PDZRN3 (E3 ligase) suppresses #Adipogenesis of Sca1+🐭#SkeletalMuscle mesenchymal progenitors (PDGFRα+TCF4+) via⏬Wnt/β-Catenin
Pdgfra-CreER::Pdzrn3 KO🐭▶️
⏫Denervation-induced intramuscular #Adipogenesis #IMAT
⏬muscle mass
Regen Ther 2025
www.sciencedirect.com/science/arti...
Pdgfra-CreER::Pdzrn3 KO🐭▶️
⏫Denervation-induced intramuscular #Adipogenesis #IMAT
⏬muscle mass
Regen Ther 2025
www.sciencedirect.com/science/arti...
February 25, 2025 at 12:35 PM
PDZRN3 (E3 ligase) suppresses #Adipogenesis of Sca1+🐭#SkeletalMuscle mesenchymal progenitors (PDGFRα+TCF4+) via⏬Wnt/β-Catenin
Pdgfra-CreER::Pdzrn3 KO🐭▶️
⏫Denervation-induced intramuscular #Adipogenesis #IMAT
⏬muscle mass
Regen Ther 2025
www.sciencedirect.com/science/arti...
Pdgfra-CreER::Pdzrn3 KO🐭▶️
⏫Denervation-induced intramuscular #Adipogenesis #IMAT
⏬muscle mass
Regen Ther 2025
www.sciencedirect.com/science/arti...
Staying trim in middle age and beyond can be a challenge.
Why?
Adipogenesis contributes to age-related visceral adipose tissue accumulation.
www.science.org/doi/10.1126/...
Why?
Adipogenesis contributes to age-related visceral adipose tissue accumulation.
www.science.org/doi/10.1126/...
April 25, 2025 at 4:25 PM
Staying trim in middle age and beyond can be a challenge.
Why?
Adipogenesis contributes to age-related visceral adipose tissue accumulation.
www.science.org/doi/10.1126/...
Why?
Adipogenesis contributes to age-related visceral adipose tissue accumulation.
www.science.org/doi/10.1126/...
Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis www.nature.com/articles/s4...
March 16, 2026 at 2:15 PM
Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis www.nature.com/articles/s4...
Who could have guessed this #obesity
#obesogens
Lots of PPAR action there, but could there be other effects as well?
What about positive feedback cycles that regulate intake , not just adipogenesis ?
#obesogens
Lots of PPAR action there, but could there be other effects as well?
What about positive feedback cycles that regulate intake , not just adipogenesis ?
February 15, 2025 at 1:32 AM
Who could have guessed this #obesity
#obesogens
Lots of PPAR action there, but could there be other effects as well?
What about positive feedback cycles that regulate intake , not just adipogenesis ?
#obesogens
Lots of PPAR action there, but could there be other effects as well?
What about positive feedback cycles that regulate intake , not just adipogenesis ?
Delighted to share a new preprint from the lab:
Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle
doi.org/10.64898/202...
#Myoblue #FAPs #IMAT #muscleregeneration #adipogenesis #skeletalmuscle
Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle
doi.org/10.64898/202...
#Myoblue #FAPs #IMAT #muscleregeneration #adipogenesis #skeletalmuscle
April 25, 2026 at 11:07 AM
Delighted to share a new preprint from the lab:
Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle
doi.org/10.64898/202...
#Myoblue #FAPs #IMAT #muscleregeneration #adipogenesis #skeletalmuscle
Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle
doi.org/10.64898/202...
#Myoblue #FAPs #IMAT #muscleregeneration #adipogenesis #skeletalmuscle
MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis
Atan Gross and colleagues
www.embopress.org/doi/full/10....
Atan Gross and colleagues
www.embopress.org/doi/full/10....
January 9, 2025 at 8:08 AM
MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis
Atan Gross and colleagues
www.embopress.org/doi/full/10....
Atan Gross and colleagues
www.embopress.org/doi/full/10....
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 10, 2025 at 9:01 AM
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
November 24, 2025 at 11:04 AM
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
🐁 Using lineage tracing in mice, the team from Qiong Annabel Wang found that >80% of adipocytes in visceral fat at 12 months (middle age) are newly generated. This active adipogenesis contrasts with low turnover in young adults.
