Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters a...

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

Demyelinating diseases, such as Multiple Sclerosis (MS), are debilitating conditions characterized by loss of the myelin sheaths, ultimately leading to neurodegeneration. Toxicity models are among the...

HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.

Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand age-related molecular chan...

A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

In 2024, several trends in multiple sclerosis research have extended evidence from previous years. First, the idea of the disease as a continuum—from exposure and risk factors to biological onset, a prodromal phase, a first clinical episode, and eventually later disease stages—has received increasing attention.1 In this context, there continues to be an intense focus on identifying biomarkers of the preclinical phase of multiple sclerosis. Colin Zamecnik and colleagues2 used the US Department of Defense Serum Repository to explore whole-proteome autoantibody profiles before and after disease onset.

Prof. Jan Antolik’s path into computational neuroscience began in artificial intelligence, at a time when the field was far from its current prominence. What started as a detour to better understand…

Prof. Jan Antolik’s path into computational neuroscience began in artificial intelligence, at a time when the field was far from its current prominence. What started as a detour to better understand…