Your mitochondria aren't batteries—they're chemical factories that produce DNA, neurotransmitters, and antioxidants. A 202…
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitochondrialdysfunction
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitoch…
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitochondrialdysfunction
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitoch…
Mitochondria Are Chemical Factories, Not Batteries
Your mitochondria aren't batteries—they're chemical factories that produce DNA, neurotransmitters, and antioxidants. A 202…
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitochondrialdysfunction
news.gmj.ge
October 14, 2026 at 7:26 AM
Your mitochondria aren't batteries—they're chemical factories that produce DNA, neurotransmitters, and antioxidants. A 202…
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitochondrialdysfunction
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitoch…
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitochondrialdysfunction
#Cellularbiosynthesis #Metabolichealth #Micronutrients #Mitochondria #Mitoch…
Explore highlights from this week's #POLG curation from L Bolliger @biomednews.bsky.social
💥 Advances in diagnosis of #mitochondrialdysfunction & #mitochondrialdisease
💥 Myokines & #mitochondria function in #cardiometabolicdiseases
& more!
lnkd.in/p/dfAfNK2b
#mitoscientists
💥 Advances in diagnosis of #mitochondrialdysfunction & #mitochondrialdisease
💥 Myokines & #mitochondria function in #cardiometabolicdiseases
& more!
lnkd.in/p/dfAfNK2b
#mitoscientists
Expanding the epilepsy spectrum in primary coenzyme Q10 deficiency with COQ4 variants - Case series and literature review. | Luca Bolliger
Enjoy our weekly curated 𝐏𝐎𝐋𝐆-𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐥𝐢𝐭𝐞𝐫𝐚𝐭𝐮𝐫𝐞 selection: https://lnkd.in/esWC_hxW
On the 4𝐭𝐡 𝐨𝐟 𝐎𝐜𝐭𝐨𝐛𝐞𝐫 1970 𝐉𝐚𝐧𝐢𝐬 𝐉𝐨𝐩𝐥𝐢𝐧 🎙️ 𝐩𝐚𝐬𝐬𝐞𝐝 𝐚𝐰𝐚𝐲: a star left us and a legend was born ✨✨ ✨ ! A quote from...
lnkd.in
October 7, 2026 at 3:04 PM
Explore highlights from this week's #POLG curation from L Bolliger @biomednews.bsky.social
💥 Advances in diagnosis of #mitochondrialdysfunction & #mitochondrialdisease
💥 Myokines & #mitochondria function in #cardiometabolicdiseases
& more!
lnkd.in/p/dfAfNK2b
#mitoscientists
💥 Advances in diagnosis of #mitochondrialdysfunction & #mitochondrialdisease
💥 Myokines & #mitochondria function in #cardiometabolicdiseases
& more!
lnkd.in/p/dfAfNK2b
#mitoscientists
An exciting advance for patients with #mitochondrialdisease as new drug gets fast tracked! See more below from Pretzel Therapeutics as they tackle #POLG #mitochondrialdysfunction :
lnkd.in/p/gftQnsCD
#mitocanda #UMDF #mitoscientists #mitochondria #mtDNA #mitochondrialtherapy
lnkd.in/p/gftQnsCD
#mitocanda #UMDF #mitoscientists #mitochondria #mtDNA #mitochondrialtherapy
Pretzel Therapeutics Receives FDA Fast Track Designation for PX578 for the Treatment of POLG-mediated Primary Mitochondrial Disorders | Pretzel Therapeutics
Another meaningful step forward for patients living with POLG disease.
We’re proud to announce that the U.S. FDA has granted Fast Track designation to PX578, our investigational, first-in-class PO...
lnkd.in
September 22, 2026 at 3:17 PM
An exciting advance for patients with #mitochondrialdisease as new drug gets fast tracked! See more below from Pretzel Therapeutics as they tackle #POLG #mitochondrialdysfunction :
lnkd.in/p/gftQnsCD
#mitocanda #UMDF #mitoscientists #mitochondria #mtDNA #mitochondrialtherapy
lnkd.in/p/gftQnsCD
#mitocanda #UMDF #mitoscientists #mitochondria #mtDNA #mitochondrialtherapy
PDR emerges as a heterogeneous disease with subtypes linked to immune defense against pathological endothelium or endothelial #MitochondrialDysfunction, while anti-#VEGF therapy influences both cellular compartments.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 18, 2026 at 6:00 AM
PDR emerges as a heterogeneous disease with subtypes linked to immune defense against pathological endothelium or endothelial #MitochondrialDysfunction, while anti-#VEGF therapy influences both cellular compartments.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
New discoveries on how #mitochondrialdysfunction drives #oocyte #aging and more featured on @biomednews.bsky.social with some creative illustrations @gzaffagnini.bsky.social !
