Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages
Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.
www.science.org
March 27, 2025 at 7:13 AM
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our labs new work is out today! Proud of this as it connects my grad work with @christhechang.bsky.social to my group's work with lipidation. Key takeaway is PRDX proteins are regulated by active-site lipidation
Congrats Tian Saara-Anne & @shubha-pani.bsky.social
authors.elsevier.com/a/1kg6b8jWWJ...
Congrats Tian Saara-Anne & @shubha-pani.bsky.social
authors.elsevier.com/a/1kg6b8jWWJ...
authors.elsevier.com
February 25, 2025 at 5:04 PM
Our labs new work is out today! Proud of this as it connects my grad work with @christhechang.bsky.social to my group's work with lipidation. Key takeaway is PRDX proteins are regulated by active-site lipidation
Congrats Tian Saara-Anne & @shubha-pani.bsky.social
authors.elsevier.com/a/1kg6b8jWWJ...
Congrats Tian Saara-Anne & @shubha-pani.bsky.social
authors.elsevier.com/a/1kg6b8jWWJ...
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 3:48 PM
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
August 26, 2025 at 11:00 AM
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...
link.springer.com
March 31, 2026 at 7:18 AM
💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Hey all you lipid freaks, join me & other lipid obsessed people talk about protein lipidation! If you've never attended, first drink is on me or @pjenkinslab.bsky.social
Roles and regulation of protein lipidation in health and disease
27-29 August 2025
Exeter College, Oxford
@biochemsoc.bsky.social
Roles and regulation of protein lipidation in health and disease
27-29 August 2025
Exeter College, Oxford
@biochemsoc.bsky.social
March 11, 2025 at 2:52 PM
Hey all you lipid freaks, join me & other lipid obsessed people talk about protein lipidation! If you've never attended, first drink is on me or @pjenkinslab.bsky.social
Roles and regulation of protein lipidation in health and disease
27-29 August 2025
Exeter College, Oxford
@biochemsoc.bsky.social
Roles and regulation of protein lipidation in health and disease
27-29 August 2025
Exeter College, Oxford
@biochemsoc.bsky.social
Do you study lipids or lipidation, but don't know where to send your newest work?
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 4:12 PM
Do you study lipids or lipidation, but don't know where to send your newest work?
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
March 25, 2025 at 11:58 AM
Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
Great to see this work published in the ACS Chemical Biology special issue Lipids and Lipidation, edited by Jeremy Baskin @jeremybaskin.bsky.social and Bryan Dickinson @chembiobryan.bsky.social. (5/5)
April 25, 2025 at 1:00 PM
Great to see this work published in the ACS Chemical Biology special issue Lipids and Lipidation, edited by Jeremy Baskin @jeremybaskin.bsky.social and Bryan Dickinson @chembiobryan.bsky.social. (5/5)
New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Nature Structural & Molecular Biology, Published online: 16 September 2025; doi:10.1038/s41594-025-01678-3Fujioka et al. show that, under starvation, yeast Atg1 forms droplets that concentrate autophagy factors, boosting Atg8 lipidation and clustering vesicles. These droplets likely serve as hubs that generate membrane seeds for autophagosome formation.
go.nature.com
September 16, 2025 at 12:00 PM
New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
This week, Metabolites-driven PTMs (focused on lipidation), metabolism, and cancer Biomed News is out ☺️ biomed.news/bims-prolim/...
April 6, 2025 at 12:30 PM
This week, Metabolites-driven PTMs (focused on lipidation), metabolism, and cancer Biomed News is out ☺️ biomed.news/bims-prolim/...
Assessing protein N-terminal myristoylation. Detailed protocols by Ed Tate's group in Methods in Enzymology. #lipidation @ispt-proteinterm.bsky.social @imperialcollegeldn.bsky.social www.sciencedirect.com/science/arti...
August 6, 2025 at 7:53 AM
Assessing protein N-terminal myristoylation. Detailed protocols by Ed Tate's group in Methods in Enzymology. #lipidation @ispt-proteinterm.bsky.social @imperialcollegeldn.bsky.social www.sciencedirect.com/science/arti...
One Step Rational #TotalSynthesis of Daptomycins
Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Lipidation Engineering in Daptomycin Biosynthesis
Lipopeptides are an important family of natural products, some of which are clinically used as antibiotics to treat multidrug-resistant pathogens. Although the lipid moieties play a crucial role in ba...
pubs.acs.org
November 19, 2024 at 3:47 PM
One Step Rational #TotalSynthesis of Daptomycins
Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
All the tested fatty acyl-CoAs fully rescued the ATP levels and partially also the synaptic function. Full rescue of the synaptic function required all three fatty acids in combination. We concluded that myristic and palmitic acid therefore likely also have non-energetic roles such as lipidation.
