What changed? #L1 affected the expression of genes/proteins in pathways linked to #HallmarksOfAging, including:
🧬 cell cycle & DNA damage (with flow validation)
⚙️ proteostasis
🧱 extracellular matrix
📡 immune signaling
🍽️ nutrient-sensing
3/7

New cell research: SIRT1 protects the genome by blocking "jumping genes" (LINE-1) from copying themselves elsewhere — a mechanistic clue behind a decade of sirtuin longevity research. Cell-based only so far, not yet in animals/people.
lifespan.io/a-mechanisti...

#GeroScience #HallmarksOfAging

Your DNA mutates every day. Repair slows with age → mutations pile up → some cell populations start to take over. A 2024 GeroScience review tracked this in blood stem cells.

This is hallmark #1: genomic instability.
🔗 link.springer.com/article/10.1007/s11357-024-01374-y

#HallmarksOfAging #AGE2026

Your DNA repair systems slow with age — letting damage accumulate. A 2025 Nature Reviews Drug Discovery paper argues we may soon be able to "supercharge" DNA repair to slow aging. Hallmark #1. pubmed.ncbi.nlm.nih.gov/40506534/

#HallmarksOfAging #AGE2026

Sulforaphane has long been praised for its anti-inflammatory and detox effects by experts like #MarkHyman and #RhondaPatrick.

But this gives us a much deeper insight:
It actually rejuvenates lysosomes — a key driver of mulitple #HallmarksofAging. 🧪

#IL15 #Longevity #HallmarksOfAging #MetabolicHealth #HealthLongevitySecrets (7/7)

The most-cited framework in aging research: 12 "hallmarks of aging," from genomic instability to cellular senescence to chronic inflammation — each a real target for intervention.
doi.org/10.1016/j.ce...

#HallmarksOfAging #GeroScience #Longevity

What happens when the body can't recover anymore?

The Integrative Hallmarks of Aging explain how small cracks become big problems.

🧠 Stem cell loss

🧹 Waste buildup

🦠 Gut imbalance

🎧 Listen to: What is Aging? – Hallmarks of Aging

#hallmarksofaging #longevity #guthealth

🎧 Our new episode is live!

Raghav & Macsue dive into the Hallmarks of Aging—from the 9 hallmarks described in 2013 to the expanded list of 12 in 2023.

What do these updates reveal about how we age?

Listen now & share your thoughts in our Spotify poll!

#DecodingLongevity #HallmarksOfAging

As the body’s repair systems slow, aging speeds up.

These are the final stages: stem cell loss, waste buildup, and gut imbalance.

🎧 Dive into the episode: What is Aging? – Hallmarks of Aging

#healthspan #hallmarksofaging #longevity

This one explains how aging begins deep inside our cells — in a way that’s easy to understand.

🎧 Listen to the full episode: What is Aging?

#longevity #hallmarksofaging #science

Tissue-specific accumulation of p16INK4a-expressing senescent cells during aging

The progressive accumulation of senescent cells — operationally defined by stable p16INK4a upregulation, irreversible cell cycle arrest.

#CellularSenescence #SASP #Senolytics #p16INK4a #HallmarksOfAging #Inflammaging

Tissue-specific telomere attrition kinetics across the human lifespan

Telomere length erosion proceeds at markedly heterogeneous rates across tissue compartments.

#Telomeres #TelomereAttrition #CellularSenescence #StemCellExhaustion #HallmarksOfAging #Geroscience #MolecularAging

Publication Volume Across Hallmarks of Aging (2024)

Horizontal bar chart quantifying approximate peer-reviewed publication output per hallmark category as defined by the López-Otín et al. 2023 updated framework.

#HallmarksOfAging #Epigenetics #CellularSenescence #Inflammaging #Autophagy

I am easily fascinated by #WordClouds and these are all about #aging! And then you get to see an atlas of the age-sensitive proteome (where are they, how much, protein interactions) #KaiZhou @buckinstitute.org #Yeast26 @genetics-gsa.bsky.social #HallmarksOfAging

New peer-reviewed findings suggest tackling two hallmarks of aging at once may outperform single-target approaches.

Link as first comment.

#longevity #geroscience #hallmarksofaging #aging #research