#reproductivehealth #reproductivemedicine #oocytes #mitoscientists #mitochondria
#reproductivehealth #reproductivemedicine #oocytes #mitoscientists #mitochondria
Happy Sunday with a great issue of #cebooc!
This week Qingling Yang and team reveal how leaky mitochondria drive oocyte aging: pubmed.ncbi.nlm.nih.gov/42665751/
The Verlhac team discovered a new super-organelle linked to translation and growth in mouse oocytes: pubmed.ncbi.nlm.nih.gov/42664359/
This week Qingling Yang and team reveal how leaky mitochondria drive oocyte aging: pubmed.ncbi.nlm.nih.gov/42665751/
The Verlhac team discovered a new super-organelle linked to translation and growth in mouse oocytes: pubmed.ncbi.nlm.nih.gov/42664359/
August 31, 2026 at 8:55 PM
New discoveries on how #mitochondrialdysfunction drives #oocyte #aging and more featured on @biomednews.bsky.social with some creative illustrations @gzaffagnini.bsky.social !
#reproductivehealth #reproductivemedicine #oocytes #mitoscientists #mitochondria
#reproductivehealth #reproductivemedicine #oocytes #mitoscientists #mitochondria
Blocking ER export overcomes #MultipleMyeloma?
This study shows that blocking COPII-dependent ER export couples ERAD-driven #mTORC1 activation with #MitochondrialDysfunction, causing energetic collapse & secretory myeloma cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that blocking COPII-dependent ER export couples ERAD-driven #mTORC1 activation with #MitochondrialDysfunction, causing energetic collapse & secretory myeloma cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
August 28, 2026 at 3:15 AM
Blocking ER export overcomes #MultipleMyeloma?
This study shows that blocking COPII-dependent ER export couples ERAD-driven #mTORC1 activation with #MitochondrialDysfunction, causing energetic collapse & secretory myeloma cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that blocking COPII-dependent ER export couples ERAD-driven #mTORC1 activation with #MitochondrialDysfunction, causing energetic collapse & secretory myeloma cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
Understanding #Alzheimers requires looking beyond a single pathway.
This review shows how #MitochondrialDysfunction, metabolic dysregulation and calcium imbalance drive disease, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows how #MitochondrialDysfunction, metabolic dysregulation and calcium imbalance drive disease, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
August 18, 2026 at 5:10 PM
Understanding #Alzheimers requires looking beyond a single pathway.
This review shows how #MitochondrialDysfunction, metabolic dysregulation and calcium imbalance drive disease, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows how #MitochondrialDysfunction, metabolic dysregulation and calcium imbalance drive disease, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
MOME August article highlight -In Press: Chronic fructose intake disrupts extracellular ATP–pyrophosphate homeostasis and increases susceptibility to aortic calcification | #MolecularMedicine #FructoseIntake #AorticCalcification #MitochondrialDysfunction link.springer.com/article/10.1...
Chronic fructose intake disrupts extracellular ATP–pyrophosphate homeostasis and increases susceptibility to aortic calcification - Molecular Medicine
Background Excessive fructose consumption has become increasingly prevalent in modern diets and is strongly associated with metabolic disorders and elevated cardiovascular risk. Vascular calcification...
link.springer.com
August 13, 2026 at 6:48 PM
MOME August article highlight -In Press: Chronic fructose intake disrupts extracellular ATP–pyrophosphate homeostasis and increases susceptibility to aortic calcification | #MolecularMedicine #FructoseIntake #AorticCalcification #MitochondrialDysfunction link.springer.com/article/10.1...
Scientists have shown that abnormal #TauProteins, altered by enzymatic changes, infiltrate #mitochondria in #neurons, disrupting #EnergyProduction and triggering a harmful cycle linked to #Alzheimers and other #NeurodegenerativeDiseases.
