Nature research paper: The integrated stress response promotes immune evasion through lipocalin 2
go.nature.com/3MR7cQv
go.nature.com/3MR7cQv
The integrated stress response promotes immune evasion through lipocalin 2 - Nature
The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several types of solid tumour by increasing anti-cancer immunity.
go.nature.com
February 19, 2026 at 5:37 PM
Nature research paper: The integrated stress response promotes immune evasion through lipocalin 2
go.nature.com/3MR7cQv
go.nature.com/3MR7cQv
Pink Floyd - When You're In
www.youtube.com/watch?v=lCn2...
www.youtube.com/watch?v=lCn2...
Pink Floyd - When You're In (Official Audio)
YouTube video by Pink Floyd
www.youtube.com
September 19, 2026 at 3:51 AM
Pink Floyd - When You're In
www.youtube.com/watch?v=lCn2...
www.youtube.com/watch?v=lCn2...
@amyxguo.bsky.social from New York, @liddelowsa.bsky.social lab, has characterized the LCN2 tdTomato mice that label reactive #astrocytes & reactive #endothelial cells. First timer at the #GRCGlia2025, she's done great asking good questions. Definitely one to follow 🔬🧬🍅✨ med.nyu.edu/faculty/shan...
March 13, 2025 at 6:12 PM
@amyxguo.bsky.social from New York, @liddelowsa.bsky.social lab, has characterized the LCN2 tdTomato mice that label reactive #astrocytes & reactive #endothelial cells. First timer at the #GRCGlia2025, she's done great asking good questions. Definitely one to follow 🔬🧬🍅✨ med.nyu.edu/faculty/shan...
An interesting example of #redoxepigenetics in the opposite direction whereby Nupr promoter demethylation drives iron sequestration by lipocalin-2 (lcn2) to reduce iron driven redox dependent cell death
After we reach advanced age, around 80, the propensity to develop cancer is markedly reduced. A discovery reported at Nature today about aged stem cells and iron insufficiency may help explain this advantage
www.nature.com/articles/d41...
www.nature.com/articles/d41...
December 4, 2024 at 11:19 PM
An interesting example of #redoxepigenetics in the opposite direction whereby Nupr promoter demethylation drives iron sequestration by lipocalin-2 (lcn2) to reduce iron driven redox dependent cell death
Bhagya Shree Choudhary, Sorab Dalal and colleagues discover that LCN2 promotes focal adhesion formation and invasion by stimulating c-Src activation.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
June 9, 2025 at 9:27 AM
Bhagya Shree Choudhary, Sorab Dalal and colleagues discover that LCN2 promotes focal adhesion formation and invasion by stimulating c-Src activation.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
This #ASNJASN study showed that while deletion of LCN2 changed interstitial iron deposition, it did not affect fibrosis or inflammation, suggesting LCN2 as a marker for toxic proteinopathy rather than a potential therapeutic target. #BasicResearch kidney.pub/JASN1077
April 14, 2026 at 6:30 PM
This #ASNJASN study showed that while deletion of LCN2 changed interstitial iron deposition, it did not affect fibrosis or inflammation, suggesting LCN2 as a marker for toxic proteinopathy rather than a potential therapeutic target. #BasicResearch kidney.pub/JASN1077
#Medsky 🧪 #IDsky #Immunosky #publichealth Using #transcriptomic & #proteomicprofiling, the study identified Lcn2 as one of the most highly upregulated proteins during #SARSCoV2 infection. Primarily produced by macrophages, Lcn2 was shown to be activated via the NLRP3 inflammasome pathway,
July 30, 2025 at 12:18 PM
#Medsky 🧪 #IDsky #Immunosky #publichealth Using #transcriptomic & #proteomicprofiling, the study identified Lcn2 as one of the most highly upregulated proteins during #SARSCoV2 infection. Primarily produced by macrophages, Lcn2 was shown to be activated via the NLRP3 inflammasome pathway,
mitochondrial dysfunction.
www.mdpi.com/1422-0067/26...
LCN2 is a biomarker altered in LC & associated with iron dysregulation & 5‑lipoxygenase activation
www.mdpi.com/1422-0067/24...
#NeuroCovid neuroinflammation operates through the same immune mechanisms LCN2 amplifies in other diseases,
www.mdpi.com/1422-0067/26...
LCN2 is a biomarker altered in LC & associated with iron dysregulation & 5‑lipoxygenase activation
www.mdpi.com/1422-0067/24...
