Applications are now open for the first Patchlinerᵐ Research Grant!
One selected recipient will receive Patchlinerᵐ in their lab for 6 months, including training, consumables, and expert support.
Apply by Sept. 25, 2026: https://ow.ly/Y9MI50ZiLh4
#patchclamp #ionchannels
One selected recipient will receive Patchlinerᵐ in their lab for 6 months, including training, consumables, and expert support.
Apply by Sept. 25, 2026: https://ow.ly/Y9MI50ZiLh4
#patchclamp #ionchannels
July 1, 2026 at 2:02 PM
Applications are now open for the first Patchlinerᵐ Research Grant!
One selected recipient will receive Patchlinerᵐ in their lab for 6 months, including training, consumables, and expert support.
Apply by Sept. 25, 2026: https://ow.ly/Y9MI50ZiLh4
#patchclamp #ionchannels
One selected recipient will receive Patchlinerᵐ in their lab for 6 months, including training, consumables, and expert support.
Apply by Sept. 25, 2026: https://ow.ly/Y9MI50ZiLh4
#patchclamp #ionchannels
On Saturday, I gave a lecture and then a seminar in the morning, and spent the rest of the day in the lab. Went back to my room a little after midnight and got up at 5 am to take my camera on a morning walk.
#Photography #Teaching #Science #IonChannels #Electrophysiology #PatchClamp
#Photography #Teaching #Science #IonChannels #Electrophysiology #PatchClamp
June 9, 2026 at 3:05 AM
On Saturday, I gave a lecture and then a seminar in the morning, and spent the rest of the day in the lab. Went back to my room a little after midnight and got up at 5 am to take my camera on a morning walk.
#Photography #Teaching #Science #IonChannels #Electrophysiology #PatchClamp
#Photography #Teaching #Science #IonChannels #Electrophysiology #PatchClamp
Scientifica is delighted to have joined the Bluesky community. We will be providing a wide range of great resources, guides, podcasts & webinars in support of the #electrophysiology community. Visit our resource centre > www.scientifica.uk.com/resources
#patchclamp #neuroscience #cardiovascular
#patchclamp #neuroscience #cardiovascular
June 5, 2026 at 1:43 PM
Scientifica is delighted to have joined the Bluesky community. We will be providing a wide range of great resources, guides, podcasts & webinars in support of the #electrophysiology community. Visit our resource centre > www.scientifica.uk.com/resources
#patchclamp #neuroscience #cardiovascular
#patchclamp #neuroscience #cardiovascular
www.nature.com/articles/s41...
Delighted to have contributed to this exciting work led by Mikhail Tarasov and Przemysław Radwański. By combining #MINFLUX #nanoscopy with #singlechannel #patchclamp, we identified #cooperative #gating of clustered NaV1.5 #sodiumchannels. 🧵
Delighted to have contributed to this exciting work led by Mikhail Tarasov and Przemysław Radwański. By combining #MINFLUX #nanoscopy with #singlechannel #patchclamp, we identified #cooperative #gating of clustered NaV1.5 #sodiumchannels. 🧵
Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels - Nature Communications
Authors show how voltage-gated sodium channels influence each other’s gating kinetics when localized in sufficient proximity to each other as part of clusters in the membrane. These nanoscale effects ...
www.nature.com
May 11, 2026 at 9:39 PM
www.nature.com/articles/s41...
Delighted to have contributed to this exciting work led by Mikhail Tarasov and Przemysław Radwański. By combining #MINFLUX #nanoscopy with #singlechannel #patchclamp, we identified #cooperative #gating of clustered NaV1.5 #sodiumchannels. 🧵
Delighted to have contributed to this exciting work led by Mikhail Tarasov and Przemysław Radwański. By combining #MINFLUX #nanoscopy with #singlechannel #patchclamp, we identified #cooperative #gating of clustered NaV1.5 #sodiumchannels. 🧵
Twenty years of experience rarely lead to small changes.