#TauTangles #MitochondrialDysfunction
#TauTangles #MitochondrialDysfunction
Alzheimer’s-implicated tau protein disrupts mitochondria in nerve cells – BioNews Central
Scientists have shown that abnormal tau proteins, altered by enzymatic changes, infiltrate mitochondria in nerve cells, disrupting energy production and triggering a harmful cycle linked to Alzheimer's and other neurodegenerative diseases. ...
sbee.link
August 7, 2026 at 9:08 PM
Scientists have shown that abnormal #TauProteins, altered by enzymatic changes, infiltrate #mitochondria in #neurons, disrupting #EnergyProduction and triggering a harmful cycle linked to #Alzheimers and other #NeurodegenerativeDiseases.
#TauTangles #MitochondrialDysfunction
#TauTangles #MitochondrialDysfunction
Thanks to Luca Bolliger for his extensive curation of #mitochondrialdisease literature this week for
@biomednews.bsky.social including genetic disease, #mitochondrialdysfunction, #mitochodnriaqualitycontrol in #aging:
biomed.news/bims-polgdi/...
#mitoscientists #POLGdisease #mitochondria
@biomednews.bsky.social including genetic disease, #mitochondrialdysfunction, #mitochodnriaqualitycontrol in #aging:
biomed.news/bims-polgdi/...
#mitoscientists #POLGdisease #mitochondria
August 3, 2026 at 7:34 PM
Thanks to Luca Bolliger for his extensive curation of #mitochondrialdisease literature this week for
@biomednews.bsky.social including genetic disease, #mitochondrialdysfunction, #mitochodnriaqualitycontrol in #aging:
biomed.news/bims-polgdi/...
#mitoscientists #POLGdisease #mitochondria
@biomednews.bsky.social including genetic disease, #mitochondrialdysfunction, #mitochodnriaqualitycontrol in #aging:
biomed.news/bims-polgdi/...
#mitoscientists #POLGdisease #mitochondria
🧠Kicking off the week with Christian Frezza's @biomednews.bsky.social curation, featuring MRI mapping of living human brain #mitochondria, signatures of bioenergetic defects & cognitive deficits:
biomed.news/bims-camemi/...
#mitoscientists #neurobiology #mitoneuro #mitochondrialdysfunction
biomed.news/bims-camemi/...
#mitoscientists #neurobiology #mitoneuro #mitochondrialdysfunction
August 3, 2026 at 7:22 PM
🧠Kicking off the week with Christian Frezza's @biomednews.bsky.social curation, featuring MRI mapping of living human brain #mitochondria, signatures of bioenergetic defects & cognitive deficits:
biomed.news/bims-camemi/...
#mitoscientists #neurobiology #mitoneuro #mitochondrialdysfunction
biomed.news/bims-camemi/...
#mitoscientists #neurobiology #mitoneuro #mitochondrialdysfunction
#Osteoporosis features severe bone loss driven by osteoblast #MitochondrialDysfunction.
Targeting N1-methyladenosine modification through tRNA methyltransferase 10C reverses these cellular defects, ameliorating disease progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
Targeting N1-methyladenosine modification through tRNA methyltransferase 10C reverses these cellular defects, ameliorating disease progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
August 3, 2026 at 1:15 PM
#Osteoporosis features severe bone loss driven by osteoblast #MitochondrialDysfunction.
Targeting N1-methyladenosine modification through tRNA methyltransferase 10C reverses these cellular defects, ameliorating disease progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
Targeting N1-methyladenosine modification through tRNA methyltransferase 10C reverses these cellular defects, ameliorating disease progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
Could restoring #MitochondrialHealth slow #ParkinsonsDisease?
This review explores how #MitochondrialDysfunction, #aging, and glial cell dysregulation converge to drive #neurodegeneration, highlighting emerging therapeutic targets.
#OpenAccess: doi.org/10.1016/j.ge...
This review explores how #MitochondrialDysfunction, #aging, and glial cell dysregulation converge to drive #neurodegeneration, highlighting emerging therapeutic targets.
#OpenAccess: doi.org/10.1016/j.ge...
July 12, 2026 at 5:02 PM
Could restoring #MitochondrialHealth slow #ParkinsonsDisease?
This review explores how #MitochondrialDysfunction, #aging, and glial cell dysregulation converge to drive #neurodegeneration, highlighting emerging therapeutic targets.
#OpenAccess: doi.org/10.1016/j.ge...
This review explores how #MitochondrialDysfunction, #aging, and glial cell dysregulation converge to drive #neurodegeneration, highlighting emerging therapeutic targets.
