Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
July 3, 2025 at 4:04 PM
Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
🏆Alexander von #Humboldt Research Fellowship for Kazuki Inaba🏆
He plans to tackle 1of #glycoscience ’s biggest challenges: controlling #stereoselectivity
His envisaged #glycosylation method: donor sugars guide the synthetic process➡️ highly tunable #glycans as tools for research
#ChemSky
He plans to tackle 1of #glycoscience ’s biggest challenges: controlling #stereoselectivity
His envisaged #glycosylation method: donor sugars guide the synthetic process➡️ highly tunable #glycans as tools for research
#ChemSky
March 27, 2025 at 7:45 AM
🏆Alexander von #Humboldt Research Fellowship for Kazuki Inaba🏆
He plans to tackle 1of #glycoscience ’s biggest challenges: controlling #stereoselectivity
His envisaged #glycosylation method: donor sugars guide the synthetic process➡️ highly tunable #glycans as tools for research
#ChemSky
He plans to tackle 1of #glycoscience ’s biggest challenges: controlling #stereoselectivity
His envisaged #glycosylation method: donor sugars guide the synthetic process➡️ highly tunable #glycans as tools for research
#ChemSky
It’s #glycotime! Looking forward to the virtual training courses in “Fundamentals in Glycoscience” from the Complex Carbohydrate Research Center. The work of Parastoo Azadi and the team at the CCRC is outstanding and highly appreciated. #glycobiology #NMR #Masspec #glycosylation
December 7, 2024 at 11:16 PM
It’s #glycotime! Looking forward to the virtual training courses in “Fundamentals in Glycoscience” from the Complex Carbohydrate Research Center. The work of Parastoo Azadi and the team at the CCRC is outstanding and highly appreciated. #glycobiology #NMR #Masspec #glycosylation
#MedSky🧪 #IDSky #Cellbiolog #ImmunoSky Cancer #glycosylation: understanding the dual implication in cancer progression and treatment approaches
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Sugar symphony: glycosylation in cancer metabolism and stemness
Glycosylation is a complex co-translational and post-translational modification (PTM)
in eukaryotes that utilizes glycosyltransferases to generate a vast array of glycoconjugate
structures. Recent stu...
www.cell.com
October 29, 2024 at 1:22 AM
#MedSky🧪 #IDSky #Cellbiolog #ImmunoSky Cancer #glycosylation: understanding the dual implication in cancer progression and treatment approaches
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Master #Glycan Assembly (AGA) for complex oligo- & #polysaccharides! Learn our lab's technique ( @peterseeberger.bsky.social ) for successful #glycosylation.
This video: solving excess water in solvents & reagents. Stay tuned for more.
#glycotime
tinyurl.com/27da9p5s
This video: solving excess water in solvents & reagents. Stay tuned for more.
#glycotime
tinyurl.com/27da9p5s
Measuring water content in solvent using Karl-Fischer titration
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
tinyurl.com
March 31, 2025 at 6:51 AM
Master #Glycan Assembly (AGA) for complex oligo- & #polysaccharides! Learn our lab's technique ( @peterseeberger.bsky.social ) for successful #glycosylation.
This video: solving excess water in solvents & reagents. Stay tuned for more.
#glycotime
tinyurl.com/27da9p5s
This video: solving excess water in solvents & reagents. Stay tuned for more.
#glycotime
tinyurl.com/27da9p5s
#Medsky🧪 #IDsky #immunosky #publichealth in this small study , the findings point to a 🔑 shift in IgG #glycosylation of #COVID patients & vaccinated individuals over time that can predict disease severity & 💉 responsiveness,
July 2, 2025 at 6:49 AM
#Medsky🧪 #IDsky #immunosky #publichealth in this small study , the findings point to a 🔑 shift in IgG #glycosylation of #COVID patients & vaccinated individuals over time that can predict disease severity & 💉 responsiveness,
Meet the BioF:GREAT Team at The Society for Glycobiology's Annual Meeting in San Diego this November and be part of the future of glycoscience! Register for SfGlycobiology here:
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
September 19, 2025 at 4:19 PM
Meet the BioF:GREAT Team at The Society for Glycobiology's Annual Meeting in San Diego this November and be part of the future of glycoscience! Register for SfGlycobiology here:
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
new #preprint: mRNA delivered degron system w/ GFP-nanobody to efficiently reduce GFP-tagged proteins in an inducible manner in 🐟 Case study: reduction of PMM2 (basis for ER-based #glycosylation) causes hypoglycosylation reported from CDG-patients www.biorxiv.org/content/10.1... #CRISPR #RareDisease
Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis
Creating hypomorphic mutations are crucial to study gene function in vivo, especially when null mutations result in (embryonic) lethality. This is especially the case for enzymes involved in glycosyla...
