It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
April 8, 2026 at 8:42 AM
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
Below the heads, the molecule becomes highly flexible and density is lost. However, using #XLMS and #AlphaFold, we were able to model these regions and identify bend 1 (A1156) as an unwinding point, enabling a full-length structure. (8/11)
April 17, 2026 at 6:23 PM
Below the heads, the molecule becomes highly flexible and density is lost. However, using #XLMS and #AlphaFold, we were able to model these regions and identify bend 1 (A1156) as an unwinding point, enabling a full-length structure. (8/11)
(3/4) We are happy to have contributed by generating the #CrossLinkingMS ( #XLMS ) data and also by using our custom data analysis workflow, which integrates the outputs of different #XLMS software like #MeroX, #xiSEARCH and #XlinkX. @irbbarcelona.org
November 18, 2025 at 8:36 AM
(3/4) We are happy to have contributed by generating the #CrossLinkingMS ( #XLMS ) data and also by using our custom data analysis workflow, which integrates the outputs of different #XLMS software like #MeroX, #xiSEARCH and #XlinkX. @irbbarcelona.org
Received a couple of xlms projects in the core, and I literally could not be happier.
December 19, 2024 at 11:28 PM
Received a couple of xlms projects in the core, and I literally could not be happier.
It's a KMFDM kind of morning, I think... www.youtube.com/watch?v=XlMS...
Hau Ruck
YouTube video by KMFDM - Topic
www.youtube.com
April 5, 2025 at 12:30 PM
It's a KMFDM kind of morning, I think... www.youtube.com/watch?v=XlMS...
aaaaaaaaaaaaaaaaaaaaazxa;xlms ;-; 😭
November 20, 2024 at 5:05 AM
aaaaaaaaaaaaaaaaaaaaazxa;xlms ;-; 😭
As a first post, a plug for our nearly month old publication in
@narjournal.bsky.social :
academic.oup.com/nar/article/...
#XLMS #proteomics #structuralproteomics #massspectrometry #structuralbiology
@narjournal.bsky.social :
academic.oup.com/nar/article/...
#XLMS #proteomics #structuralproteomics #massspectrometry #structuralbiology
Validate User
academic.oup.com
July 14, 2025 at 6:20 PM
As a first post, a plug for our nearly month old publication in
@narjournal.bsky.social :
academic.oup.com/nar/article/...
#XLMS #proteomics #structuralproteomics #massspectrometry #structuralbiology
@narjournal.bsky.social :
academic.oup.com/nar/article/...
#XLMS #proteomics #structuralproteomics #massspectrometry #structuralbiology
Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu
and read about it here->
www.nature.com/articles/s41...
and read about it here->
www.nature.com/articles/s41...
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
www.nature.com
May 28, 2025 at 5:09 PM
Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu
and read about it here->
www.nature.com/articles/s41...
and read about it here->
www.nature.com/articles/s41...
Shifting the Executive Mindset from Forecasting to Trend Auditing -- bradenkelley.com/2020/02/tren... -- From Reactive to Proactive -- #leadership
From Forecasting to Trend Auditing: Shifting Executive Mindsets
Stop chasing static forecasts. Discover how a human-centered Trend Audit uses XLMs and the XMO to track real-world signals and drive agile innovation.
bradenkelley.com
July 5, 2026 at 5:09 PM
Shifting the Executive Mindset from Forecasting to Trend Auditing -- bradenkelley.com/2020/02/tren... -- From Reactive to Proactive -- #leadership
全部「規模のデカい言語モデル」には違いないからまとめて話すにはLLMでいいらしい。なるほどね…… / xLMs are LARGE Language Module too (Tech Bros put into them huge amount data), so when we talk about them, we can call it only "LLM", I heard. Okey!
February 16, 2026 at 7:20 AM
全部「規模のデカい言語モデル」には違いないからまとめて話すにはLLMでいいらしい。なるほどね…… / xLMs are LARGE Language Module too (Tech Bros put into them huge amount data), so when we talk about them, we can call it only "LLM", I heard. Okey!