#OpenAccess: doi.org/10.1016/j.ge...
Recovery after #SpinalCordInjury depends on limiting secondary damage.
This review highlights #MitochondrialDysfunction as a driver of #neuroinflammation and explores #mitochondria-targeted therapies to improve outcomes. #Mitophagy
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights #MitochondrialDysfunction as a driver of #neuroinflammation and explores #mitochondria-targeted therapies to improve outcomes. #Mitophagy
#OpenAccess: doi.org/10.1016/j.ge...
July 10, 2026 at 3:19 PM
Recovery after #SpinalCordInjury depends on limiting secondary damage.
This review highlights #MitochondrialDysfunction as a driver of #neuroinflammation and explores #mitochondria-targeted therapies to improve outcomes. #Mitophagy
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights #MitochondrialDysfunction as a driver of #neuroinflammation and explores #mitochondria-targeted therapies to improve outcomes. #Mitophagy
#OpenAccess: doi.org/10.1016/j.ge...
Why do identical #mitochondrialdysfunction cause different disease outcomes? A Perspective in EXO proposes that clonal lineage mosaicism and cellular history may help explain tissue-specific vulnerability in #mitochondrialdisease.
🔗Read: www.sciexplor.com/exo/articles...
#SpatialOmics #Mitochondria
🔗Read: www.sciexplor.com/exo/articles...
#SpatialOmics #Mitochondria
July 10, 2026 at 9:54 AM
Why do identical #mitochondrialdysfunction cause different disease outcomes? A Perspective in EXO proposes that clonal lineage mosaicism and cellular history may help explain tissue-specific vulnerability in #mitochondrialdisease.
🔗Read: www.sciexplor.com/exo/articles...
#SpatialOmics #Mitochondria
🔗Read: www.sciexplor.com/exo/articles...
#SpatialOmics #Mitochondria
This study demonstrates that #Icariin inhibits excessive #Autophagy and alleviates #MitochondrialDysfunction by blocking mPTP opening, underscoring its potential as a #therapeutic strategy to preserve #CellularHealth.
To read: doi.org/10.1007/s115...
#OxidativeStress #Pharmacology
To read: doi.org/10.1007/s115...
#OxidativeStress #Pharmacology
June 24, 2026 at 3:15 PM
This study demonstrates that #Icariin inhibits excessive #Autophagy and alleviates #MitochondrialDysfunction by blocking mPTP opening, underscoring its potential as a #therapeutic strategy to preserve #CellularHealth.
To read: doi.org/10.1007/s115...
#OxidativeStress #Pharmacology
To read: doi.org/10.1007/s115...
#OxidativeStress #Pharmacology
#Necroptotic intestinal epithelia drive #sepsis injury through the RIPK3–STAT1–PTGS2/PTGES pathway, generating PGE₂ that triggers EP1-dependent #ferroptosis and #MitochondrialDysfunction; EP1 blockade improves survival and reduces #IntestinalInjury.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
June 21, 2026 at 4:28 AM
#Necroptotic intestinal epithelia drive #sepsis injury through the RIPK3–STAT1–PTGS2/PTGES pathway, generating PGE₂ that triggers EP1-dependent #ferroptosis and #MitochondrialDysfunction; EP1 blockade improves survival and reduces #IntestinalInjury.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
This research demonstrates that maternal infections induced by #LPS and poly(I:C) disrupt offspring #CardiacDevelopment by causing persistent #MitochondrialDysfunction and severe metabolic alterations.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
June 6, 2026 at 12:58 PM
This research demonstrates that maternal infections induced by #LPS and poly(I:C) disrupt offspring #CardiacDevelopment by causing persistent #MitochondrialDysfunction and severe metabolic alterations.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
😰 Is #depression a disease of #mitochondrialdysfunction? Dr. Cullen finds altered #mitochondria output & ATP in patients, potentially contributing to #fatigue. See the Mitoblog!
mitoworld.org/atp-bioenerg...
#TranslationalPsychiatry @natureportfolio.nature.com
@mayoclinic.org #UMDF #mitoscientists
mitoworld.org/atp-bioenerg...
