#vascularCalcification
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haoyin.bsky.social
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭

BMP4 BMPER as direct targets of KLF2

LSS
⏫BMPER
⏬BMP4 MGP FST

OsteoSense 680 to image aortic calcification in vivo

#CircRes 2021 @ahascience.bsky.social

www.ahajournals.org/doi/10.1161/...
November 23, 2024 at 8:24 PM
sthilaire.bsky.social
That happy feeling when someone features a graphic you made in their talk 😇 #ASBMR2025 #vascularcalcification #ACDCmedical #MAC
September 4, 2025 at 10:08 PM
haoyin.bsky.social
How does Genomic Instability cause #VascularCalcification?

A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification

Which type of DNA lesions activates STING in calcifying SMC?🧐

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
April 10, 2025 at 6:53 PM
haoyin.bsky.social
#VascularCalcification

#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
September 12, 2025 at 12:23 PM
haoyin.bsky.social
#Ferroptosis #VascularCalcification

SREBP1 transcriptionally⏫iASPP (likely FASN▶️FAO, BHLHE40▶️Circadian, too)➡️ ⏬#SmoothMuscleCell #Ferroptosis #Osteogenesis (BMP2 RUNX2 Calcification)

#CardiovascDiabetol 2025
cardiab.biomedcentral.com/articles/10....
May 3, 2026 at 7:01 PM
haoyin.bsky.social
#VascularCalcification #SmoothMuscleCell m6A Epitranscriptomics

High Pi ⏬METTL3 in SMCs

METTL3-YTHDF2 destabilizes RUNX2 mRNA & ⏬ SMC Osteogenesis

S-Adenosylhomocysteine METTL3/14i aggravates aortic calcification in CKD 🐭 (adenine + hi Pi diet)

#CommsBio 2025
www.nature.com/articles/s42...
November 4, 2025 at 8:04 PM
haoyin.bsky.social
Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT

#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis

Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...
March 24, 2025 at 11:28 AM
haoyin.bsky.social
#VascularCalcification

🐭aortic #SmoothMuscleCell in anchored 3D fibrin hydrogel for 14 d
👉Accumulate proteoglycan (IHC Proteomics)
👉No elastin fiber formation
👉TGFβ-responsive
👉Calcifiable, retaining similar individual sensitivity to 2D culture

www.sciencedirect.com/science/arti...
February 3, 2026 at 12:59 PM
haoyin.bsky.social
#VascularCalcification Mechanobiology

#HydrostaticPressure 120 mmHg 7 d➡️
⏫#Piezo1➡️ (⏫ #ERStress GPR78 CHOP➡️)
⏫ #SmoothMuscleCell Calcification (~20% level by 4 mM Pi)

#BBAMolBasisDis 2025
www.sciencedirect.com/science/arti...
October 20, 2025 at 11:33 AM
haoyin.bsky.social
#vascularCalcification

DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification

ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet

@jci.org 2021
www.jci.org/articles/vie...
October 12, 2025 at 6:58 PM
haoyin.bsky.social
#EndothelialCell to #SmoothMuscleCell communications in #VascularCalcification

CPP2, secondary calciprotein crystalline nanoaggregate, is internalized by EC(▶️Inflammation + altered secretome) & SMC (▶️calcification w/o osteogenic reprogram RUNX2 in 24 h)

#CMLS 2025
link.springer.com/article/10.1...
June 17, 2025 at 8:21 PM
haoyin.bsky.social
#SIRT6 #VascularCalcification

Rat #HighFatDiet + VitD3 + Nicotine
▶️Aortic medial calcification & ⏬SIRT6

SIRT6 overexpression ⏬Palmitic acid-induced #SmoothMuscleCell Apoptosis & Osteogenesis

#JHyperten 2023
journals.lww.com/jhypertensio...
March 8, 2026 at 7:07 PM
haoyin.bsky.social
#VascularCalcification

#Glutaminase1 (GLS1)-derived Glutamate drives #SmoothMuscleCell #Osteogenesis via NMDAR (▶️Ca2+/β-at), not AMPAR, mGlu

Both GLS1 & NMDAR ⏫in 👤calcified arteries #CKD

BPTES (GLS1i)⏬🐭arterial calcification (VitD3)

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
August 2, 2025 at 1:36 PM
haoyin.bsky.social
#PCSK9 #VascularCalcification

50%⏫plasma PCSK9 in👤CKD+atherosclerotic calcification n=104 vs 330 Ctrl

300%⏫plasma PCSK9 in uremic rats
kidney as a PCSK9 source

#SmoothMuscleCell+PCSK9 OE secretes⏫calcific #ExtracellularVesicle

#Atherosclerosis 2022
www.atherosclerosis-journal.com/article/S002...
January 3, 2024 at 8:26 PM
sigtrans-sttt.bsky.social
DT-109 significantly reduces #atherosclerotic lesions and #VascularCalcification in #primates by downregulating #inflammation and #osteogenic markers, highlighting DT-109 as a promising therapy for #CardiovascularDisease.