www.biorxiv.org
May 26, 2025 at 8:22 AM
new #preprint: mRNA delivered degron system w/ GFP-nanobody to efficiently reduce GFP-tagged proteins in an inducible manner in 🐟 Case study: reduction of PMM2 (basis for ER-based #glycosylation) causes hypoglycosylation reported from CDG-patients www.biorxiv.org/content/10.1... #CRISPR #RareDisease
Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners
#glycotime #glycosylation #science #artificialsweeteners
23] Facts About: Sugar Alcohols
research.bidmc.org
December 5, 2025 at 4:52 PM
Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners
#glycotime #glycosylation #science #artificialsweeteners
Special guest Thomas Boltje from Radboud University captures glimpses of elusive & short-lived chemical compounds crucial for #glycosylation (the making of complex sugars) through Exchange Nuclear Magnetic Resonance.
➡️ His research improves our understanding &prediction of glycosylation processes.
➡️ His research improves our understanding &prediction of glycosylation processes.
May 16, 2024 at 7:09 AM
Special guest Thomas Boltje from Radboud University captures glimpses of elusive & short-lived chemical compounds crucial for #glycosylation (the making of complex sugars) through Exchange Nuclear Magnetic Resonance.
➡️ His research improves our understanding &prediction of glycosylation processes.
➡️ His research improves our understanding &prediction of glycosylation processes.
Incredible work just published yesterday using the ZenoTOF 7600
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...
Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry
In our previous publication [Anal. Chem. 2023, 95, 7458–7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging b...
pubs.acs.org
February 18, 2026 at 5:57 PM
Incredible work just published yesterday using the ZenoTOF 7600
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
January 15, 2026 at 3:52 PM
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
Excited to share our new ChemPhysChem paper 🎉
🔗 doi.org/10.1002/cphc...
MD simulations reveal how glycan fluctuations impact water networks & proton shuttle dynamics in this cancer-linked enzyme.
#CompChem #MolecularDynamics #EnzymeCatalysis #Glycosylation
🔗 doi.org/10.1002/cphc...
MD simulations reveal how glycan fluctuations impact water networks & proton shuttle dynamics in this cancer-linked enzyme.
#CompChem #MolecularDynamics #EnzymeCatalysis #Glycosylation
Effect of Glycosylation on the Reorganization at the Active Site of Human Carbonic Anhydrase IX
Coupled dynamics of a distal glycan chain and active site reorganization is reported from simulations of catalytic domain of human carbonic anhydrase IX in water. Glycan conformations, extended away ....
doi.org
September 20, 2025 at 6:27 PM
Excited to share our new ChemPhysChem paper 🎉
🔗 doi.org/10.1002/cphc...
MD simulations reveal how glycan fluctuations impact water networks & proton shuttle dynamics in this cancer-linked enzyme.
#CompChem #MolecularDynamics #EnzymeCatalysis #Glycosylation
🔗 doi.org/10.1002/cphc...
MD simulations reveal how glycan fluctuations impact water networks & proton shuttle dynamics in this cancer-linked enzyme.
#CompChem #MolecularDynamics #EnzymeCatalysis #Glycosylation
This is interesting, the more we learn about the highly complex #glycosylation of DAG1 the more I wonder how many other glycoproteins are equally complex and we just don't know yet!
New #SkeletalMuscle paper: Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan. #MyoBlue tinyurl.com/5a2u77by
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan - Skeletal Muscle
Background Maintaining the connection between skeletal muscle fibers and the surrounding basement membrane is essential for muscle function. Dystroglycan (DG) serves as a basement membrane extracellul...
tinyurl.com
January 9, 2025 at 2:14 PM
This is interesting, the more we learn about the highly complex #glycosylation of DAG1 the more I wonder how many other glycoproteins are equally complex and we just don't know yet!
