#EPCAM
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stowersinstitute.bsky.social
This week's beautiful #MicroscopyMonday shows a killifish larva after hatching, transgenic for a fluorescent epithelial marker (EPCAM, magenta) and a lateral line marker (she, cyan). @aurhin.bsky.social (Piotrowski Lab)
December 9, 2024 at 3:37 PM
fluorist.bsky.social
Dropping another one for #FluorescenceFriday #Valentine's.

FFPE Human Duodenum Tissue, EVOS M7000 20X. Primary antibody staining for P53, SMA, PCNA, EpCam, HLA-DR plus DAPI.
February 14, 2025 at 11:41 PM
stowersinstitute.bsky.social
This week's beautiful #MicroscopyMonday shows a #killifish larva after hatching, transgenic for a fluorescent epithelial marker (EPCAM, magenta) and a lateral line marker (she, cyan). 🔬 (Piotrowski Lab) #ResearchSky #SciSky
December 1, 2025 at 5:01 PM
biorxiv-devbio.bsky.social
EpCAM sustains crypt mechanics and prevents aberrant remodeling https://www.biorxiv.org/content/10.64898/2026.04.27.721034v1
April 30, 2026 at 9:30 PM
An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells

www.embopress.org/doi/full/10....
An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells | The EMBO Journal
imageimageCell adhesion and cell cortex contractility are important determinants of the morphogenetic properties of solid tissues, including tumours. This study shows that EpCAM and Trop2, two closely...
www.embopress.org
November 22, 2024 at 1:03 PM
stowersinstitute.bsky.social
This week's beautiful #MicroscopyMonday shows a #killifish larva after hatching, transgenic for a fluorescent epithelial marker (EPCAM, magenta) and a lateral line marker (she, cyan). 🔬 (Piotrowski Lab) #SciSky
June 23, 2025 at 4:21 PM
stemcell.com
Colorectal cancer #organoids are bridging the gap between stem cell research and therapeutic breakthroughs!

🟢 Ki67
🔴 EpCAM
🔵 DAPI

Are you using colorectal organoids in your research?
Immunofluorescence of colorectal organoids. Stained green: Ki67, red: EpCAM, and blue: DAPI.
September 5, 2025 at 3:12 PM
fluorist.bsky.social
TGIF and happy #fluorescencefriday.
Today it's FFPE human duodenum at 20x.
🔵Alexa Fluor 532 SMA
🟢Alexa Fluor 568 HLA-DR
🟣Alexa Fluor 647 PCNA
🔴Alexa Fluor 790 EpCAM
January 17, 2025 at 5:43 PM
oncodaily.bsky.social
Bispecific Antibody M701 Offers a Novel Treatment Option for Malignant Ascites

oncodaily.com/science/bisp...

#AdvancedBreastCancer #ColorectalCancer #M701 #GastricCancer #LungCancer #OvarianCancer #Antibody #ASCO24 #BispecificAntibody #Catumaxomab #EpCAM #ESMO #Immunotherapy#TargetedOncology
Bispecific Antibody M701 Offers a Novel Treatment Option for Malignant Ascites - OncoDaily
Bispecific Antibody M701 Offers a Novel Treatment Option for Malignant Ascites / Advanced Breast Cancer, advanced cancer, advanced colorectal cancer, Advanced
oncodaily.com
December 12, 2024 at 3:41 PM
trr241.bsky.social
In today´s #fluorescencefriday we see human colon with a lymphoid follicle stained for alpha smooth muscle actin, EpCAM, CD3 (T cells), CD20 (B cells), CD68 (macrophages) and CD11b (neutrophils and monocytes). In this image, fluorescent markers were played with -and forgot which ones they were.
July 18, 2025 at 11:27 AM
healthcare.nikon.com
🖼️ Image from @moffittnews.bsky.social shows a patient-derived xenograft model of ovarian cancer.

🔬 Imaging was performed using a Nikon AX R #Confocal #Microscope system. Cell nuclei are in blue, epithelial cells in green (EpCAM), infiltrating T cells in red (CD4), and actin in magenta.

#Microscopy
July 10, 2025 at 6:28 PM
vitex.f.cz.ap.brid.gy
The 24 years old Creative’s PD1001 (JR012 / EP800, USB 041e:400d) driver #backport for modern #linux #kernel is here!

