questions raised about his quality of life and the ethics of turning life extension into a commercial enterprise. Finally, we ask the question that affects us all: in a world of limited resources, what is the ecological and social cost of radically extended lifespans? Is Bryan Johnson a visionary pioneer showing us the future, or a cautionary tale about losing your life in the quest to save it? Subscribe now to join the ultimate debate on the future of human existence and decide for yourself.

Caloric restriction (CR) without malnutrition extends lif...

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