January 6, 2025 at 12:37 AM
(4/4) #XLMS results support the structural analyses done by Eva’s team, which uncovered how the #GlucocorticoidReceptor (GR) self-assembles into its active forms. This deepens into the understanding of disease-linked GR mutations and establishes a framework for designing selective GR modulators.
November 18, 2025 at 8:36 AM
(4/4) #XLMS results support the structural analyses done by Eva’s team, which uncovered how the #GlucocorticoidReceptor (GR) self-assembles into its active forms. This deepens into the understanding of disease-linked GR mutations and establishes a framework for designing selective GR modulators.
The Pulse of Experience -- bradenkelley.com/2026/07/mult... -- Multimodal Affective Computing via Remote Photoplethysmography (rPPG) -- #technology
Multimodal Affective Computing: The Future of XLMs
Move beyond basic emotion AI. Discover how multimodal affective computing via rPPG tracks real-time physiological metrics to power true Experience Level Measures.
bradenkelley.com
July 11, 2026 at 1:20 AM
The Pulse of Experience -- bradenkelley.com/2026/07/mult... -- Multimodal Affective Computing via Remote Photoplethysmography (rPPG) -- #technology
I think that’s actually untrue wrt xLMs (they’re not all Large anymore) but not wrt tech, because, well, pick one: SaaS or planned obsolescence. We’ve hit perf walls in general computing. Nothing is ever going to be noticeably faster when you buy it in our lifetimes and companies have payroll
September 12, 2024 at 2:49 PM
I think that’s actually untrue wrt xLMs (they’re not all Large anymore) but not wrt tech, because, well, pick one: SaaS or planned obsolescence. We’ve hit perf walls in general computing. Nothing is ever going to be noticeably faster when you buy it in our lifetimes and companies have payroll
The Rise of xLMs: Why One-Size-Fits-All AI Models Are Fading The AI large language model (LLM) ma...
https://thenewstack.io/the-rise-of-xlms-why-one-size-fits-all-ai-models-are-fading/
#AI #Engineering #Data #Large #Language #Models #Contributed
Result Details
https://thenewstack.io/the-rise-of-xlms-why-one-size-fits-all-ai-models-are-fading/
#AI #Engineering #Data #Large #Language #Models #Contributed
Result Details
The Rise of xLMs: Why One-Size-Fits-All AI Models Are Fading
LLMs are evolving into a landscape of smaller, purpose-built models.
thenewstack.io
May 11, 2025 at 4:50 PM
The Rise of xLMs: Why One-Size-Fits-All AI Models Are Fading The AI large language model (LLM) ma...
https://thenewstack.io/the-rise-of-xlms-why-one-size-fits-all-ai-models-are-fading/
#AI #Engineering #Data #Large #Language #Models #Contributed
Result Details
https://thenewstack.io/the-rise-of-xlms-why-one-size-fits-all-ai-models-are-fading/
#AI #Engineering #Data #Large #Language #Models #Contributed
Result Details
reverse engineering people's shimeji xlms and now i'm hyperfixated on making a hoshina one
this is stardew valley all over again
this is stardew valley all over again
January 9, 2025 at 10:31 AM
reverse engineering people's shimeji xlms and now i'm hyperfixated on making a hoshina one
this is stardew valley all over again
this is stardew valley all over again
It took me about 15 months to type the history of the R&B charts into a spreadsheet so that I could organize by the date the song entered the charts.
3021 of 22,828
Mary Wells
"Never, Never Leave Me"
March 20, 1965
#musicsky
www.youtube.com/watch?v=XlMS...
3021 of 22,828
Mary Wells
"Never, Never Leave Me"
March 20, 1965
#musicsky
www.youtube.com/watch?v=XlMS...
1965 Mary Wells - Never, Never Leave Me
YouTube video by The45Prof
www.youtube.com
November 23, 2025 at 5:24 AM
It took me about 15 months to type the history of the R&B charts into a spreadsheet so that I could organize by the date the song entered the charts.
3021 of 22,828
Mary Wells
"Never, Never Leave Me"
March 20, 1965
#musicsky
www.youtube.com/watch?v=XlMS...
3021 of 22,828
Mary Wells
"Never, Never Leave Me"
March 20, 1965
#musicsky
www.youtube.com/watch?v=XlMS...