• V4L2 capture (BGR24)
• Snapshot button → KEY_CAMERA
• DKMS #debian/#Ubuntu packages

https://github.com/VitexSoftware/epcam-pd1001

#linux #v4l2 #dkms #opensource #raspberrypi […]
Original post on f.cz
f.cz
September 21, 2026 at 7:56 PM
exceedhergrasp1.bsky.social
SLIDE TITLE: Shared Spatial Transcriptomic Programs Across Lesion Types High-resolution spatial transcriptomics identified the same basic tissue organization in ovarian and peritoneal endometriosis lesions: an EPCAM-positive epithelial core surrounded by MME-positive “close stroma” and then OGN-positive “far stroma.” UMAP plots show substantial overlap between ovarian and peritoneal samples. A correlation heatmap further indicates that gene-expression patterns group primarily by spatial cell compartment rather than by lesion location, supporting shared molecular programs across lesion types. PATHWAY ENRICHMENT: Both ovarian and peritoneal lesions show positive enrichment for sensory and neural processes, including: • Sensory perception of smell • Sensory perception of chemical stimulus • Detection of stimulus involved in sensory perception Ovarian lesions additionally show positive regulation of axon extension and negative enrichment for B-cell processes, including B-cell activation, B-cell-mediated immunity, and B-cell receptor signaling. Peritoneal lesions additionally show enrichment for synapse pruning and negative enrichment for lymphatic processes, including lymph-vessel morphogenesis, lymph-vessel development, and lymphangiogenesis. Overall, the data suggest that different anatomical lesion types share a conserved spatial architecture and sensory/neural transcriptional program, while retaining some site-specific immune and lymphatic features. CONTRIBUTORS: Elaheh Alizadeh, Brian White REFERENCE: Haney et al., 2026, *Nature Communications*, in press.
September 24, 2026 at 2:11 PM
haoyin.bsky.social
#CRISPR #GeneEditing of Lung basal stem cells in mice CFTR R553X/+

Lung SORT #LipidNanoparticle-#AdenosineBaseEditor
i.v. 10 d
50% NGFR+EpCAM+ Basal Stem cell edited!😎

How about AT2 & endothelial cells?😁

Daniel Siegwart lab #Science 2024
www.science.org/doi/10.1126/...
November 1, 2024 at 4:09 AM
hansclevers.bsky.social
📢Roche's Institute of Human Biology seeks 2 visionary scientific leaders: Head of Computational Biology & Head of Exploratory Biology. Drive pioneering research, shape scientific strategy and lead innovation at the crossroad of academia and industry!🔗https://go.roche.com/ls0un #organoids #TeamIHB
Image credit: Silvia Berger, Saba Rezakhani, Irineja Cubela (Roche's IHB) About the image: Kidney organoids with glomeruli - paraffin section stained for nuclei (blue). Glomerular markers: Nephrin (red) and Synaptopodin (green), and tubule marker EpCam (grey). Acquired with Nikon Ti2 25x water immersion objective.
December 20, 2024 at 3:04 PM
bettycjung.bsky.social
The National Comprehensive Cancer Network (NCCN) guidelines recommend genetic testing for ovarian cancer susceptibility genes (ATM, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, EPCAM, PALB2, RAD51C, and RAD51D) in individuals
July 21, 2025 at 10:28 PM
acir-org.bsky.social
Golubovskaya et al. showed that intratumoral delivery of an anti-human EpCAM-CD3 BiTE mRNA-LNP stops growth of only directly injected EpCAM+ human tumor xenografts in immuno-incompetent mice (with i.v. human T cells). bit.ly/3Typnha
September 18, 2026 at 11:45 AM
exceedhergrasp1.bsky.social
I'm paying so much attention to describing the images that I'm not able to really take note of what she's saying as well.