#NeuroCovid neuroinflammation operates through the same immune mechanisms LCN2 amplifies in other diseases,
March 12, 2026 at 9:39 AM
mitochondrial dysfunction.
www.mdpi.com/1422-0067/26...
LCN2 is a biomarker altered in LC & associated with iron dysregulation & 5‑lipoxygenase activation
www.mdpi.com/1422-0067/24...
#NeuroCovid neuroinflammation operates through the same immune mechanisms LCN2 amplifies in other diseases,
www.mdpi.com/1422-0067/26...
LCN2 is a biomarker altered in LC & associated with iron dysregulation & 5‑lipoxygenase activation
www.mdpi.com/1422-0067/24...
#NeuroCovid neuroinflammation operates through the same immune mechanisms LCN2 amplifies in other diseases,
#Tumor-derived #LCN2 drives #LungCancer #BrainMetastasis via IL-1β feedback and SLC22A17–JAK2–STAT3–VEGF-A signaling; blocking STAT3 or VEGF-A suppresses growth, positioning LCN2 as a key #biomarker.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
February 13, 2026 at 3:04 PM
#Tumor-derived #LCN2 drives #LungCancer #BrainMetastasis via IL-1β feedback and SLC22A17–JAK2–STAT3–VEGF-A signaling; blocking STAT3 or VEGF-A suppresses growth, positioning LCN2 as a key #biomarker.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Kolon kanserinin tespiti için yeni biyobelirteçler belirlendi.
Yeni protein biyobelirteçleri kolorektal kanser teşhisini iyileştirme potansiyeline sahip.
Yakından ilişkili üç protein: TFF3, LCN2 ve CEACAM5
Yeni protein biyobelirteçleri kolorektal kanser teşhisini iyileştirme potansiyeline sahip.
Yakından ilişkili üç protein: TFF3, LCN2 ve CEACAM5
New biomarkers to detect Colorectal cancer - University of Birmingham
Health data research used to identify three new protein biomarkers with the potential to improve diagnostic tools for Colorectal cancer
www.birmingham.ac.uk
January 22, 2025 at 2:22 PM
Kolon kanserinin tespiti için yeni biyobelirteçler belirlendi.
Yeni protein biyobelirteçleri kolorektal kanser teşhisini iyileştirme potansiyeline sahip.
Yakından ilişkili üç protein: TFF3, LCN2 ve CEACAM5
Yeni protein biyobelirteçleri kolorektal kanser teşhisini iyileştirme potansiyeline sahip.
Yakından ilişkili üç protein: TFF3, LCN2 ve CEACAM5
Yes!!! LCN2 is best known as an anti-microbial peptide that helps fight microbial infection but it also directly helped promote skin scratch closure! LCN2 expression was partially dependent on Janus kinase/signal transducer and activator of transcription signalling.
July 22, 2025 at 3:06 PM
Yes!!! LCN2 is best known as an anti-microbial peptide that helps fight microbial infection but it also directly helped promote skin scratch closure! LCN2 expression was partially dependent on Janus kinase/signal transducer and activator of transcription signalling.
- In #sepsis models, LCN2 directly triggers neuronal loss & cognitive deficits; blocking LCN2 prevents them
@nature.com
www.nature.com/articles/s41...
www.dovepress.com/identificati...
-LCN2, Postoperative Neuroinflammation, and Persistent Symptoms
@nature.com
www.nature.com/articles/s41...
www.dovepress.com/identificati...
-LCN2, Postoperative Neuroinflammation, and Persistent Symptoms
LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments - Cell Death & Disease
Cell Death & Disease - LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments
www.nature.com
March 12, 2026 at 9:30 AM
- In #sepsis models, LCN2 directly triggers neuronal loss & cognitive deficits; blocking LCN2 prevents them
@nature.com
www.nature.com/articles/s41...
www.dovepress.com/identificati...
-LCN2, Postoperative Neuroinflammation, and Persistent Symptoms
@nature.com
www.nature.com/articles/s41...
www.dovepress.com/identificati...
-LCN2, Postoperative Neuroinflammation, and Persistent Symptoms
Let’s explore lipocalin-2 (LCN2)—a hormone linked to inflammation, aging, and metabolism. Recent research suggests exercise may lower its levels, but the story is nuanced. Here’s what we know and where questions remain. 🧵
January 26, 2025 at 2:30 PM
Let’s explore lipocalin-2 (LCN2)—a hormone linked to inflammation, aging, and metabolism. Recent research suggests exercise may lower its levels, but the story is nuanced. Here’s what we know and where questions remain. 🧵
-LCN2 amplifies glial activation & cytokine release
-LCN2 promotes pro‑inflammatory phenotypes in microglia & astrocytes, driving IL‑6, TNF‑α & IL‑1β release
@academic.oup.com
academic.oup.com/jleukbio/art...