This is a really nice application of XLMS to look at viral-host protein interaction. Impressive work from Fan Liu, giving me lots of ideas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Influenza A virus (IAV) exploits the host cellular machinery to facilitate its replication, yet many host-IAV interactions remain unexplored in the cellular context. Detailed information about interac...
www.biorxiv.org
March 30, 2025 at 12:21 PM
This is a really nice application of XLMS to look at viral-host protein interaction. Impressive work from Fan Liu, giving me lots of ideas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our latest bioRxiv preprint on the molecular mechanisms underlying #Pex8's essential role in Peroxisomal Protein Import
A huge thanks to all authors and collaborators for their crucial support! 🙏
doi.org/10.1101/2025...
#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3
A huge thanks to all authors and collaborators for their crucial support! 🙏
doi.org/10.1101/2025...
#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3
Structure of Pex8 in complex with peroxisomal receptor Pex5 reveals its essential role in peroxisomal cargo translocation
Peroxisomes are essential cellular organelles that enable the sequestered execution of a broad range of metabolic processes. Due to the lack of an internal protein synthesis machinery, they entirely d...
doi.org
September 3, 2025 at 8:30 AM
Our latest bioRxiv preprint on the molecular mechanisms underlying #Pex8's essential role in Peroxisomal Protein Import
A huge thanks to all authors and collaborators for their crucial support! 🙏
doi.org/10.1101/2025...
#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3
A huge thanks to all authors and collaborators for their crucial support! 🙏
doi.org/10.1101/2025...
#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3
9/2026 Issue ➡️ link.springer.com/journal/4432...
#XLMS analysis, multi-omics integration, skeletal muscle insulin resistance, sweeteners affect gut microbes, nonenzymatic protein functions
Cover: E. coli engineered to swarm in various patterns
#XLMS analysis, multi-omics integration, skeletal muscle insulin resistance, sweeteners affect gut microbes, nonenzymatic protein functions
Cover: E. coli engineered to swarm in various patterns
September 11, 2026 at 4:13 PM
9/2026 Issue ➡️ link.springer.com/journal/4432...
#XLMS analysis, multi-omics integration, skeletal muscle insulin resistance, sweeteners affect gut microbes, nonenzymatic protein functions
Cover: E. coli engineered to swarm in various patterns
#XLMS analysis, multi-omics integration, skeletal muscle insulin resistance, sweeteners affect gut microbes, nonenzymatic protein functions
Cover: E. coli engineered to swarm in various patterns
(J Proteom) Protein-protein interactions in Escherichia coli: Using cross-linking/mass spectrometry (XLMS) to reveal our current knowledge gaps in interactomes: Publication date: Available online 4 June 2026
Source: Journal of Proteomics
Author(s): Giovanna Lopes de Araújo, Guilherme… #MassSpecRSS
Source: Journal of Proteomics
Author(s): Giovanna Lopes de Araújo, Guilherme… #MassSpecRSS
Protein-protein interactions in Escherichia coli: Using cross-linking/mass spectrometry (XLMS) to reveal our current knowledge gaps in interactomes
Publication date: Available online 4 June 2026
Source: Journal of Proteomics
Author(s): Giovanna Lopes de Araújo, Guilherme Reis-de-Oliveira, Fabio Gozzo
dlvr.it
June 5, 2026 at 4:06 PM
(J Proteom) Protein-protein interactions in Escherichia coli: Using cross-linking/mass spectrometry (XLMS) to reveal our current knowledge gaps in interactomes: Publication date: Available online 4 June 2026
Source: Journal of Proteomics
Author(s): Giovanna Lopes de Araújo, Guilherme… #MassSpecRSS
Source: Journal of Proteomics
Author(s): Giovanna Lopes de Araújo, Guilherme… #MassSpecRSS
LLMs are evolving into a landscape of smaller, purpose-built models.
The Rise of xLMs: Why One-Size-Fits-All AI Models Are Fading
LLMs are evolving into a landscape of smaller, purpose-built models.
bit.ly
May 28, 2025 at 11:00 AM
LLMs are evolving into a landscape of smaller, purpose-built models.