#OpenAccess in #STTT: doi.org/10.1038/s413...
December 15, 2025 at 12:30 PM
drjenniexu.bsky.social
Chronic Kidney Disease—Mineral and Bone Disorder (CKD-MBD), from Bench to Bedside

#OpenAccess
Full text 👉https://buff.ly/XY11LOV

#CKD
#KidneyHealth
#Dialysis
#BoneDisorder
#VascularCalcification
#Nephrology
#KidneyCare
#nephsky
#medsky
August 13, 2025 at 12:23 AM
haoyin.bsky.social
#VascularCalcification
Resorbed or not?

When s.c. implanted in B6🐭, Calcium in Hydroxyapatite powder⏬
resorbed by TRAP-neg Multinucleated giant cells

In comparison
1⃣Calcified 👤tibial arteries 2⃣Pulverized🦴particles are resistant to calcium resorption

#ATVB 2025
www.ahajournals.org/doi/10.1161/...
February 4, 2026 at 8:50 PM
haoyin.bsky.social
#SIRT7 protects against VitD3-induced🐭#VascularCalcification

SIRT7 does Not directly modify osteogenic factors RUNX2/BMP2 or contractile markers in 🐭aortic #SmoothMuscleCell +high Pi
Instead, SIRT7 appears antioxidant & anti-senescent

#FreeRadicBiolMed 2024
www.sciencedirect.com/science/arti...
August 9, 2024 at 7:28 PM
gmj-georgia.bsky.social
Your body has a ruthless priority system for vitamin K: blood clotting first, bone health second. At current recommended intakes (90–12…

#Bonehealth #Micronutrients #Nutritionalbiochemistry #Vascularcalcification #VitaminK

#Bonehealth #Micronutrients #Nutritionalbiochemistry #Vascularcalcificat…
Why Your Body Starves Bone for Blood Clotting
Your body has a ruthless priority system for vitamin K: blood clotting first, bone health second. At current recommended intakes (90–12… #Bonehealth #Micronutrients #Nutritionalbiochemistry #Vascularcalcification #VitaminK
news.gmj.ge
July 25, 2026 at 5:29 PM
tenuretracker.bsky.social
Kings College London is hiring:
Postdoctoral Research Associate in Vascular Calcification

#postdoc #vascularcalcification #biologicalengineering
July 22, 2026 at 3:51 AM
sigtrans-sttt.bsky.social
Targeted therapies for #VascularCalcification remain limited. This study shows that LINE-1 inhibition by nucleoside reverse transcriptase inhibitors reduces vascular calcification and offers a potential therapeutic approach.

#STTT #OpenAccess: doi.org/10.1038/s413...
#TranslationalMedicine
Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification
July 20, 2026 at 6:30 AM
sigtrans-sttt.bsky.social
#Atherosclerosis and #VascularCalcification remain difficult to treat. This study shows that the tripeptide DT-109 reduces these pathologies in primates by targeting #OxidativeStress, supporting its translational potential.

#STTT #OpenAccess: doi.org/10.1038/s413...
Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates
July 13, 2026 at 6:30 AM
haoyin.bsky.social
DJ-1/PARK7 (causal gene of #ParkinsonDisease)⏬Diabetic #VascularCalcification

Acetylation (by NAT10)-Ubiquitination (by TRIM32) cascade degrades DJ-1▶️
⏫STAT1 & RAGE
⏫#SmoothMuscleCell Osteogenesis
⏫SMC MFGE8+ #MatrixVesicle▶️
⏫MV-collagen binding

#CardiovascRes 2024
academic.oup.com/cardiovascre...
February 10, 2025 at 12:34 PM
kateisabelle24.bsky.social
@JenniferLees85 presents her work on #vascularcalcification & #vitaminK @Jamietraynor01 @drpaddymark @Kidney_Research @UofGICAMS #eraedta18
November 16, 2024 at 10:37 PM
sigtrans-sttt.bsky.social
#LINE1 upregulation is identified as a driver of #VascularCalcification; silencing LINE1 or using #NRTIs suppresses cGAS‑STING signaling and mitigates VC—highlighting LINE1 inhibition and NRTIs as promising therapeutic strategies.

#OpenAccess in #STTT: doi.org/10.1038/s413...
December 21, 2025 at 1:55 AM