#Carbohydrate Synthesis — fast, precise, and customizable.
Our scientists have found how to handle anhydrous solvents to ensure high-yield #glycosylation.
Learn how in this tutorial from the Automated #Glycans Assembly team led by @peterseeberger.bsky.social
www.youtube.com/watch?si=sUU...
Our scientists have found how to handle anhydrous solvents to ensure high-yield #glycosylation.
Learn how in this tutorial from the Automated #Glycans Assembly team led by @peterseeberger.bsky.social
www.youtube.com/watch?si=sUU...
preparing anhydrous solvent
YouTube video by Peter Seeberger
www.youtube.com
April 14, 2025 at 12:50 PM
#Carbohydrate Synthesis — fast, precise, and customizable.
Our scientists have found how to handle anhydrous solvents to ensure high-yield #glycosylation.
Learn how in this tutorial from the Automated #Glycans Assembly team led by @peterseeberger.bsky.social
www.youtube.com/watch?si=sUU...
Our scientists have found how to handle anhydrous solvents to ensure high-yield #glycosylation.
Learn how in this tutorial from the Automated #Glycans Assembly team led by @peterseeberger.bsky.social
www.youtube.com/watch?si=sUU...
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...
#glycans #glycosylation #posttranslationalmodification #glycotime
👉 research.bidmc.org/ncfg/blog/21...
#glycans #glycosylation #posttranslationalmodification #glycotime
21] Facts About: Intracellular Protein Glycosylation
research.bidmc.org
October 8, 2025 at 3:04 PM
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...
#glycans #glycosylation #posttranslationalmodification #glycotime
👉 research.bidmc.org/ncfg/blog/21...
#glycans #glycosylation #posttranslationalmodification #glycotime
Meet SHIELD! ✋
Today: The Synthetic Organic Chemistry Group at Radboud University is developing new chemical biology approaches to study glycosylation in context of viral infections.
www.ru.nl/en/departmen...
#Glycosylation #ViralInfections #SHIELDproject #SyntheticChemistry #RadboudUniversity
Today: The Synthetic Organic Chemistry Group at Radboud University is developing new chemical biology approaches to study glycosylation in context of viral infections.
www.ru.nl/en/departmen...
#Glycosylation #ViralInfections #SHIELDproject #SyntheticChemistry #RadboudUniversity
July 15, 2025 at 12:12 PM
Meet SHIELD! ✋
Today: The Synthetic Organic Chemistry Group at Radboud University is developing new chemical biology approaches to study glycosylation in context of viral infections.
www.ru.nl/en/departmen...
#Glycosylation #ViralInfections #SHIELDproject #SyntheticChemistry #RadboudUniversity
Today: The Synthetic Organic Chemistry Group at Radboud University is developing new chemical biology approaches to study glycosylation in context of viral infections.
www.ru.nl/en/departmen...
#Glycosylation #ViralInfections #SHIELDproject #SyntheticChemistry #RadboudUniversity
For #FluorescenceFriday
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation
April 9, 2026 at 9:42 PM
For #FluorescenceFriday
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation
Our latest cryo-EM study reveals the architecture of the KOGG complex, a key player in collagen lysine O-link glycosylation. This LH3/ColGalT1 enzyme machinery ensures proper collagen maturation and may even form fiber-like supercomplexes! #Glycosylation #Collagen
doi.org/10.1038/s41467-025-57768-9
doi.org/10.1038/s41467-025-57768-9
The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation - Nature Communications
This study reveals the structural basis of collagen processing by the KOGG complex, revealing how it catalyzes lysine hydroxylation and dual-glycosylation, essential for collagen folding and stability...
www.nature.com
March 15, 2025 at 4:47 AM
Our latest cryo-EM study reveals the architecture of the KOGG complex, a key player in collagen lysine O-link glycosylation. This LH3/ColGalT1 enzyme machinery ensures proper collagen maturation and may even form fiber-like supercomplexes! #Glycosylation #Collagen
doi.org/10.1038/s41467-025-57768-9
doi.org/10.1038/s41467-025-57768-9
📜 Pour some sugar on me: The diverse functions of phenylpropanoid glycosylation
🧑🔬 Arthur de Barros Rates, @icesarino.bsky.social
📔 Journal of Plant Physiology
🔗 www.sciencedirect.com/science/arti...