2/8
2/8
May 1, 2025 at 6:42 AM
🐁 Using lineage tracing in mice, the team from Qiong Annabel Wang found that >80% of adipocytes in visceral fat at 12 months (middle age) are newly generated. This active adipogenesis contrasts with low turnover in young adults.
2/8
2/8
Speaker Spotlight: Dr. Rana Gupta @duke-university.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk!
🔗 Register now – adiposebiology.com
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk!
🔗 Register now – adiposebiology.com
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
March 24, 2025 at 6:09 PM
Speaker Spotlight: Dr. Rana Gupta @duke-university.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk!
🔗 Register now – adiposebiology.com
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk!
🔗 Register now – adiposebiology.com
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
🏔️ The culprit? A newly identified cell type: CP-As (committed preadipocyte, age-enriched). These cells are rare in youth, peak at 12 months, then decline, mirroring the “inverted U” of adipogenesis.
3/8
3/8
May 1, 2025 at 6:42 AM
🏔️ The culprit? A newly identified cell type: CP-As (committed preadipocyte, age-enriched). These cells are rare in youth, peak at 12 months, then decline, mirroring the “inverted U” of adipogenesis.
3/8
3/8
The cellular basis for middle-age spread
Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/... 🧪
Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/... 🧪
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat un...
www.science.org
April 24, 2025 at 7:15 PM
The cellular basis for middle-age spread
Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/... 🧪
Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/... 🧪
How Exercise Fights Osteoporosis
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
February 18, 2026 at 2:30 PM
How Exercise Fights Osteoporosis
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop 🧪
www.nature.com/articles/s41...
A previously unrecognized link between mechanotransduction, inflammation, and cell fate determination.
Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells
"The multifaceted impact of microplastic exposure on adipose tissue: its role in inducing cellular senescence, amplifying inflammatory responses, and impairing differentiation capacity"
doi.org/10.1038/s415...
"The multifaceted impact of microplastic exposure on adipose tissue: its role in inducing cellular senescence, amplifying inflammatory responses, and impairing differentiation capacity"
doi.org/10.1038/s415...
Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells - Scientific Reports
Scientific Reports - Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells
doi.org
December 8, 2024 at 5:23 PM
Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells
"The multifaceted impact of microplastic exposure on adipose tissue: its role in inducing cellular senescence, amplifying inflammatory responses, and impairing differentiation capacity"
doi.org/10.1038/s415...
"The multifaceted impact of microplastic exposure on adipose tissue: its role in inducing cellular senescence, amplifying inflammatory responses, and impairing differentiation capacity"
doi.org/10.1038/s415...
in stretch goals i hope it gives me stretched shirts and stretch marks in all the key secondary and tertiary characteristic areas, on account of dummy fast accelerated adipogenesis
September 5, 2025 at 7:50 PM
in stretch goals i hope it gives me stretched shirts and stretch marks in all the key secondary and tertiary characteristic areas, on account of dummy fast accelerated adipogenesis
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis:
buff.ly/ledJVyB
Margo P. Emont and Jun Wu provide a Commentary on Yesian et al. (buff.ly/MpzsyWp)
buff.ly/ledJVyB
Margo P. Emont and Jun Wu provide a Commentary on Yesian et al. (buff.ly/MpzsyWp)
June 6, 2025 at 3:33 PM
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis:
buff.ly/ledJVyB
Margo P. Emont and Jun Wu provide a Commentary on Yesian et al. (buff.ly/MpzsyWp)
buff.ly/ledJVyB
Margo P. Emont and Jun Wu provide a Commentary on Yesian et al. (buff.ly/MpzsyWp)
We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
April 23, 2025 at 1:00 PM
We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
New study links #Microbiome to creeping fat in #CrohnsDisease via #Kynurenine metabolism
Highlights:
Commensal A. pulmonis drives CrF via macrophage-derived L-kynurenine
Kynurenine activates AHR in adipocytes, promoting fat formation
Blocking IDO1 or degrading kynurenine reduces CrF in mice
Highlights:
Commensal A. pulmonis drives CrF via macrophage-derived L-kynurenine
Kynurenine activates AHR in adipocytes, promoting fat formation
Blocking IDO1 or degrading kynurenine reduces CrF in mice
Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease
Wu et al. reveal that the commensal Achromobacter pulmonis induces mesenteric adipogenesis through macrophages alteration. Mechanistically, macrophage-derived L-kynurenine via indoleamine 2,3-dioxygenase 1 (IDO1) promotes adipogenesis by aryl hydrocarbon receptor (AHR) activation in adipocytes. Targeting kynurenine metabolism with an IDO1 inhibitor or bacteria engineered to degrade L-kynurenine alleviates mesenteric adipogenesis.
