November 8, 2025 at 3:46 PM
September 26, 2026 at 5:45 PM
Main Finding 1: Along with many organs, we discovered spike accumulations in the skull marrow niches and recently discovered skull-meninges connections (SMCs), revealing a new route of pathogens into the brain.
November 29, 2024 at 4:01 PM
Main Finding 1: Along with many organs, we discovered spike accumulations in the skull marrow niches and recently discovered skull-meninges connections (SMCs), revealing a new route of pathogens into the brain.
I CAN'T WAIT TO START WORK ON SMCS!!!!!
May 28, 2025 at 10:29 PM
I CAN'T WAIT TO START WORK ON SMCS!!!!!
starting to notice a pattern
September 5, 2026 at 7:44 PM
starting to notice a pattern
Fabricate a 3D GelMA channel with #SmoothMuscleCell Circumferential Wrapping🤠
SMCs seeded fibronectin-coated Gelatin Microribbons
Miroribbons wrapped around a 25-G needle & encapsulated in GelMA
👉Artery-on-a-chip with multilayered SMCs?😁
#Biofabrication 2024
iopscience.iop.org/article/10.1...
SMCs seeded fibronectin-coated Gelatin Microribbons
Miroribbons wrapped around a 25-G needle & encapsulated in GelMA
👉Artery-on-a-chip with multilayered SMCs?😁
#Biofabrication 2024
iopscience.iop.org/article/10.1...
November 14, 2024 at 9:05 PM
Fabricate a 3D GelMA channel with #SmoothMuscleCell Circumferential Wrapping🤠
SMCs seeded fibronectin-coated Gelatin Microribbons
Miroribbons wrapped around a 25-G needle & encapsulated in GelMA
👉Artery-on-a-chip with multilayered SMCs?😁
#Biofabrication 2024
iopscience.iop.org/article/10.1...
SMCs seeded fibronectin-coated Gelatin Microribbons
Miroribbons wrapped around a 25-G needle & encapsulated in GelMA
👉Artery-on-a-chip with multilayered SMCs?😁
#Biofabrication 2024
iopscience.iop.org/article/10.1...
Good news from the North! 🇨🇦 Canada published their official SMCS policy! $ASTS. They requested comments in 2024 and now the policy is out. Perfect fit for AST's low band BlueBirds and mid-band when they are ready.
ised-isde.canada.ca/site/spectru...
ised-isde.canada.ca/site/spectru...
February 21, 2025 at 5:49 PM
Good news from the North! 🇨🇦 Canada published their official SMCS policy! $ASTS. They requested comments in 2024 and now the policy is out. Perfect fit for AST's low band BlueBirds and mid-band when they are ready.
ised-isde.canada.ca/site/spectru...
ised-isde.canada.ca/site/spectru...
#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃
"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"
#JDBMDPI 2025
www.mdpi.com/2221-3759/13...
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃
"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"
#JDBMDPI 2025
www.mdpi.com/2221-3759/13...
April 27, 2025 at 7:39 PM
#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃
"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"
#JDBMDPI 2025
www.mdpi.com/2221-3759/13...
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃
"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"
#JDBMDPI 2025
www.mdpi.com/2221-3759/13...
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
June 25, 2025 at 6:59 AM
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
Out testing the new 690 cruise control, good chance we're the first SMCs in the country with it installed.
The good, it works well.
The bad, needs third gear and 25mph or higher.
#motosky #motorcycle #werideorange #motorbike
The good, it works well.
The bad, needs third gear and 25mph or higher.
#motosky #motorcycle #werideorange #motorbike
October 4, 2026 at 6:49 PM
Out testing the new 690 cruise control, good chance we're the first SMCs in the country with it installed.
The good, it works well.
The bad, needs third gear and 25mph or higher.
#motosky #motorcycle #werideorange #motorbike
The good, it works well.
The bad, needs third gear and 25mph or higher.
#motosky #motorcycle #werideorange #motorbike
Latest paper where our #CDlab contributed now in NAR: academic.oup.com/nar/article/...
The work shows that all SMCs, from yeast to human SMCs, form DNA-SMC biomolecular condensates at higher concentrations.
The work shows that all SMCs, from yeast to human SMCs, form DNA-SMC biomolecular condensates at higher concentrations.
Validate User
academic.oup.com
September 3, 2026 at 9:30 PM
Latest paper where our #CDlab contributed now in NAR: academic.oup.com/nar/article/...
The work shows that all SMCs, from yeast to human SMCs, form DNA-SMC biomolecular condensates at higher concentrations.
