Wang et al. summarize current knowledge on tumour innervation, neuro–immune crosstalk, and their metabolic basis, and discuss how neural regulation may shape #immunotherapy responses and offer new opportunities for precision immunomodulation in cancer.
doi.org/10.59717/j.x...
#immunemicroenvironment

A review on the role of #MDM2 in regulating the #ImmuneMicroenvironment, tumor #ImmuneEvasion, & hyperprogression during #immunotherapy, with insights on the application of MDM2 inhibitors in combination with immunotherapy in tumors with MDM2 overexpression. #medsky

www.sciencedirect.co...

This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells.

#OpenAccess: www.sciencedirect.com/science/arti...

This review explores the intricate interplay between different components of the #ImmuneMicroenvironment and the associated mechanisms in the #pathogenesis of #ADPKD, and summarizes the currently available & potential #Immunotherapeutic approaches. #RenalDysfunction #medsky

buff.ly/yR6zEod

The exocyst complex component EXOC6B is a key mediator of fungal-induced IL-33 secretion from pancreatic cancer cells, unraveling a novel mechanism by which the #TumorMycobiome modulates the #ImmuneMicroenvironment. @roswellpark.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

👀 for a #postdoc to join us. #Ttanslational #Radiobiology #Immunemicroenvironment If you're interested, get in touch @mcrcnews.bsky.social @uniofmanchester.bsky.social
www.jobs.manchester.ac.uk/Job/JobDetai...

This paper describes iAtlas, our open source #Shiny app for data exploration and discovery in the context of tumors and their interactions with the #immunemicroenvironment. This is a collaboration between #ISB,
#UNCChapelHill, and #SageBionetworks, funded by @CancerResearch 2/3

Can #proteomics explain #SCLC treatment differences?
Profiling revealed distinct subtypes and immune landscapes linked to prognosis and immunotherapy response, offering a path to personalized therapy. #ImmuneMicroenvironment
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

🏅Editor's Choice #Review
#Lipid Metabolism Reprogramming in Diffuse Large B-Cell Lymphoma (#DLBCL): Mechanisms and Treatment Strategies
🧑‍🔬Yue-E Ding, Yi-Ran Zhong et al.
Unlock🔓 www.mdpi.com/2072-6694/18...
#lymphoma #metabolism #ImmuneMicroenvironment #ferroptosis

Breakthrough research identifies immune system changes and RNA patterns that can predict which precancerous colorecta…

#Biomarkers #Cancerprevention #Colorectalcancer #Immunemicroenvironment #NoncodingRNA

#Biomarkers #Cancerprevention #Colorectalcancer #Immunemicroenvironment #NoncodingRNA

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Host-derived FSTL1 potentiates Ly6C+ monocytes /macrophages recruitment via the CD14/TLR4/NF-κB axis to modulate the hepatic #Fibrotic #ImmuneMicroenvironment, serving as a key #Biomarker for #MesenchymalStemCell therapy outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT study identified selective SAMHD1 depletion as a dual-action strategy to sensitize tumors to #Chemotherapy and prime the #ImmuneMicroenvironment, offering a novel approach to overcome therapeutic resistance.

#OpenAccess: doi.org/10.1038/s413...

FSTL1 promotes CCR2 recycling and early Ly6C⁺ monocyte/macrophage recruitment in the fibrotic #ImmuneMicroenvironment, thus showing potential as a biomarker of #StemCellTherapy response in #LiverCirrhosis. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This review highlights the critical role of the #ImmuneMicroenvironment in #ADPKD progression, detailing how immune cells, #inflammation, complement activation, and immune checkpoints like PD-1/PD-L1 contribute to #CystGrowth and #fibrosis.

#OpenAccess: doi.org/10.1016/j.ge...

#SingleCellSequencing in CML patients reveals expansion and diversity of #Tcell subsets and how the interaction between bone marrow microenvironment cells and T cell subsets influences #ImmuneMicroenvironment changes. #medsky
#MostRead

#OpenAccess:
buff.ly/b5ai8J0

Exciting read! Most downloaded article!

This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells. #ImmuneCheckpoint #medsky

#OpenAccess: buff.ly/KxlgQHt

This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells.

#OpenAccess: https://buff.ly/4alwIVf