www.cell.com
January 7, 2025 at 4:42 PM
New study links #Microbiome to creeping fat in #CrohnsDisease via #Kynurenine metabolism
Highlights:
Commensal A. pulmonis drives CrF via macrophage-derived L-kynurenine
Kynurenine activates AHR in adipocytes, promoting fat formation
Blocking IDO1 or degrading kynurenine reduces CrF in mice
Highlights:
Commensal A. pulmonis drives CrF via macrophage-derived L-kynurenine
Kynurenine activates AHR in adipocytes, promoting fat formation
Blocking IDO1 or degrading kynurenine reduces CrF in mice
Congrats to Dr. Sabri Rial !
He investigated the mechanisms of how 14-3-3zeta influences adipogenesis.
FYI, he's on the PI job market and would make a fantastic colleague ;)
@crchum.bsky.social @umontreal.ca l @facmed-umontreal.bsky.social
www.sciencedirect.com/science/arti...
He investigated the mechanisms of how 14-3-3zeta influences adipogenesis.
FYI, he's on the PI job market and would make a fantastic colleague ;)
@crchum.bsky.social @umontreal.ca l @facmed-umontreal.bsky.social
www.sciencedirect.com/science/arti...
14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation
We previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but the temporal specificity of its acti…
www.sciencedirect.com
May 2, 2025 at 11:28 AM
Congrats to Dr. Sabri Rial !
He investigated the mechanisms of how 14-3-3zeta influences adipogenesis.
FYI, he's on the PI job market and would make a fantastic colleague ;)
@crchum.bsky.social @umontreal.ca l @facmed-umontreal.bsky.social
www.sciencedirect.com/science/arti...
He investigated the mechanisms of how 14-3-3zeta influences adipogenesis.
FYI, he's on the PI job market and would make a fantastic colleague ;)
@crchum.bsky.social @umontreal.ca l @facmed-umontreal.bsky.social
www.sciencedirect.com/science/arti...
Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
May 6, 2025 at 12:52 PM
Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Sharing our latest paper in Molecular Metabolism, led by Jake Willows w our dental school collaborator Sarah Peters. A semaphorin 7a KO had altered adipose innervation, especially across development, showing Sema acts on the nerves, not just adipocytes. tinyurl.com/3x8x6yy2 🧪🧪
Semaphorin 7A Regulates Axon Outgrowth in Subcutaneous White Adipose Tissue
Adipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maintain these…
tinyurl.com
February 5, 2026 at 7:52 PM
Sharing our latest paper in Molecular Metabolism, led by Jake Willows w our dental school collaborator Sarah Peters. A semaphorin 7a KO had altered adipose innervation, especially across development, showing Sema acts on the nerves, not just adipocytes. tinyurl.com/3x8x6yy2 🧪🧪
Our findings suggest that #miR-10b-5p regulates early #adipogenesis by influencing cell fate bias toward the #paraxialMesoderm lineage through modulation of the #Gata6 / #Bmp2 signaling axis.
#NTU_Metabolic #SHIMR_NTU
@ntumeta.bsky.social @mark-christian-lab.bsky.social @ntuyourlibrary.bsky.social
#NTU_Metabolic #SHIMR_NTU
@ntumeta.bsky.social @mark-christian-lab.bsky.social @ntuyourlibrary.bsky.social
May 19, 2026 at 2:41 PM
Our findings suggest that #miR-10b-5p regulates early #adipogenesis by influencing cell fate bias toward the #paraxialMesoderm lineage through modulation of the #Gata6 / #Bmp2 signaling axis.
#NTU_Metabolic #SHIMR_NTU
@ntumeta.bsky.social @mark-christian-lab.bsky.social @ntuyourlibrary.bsky.social
#NTU_Metabolic #SHIMR_NTU
@ntumeta.bsky.social @mark-christian-lab.bsky.social @ntuyourlibrary.bsky.social
@jclinical-invest.bsky.social preview:
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...
June 4, 2025 at 2:30 AM
@jclinical-invest.bsky.social preview:
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...