-LCN2 promotes pro‑inflammatory phenotypes in microglia & astrocytes, driving IL‑6, TNF‑α & IL‑1β release
@academic.oup.com
academic.oup.com/jleukbio/art...
Frontiers | The interaction of lipocalin-2 and astrocytes in neuroinflammation: mechanisms and therapeutic application
Neuroinflammation is a common pathological process in various neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, and others....
www.frontiersin.org
March 12, 2026 at 9:30 AM
-LCN2 amplifies glial activation & cytokine release
-LCN2 promotes pro‑inflammatory phenotypes in microglia & astrocytes, driving IL‑6, TNF‑α & IL‑1β release
@academic.oup.com
academic.oup.com/jleukbio/art...
-LCN2 promotes pro‑inflammatory phenotypes in microglia & astrocytes, driving IL‑6, TNF‑α & IL‑1β release
@academic.oup.com
academic.oup.com/jleukbio/art...
But questions remain:
• Exercise broadly lowers inflammation, so reduced LCN2 could reflect this overall anti-inflammatory effect rather than direct modulation.
• Reverse causation: Does fitness lower LCN2, or does lower LCN2 enable better metabolic health?
• Exercise broadly lowers inflammation, so reduced LCN2 could reflect this overall anti-inflammatory effect rather than direct modulation.
• Reverse causation: Does fitness lower LCN2, or does lower LCN2 enable better metabolic health?
January 26, 2025 at 2:30 PM
But questions remain:
• Exercise broadly lowers inflammation, so reduced LCN2 could reflect this overall anti-inflammatory effect rather than direct modulation.
• Reverse causation: Does fitness lower LCN2, or does lower LCN2 enable better metabolic health?
• Exercise broadly lowers inflammation, so reduced LCN2 could reflect this overall anti-inflammatory effect rather than direct modulation.
• Reverse causation: Does fitness lower LCN2, or does lower LCN2 enable better metabolic health?
Exercise’s benefits extend across systems. Whether LCN2 is a driver or passenger, staying active improves healthspan. Let’s follow the science!
Full study here: academic.oup.com/jbm...
Full study here: academic.oup.com/jbm...
Circulating lipocalin-2 across the adult lifespan
Abstract. Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including card
academic.oup.com
January 26, 2025 at 2:31 PM
Exercise’s benefits extend across systems. Whether LCN2 is a driver or passenger, staying active improves healthspan. Let’s follow the science!
Full study here: academic.oup.com/jbm...
Full study here: academic.oup.com/jbm...
Targeting LCN2/NLRP3 axis inhibits pyroptosis and aids mitochondrial rescue, exerting dual anti-epileptic therapeutic effects through Tunneling nanotube-mediated astrocyte-neuron mitochondria transfer #neuroscience #tunnelingnanotubes #cell-cellcommunication
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Astrocytic LCN2 drives neuronal dysfunction in epilepsy by suppressing tunnel nanotube-mediated mitochondrial transfer via NLRP3 inflammasome activation
Epileptic seizures disrupt brain homeostasis not only by directly challenging neuronal excitability but also by impairing the intricate astrocyte-neur…
www.sciencedirect.com
January 16, 2026 at 9:51 AM
Targeting LCN2/NLRP3 axis inhibits pyroptosis and aids mitochondrial rescue, exerting dual anti-epileptic therapeutic effects through Tunneling nanotube-mediated astrocyte-neuron mitochondria transfer #neuroscience #tunnelingnanotubes #cell-cellcommunication
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Novel insights for GBA1-PD treatment strategies:
“GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️
nature.com/articles/s41...
“GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️
nature.com/articles/s41...
GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration - Cell Death & Differentiation
Cell Death & Differentiation - GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration
nature.com
April 1, 2026 at 10:31 AM
Novel insights for GBA1-PD treatment strategies:
“GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️
nature.com/articles/s41...
“GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️
nature.com/articles/s41...
suggesting LCN2 may perpetuate long‑term neuroinflammatory states.
