LightNews — News, ranked by scholars

@currentmedscience.bsky.social

Combination therapy shows promise in #schistosomiasis care.

YCHD and PZQ reduce #granulomatous inflammation and #fibrosis by inhibiting apoptosis and ER stress, offering therapeutic promise. #medsky

To read: doi.org/10.1007/s115...
#currentmedicalscience #Hepatology

Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice

September 23, 2026 at 2:15 AM

Current Medical Science

@currentmedscience.bsky.social

#mRNAVaccines hold promise in #Oncology.

This review highlights RNA design, lipid nanoparticle delivery, antigen encoding, and immunomodulators as strategies to overcome TME barriers in cancer #immunotherapy. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience

Development of mRNA Cancer Vaccines: Delivery Strategies and Immunogenicity Optimization

September 27, 2026 at 1:15 PM

Current Medical Science

@currentmedscience.bsky.social

This review highlights altered tryptophan #Metabolism in #obesity, underscoring its potential as a therapeutic target for metabolic and psychological comorbidities. #medsky

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#currentmedicalscience #ClinicalScience

Tryptophan Metabolism in Obesity: Pathways, Mechanisms, and Therapeutic Perspectives

September 25, 2026 at 7:00 AM

Current Medical Science

@currentmedscience.bsky.social

This review highlights #GutMicrobiota-derived metabolites as links between early-life exposures & diet and childhood #MetabolicDisorders. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #PediatricResearch #MetabolicHealth #Metabolomics #Pediatrics

Microbiota-Derived Metabolites in Developmental Programming: Bridging Early-Life Gut Microbiota to Childhood Metabolic Disorders

July 9, 2026 at 12:45 PM

Current Medical Science

@currentmedscience.bsky.social

By analyzing #CD8+, CD4+, NKT, and γδ T cells, this study underscores the promise of TCR‑T, #CART, and checkpoint inhibitors in achieving long‑term AML control and advancing future therapeutic strategies. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Oncology

T-Cell Responses and T-Cell-Based Therapy in Acute Myeloid Leukemia

September 26, 2026 at 2:30 PM

Current Medical Science

@currentmedscience.bsky.social

Reciprocal activation between S100A9 and TLR2 amplifies hypertrophic signaling in mechanically stretched #cardiomyocytes, exacerbating maladaptive remodeling and likely accelerating HF progression, highlighting therapeutic targets. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience

Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy

September 24, 2026 at 1:35 PM

Current Medical Science

@currentmedscience.bsky.social

Study links decreased Akkermansia with higher inflammatory risk in unstable angina, pointing to the microbiota’s role in disease & the need for mechanistic clarity. @2024_HUST

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#currentmedicalscience #ClinicalScience #GutMicrobiota

Association of Decreased Fecal Microbiota Akkermansia with Increased
High‑Sensitivity C‑Reactive Protein Levels in Patients with Unstable

September 25, 2026 at 1:02 PM

Current Medical Science

@currentmedscience.bsky.social

#Voclosporin marks a therapeutic advance in #LupusNephritis, improving remission rates, reducing #Proteinuria, and enabling low steroid regimens with safety and cost effectiveness. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Nephrology #AutoimmuneDisease

Does Voclosporin Redefine Lupus Nephritis Treatment? A Tri-Focal View of Efficacy, Safety, and Costs

July 15, 2026 at 7:15 AM

Current Medical Science

@currentmedscience.bsky.social

This review highlights how #optogenetics dissects neural mechanisms using light to precisely activate or inhibit specific neurons, combined with behavioral & #electrophysiological analyses. #medsky

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#currentmedicalscience #Neuroscience #Neurobiology

Application of Optogenetic Neuromodulation in Regulating Depression

September 13, 2026 at 2:15 PM

Current Medical Science

@currentmedscience.bsky.social

SAE drives high morbidity and mortality. This review shows how #lncRNAs modulate #inflammation, metabolism, and immune function — impacting the blood brain barrier and neurons. #medsky

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#currentmedicalscience #Neurobiology #Sepsis

Unveiling the Role of LncRNA in Sepsis-Associated Encephalopathy

September 18, 2026 at 7:00 AM

Current Medical Science

@currentmedscience.bsky.social

The #MUFA content of #Avocado oil varies by cultivar.

