#Syndrome_T
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drjwdietrich.bsky.social
#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes.

#hypothyroidism #thyroid #SORSHOT

doi.org/10.1007/978-...
Therapeutic flow chart: Proposed algorithm for the treatment of syndrome T (SORSHOT). The approach includes optimising dosage and modality of treatment, considering treatment with L-T3, treating common and important comorbidities and correcting mineral and vitamin D deficiencies.
July 26, 2025 at 12:56 PM
drjwdietrich.bsky.social
Read: Both sensorimotor and autonomic neuropathy may be common in #hypothyroidism, despite treatment. Affection of the nervous system may be another, commonly overlooked, complication of #syndrome_T.
www.growkudos.com/publications...
Both sensorimotor and autonomic neuropathy may be common in hypothyroidism, despite treatment
A new study may provide a previously unknown reason for reduced quality of life in treated hypothyroidism (syndrome T). Systematic investigations of persons with treated hypothyroidism revealed uniqu...
www.growkudos.com
August 15, 2026 at 5:01 PM
drjwdietrich.bsky.social
Given the possibility of #Syndrome_T, not all patients who undergo #hemithyroidectomy will benefit. Two new risk scores identify predictors for #hypothyroidism, warranting therapy with #levothyroxine.

#thyroid #QoL

doi.org/10.3390/diag...

🧪 🩺 #MedSky @medsky.social Endocrinology #Endosky
Table: Two simplified clinical risk scores for predicting postoperative hypothyroidism after hemithyroidectomy. Score 1 contains preoperative TSH, remnant thyroid volume and heterogeneity in ultrasound. Score 2 includes TSH and thyroid autoantibodies.
August 13, 2026 at 6:22 PM
spinateam.bsky.social
Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression.

pubmed.ncbi.nlm.nih.gov/38811750/

doi.org/10.1038/s415...
Scatterplots showing a significant correlation of functional parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) with the mechanical pain sensitivity (MPS) of QST (A), respiratory arrhythmia in HRV analysis (B) and depression percentiles in HADS (C).
February 8, 2025 at 10:18 AM
drjwdietrich.bsky.social
Our newest paper provides new insights into the conundrum of #syndrome_T / #SORSHOT. #Anxiety and #depression are significantly more common in autoimmune #thyroiditis compared to healthy controls. 🧪🩺

#thyroid #qol

doi.org/10.1038/s415...
Bar and dot plots show that both anxiety and depression are more common in autoimmune thyroiditis compared to healthy controls. Anxiety and depression in three zones of autoimmunity. p** < 0.01, **** < 1e−4, ***** < 1e−5 compared to group with low antibody titres (anti-TPO Ab < 60 U/mL). Anxiety and depression in autoimmune thyroiditis depend on autoimmunity. Shown are HADS percentiles in three zones of antibody titres.
May 29, 2024 at 9:21 PM
drjwdietrich.bsky.social
Should we, therefore, classify #syndrome_T as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic #neuropathy that depend on autoimmunity and #thyroid's secretory capacity (#SPINA_GT).
Bar plot showing a significant association of markers of respiratory arrhythmia with anti-TPO antibody titres. Shown are means ± SEM (bars and whiskers) as well as results of individual participants (dots) Significant correlation of functional parameters of thyroid homeostasis with the mechanical pain sensitivity (MPS) of QST (A), respiratory arrhythmia in HRV analysis (B) and depression percentiles in HADS (C)
May 29, 2024 at 9:34 PM
drjwdietrich.bsky.social
Is reduced quality of life in #hypothyroidism a psychological issue? A poster presented at #ECE2023 suggests this. It is, however, impossible to prove causality in a case-control study. We need prospective studies to understand #syndrome_T / #SORSHOT. doi.org/10.1530/endo...
Abstract of a poster presented at ECE 2023
October 8, 2023 at 7:03 AM
drjwdietrich.bsky.social
Does impaired transport of #thyroid hormones into the central nervous system contribute to #syndrome_T / #SORSHOT? A recent study observed CSF/serum FT4 ratio to be associated with #QoL in treated #hypothyroidism. doi.org/10.1111/jne....
Correlations between changes in neurogranin, CSF/serum FT4 ratio and quality of life are significant.
October 8, 2023 at 9:45 AM