September 22, 2026 at 8:59 PM
All the tested fatty acyl-CoAs fully rescued the ATP levels and partially also the synaptic function. Full rescue of the synaptic function required all three fatty acids in combination. We concluded that myristic and palmitic acid therefore likely also have non-energetic roles such as lipidation.
Ever wonder how your cells handle stress? Cells use ROS for important jobs, but too much can lead to disease. In a new study by the Bryan Dickinson Lab, researchers discovered a key process, PRDX S-acylation, that regulates cellular stress & created a tool to track it.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Dynamic PRDX S-acylation modulates ROS stress and signaling
PRDXs are key regulators of ROS. Qiu et al. report that the entire family of PRDXs
is regulated by lipidation. They demonstrate that both PRDX lipidation and APT activity
respond differentially to str...
www.cell.com
March 25, 2025 at 5:48 PM
Ever wonder how your cells handle stress? Cells use ROS for important jobs, but too much can lead to disease. In a new study by the Bryan Dickinson Lab, researchers discovered a key process, PRDX S-acylation, that regulates cellular stress & created a tool to track it.
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
New online! Rapid screening platform for peptide prenyltransferases to diversify pseudo-natural prenylated peptides: Nature Catalysis, Published online: 01 July 2026; doi:10.1038/s41929-026-01560-5Late-stage peptide lipidation remains limited by the scarcity of broadly useful late-stage…
Rapid screening platform for peptide prenyltransferases to diversify pseudo-natural prenylated peptides
Nature Catalysis, Published online: 01 July 2026; doi:10.1038/s41929-026-01560-5Late-stage peptide lipidation remains limited by the scarcity of broadly useful late-stage biocatalysts. Now a rapid screening platform reveals 14 cyanobactin prenyltransferases with diverse reaction patterns, prenyl donor scope and structures that support combinatorial peptide lipidation.
go.nature.com
July 1, 2026 at 10:17 AM
New online! Rapid screening platform for peptide prenyltransferases to diversify pseudo-natural prenylated peptides: Nature Catalysis, Published online: 01 July 2026; doi:10.1038/s41929-026-01560-5Late-stage peptide lipidation remains limited by the scarcity of broadly useful late-stage…
8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/
proteintermini.org/meeting/
Protein Termini 2026 – International Society for Protein Termini (ISPT)
proteintermini.org
February 23, 2026 at 9:16 AM
8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/
proteintermini.org/meeting/
Attending "Roles and regulation of protein lipidation in health and disease" Day 1! #BiochemEvent @biochemsoc.bsky.social
August 27, 2025 at 12:05 PM
Attending "Roles and regulation of protein lipidation in health and disease" Day 1! #BiochemEvent @biochemsoc.bsky.social
ICYMI: New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Nature Structural & Molecular Biology, Published online: 16 September 2025; doi:10.1038/s41594-025-01678-3Fujioka et al. show that, under starvation, yeast Atg1 forms droplets that concentrate autophagy factors, boosting Atg8 lipidation and clustering vesicles. These droplets likely serve as hubs that generate membrane seeds for autophagosome formation.
go.nature.com
September 17, 2025 at 12:01 PM
ICYMI: New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Great @led3hub.bsky.social Lecture by Ed Tate. He talked about his group's work on better understanding and manipulating posttranslational modifications. Exciting insights into degrader development, genetic code expansion and drug discovery on lipidation pathways.
#chemsky #ChemBio #DrugDiscovery
#chemsky #ChemBio #DrugDiscovery
May 22, 2025 at 2:47 PM
Great @led3hub.bsky.social Lecture by Ed Tate. He talked about his group's work on better understanding and manipulating posttranslational modifications. Exciting insights into degrader development, genetic code expansion and drug discovery on lipidation pathways.
#chemsky #ChemBio #DrugDiscovery
#chemsky #ChemBio #DrugDiscovery
Highly dynamic membrane-repair mechanisms are triggered upon lysosomal damage–
@dichen02.bsky.social , @maxgg.bsky.social et al show that it is the leakage of calcium ions that initiates this process
link.springer.com/article/10.1...
@dichen02.bsky.social , @maxgg.bsky.social et al show that it is the leakage of calcium ions that initiates this process
link.springer.com/article/10.1...
Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...
link.springer.com
March 23, 2026 at 11:58 AM
Highly dynamic membrane-repair mechanisms are triggered upon lysosomal damage–
@dichen02.bsky.social , @maxgg.bsky.social et al show that it is the leakage of calcium ions that initiates this process
link.springer.com/article/10.1...
@dichen02.bsky.social , @maxgg.bsky.social et al show that it is the leakage of calcium ions that initiates this process
link.springer.com/article/10.1...
And that's why you fit right in with us protein lipidation/acylation folks 🐐
February 11, 2024 at 3:22 PM
And that's why you fit right in with us protein lipidation/acylation folks 🐐
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins - Nature Communications
Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.
www.nature.com
September 28, 2025 at 10:54 AM
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...