🔥Mechanism by which LCN2 perpetuates postoperative, post-infectious, long COVID & sepsis-driven neuroinflammation and anxiety-like behavior
🔥Infection/stress/surgery → LCN2 upregulation (liver, microglia, astrocytes, neutrophils)
🔥Mechanism by which LCN2 perpetuates postoperative, post-infectious, long COVID & sepsis-driven neuroinflammation and anxiety-like behavior
🔥Infection/stress/surgery → LCN2 upregulation (liver, microglia, astrocytes, neutrophils)
March 12, 2026 at 9:39 AM
suggesting LCN2 may perpetuate long‑term neuroinflammatory states.
🔥Mechanism by which LCN2 perpetuates postoperative, post-infectious, long COVID & sepsis-driven neuroinflammation and anxiety-like behavior
🔥Infection/stress/surgery → LCN2 upregulation (liver, microglia, astrocytes, neutrophils)
🔥Mechanism by which LCN2 perpetuates postoperative, post-infectious, long COVID & sepsis-driven neuroinflammation and anxiety-like behavior
🔥Infection/stress/surgery → LCN2 upregulation (liver, microglia, astrocytes, neutrophils)
What about exercise? Studies suggest LCN2 may be modifiable:
• Resistance training (15 weeks): Reduced LCN2 and improved insulin sensitivity in postmenopausal women.
• Aerobic training (8 weeks): Lowered LCN2 and inflammatory markers in overweight/obese men.
• Resistance training (15 weeks): Reduced LCN2 and improved insulin sensitivity in postmenopausal women.
• Aerobic training (8 weeks): Lowered LCN2 and inflammatory markers in overweight/obese men.
January 26, 2025 at 2:30 PM
What about exercise? Studies suggest LCN2 may be modifiable:
• Resistance training (15 weeks): Reduced LCN2 and improved insulin sensitivity in postmenopausal women.
• Aerobic training (8 weeks): Lowered LCN2 and inflammatory markers in overweight/obese men.
• Resistance training (15 weeks): Reduced LCN2 and improved insulin sensitivity in postmenopausal women.
• Aerobic training (8 weeks): Lowered LCN2 and inflammatory markers in overweight/obese men.
How Exercise Fights Osteoporosis
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
February 18, 2026 at 2:30 PM
How Exercise Fights Osteoporosis
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
ARG also increased skin Anti-microbials like beta defensin and lipocalin that may help against infections. These were reduced if Arg was blocked and could be rescued by products of Arg Activity like putrescine
March 27, 2025 at 5:25 PM
ARG also increased skin Anti-microbials like beta defensin and lipocalin that may help against infections. These were reduced if Arg was blocked and could be rescued by products of Arg Activity like putrescine
In PTSD models, LCN2 overexpression in the PFC increases anxiety and fear behavior, while suppressing LCN2 reverses these behaviors
www.sciencedirect.com/science/arti...
Chronic neuropathic pain induces anxiety-like behavior, with inflammatory pathways similar to those modulated by LCN2
www.sciencedirect.com/science/arti...
Chronic neuropathic pain induces anxiety-like behavior, with inflammatory pathways similar to those modulated by LCN2
March 12, 2026 at 9:30 AM
In PTSD models, LCN2 overexpression in the PFC increases anxiety and fear behavior, while suppressing LCN2 reverses these behaviors
www.sciencedirect.com/science/arti...
Chronic neuropathic pain induces anxiety-like behavior, with inflammatory pathways similar to those modulated by LCN2
www.sciencedirect.com/science/arti...
Chronic neuropathic pain induces anxiety-like behavior, with inflammatory pathways similar to those modulated by LCN2
METTL1/USP48 Axis Stabilizes LCN2 Expression to Promote the Malignant Phenotypes of Cutaneous Squamous Cell Carcinoma
Applied biochemistry and biotechnology · Li et al.
doi.org/10.1007/s12010-026-05927-z
#RNAsky #RNAmods
Applied biochemistry and biotechnology · Li et al.
doi.org/10.1007/s12010-026-05927-z
#RNAsky #RNAmods
METTL1/USP48 Axis Stabilizes LCN2 Expression to Promote the Malignant Phenotypes of Cutaneous Squamous Cell Carcinoma
Applied biochemistry and biotechnology · Li X, Shu L, Li X, Du M.
doi.org
September 23, 2026 at 9:06 PM
METTL1/USP48 Axis Stabilizes LCN2 Expression to Promote the Malignant Phenotypes of Cutaneous Squamous Cell Carcinoma
Applied biochemistry and biotechnology · Li et al.
doi.org/10.1007/s12010-026-05927-z
#RNAsky #RNAmods
Applied biochemistry and biotechnology · Li et al.
doi.org/10.1007/s12010-026-05927-z
#RNAsky #RNAmods