(Reminder for our early career researchers: never less than 1 minute per slide, and slides like this should take >1 min to describe and explain.)
SLIDE TITLE: Single Cell Atlas of Endometriosis PRESENTER: Yuliana Tan, PhD STUDY DESIGN: Samples included endometrial biopsies from control participants and patients with endometriosis, as well as peritoneal endometriosis and ovarian lesions from patients with rASRM stage III/IV disease. Hormonal-contraceptive treatment was matched between groups. MAIN FINDING: “Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues.” Single-cell RNA sequencing identified epithelial, stromal, endothelial, lymphocyte, and myeloid cell populations and their distinct transcriptional profiles. COMPARISON WITH BULK RNA SEQUENCING: Single-cell pseudo-bulk and bulk RNA-sequencing results were strongly correlated (ρ = 0.91), showing that the single-cell atlas captured much of the tissue’s biology. However, single-cell datasets reflected most—but not all—of the tissue composition. Missing or underrepresented populations included erythrocytes, adipocytes, muscle cells, and especially neurons or neuronal projections. The findings were also supported through transcript and ligand–receptor analyses, spatial proteomics, and HiPlex antibody-based proteomics. REFERENCE: Tan Y. et al., 2022, Nature Cell Biology The upper-left corner contains a photograph of Yuliana Tan, and the upper-right corner contains the “From Mechanisms to Medicine 2026” logo. SLIDE TITLE: Working Model PRESENTER: Caroline Haney, PhD, The Jackson Laboratory High-resolution spatial transcriptomics using 10x Genomics Visium HD revealed a shared, layered organization in both superficial peritoneal and ovarian endometriosis lesions: • A central epithelial compartment expressing EPCAM • A surrounding “close stroma” enriched for MME, also known as CD10 • A more distant “far stroma” enriched for OGN Spatial maps, marker-gene heatmaps, and multiplex protein imaging confirm that MME-positive fibroblasts cluster immediately around epithelial glands, while OGN-positive fibroblasts occupy tissue farther from the epithelial boundary. A distance plot shows the close-stroma signal highest near the gland and the far-stroma signal peaking farther away. The model indicates that endometriosis lesions are spatially organized microenvironments rather than uniform masses of cells. The broader study also maps immune-cell infiltration and distinct neuronal and macrophage populations, helping identify local cellular interactions that may contribute to lesion persistence and pain. REFERENCE: Haney et al., 2026, *Nature Communications*, in press; “High-Resolution Spatial Transcriptomics Reveals Fibroblast and Neuroimmune Microenvironments in Endometriosis Lesions.”
September 24, 2026 at 2:11 PM
mattokrebs.bsky.social
🎤 EpCAM REVIVAL!

lnkd.in/gGmJaq8W

EpCAM is back on center stage. This time with conditionally activated ADCs, smarter bispecifics, and even CAR Ts?

lnkd.in/gGmJaq8W
lnkd.in
May 24, 2025 at 7:26 PM
asimresearcher.bsky.social
A LncRNA panel within EpCAM-specific exosomes for noninvasive early diagnosing non-small cell lung cancer https://pubmed.ncbi.nlm.nih.gov/40223051/
April 14, 2025 at 10:48 AM
nmriley.bsky.social
We then took a deeper dive into our EpCAM data to look at what integrating bottom-up glycopeptide and intact glycoproteoform measurements can get us, and @emmajays.bsky.social helped us use @glycoshape.org to model how a glycoproteoform with two occupied N-glycosites might look like.
August 28, 2026 at 3:16 PM
stowersinstitute.bsky.social
This week's beautiful #MicroscopyMonday shows a #killifish larva after hatching, transgenic for a fluorescent epithelial marker (EPCAM, magenta) and a lateral line marker (she, cyan). 🔬 (Piotrowski Lab)
February 23, 2026 at 3:23 PM
dmmjournal.bsky.social
In this #EditorsChoice, Wu, @richardbartfai.bsky.social & co reveal gene regulatory mechanisms likely accounting for the observed differences in hepatocyte maturation between organoid-derived and primary cells, which may lead to improved hepatocyte differentiation protocols. doi.org/10.1242/dmm....
A human bile duct organoid derived from patient bile duct cells, stained in green for EPCAM, a marker of bile duct cells. DNA is stained in blue.
April 29, 2025 at 3:08 PM
rridrobot.bsky.social
The authors included RRIDs in their None paper! RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #STMpublishing
EpCAM-targeted near-infrared photoimmunotherapy (NIR-PIT) for the treatment of breast cancer
doi.org
August 17, 2025 at 7:00 AM
geiselbiofilm.bsky.social
New in JB: Kobayashi, Yamanaka et al. show that the serine protease of A. veronii cleaves pro-aerolysin into a hemolytically active toxin, to facilitate crossing the host epithelial barrier via targeting host EpCAM.
pubmed.ncbi.nlm.nih.gov/42429552/
@asm.org #JBacteriol @microsky.bsky.social
September 16, 2026 at 6:37 PM