The work shows that all SMCs, from yeast to human SMCs, form DNA-SMC biomolecular condensates at higher concentrations.
smcs 3 is out www.youtube.com/watch?v=_0eS...
April 25, 2026 at 8:56 PM
smcs 3 is out www.youtube.com/watch?v=_0eS...
imagine smcs tentadick wrapped around them too (his hair counts when he wants it too)
April 20, 2026 at 12:45 PM
imagine smcs tentadick wrapped around them too (his hair counts when he wants it too)
Senescent cell identification SenCID
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
January 22, 2025 at 12:49 PM
Senescent cell identification SenCID
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
🌽🔬
A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis @pnas.org
www.pnas.org/doi/10.1073/...
Movie: Oblique asymmetric cell divisions of SMCs in kai1-1 mutants.
A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis @pnas.org
www.pnas.org/doi/10.1073/...
Movie: Oblique asymmetric cell divisions of SMCs in kai1-1 mutants.
July 21, 2026 at 3:22 PM
🌽🔬
A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis @pnas.org
www.pnas.org/doi/10.1073/...
Movie: Oblique asymmetric cell divisions of SMCs in kai1-1 mutants.
A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis @pnas.org
www.pnas.org/doi/10.1073/...
Movie: Oblique asymmetric cell divisions of SMCs in kai1-1 mutants.
My continued biomedical education
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
August 2, 2025 at 7:21 PM
My continued biomedical education
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Utterly idiotic and certainly written by one specific group or person who complained about them and was just annoying enough that the complaint desk codified it. The SMCs land use code is 1,407 pages of useless crap
August 24, 2026 at 4:57 AM
Utterly idiotic and certainly written by one specific group or person who complained about them and was just annoying enough that the complaint desk codified it. The SMCs land use code is 1,407 pages of useless crap
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
December 3, 2024 at 8:50 PM
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
primarily towards smcs and marioverse 2
August 20, 2025 at 11:29 PM
primarily towards smcs and marioverse 2
Werdet zu „Deckers“ in dem gleichnamigen Spiel von Deep Print Games und hackt euch in ein Netzwerk. Bekämpft einen von sieben Supermassiven Computern (SMCs) und befreit die Menschheit aus seinen Fängen. Ladet Protokolle hoch, entfernt Marker des SMCs und erlangt so die Kontrolle.
September 5, 2025 at 9:32 AM
Werdet zu „Deckers“ in dem gleichnamigen Spiel von Deep Print Games und hackt euch in ein Netzwerk. Bekämpft einen von sieben Supermassiven Computern (SMCs) und befreit die Menschheit aus seinen Fängen. Ladet Protokolle hoch, entfernt Marker des SMCs und erlangt so die Kontrolle.
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
December 25, 2024 at 11:53 AM
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
👀SMC 🛵 on 🧬 induce 🥨 at each➰
www.science.org/doi/10.1126/...
by @ceesdekker.bsky.social @romanbarth.bsky.social et al.
www.science.org/doi/10.1126/...
by @ceesdekker.bsky.social @romanbarth.bsky.social et al.
December 13, 2024 at 8:54 PM
👀SMC 🛵 on 🧬 induce 🥨 at each➰
www.science.org/doi/10.1126/...
by @ceesdekker.bsky.social @romanbarth.bsky.social et al.
www.science.org/doi/10.1126/...
by @ceesdekker.bsky.social @romanbarth.bsky.social et al.
I want to draw and upload my art... BUT INSTEAD I HAVE BEEN GOING FULL HYPER FOCUSED ON TOMODACHI LIFE AND BEEN MAKING MORE SMCs AND THE CREATURES THAT LIVE IN THE SPIRE AND JUST MAKING THE ENTIRE SPIRE THIS ENTIRE TIME!!!
AAAA
I FOUND MY STYLIST FOR MY SWITCH 2 AND JUST BEEN OUT OF IT, VRO
AAAA
I FOUND MY STYLIST FOR MY SWITCH 2 AND JUST BEEN OUT OF IT, VRO
May 20, 2026 at 4:02 PM
I want to draw and upload my art... BUT INSTEAD I HAVE BEEN GOING FULL HYPER FOCUSED ON TOMODACHI LIFE AND BEEN MAKING MORE SMCs AND THE CREATURES THAT LIVE IN THE SPIRE AND JUST MAKING THE ENTIRE SPIRE THIS ENTIRE TIME!!!
AAAA
I FOUND MY STYLIST FOR MY SWITCH 2 AND JUST BEEN OUT OF IT, VRO
AAAA
I FOUND MY STYLIST FOR MY SWITCH 2 AND JUST BEEN OUT OF IT, VRO
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
January 18, 2026 at 1:44 PM
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...