hESC-derived #BloodVesselOrganoid with dual #EndothelialCell (PECAM1-mRuby3-secNluc) & #SmoothMuscleCell (ACTA2-EGFP) lineage reporters
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
January 28, 2025 at 1:00 PM
hESC-derived #BloodVesselOrganoid with dual #EndothelialCell (PECAM1-mRuby3-secNluc) & #SmoothMuscleCell (ACTA2-EGFP) lineage reporters
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField
Their transcript profiles by scRNAseq + snATACseq👇
#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField
Their transcript profiles by scRNAseq + snATACseq👇
#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
January 26, 2025 at 1:39 PM
Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField
Their transcript profiles by scRNAseq + snATACseq👇
#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField
Their transcript profiles by scRNAseq + snATACseq👇
#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
A constitutive #SmoothMuscleCell specific Cre mice under precise control of endogenous Myh11 loci🤠
This time, we do not need to worry about off-targeting embryonic cardiomyocyte or male gamete😁
Jiliang Zhou lab bioRxiv 2024
www.biorxiv.org/content/10.1...
This time, we do not need to worry about off-targeting embryonic cardiomyocyte or male gamete😁
Jiliang Zhou lab bioRxiv 2024
www.biorxiv.org/content/10.1...
March 21, 2025 at 6:52 PM
A constitutive #SmoothMuscleCell specific Cre mice under precise control of endogenous Myh11 loci🤠
This time, we do not need to worry about off-targeting embryonic cardiomyocyte or male gamete😁
Jiliang Zhou lab bioRxiv 2024
www.biorxiv.org/content/10.1...
This time, we do not need to worry about off-targeting embryonic cardiomyocyte or male gamete😁
Jiliang Zhou lab bioRxiv 2024
www.biorxiv.org/content/10.1...
Liver-to-Aorta communication😎
#Atheroasclerosis #MAFLD #MedialArterialCalcification
Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
#Atheroasclerosis #MAFLD #MedialArterialCalcification
Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
January 1, 2025 at 4:13 PM
Liver-to-Aorta communication😎
#Atheroasclerosis #MAFLD #MedialArterialCalcification
Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
#Atheroasclerosis #MAFLD #MedialArterialCalcification
Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
#Pericyte #PulmonaryHypertension
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
January 27, 2025 at 1:41 PM
#Pericyte #PulmonaryHypertension
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
#SpatialTranscriptomics #Atherosclerosis
Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions
scRNAseq GeoMx
🔥 #SmoothMuscleCell Fibroblast T
#Senolytic ABT-737 ⏫plaque collagen fibers ⏬necrotic core ⏬serum cytokines
#NatAging 2025
www.nature.com/articles/s43...
Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions
scRNAseq GeoMx
🔥 #SmoothMuscleCell Fibroblast T
#Senolytic ABT-737 ⏫plaque collagen fibers ⏬necrotic core ⏬serum cytokines
#NatAging 2025
www.nature.com/articles/s43...
July 15, 2025 at 7:17 PM
#SpatialTranscriptomics #Atherosclerosis
Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions
scRNAseq GeoMx
🔥 #SmoothMuscleCell Fibroblast T
#Senolytic ABT-737 ⏫plaque collagen fibers ⏬necrotic core ⏬serum cytokines
#NatAging 2025
www.nature.com/articles/s43...
Mapping the Senescence (SenMayo CellAge) in p16 reporter🐭aortic atherosclerotic lesions
scRNAseq GeoMx
🔥 #SmoothMuscleCell Fibroblast T
#Senolytic ABT-737 ⏫plaque collagen fibers ⏬necrotic core ⏬serum cytokines
#NatAging 2025
www.nature.com/articles/s43...
My continued biomedical education
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
August 2, 2025 at 7:21 PM
My continued biomedical education
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Uterine fibroids at single-cell resolution
Integrated digestion of canonical Genetics (MED12 HMGA2 FH) & Clonality & scRNAseq
3 #SmoothMuscleCell states
"only fibroid SMCs bear the MED12 variant, excluding fibroblasts"
#AJOG 2025
www.ajog.org/article/S000...
Cross-species👤🐷🐭 analysis of elastic or coronary artery mesenchymal cells in #Atherosclerosis
75% mesenchymal cells shared as
Contractile (ACTA2 CNN1 FLNA)-
Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2)
#SmoothMuscleCell states
www.biorxiv.org/content/10.1...
75% mesenchymal cells shared as
Contractile (ACTA2 CNN1 FLNA)-
Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2)
#SmoothMuscleCell states
www.biorxiv.org/content/10.1...
September 23, 2025 at 11:47 AM
Cross-species👤🐷🐭 analysis of elastic or coronary artery mesenchymal cells in #Atherosclerosis
75% mesenchymal cells shared as
Contractile (ACTA2 CNN1 FLNA)-
Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2)
#SmoothMuscleCell states
www.biorxiv.org/content/10.1...
