#THY1
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thepurplelilac.bsky.social
Retinal ganglion cells stained in red (Thy1) and green (Brn3b) 👁️

#FluorescenceFriday #sciart #neurons #visionscience #stemcells #organoids
May 16, 2025 at 8:46 PM
wythelab.bsky.social
Happy #FluorescenceFriday. Adult murine thy1:GFP brain cleared using EZClear:
elifesciences.org/articles/77419
step by step protocol here:
www.sciencedirect.com/science/arti...
November 22, 2024 at 2:03 PM
thepurplelilac.bsky.social
A microscopic #autumn: Thy1-stained neurons glow like a pile of red maple leaves caught in mid #fall. Proof that nature loves using the same beautiful branching patterns, whether in the canopy of a forest or the architecture of our minds #sciart
September 28, 2026 at 8:30 PM
scienceofpd.bsky.social
New research finds that oral treatment with Faecalibacterium prausnitzii, which is depleted in the #Parkinsons patient microbiome, improves motor deficits in α-synuclein overexpressing (Thy1-ASO) mice
www.nature.com/articles/s41...
March 6, 2026 at 8:37 PM
natcellbio.nature.com
☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis.
👉https://rdcu.be/e51HE
bit.ly/3ZZRw0q
THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology
Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...
bit.ly
February 27, 2026 at 1:02 PM
javisburgos.bsky.social
Se trata de un ratón transgénico con hasta 5 mutaciones y con un promotor exógeno (Thy1), que hace que se sobreexpresen las proteínas anómalas en sistema nervioso. Es decir, es un modelo muy forzado de deposición de placas amiloides antes que de enfermedad
December 29, 2025 at 3:17 PM
brianmsweis.bsky.social
#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬
September 13, 2025 at 1:59 AM
neurovenki.bsky.social
An old image from our lab. Coronal section of the brain from one of the early thy1-YFP mouse lines with a (random?) sub-population of neurons labeled. (Feng et al Neuron 28:41). #neuroscience 🧪
September 1, 2023 at 8:34 PM
simonschultz.bsky.social
Has anyone got any experience with gcamp8 transgenic mice yet? Eg the Thy1-GCaMP8s line?

janelia.figshare.com/articles/dat...
jGCaMP8 transgenic mice
The GENIE Project Team at HHMI Janelia Research Campus have developed and characterized multiple transgenic mice expressing jGCaMP8s and jGCaMP8m and deposited the lines at The Jackson Laboratory (JAX...
janelia.figshare.com
July 15, 2025 at 9:30 AM
scienceofpd.bsky.social
Researchers report that dysregulation of mitochondria-associated genes & hyperactive striatal mitochondria are induced by the microbiome in α-synuclein- #Parkinsons (Thy1-ASO) mouse model; Treatment with N-Acetyl cysteine (NAC) ameliorates motor deficits
www.nature.com/articles/s41...
October 20, 2025 at 6:01 PM
markhisted.org
Excellent seminar today at #NIH by Yi Zuo from UCSC. What an honor to have her, and a pleasure to hear about her group’s work.

It remains amazing that scientists can see changes in synaptic connectivity in the brains of mice as they learn new things. 🧪
Synapses that change as animals learn new things - YFP-H and other Thy1 lines Yi Zuo
June 1, 2026 at 5:16 PM
brittonrae.bsky.social
#FluorescenceFriday still from the archives - Thy1-YFP+ neuron in mouse cortex
Neuron labeled with YFP for dendritic spine morphology, pseudocolored cyan in ImageJ
November 22, 2024 at 6:20 PM
olifiersl.bsky.social
We only have Thy1-YFP but it's not sparsely labelled...
December 17, 2025 at 4:10 PM
thepurplelilac.bsky.social
Retinal ganglion cells grown from pluripotent #stemcells (green: Brn3b - Red: Thy1 - Blue: Dapi) #FluorescenceFriday #visionresearch #glaucoma #organoids
November 1, 2024 at 9:02 PM
alertainshallah.bsky.social
m.youtube.com/watch?v=THy1...
Ella Fitzerald, Stevie Wonder - You are the Sunshine of my Life (live,1977)
New Orleans, 04/01/1977
m.youtube.com
May 12, 2024 at 10:16 AM
lucyhjackson-j.bsky.social
www.nature.com/articles/s41...

