☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown.
bit.ly/45WSNbP
bit.ly/45WSNbP
The G3BP stress-granule proteins reinforce the integrated stress response translation programme - Nature Cell Biology
Smith and Bartel show that mRNA recruitment to stress granules imparts resistance to the integrated stress response translational shutdown.
bit.ly
February 8, 2026 at 2:53 PM
☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown.
bit.ly/45WSNbP
bit.ly/45WSNbP
Outstanding talk by Milos Filipovic at #h2s2026 !
#Redox regulation of #condensates !
#stressgranules #ROS #RSS #Cysteine #Cys
@vanbreusegemlab.bsky.social @glasgow.ac.uk @unifr.bsky.social
#Redox regulation of #condensates !
#stressgranules #ROS #RSS #Cysteine #Cys
@vanbreusegemlab.bsky.social @glasgow.ac.uk @unifr.bsky.social
July 3, 2026 at 7:58 AM
Outstanding talk by Milos Filipovic at #h2s2026 !
#Redox regulation of #condensates !
#stressgranules #ROS #RSS #Cysteine #Cys
@vanbreusegemlab.bsky.social @glasgow.ac.uk @unifr.bsky.social
#Redox regulation of #condensates !
#stressgranules #ROS #RSS #Cysteine #Cys
@vanbreusegemlab.bsky.social @glasgow.ac.uk @unifr.bsky.social
🚨Condensate of the Month is Stress Granule!
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
November 13, 2024 at 10:01 AM
🚨Condensate of the Month is Stress Granule!
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
#StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses.
🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.
Acetic acid–induced #StressGranules function as scaffolding complexes for Hog1 activation by Pbs2, say Jongmin Lee, Kazuo Tatebayashi, and David Levin. rupress.org/jcb/article/...
#CellSignaling #Genetics
#CellSignaling #Genetics
March 18, 2025 at 1:48 PM
Acetic acid–induced #StressGranules function as scaffolding complexes for Hog1 activation by Pbs2, say Jongmin Lee, Kazuo Tatebayashi, and David Levin. rupress.org/jcb/article/...
#CellSignaling #Genetics
#CellSignaling #Genetics
Sridevi Challa et al. show that RACK1 MARylation regulates translation and #StressGranules in #OvarianCancer cells. rupress.org/jcb/article/...
📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25
📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25
April 24, 2025 at 3:31 PM
Sridevi Challa et al. show that RACK1 MARylation regulates translation and #StressGranules in #OvarianCancer cells. rupress.org/jcb/article/...
📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25
📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25
#RNAbindingproteins (RBPs):
On day 3️⃣ of the #EMBLRBP meeting, we are excited to learn about RBPs in #BiologicalCondensates and the implications for disease!
#StressGranules #Neurodegeneration #PhaseSeparation
@events.embl.org
On day 3️⃣ of the #EMBLRBP meeting, we are excited to learn about RBPs in #BiologicalCondensates and the implications for disease!
#StressGranules #Neurodegeneration #PhaseSeparation
@events.embl.org
March 13, 2025 at 8:00 AM
#RNAbindingproteins (RBPs):
On day 3️⃣ of the #EMBLRBP meeting, we are excited to learn about RBPs in #BiologicalCondensates and the implications for disease!
#StressGranules #Neurodegeneration #PhaseSeparation
@events.embl.org
On day 3️⃣ of the #EMBLRBP meeting, we are excited to learn about RBPs in #BiologicalCondensates and the implications for disease!
#StressGranules #Neurodegeneration #PhaseSeparation
@events.embl.org
Lee, Tatebayashi & Levin reveal that #StressGranules induced by acetic acid exposure function as a scaffold to bring the yeast SAPK Hog1 together with its activating kinase Pbs2 without stimulation of the canonical HOG pathway beyond basal levels. rupress.org/jcb/article/...
March 11, 2025 at 7:44 PM
Lee, Tatebayashi & Levin reveal that #StressGranules induced by acetic acid exposure function as a scaffold to bring the yeast SAPK Hog1 together with its activating kinase Pbs2 without stimulation of the canonical HOG pathway beyond basal levels. rupress.org/jcb/article/...
Stress Granules: The Possible Hidden Trigger in Alzheimer's Disease
#AlzheimersResearch #Neurodegeneration #StressGranules
#AlzheimersResearch #Neurodegeneration #StressGranules
February 14, 2025 at 11:36 PM
Stress Granules: The Possible Hidden Trigger in Alzheimer's Disease
#AlzheimersResearch #Neurodegeneration #StressGranules
#AlzheimersResearch #Neurodegeneration #StressGranules
Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
Virus-like proteins help our cells respond to environmental stress.
www.science.org
July 19, 2025 at 10:50 PM
Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules
www.science.org/doi/full/10....
www.science.org/doi/full/10....
It's out! 🎉 Excited to share our latest paper in @plos.org Pathogens!
We set out to understand the role of #StressGranules in the #antiviral response against #RNAviruses, using #FMDV as our model. Here's what we found:
dx.plos.org/10.1371/jour...
We set out to understand the role of #StressGranules in the #antiviral response against #RNAviruses, using #FMDV as our model. Here's what we found:
dx.plos.org/10.1371/jour...
The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling
Author summary Biomolecular condensates, including stress granules, are key regulatory compartments that control fundamental cellular processes. By condensing RNAs and proteins, these structures enabl...
dx.plos.org
July 14, 2026 at 7:52 AM
It's out! 🎉 Excited to share our latest paper in @plos.org Pathogens!