#TranslationalPsychiatry @natureportfolio.nature.com
@mayoclinic.org #UMDF #mitoscientists
ATP Bioenergetics, Fatigue Depression in Young Adults - MitoWorld
Led by Kathryn Cullen, a research team at the University of Minnesota, the University of Queensland, and the Mayo Clinic studied depression and fatigue in young adults with and without early-stage dep...
mitoworld.org
June 5, 2026 at 4:10 PM
😰 Is #depression a disease of #mitochondrialdysfunction? Dr. Cullen finds altered #mitochondria output & ATP in patients, potentially contributing to #fatigue. See the Mitoblog!
mitoworld.org/atp-bioenerg...
#TranslationalPsychiatry @natureportfolio.nature.com
@mayoclinic.org #UMDF #mitoscientists
mitoworld.org/atp-bioenerg...
#TranslationalPsychiatry @natureportfolio.nature.com
@mayoclinic.org #UMDF #mitoscientists
This review describes #MitochondrialDysfunction as a key driver of #OxidativeStress, #Inflammation, and #Aging, highlighting how therapeutic strategies targeting mitochondrial pathways mitigate diverse age-related and chronic diseases.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
June 2, 2026 at 1:01 PM
This review describes #MitochondrialDysfunction as a key driver of #OxidativeStress, #Inflammation, and #Aging, highlighting how therapeutic strategies targeting mitochondrial pathways mitigate diverse age-related and chronic diseases.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Intracellular NAD⁺ Decline Across the Lifespan
Line plot depicting age-associated decline in relative intracellular NAD⁺ concentrations, expressed as percentage of young adult baseline.
#NAD #NAMPT #Sirtuins #MitochondrialDysfunction #MetabolicAging #Epigenetics #AgingBiology
Line plot depicting age-associated decline in relative intracellular NAD⁺ concentrations, expressed as percentage of young adult baseline.
#NAD #NAMPT #Sirtuins #MitochondrialDysfunction #MetabolicAging #Epigenetics #AgingBiology
May 17, 2026 at 5:18 PM
Intracellular NAD⁺ Decline Across the Lifespan
Line plot depicting age-associated decline in relative intracellular NAD⁺ concentrations, expressed as percentage of young adult baseline.
#NAD #NAMPT #Sirtuins #MitochondrialDysfunction #MetabolicAging #Epigenetics #AgingBiology
Line plot depicting age-associated decline in relative intracellular NAD⁺ concentrations, expressed as percentage of young adult baseline.
#NAD #NAMPT #Sirtuins #MitochondrialDysfunction #MetabolicAging #Epigenetics #AgingBiology
This review in #STTT outlines key hallmarks and signaling pathways in #CardiovascularAgeing, including #Inflammation and #MitochondrialDysfunction, and highlights #TherapeuticTargets to address age-related #CardiovascularDiseases. @fudan-university.bsky.social
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
May 3, 2026 at 3:30 PM
This review in #STTT outlines key hallmarks and signaling pathways in #CardiovascularAgeing, including #Inflammation and #MitochondrialDysfunction, and highlights #TherapeuticTargets to address age-related #CardiovascularDiseases. @fudan-university.bsky.social
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Endothelial GABA provides protection against #AorticDissection by mitigating #MitochondrialDysfunction and preserving #VascularHomeostasis, representing a potential #TherapeuticTarget for cardiovascular stability.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
May 2, 2026 at 2:30 PM
Endothelial GABA provides protection against #AorticDissection by mitigating #MitochondrialDysfunction and preserving #VascularHomeostasis, representing a potential #TherapeuticTarget for cardiovascular stability.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review describes #MitochondrialDysfunction as a key driver of #OxidativeStress, #Inflammation, and #Aging, highlighting how therapeutic strategies targeting mitochondrial pathways mitigate diverse age-related and chronic diseases.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
April 15, 2026 at 1:15 PM
This review describes #MitochondrialDysfunction as a key driver of #OxidativeStress, #Inflammation, and #Aging, highlighting how therapeutic strategies targeting mitochondrial pathways mitigate diverse age-related and chronic diseases.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review shows how #MitochondrialDysfunction in dynamics and energetics drives #TNBC progression and #chemoresistance, while targeted strategies restoring homeostasis and disrupting #TumorMetabolism offer therapeutic promise.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
April 4, 2026 at 11:00 AM
This review shows how #MitochondrialDysfunction in dynamics and energetics drives #TNBC progression and #chemoresistance, while targeted strategies restoring homeostasis and disrupting #TumorMetabolism offer therapeutic promise.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...