Well this is wild! #Immunometabolism #Neutrophils #Mitochondria
THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology
Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...
www.nature.com
February 16, 2026 at 3:29 PM
spencerlaveresmith.bsky.social
It has been over a decade since @hongkuizeng.bsky.social developed her amazingly impactful gcamp6 TIGRE mice. There is @crisniell.bsky.social ‘s nice thy1 gcamp6 too. Despite improvements in gcamp, these old lines are still the best for large field of view work.
July 15, 2025 at 5:14 PM
haoyin.bsky.social
Deep subclustering of #SmoothMuscleCell in👤🐭 #Atherosclerosis

Human: scRNAseq n=21 + CITEseq 274 antibodies n=6

Universal surface markers of👤SMC
CD49a/ITGA1 CD146/MCAM CD29/ITGB1 EGFR

CD90/Thy1⬆️ CD142/F3⬇️ in modulated SMC

#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
September 9, 2025 at 11:18 AM
kpmproject.bsky.social
📑 Need something to read this weekend? If so, you're in luck!

"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org

www.science.org/doi/10.1126/...
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules
The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.
www.science.org
August 15, 2025 at 8:15 PM
npanayotis.bsky.social
Hi everyone, it seems difficult to obtain the Thy1-RFP mice originally generated by G. Feng et al. Does anyone know of an alternative mouse line that expresses an RFP sparsely and suitable for morphological analyses using confocal or light-sheet imaging? Thanks in advance. 🙏
December 17, 2025 at 3:13 PM
simonepapa.bsky.social
Thy1-GFP mouse brain cleared with the PEGASOS solvent-based method and imaged with the 1.5x / 0.37NA objective in 90 minutes. SlideBook 3D visualization with lookup tables by depth.
Courtesy of Dr. H. Zhao, Beijing Institute for Brain Research.
#brain #neuroscience #InstituteforBrainResearch
May 20, 2025 at 2:13 PM
programmerhumor-io.bsky.social
After RAM Price Increase....

#programming #hardware #Techhumor #Ram #Computerhardware

https://programmerhumor.io/hardware-memes/after-ram-price-increase-thy1
After RAM Price Increase....
May 5, 2026 at 10:32 AM
jmenezes.bsky.social
Thy1? CAT 301? A CTIP2 antibody that works in humans? (This one is harder since CTIP doesn't label cytoplasm very well)
March 16, 2025 at 5:50 PM
obialik.bsky.social
The brain uses a lot of energy. But it's not using that energy all the time and at the same intensity. It's not just more neuronal activity = more energy. There is also a lot of background process demending energy. 🧪

Link: https://www.nature.com/articles/s42003-026-10646-6​
a, b Representative recordings from an Mlc1-tTA::tetO-PYRS mouse expressing a pyruvate sensor in astrocytes (panels a, c, d, g, i, k) and a Thy1-ATeam mouse expressing an ATP sensor in neurons (panels b, e, f, h, j, l). ECoG spectrograms, raw ECoG, and EMG traces indicate sleep-wake states. c–f Fluorescence signals from four cortical regions: secondary motor cortex (MOs), somatosensory upper limb cortex (SSu), primary visual cortex (V1), and retrosplenial cortex (RSC). Astrocytic pyruvate (d) and neuronal ATP (f) signals were calculated by correcting FRET signal (fYFP) with dYFP to remove blood volume and pH change effects (pyruvate: – (fYFP – dYFP; ATP: fYFP – dYFP). Astrocytic pyruvate (d) increased during REM sleep and declined gradually after awakening, whereas neuronal ATP (f) decreased during REM sleep and recovered rapidly upon awakening. g, h Trajectories astrocytic pyruvate (g) or neuronal ATP (h) signals versus inverted dYFP (idYFP, a proxy for BBV) during pre-REM (100 s before REM onset; black), REM (last 50 s before awakening; light blue), and WAKE (50 s after awakening; orange) periods. Red circles indicate the mean values for each period. Arrows indicate the temporal progression direction of trajectories. Cortical maps of idYFP and astrocytic pyruvate (i) and neuronal ATP (j), averaged over each sleep period. All cortical maps represent absolute ΔF/F values. k, l Scatter plots summarizing mean astrocytic pyruvate (k) and neuronal ATP (l) signal changes against idYFP in eight cortical regions (26 episodes from n = 3 mice) for pre-REM, REM, and WAKE periods. Data are presented as mean ± SEM. During REM sleep, posterior regions (e.g., RSC, V1) showed larger increases in idYFP and astrocytic pyruvate and stronger decreases in neuronal ATP.
August 1, 2026 at 2:33 PM
josephdzak.bsky.social
Hi Matteo, thank you and please feel free to use it for any purpose. The image is unpublished and taken by me, but it’s quite old! Conditional Thy1-yfp is crossed with Cre-ER. Taken in from the mouse orbitofrontal cortex.
November 15, 2024 at 12:42 AM