#Pericyte #TunnelingNanoTube

Pericyte-Astrocyte TNT ⏫by #OxygenGlucoseDeprivation
Pericyte-to-Astrocyte Mitochondria transfer occurs on dish (via TNT or direct contact) or in 3D #Assembloid (via TNT or not?🤔), likely⏬Astrocyte Apoptosis

#CellDeathDis 2022
www.nature.com/articles/s41...

Casein kinase 2 inhibitor, TBB as a novel #Senolytic

TBB quenches DDR in senescent cells▶️
⏫unrepaired DNA damage
⏫Apoptosis

in Zmpste24 KO🐭
extends lifespan (18->24 wk)
⏫trabecular bone vol
⏬#CellularSenescence in kidney spleen

#CellDeathDis 2024
www.nature.com/articles/s41...

PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation

SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment

#CellDeathDis 2022
www.nature.com/articles/s41...

#LncRNA #Autophagy #Atherosclerosis

ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy

Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux

#CellDeathDis 2025
www.nature.com/articles/s41...

#HGPS #Aortopathy

The age-related accumulation of immature Lamin A, #Progerin or Farnesyl-Prelamin A, ⏫Stretch-induced loss of aortic #SmoothMuscleCell

Comparative analysis among
1⃣LmnaG609G/+
2⃣Zmpste24-/-
3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭

#CellDeathDis 2025
www.nature.com/articles/s41...

#EndothelialCell Robo4
👉⏬irradiation-induced #EndMT
👉Modulates #HematopoieticStemProgenitorCell quiescence & lineage potentials

Evidence of bEND3🐭microvascular EC

Robo4-KD EC coculture▶️
HSPC ⏫G0 quiescence ⏫apoptosis
⏫Erythrocyte
⏫Megakaryocyte

#CellDeathDis 2024
www.nature.com/articles/s41...

Congrats to #jyoti_k_jaiswal, James Novak, and colleagues on their new #CellDeathDis paper: Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy. #Myoblue tinyurl.com/57p7p588

Comprehensive secretome profiling and CRISPR screen identifies SFRP1 as a key inhibitor of epidermal progenitor proliferation #CellDeathDis #MassSpec www.nature.com/articles/s41...