75% mesenchymal cells shared as
Contractile (ACTA2 CNN1 FLNA)-
Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2)
#SmoothMuscleCell states
www.biorxiv.org/content/10.1...
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
December 3, 2024 at 8:50 PM
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
RBPMS (splicing factor)-CreERT2 mice
Active in a broad collection of cell types, incld #SmoothMuscleCell #Pericyte #Cardiomyocyte & more & more
@cp-iscience.bsky.social 2023
www.cell.com/iscience/ful...
Active in a broad collection of cell types, incld #SmoothMuscleCell #Pericyte #Cardiomyocyte & more & more
@cp-iscience.bsky.social 2023
www.cell.com/iscience/ful...
March 8, 2025 at 8:05 PM
RBPMS (splicing factor)-CreERT2 mice
Active in a broad collection of cell types, incld #SmoothMuscleCell #Pericyte #Cardiomyocyte & more & more
@cp-iscience.bsky.social 2023
www.cell.com/iscience/ful...
Active in a broad collection of cell types, incld #SmoothMuscleCell #Pericyte #Cardiomyocyte & more & more
@cp-iscience.bsky.social 2023
www.cell.com/iscience/ful...
#VascularCalcification
#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
September 12, 2025 at 12:23 PM
#VascularCalcification
#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
One can isolate #ExtracellularVesicle from🐭Bone (tibia/femur, not bone marrow)!?😮
Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭
Matrix Biol 2024
www.sciencedirect.com/science/arti...
Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭
Matrix Biol 2024
www.sciencedirect.com/science/arti...
November 25, 2024 at 8:24 PM
One can isolate #ExtracellularVesicle from🐭Bone (tibia/femur, not bone marrow)!?😮
Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭
Matrix Biol 2024
www.sciencedirect.com/science/arti...
Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭
Matrix Biol 2024
www.sciencedirect.com/science/arti...
How does Genomic Instability cause #VascularCalcification?
A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification
Which type of DNA lesions activates STING in calcifying SMC?🧐
#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification
Which type of DNA lesions activates STING in calcifying SMC?🧐
#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
April 10, 2025 at 6:53 PM
How does Genomic Instability cause #VascularCalcification?
A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification
Which type of DNA lesions activates STING in calcifying SMC?🧐
#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification
Which type of DNA lesions activates STING in calcifying SMC?🧐
#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Evidence for an active role of #EndothalialCell in #Aortopathy
EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide
#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...
EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide
#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...
November 28, 2024 at 8:57 PM
Evidence for an active role of #EndothalialCell in #Aortopathy
EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide
#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...
EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide
#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
November 12, 2025 at 7:59 PM
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
So Happy to contribute a small part to this work from my PhD supervisor, Dr. Xi-Long Zheng lab 😆
The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
May 22, 2025 at 6:59 PM
So Happy to contribute a small part to this work from my PhD supervisor, Dr. Xi-Long Zheng lab 😆
The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
The role of epigenomic reader #BRD4 in #SmoothMuscleCell #Microtubule #Autophagy #Senescence #IntimalHyperplasia #VascularAging😎
#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Regionalized & Sex-dependent scRNAseq of 🐭Aorta
Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell
Arch
#SecondHeartField vs #NeuralCrest SMC
339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS
#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...
Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell
Arch
#SecondHeartField vs #NeuralCrest SMC
339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS
#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...
September 30, 2025 at 10:48 AM
Regionalized & Sex-dependent scRNAseq of 🐭Aorta
Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell
Arch
#SecondHeartField vs #NeuralCrest SMC
339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS
#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...
Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell
Arch
#SecondHeartField vs #NeuralCrest SMC
339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS
#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...
Not sure I am a guru on #SmoothMuscleCell😀
May 2, 2025 at 11:28 PM
Not sure I am a guru on #SmoothMuscleCell😀
#HutchinsonGilfordProgeriaSyndrome
#SmoothMuscleCell Progerin transgene drives #EndMT #Atherosclerosis🐭
⏫Aortic Endothelial Cell permeability
⏫Lesional EC infiltr▶️ColIV- & TGFβ1-rich plaque😮
Paracrine of progeroid aortic SMC?😆
#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
#SmoothMuscleCell Progerin transgene drives #EndMT #Atherosclerosis🐭
⏫Aortic Endothelial Cell permeability
⏫Lesional EC infiltr▶️ColIV- & TGFβ1-rich plaque😮
Paracrine of progeroid aortic SMC?😆
#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
December 4, 2025 at 11:55 AM
#HutchinsonGilfordProgeriaSyndrome
#SmoothMuscleCell Progerin transgene drives #EndMT #Atherosclerosis🐭
⏫Aortic Endothelial Cell permeability
⏫Lesional EC infiltr▶️ColIV- & TGFβ1-rich plaque😮
Paracrine of progeroid aortic SMC?😆
#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
#SmoothMuscleCell Progerin transgene drives #EndMT #Atherosclerosis🐭
⏫Aortic Endothelial Cell permeability
⏫Lesional EC infiltr▶️ColIV- & TGFβ1-rich plaque😮
Paracrine of progeroid aortic SMC?😆
#CircAHA 2024
www.ahajournals.org/doi/10.1161/...