This study highlights metabolic promise but calls for standardization of therapeutic applications across cultivars. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #FoodScience #ClinicalNutrition

Avocado Oil: Recent Advances in Its Anti-diabetic Potential

September 22, 2026 at 1:15 PM

Current Medical Science

@currentmedscience.bsky.social

#OpenAccess review on metabolic regulation of macrophage polarization in #DiabeticKidneyDisease, detailing mechanisms & therapeutic strategies to mitigate #RenalInflammation & #Fibrosis. #medsky

See: doi.org/10.1007/s115...

#currentmedicalscience #Nephrology #Immunometabolism

Therapeutic Regulation of Macrophage Polarization for Diabetic Kidney Disease by Targeted Metabolic Reprogramming

July 11, 2026 at 1:02 PM

Current Medical Science

@currentmedscience.bsky.social

This review explores peptide advances & adoptive #immunotherapies and highlights that targeting HLA‑E may advance current treatments and improve #Cancer prognosis. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #CancerResearch #Immunotherapy

HLA-E as an Emerging Checkpoint and Biomarker in Personalized Cancer Immunotherapy

August 4, 2026 at 12:45 PM

Current Medical Science

@currentmedscience.bsky.social

The global burden of PAH is rising unevenly, with high SDI regions seeing more cases. The study calls for equitable resources and better diagnostics. #medsky

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#currentmedicalscience #Cardiology #HealthEquity #GlobalHealth

Global, Regional, and National Burden of Pulmonary Arterial Hypertension from 1990 to 2021 and Projections to 2040: A Systematic Analysis of Incidence, Mortality, and Disability-Adjusted Life Years

September 23, 2026 at 1:34 PM

Current Medical Science

@currentmedscience.bsky.social

Salivary HGA may serve as a non-invasive #Biomarker for #AlzheimersDisease.

Targeting HGA metabolism or the #BloodBrainBarrier offers promising strategies for early intervention. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Neuroscience #AlzheimersResearch

Homogentisic Acid Disrupts the Blood–Brain Barrier and Promotes Aβ Aggregation in Alzheimer’s Disease

July 29, 2026 at 7:00 AM

Current Medical Science

@currentmedscience.bsky.social

Evidence shows that #Safranal ameliorates #RenalDamage, #Inflammation, and #Podocyte injury in #MembranousNephropathy via #SIRT1 upregulation and #NFκB inhibition. #medsky

#OpenAccess: doi.org/10.1007/s115...

#currentmedicalscience #Nephrology #KidneyHealth #BiomedicalResearch

Safranal Ameliorates Renal Damage, Inflammation, and Podocyte Injury in Membranous Nephropathy via SIRT/NF-κB Signalling

August 13, 2026 at 12:45 PM

Current Medical Science

@currentmedscience.bsky.social

#COVID19 altered #BacterialEcology & resistance in LRTIs; stringent measures enabled drug-resistant strains, underscoring the need for continuous surveillance & reinforced #infectioncontrol. #medsky

Read: doi.org/10.1007/s115...

#currentmedicalscience #BiomedicalResearch

Changes in Bacterial Etiology and Antimicrobial Resistance of Lower Respiratory Tract Infections Following the COVID-19 Pandemic: A Five-Year Comparative Study in Central China

July 30, 2026 at 12:30 PM

Current Medical Science

@currentmedscience.bsky.social

Reduced #DNArepair & lower XPA/XPB expression are linked to higher #HNSCC risk. This study suggests that these NER #Biomarkers could provide a novel model for risk assessment. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #CancerResearch

Integrated DNA Repair Capacity and NER Gene Expression for Improving Risk Prediction in Head and Neck Squamous Cell Carcinoma

July 19, 2026 at 12:45 PM

Current Medical Science

@currentmedscience.bsky.social

This study demonstrates that #CHOP deficiency intensifies inflammation, epithelial #apoptosis, and injury in OAB mice by suppressing #ERStress, pointing to CHOP as a therapeutic axis. #medsky

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#currentmedicalscience #Urology

Chop Deficiency Exacerbates Cyclophosphamide-Induced Overactive Bladder via Impaired Macrophage Apoptosis

September 21, 2026 at 1:49 PM

Current Medical Science

@currentmedscience.bsky.social

This review highlights #sialylation as a key regulator of OC progression, metastasis, and drug resistance, pointing toward novel therapeutic strategies. #medsky

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#currentmedicalscience #Oncology #Glycosylation

Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles

September 14, 2026 at 1:20 PM

Current Medical Science

@currentmedscience.bsky.social

This study summarizes the role of #TranscriptionFactors in #ALD pathology—from lipid metabolism to ER stress—and highlights promising targeted therapies for ALD treatment. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Hepatology #Epigenetics