We set out to understand the role of #StressGranules in the #antiviral response against #RNAviruses, using #FMDV as our model. Here's what we found:
dx.plos.org/10.1371/jour...
We set out to understand the role of #StressGranules in the #antiviral response against #RNAviruses, using #FMDV as our model. Here's what we found:
dx.plos.org/10.1371/jour...
Very much similar to stress granule condensates in animal cells, mRNA storage within aggresomes confers an advantage for bacterial survival and recovery from stress.
#stressgranules #stressresistance
#stressgranules #stressresistance
Aggresomes protect mRNA under stress in Escherichia coli
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky
Aggresomes protect mRNA under stress in Escherichia coli - Nature Microbiology
Ribonucleoprotein aggresomes exclude ribonucleases and protect mRNA to promote rapid translation reactivation and cellular recovery after stress alleviation in Escherichia coli.
www.nature.com
August 27, 2025 at 10:10 PM
Very much similar to stress granule condensates in animal cells, mRNA storage within aggresomes confers an advantage for bacterial survival and recovery from stress.
#stressgranules #stressresistance
#stressgranules #stressresistance
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
August 19, 2026 at 12:55 PM
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
August 18, 2026 at 7:55 AM
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
🧵3/6 - N* is a double-stranded RNA binding protein that blunts various human antiviral pathways.
Most interestingly, N* is VERY good at blocking #StressGranules and #RLBs, and it does so by sequestering double-stranded RNAs.
Most interestingly, N* is VERY good at blocking #StressGranules and #RLBs, and it does so by sequestering double-stranded RNAs.
April 2, 2026 at 5:51 PM
🧵3/6 - N* is a double-stranded RNA binding protein that blunts various human antiviral pathways.
Most interestingly, N* is VERY good at blocking #StressGranules and #RLBs, and it does so by sequestering double-stranded RNAs.
Most interestingly, N* is VERY good at blocking #StressGranules and #RLBs, and it does so by sequestering double-stranded RNAs.
Interested in joining the group as a motivated Master's or PhD student?
Reach out to Dr. Nina Ripin at nina.ripin(at)ur.de.
More news and job ads coming soon – stay tuned! 🚀
#RNA #Condensates #StressGranules #G3BP1
Reach out to Dr. Nina Ripin at nina.ripin(at)ur.de.
More news and job ads coming soon – stay tuned! 🚀
#RNA #Condensates #StressGranules #G3BP1
June 25, 2025 at 7:28 AM
Interested in joining the group as a motivated Master's or PhD student?
Reach out to Dr. Nina Ripin at nina.ripin(at)ur.de.
More news and job ads coming soon – stay tuned! 🚀
#RNA #Condensates #StressGranules #G3BP1
Reach out to Dr. Nina Ripin at nina.ripin(at)ur.de.
More news and job ads coming soon – stay tuned! 🚀
#RNA #Condensates #StressGranules #G3BP1
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
August 20, 2026 at 4:25 PM
Stress granules help #antiviral defense, but what do they do during RNA #virus infection? Reto Lang, @profvolkerthiel.bsky.social &co show that #coronavirus & #alphavirus infections generate #StressGranules with distinct kinetics, proteomes & viral RNA content @plosbiology.org 🧪 plos.io/4wARYzZ
Emmanuel Amzallag, Eran Hornstein and colleagues show that the E3 #ubiquitin ligase MKRN2 maintains granulostasis by preventing the accumulation of misfolding-prone DRiPs into #StressGranules.
-> link.springer.com/article/10.1...
-> link.springer.com/article/10.1...
The E3 ligase MKRN2 prevents DRiP accumulation in stress granules and maintains granulostasis - EMBO Reports
Stress granules (SGs) are transient cytoplasmic biomolecular condensates that play a role in the cellular response to proteotoxic stress. It has been previously shown that ubiquitination regulates SG ...
link.springer.com
June 15, 2026 at 6:52 PM
Emmanuel Amzallag, Eran Hornstein and colleagues show that the E3 #ubiquitin ligase MKRN2 maintains granulostasis by preventing the accumulation of misfolding-prone DRiPs into #StressGranules.
-> link.springer.com/article/10.1...
-> link.springer.com/article/10.1...
This review highlights #StressGranules as cytoplasmic condensates formed via liquid‑liquid phase separation, whose abnormal assembly—often driven by mutations in components like #TDP43 or Tau—links to #NeurodegenerativeDiseases and #ViralInfections.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
July 2, 2026 at 9:25 AM
This review highlights #StressGranules as cytoplasmic condensates formed via liquid‑liquid phase separation, whose abnormal assembly—often driven by mutations in components like #TDP43 or Tau—links to #NeurodegenerativeDiseases and #ViralInfections.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth, say Daniel Caballero, Benjamin Tu and colleagues (University of Texas Southwestern Medical Center): rupress.org/jcb/article/...
#Metabolism #Mitochondria #Autophagy #StressGranules
#Metabolism #Mitochondria #Autophagy #StressGranules
August 20, 2025 at 3:30 PM
The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth, say Daniel Caballero, Benjamin Tu and colleagues (University of Texas Southwestern Medical Center): rupress.org/jcb/article/...
#Metabolism #Mitochondria #Autophagy #StressGranules
#Metabolism #Mitochondria #Autophagy #StressGranules