This is just a glimpse of what we’ve been working on, shaped by:
✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology
Full reveal at #BPS2026
#PatchClamp #20years
This is just a glimpse of what we’ve been working on, shaped by:
✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology
Full reveal at #BPS2026
#PatchClamp #20years
February 17, 2026 at 1:01 PM
Twenty years of experience rarely lead to small changes.
This is just a glimpse of what we’ve been working on, shaped by:
✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology
Full reveal at #BPS2026
#PatchClamp #20years
This is just a glimpse of what we’ve been working on, shaped by:
✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology
Full reveal at #BPS2026
#PatchClamp #20years
We love to hear how our reagents perform in the lab. An electrophysiologist at Stanford University shared great feedback on our ready-made Cesium Gluconate 👨🔬🔬
We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn
#electrophysiology #patchclamp
We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn
#electrophysiology #patchclamp
January 28, 2026 at 4:01 PM
We love to hear how our reagents perform in the lab. An electrophysiologist at Stanford University shared great feedback on our ready-made Cesium Gluconate 👨🔬🔬
We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn
#electrophysiology #patchclamp
We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn
#electrophysiology #patchclamp
The Cantu-syndrom H60Y mutation in the SUR2 subunit of ATP-sensitive potassium channels results in gain of function only when paired with Kir6.1. New Dynaflow publication in Journal of Biological Chemistry.
👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels
👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels
Cantu syndrome–associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels
Gain-of-function (GOF) mutations in either Kir6.1 (encoded by KCNJ8) or SUR2 (encoded
by ABCC9) are causally associated with Cantu syndrome (CS), characterized by coarse
facial appearance, hypertricho...
www.jbc.org
January 27, 2026 at 9:41 AM
The Cantu-syndrom H60Y mutation in the SUR2 subunit of ATP-sensitive potassium channels results in gain of function only when paired with Kir6.1. New Dynaflow publication in Journal of Biological Chemistry.
👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels
👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels
Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
December 10, 2025 at 8:04 AM
Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
November 11, 2025 at 4:01 AM
The last two cells I patched! They are by no means my best fills, but definitely the most memorable. Also a reminder to new patchers that lousy fills do not indicate bad cells- some of my best recordings didn’t have great fills. (Ah I miss patching🥹)
#patchclamp #electrophysiology
#patchclamp #electrophysiology
November 6, 2025 at 9:40 AM
The last two cells I patched! They are by no means my best fills, but definitely the most memorable. Also a reminder to new patchers that lousy fills do not indicate bad cells- some of my best recordings didn’t have great fills. (Ah I miss patching🥹)
#patchclamp #electrophysiology
#patchclamp #electrophysiology
One of the most beautiful things in the world❤️ #patchclamp #EIRatio
October 17, 2025 at 5:14 PM
One of the most beautiful things in the world❤️ #patchclamp #EIRatio
🔬 The patch-clamp technique enables precise recording of ion channel and neuronal activity—key for studying excitability and synaptic transmission.
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...
#PatchClamp #Neural
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...
#PatchClamp #Neural
Research Service | Cell and Tissue Patch-Clamp Recording and Analysis Services
Explore Brain Case Biotech’s cell and tissue patch-clamp recording services—offering precise ion channel, synaptic, and electrophysiological analysis for neuroscience
www.ebraincase.com
October 17, 2025 at 8:20 AM
🔬 The patch-clamp technique enables precise recording of ion channel and neuronal activity—key for studying excitability and synaptic transmission.
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...
#PatchClamp #Neural
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...
