Tee Research Lab
@ssteelab.bsky.social
There has been an increasing appreciation that #fructose impacts multiple tissues, including the #brain. In our latest study, we asked if #neurons and #microglia handle fructose differently.
TL;DR: They do!
Link for full paper and details in comments 👇
TL;DR: They do!
Link for full paper and details in comments 👇
July 10, 2026 at 2:01 PM
There has been an increasing appreciation that #fructose impacts multiple tissues, including the #brain. In our latest study, we asked if #neurons and #microglia handle fructose differently.
TL;DR: They do!
Link for full paper and details in comments 👇
TL;DR: They do!
Link for full paper and details in comments 👇
Super interesting read : In Aldob-KO models, inhibiting lipogenesis reduces hepatic TGs but does not rescue the fasting phenotype. 🧬⬇️
Points to a defect beyond lipids: impaired nutrient sensing /signaling, not metabolism alone.
#HFI #Metabolism #LiverDisease #NutrientSensing
Points to a defect beyond lipids: impaired nutrient sensing /signaling, not metabolism alone.
#HFI #Metabolism #LiverDisease #NutrientSensing
December 23, 2025 at 3:42 PM
Super interesting read : In Aldob-KO models, inhibiting lipogenesis reduces hepatic TGs but does not rescue the fasting phenotype. 🧬⬇️
Points to a defect beyond lipids: impaired nutrient sensing /signaling, not metabolism alone.
#HFI #Metabolism #LiverDisease #NutrientSensing
Points to a defect beyond lipids: impaired nutrient sensing /signaling, not metabolism alone.
#HFI #Metabolism #LiverDisease #NutrientSensing
New study with #JHU! Single-cell Raman imaging 🔬 shows fructose impairs brown adipocyte differentiation 🧬, leading to higher lipid unsaturation + esterification and stalled maturation. Glucose drives healthier BAT development. ⚡️
#RamanImaging #Adipogenesis #Metabolism #Fructose #BAT #SingleCell
#RamanImaging #Adipogenesis #Metabolism #Fructose #BAT #SingleCell
November 25, 2025 at 6:30 PM
New study with #JHU! Single-cell Raman imaging 🔬 shows fructose impairs brown adipocyte differentiation 🧬, leading to higher lipid unsaturation + esterification and stalled maturation. Glucose drives healthier BAT development. ⚡️
#RamanImaging #Adipogenesis #Metabolism #Fructose #BAT #SingleCell
#RamanImaging #Adipogenesis #Metabolism #Fructose #BAT #SingleCell
🚨 New from our lab!
We used optical diffraction tomography to visualize how glucose and fructose shape human brown adipocyte differentiation — revealing that sugar composition, not just presence, drives lipid buildup and cell morphology.
🧬 Read: doi.org/10.1002/jcb....
We used optical diffraction tomography to visualize how glucose and fructose shape human brown adipocyte differentiation — revealing that sugar composition, not just presence, drives lipid buildup and cell morphology.
🧬 Read: doi.org/10.1002/jcb....
Sweet Science: Exploring the Impact of Fructose and Glucose on Brown Adipocyte Differentiation Using Optical Diffraction Tomography
The thermogenic capacity of brown adipose tissue (BAT) has garnered much attention for its potential to regulate systemic energy balance. BAT depot size and function need to be tightly regulated to p...
doi.org
November 6, 2025 at 6:33 PM
🚨 New from our lab!
We used optical diffraction tomography to visualize how glucose and fructose shape human brown adipocyte differentiation — revealing that sugar composition, not just presence, drives lipid buildup and cell morphology.
🧬 Read: doi.org/10.1002/jcb....
We used optical diffraction tomography to visualize how glucose and fructose shape human brown adipocyte differentiation — revealing that sugar composition, not just presence, drives lipid buildup and cell morphology.
🧬 Read: doi.org/10.1002/jcb....
Stem cells isolated from aged mice can be reprogrammed to become adipose (fat) cells! 🧬 In this image, a red dye highlights fat droplets within a cell, while the blue dye marks DNA in the nucleus. A glimpse into cellular transformation!
#lipids #metabolism #adipocyte #aging #stemcells
#lipids #metabolism #adipocyte #aging #stemcells
February 6, 2025 at 4:34 PM
Stem cells isolated from aged mice can be reprogrammed to become adipose (fat) cells! 🧬 In this image, a red dye highlights fat droplets within a cell, while the blue dye marks DNA in the nucleus. A glimpse into cellular transformation!
#lipids #metabolism #adipocyte #aging #stemcells
#lipids #metabolism #adipocyte #aging #stemcells
Reposted by Tee Research Lab
As promised, a (maybe long!) 🧵 on the history of sugar:
1/ Sugar cane began to grow wild in India and south-east Asia about a hundred million years ago, when grasses evolved from earlier plants.
1/ Sugar cane began to grow wild in India and south-east Asia about a hundred million years ago, when grasses evolved from earlier plants.
January 31, 2025 at 4:39 PM
As promised, a (maybe long!) 🧵 on the history of sugar:
1/ Sugar cane began to grow wild in India and south-east Asia about a hundred million years ago, when grasses evolved from earlier plants.
1/ Sugar cane began to grow wild in India and south-east Asia about a hundred million years ago, when grasses evolved from earlier plants.
Hot off the microscope! A metabolic enzyme, tagged with green fluorescent protein shows dynamic movement in a liver cancer cell! #metabolism #enzyme #microscopy
January 31, 2025 at 6:51 PM
Hot off the microscope! A metabolic enzyme, tagged with green fluorescent protein shows dynamic movement in a liver cancer cell! #metabolism #enzyme #microscopy
Excited to share our latest findings on how nutrients affect stem cell behavior! Replacing glucose with fructose induces stress and fails to induce adipocyte differentiation. Instead, it prompts release of senescence-associated cytokines. #StemCells #Metabolism #Adipogenesis #Cytokines
January 24, 2025 at 6:33 PM
Excited to share our latest findings on how nutrients affect stem cell behavior! Replacing glucose with fructose induces stress and fails to induce adipocyte differentiation. Instead, it prompts release of senescence-associated cytokines. #StemCells #Metabolism #Adipogenesis #Cytokines