2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
November 30, 2024 at 1:22 PM
2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
#Ferroptosis #VascularCalcification
SREBP1 transcriptionally⏫iASPP (likely FASN▶️FAO, BHLHE40▶️Circadian, too)➡️ ⏬#SmoothMuscleCell #Ferroptosis #Osteogenesis (BMP2 RUNX2 Calcification)
#CardiovascDiabetol 2025
cardiab.biomedcentral.com/articles/10....
SREBP1 transcriptionally⏫iASPP (likely FASN▶️FAO, BHLHE40▶️Circadian, too)➡️ ⏬#SmoothMuscleCell #Ferroptosis #Osteogenesis (BMP2 RUNX2 Calcification)
#CardiovascDiabetol 2025
cardiab.biomedcentral.com/articles/10....
May 3, 2026 at 7:01 PM
#Ferroptosis #VascularCalcification
SREBP1 transcriptionally⏫iASPP (likely FASN▶️FAO, BHLHE40▶️Circadian, too)➡️ ⏬#SmoothMuscleCell #Ferroptosis #Osteogenesis (BMP2 RUNX2 Calcification)
#CardiovascDiabetol 2025
cardiab.biomedcentral.com/articles/10....
SREBP1 transcriptionally⏫iASPP (likely FASN▶️FAO, BHLHE40▶️Circadian, too)➡️ ⏬#SmoothMuscleCell #Ferroptosis #Osteogenesis (BMP2 RUNX2 Calcification)
#CardiovascDiabetol 2025
cardiab.biomedcentral.com/articles/10....
#PsoriasisVulgaris #AutoimmuneDisease #SpatialTranscriptomics StereoSeq
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
December 15, 2024 at 1:08 PM
#PsoriasisVulgaris #AutoimmuneDisease #SpatialTranscriptomics StereoSeq
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
hu.MAP3.0
>25k #Proteomics experiments
>15k human protein complexes covering ~70% human proteins🤠
humap3.proteincomplexes.org
How does the MYH11-ZFAND5 complex function in #SmoothMuscleCell?😄
@ksdrew.bsky.social
#MolSystBiol 2025
www.embopress.org/doi/full/10....
>25k #Proteomics experiments
>15k human protein complexes covering ~70% human proteins🤠
humap3.proteincomplexes.org
How does the MYH11-ZFAND5 complex function in #SmoothMuscleCell?😄
@ksdrew.bsky.social
#MolSystBiol 2025
www.embopress.org/doi/full/10....
hu.MAP 3.0
humap3.proteincomplexes.org
July 27, 2025 at 12:21 PM
hu.MAP3.0
>25k #Proteomics experiments
>15k human protein complexes covering ~70% human proteins🤠
humap3.proteincomplexes.org
How does the MYH11-ZFAND5 complex function in #SmoothMuscleCell?😄
@ksdrew.bsky.social
#MolSystBiol 2025
www.embopress.org/doi/full/10....
>25k #Proteomics experiments
>15k human protein complexes covering ~70% human proteins🤠
humap3.proteincomplexes.org
How does the MYH11-ZFAND5 complex function in #SmoothMuscleCell?😄
@ksdrew.bsky.social
#MolSystBiol 2025
www.embopress.org/doi/full/10....
TEAD1/YAP/TAZ mediate FSP1/FN1/COL3A1-hi fibroblast-like, plaque-healing #SmoothMuscleCell in #Atherosclerosis
TEAD1⬆️Wnt4 transcription
Another #YAP -collagenous matrix link🤠
Tandem stenosis of common carotid artery-> plaque rupture & healing
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
TEAD1⬆️Wnt4 transcription
Another #YAP -collagenous matrix link🤠
Tandem stenosis of common carotid artery-> plaque rupture & healing
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
December 23, 2024 at 1:52 PM
TEAD1/YAP/TAZ mediate FSP1/FN1/COL3A1-hi fibroblast-like, plaque-healing #SmoothMuscleCell in #Atherosclerosis
TEAD1⬆️Wnt4 transcription
Another #YAP -collagenous matrix link🤠
Tandem stenosis of common carotid artery-> plaque rupture & healing
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
TEAD1⬆️Wnt4 transcription
Another #YAP -collagenous matrix link🤠
Tandem stenosis of common carotid artery-> plaque rupture & healing
#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...
PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
November 20, 2025 at 8:10 PM
PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery
Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5
PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC
#CardioVascRes 2023
academic.oup.com/cardiovascre...