#PatchClamp #Neural
Our patch-clamp single-cell proteomics preprint is out! Long story short: we show you how combining patch-clamp with mass spectrometry can reveal ion channels, GPCRs, and other proteins directly linked to neuronal excitability and signaling #patchclamp #electrophysiology #singlecellproteomics
Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation
Single-cell proteomics (SCP) is a powerful method for interrogating the molecular composition of neurons, yet its application to acute brain slices has remained limited. Patch-clamp electrophysiology ...
www.biorxiv.org
October 9, 2025 at 9:43 PM
Our patch-clamp single-cell proteomics preprint is out! Long story short: we show you how combining patch-clamp with mass spectrometry can reveal ion channels, GPCRs, and other proteins directly linked to neuronal excitability and signaling #patchclamp #electrophysiology #singlecellproteomics
Planning to record LTP or LTD in acute brain slices with whole-cell patch clamp? Give my latest article on Scientifica's NeuroWire a look! www.scientifica.uk.com/learning-zon... #plasticity #patchclamp #electrophysiology #ephys 🔬🪄⚡️
Electrophysiology protocols for LTP and LTD: Recording synaptic…
Learn how to record LTP and LTD using whole-cell patch clamp. Step-by-step guide to measuring synaptic plasticity in individual neurons
www.scientifica.uk.com
September 1, 2025 at 4:25 AM
Planning to record LTP or LTD in acute brain slices with whole-cell patch clamp? Give my latest article on Scientifica's NeuroWire a look! www.scientifica.uk.com/learning-zon... #plasticity #patchclamp #electrophysiology #ephys 🔬🪄⚡️
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
July 29, 2025 at 5:15 PM
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)
July 8, 2025 at 12:04 PM
During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
July 7, 2025 at 6:48 AM
patch clamp technique #patchclamp #metinaytekin
June 13, 2025 at 11:37 PM
patch clamp technique #patchclamp #metinaytekin
How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?
Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.
📍https://ow.ly/PxZY50W72H7
#PatchClamp #Channelopathies #IonChannels
Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.
📍https://ow.ly/PxZY50W72H7
#PatchClamp #Channelopathies #IonChannels
June 10, 2025 at 2:29 PM
How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?
Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.
📍https://ow.ly/PxZY50W72H7
#PatchClamp #Channelopathies #IonChannels
Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.
📍https://ow.ly/PxZY50W72H7
#PatchClamp #Channelopathies #IonChannels
#neuroscience #micromanipulation #electrophysiology #ScanImage #autopatch #patchclamp #LifeSciences #labautomation #neurotech #researchtools
June 2, 2025 at 3:48 PM
Some beautiful IPSCs for your Friday! #patchclamp
May 16, 2025 at 5:42 PM
Some beautiful IPSCs for your Friday! #patchclamp
In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.
Read more here:
www.nanion.de/news/automat...
Read more here:
www.nanion.de/news/automat...
Automated patch clamp for ENaC drug discovery - Nanion Technologies
The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...
www.nanion.de
May 15, 2025 at 3:45 PM
In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.
Read more here:
www.nanion.de/news/automat...
Read more here:
www.nanion.de/news/automat...
All those GABAs from mouse V1 #patchclamp
(Should mention these are recorded with a high Cl internal thus the outward currents)
(Should mention these are recorded with a high Cl internal thus the outward currents)
March 29, 2025 at 10:25 PM
All those GABAs from mouse V1 #patchclamp
(Should mention these are recorded with a high Cl internal thus the outward currents)
(Should mention these are recorded with a high Cl internal thus the outward currents)
We are all set at the Göttingen Meeting of the @neurowissg.bsky.social... Drop by booth 62 to see what we have brought along ( #patchclamp and #imaging ), but also to share stories of your biggest experimental victories 🥳 and challenges 😶🌫️!
March 26, 2025 at 3:55 PM
We are all set at the Göttingen Meeting of the @neurowissg.bsky.social... Drop by booth 62 to see what we have brought along ( #patchclamp and #imaging ), but also to share stories of your biggest experimental victories 🥳 and challenges 😶🌫️!
Such a good feeling to get data again #patchclamp
March 20, 2025 at 6:23 PM
Such a good feeling to get data again #patchclamp