#️⃣ (Feeds) #PlantScience #Glycosylation #Lignin #PlantCellWalls #DefLeppard
🧑🔬 Arthur de Barros Rates, @icesarino.bsky.social
📔 Journal of Plant Physiology
🔗 www.sciencedirect.com/science/arti...
#️⃣ (Feeds) #PlantScience #Glycosylation #Lignin #PlantCellWalls #DefLeppard
Pour some sugar on me: The diverse functions of phenylpropanoid glycosylation
The phenylpropanoid metabolism is the source of a vast array of specialized metabolites that play diverse functions in plant growth and development an…
www.sciencedirect.com
November 14, 2023 at 11:44 AM
📜 Pour some sugar on me: The diverse functions of phenylpropanoid glycosylation
🧑🔬 Arthur de Barros Rates, @icesarino.bsky.social
📔 Journal of Plant Physiology
🔗 www.sciencedirect.com/science/arti...
#️⃣ (Feeds) #PlantScience #Glycosylation #Lignin #PlantCellWalls #DefLeppard
🧑🔬 Arthur de Barros Rates, @icesarino.bsky.social
📔 Journal of Plant Physiology
🔗 www.sciencedirect.com/science/arti...
#️⃣ (Feeds) #PlantScience #Glycosylation #Lignin #PlantCellWalls #DefLeppard
📚 A Review for your weekend reading!
🦠 Protein O-glycosylation in the Bacteroidota phylum
👉 buff.ly/HO2RBlj
🖊️ @mateuslab.com @andrenmateus.bsky.social
#Glycosylation #Microbiome
🦠 Protein O-glycosylation in the Bacteroidota phylum
👉 buff.ly/HO2RBlj
🖊️ @mateuslab.com @andrenmateus.bsky.social
#Glycosylation #Microbiome
September 11, 2025 at 9:58 AM
📚 A Review for your weekend reading!
🦠 Protein O-glycosylation in the Bacteroidota phylum
👉 buff.ly/HO2RBlj
🖊️ @mateuslab.com @andrenmateus.bsky.social
#Glycosylation #Microbiome
🦠 Protein O-glycosylation in the Bacteroidota phylum
👉 buff.ly/HO2RBlj
🖊️ @mateuslab.com @andrenmateus.bsky.social
#Glycosylation #Microbiome
This review highlights #sialylation as a key regulator of OC progression, metastasis, and drug resistance, pointing toward novel therapeutic strategies. #medsky
Learn more: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #Glycosylation
Learn more: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #Glycosylation
September 14, 2026 at 1:20 PM
This review highlights #sialylation as a key regulator of OC progression, metastasis, and drug resistance, pointing toward novel therapeutic strategies. #medsky
Learn more: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #Glycosylation
Learn more: doi.org/10.1007/s115...
#currentmedicalscience #Oncology #Glycosylation
The Therapeutic Future for Congenital Disorders of Glycosylation
Read it here: 👉https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70011
#glycosylation
Read it here: 👉https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70011
#glycosylation
March 11, 2025 at 3:43 PM
The Therapeutic Future for Congenital Disorders of Glycosylation
Read it here: 👉https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70011
#glycosylation
Read it here: 👉https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70011
#glycosylation
Gut #bacteria can alter #brain #proteins: New #glycosylation method uncovers link.
#microbiome
phys.org/news/2025-02...
#microbiome
phys.org/news/2025-02...
Gut bacteria can alter brain proteins: New glycosylation method uncovers link
Our guts are home to trillions of bacteria, and research over the last few decades has established how essential they are to our physiology—in health and disease. A new study from EMBL Heidelberg rese...
phys.org
February 10, 2025 at 4:44 PM
Gut #bacteria can alter #brain #proteins: New #glycosylation method uncovers link.
#microbiome
phys.org/news/2025-02...
#microbiome
phys.org/news/2025-02...
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s?
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
March 3, 2025 at 10:53 AM
Why did 2.3.4.4b clade #H5N1 need a long stalk N1, unlike the previous clades H5N1s?
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.
We identified the emergence of 2.3.4.4b #H5 HA with a distinct #glycosylation pattern in its RBD that drove its preferential pairing with long stalk N1 and the emergence of this novel variant.