##NucleicAcids
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narjournal.bsky.social
🧬 Happy National DNA Day! 🧬
Today we celebrate the completion of the human genome project (2003) and discovery of the double helix (1953). From genome editing to RNA therapeutics, research into nucleic acids continues to drive scientific breakthroughs #NationalDNADay #NucleicAcids #DNAday2025
April 25, 2025 at 8:02 AM
tum.de
Read the interview with Stefan Engelhardt, our Professor of #Pharmacology and #Toxicology, who talks about the new #ClusterofExcellence, #NUCLEATE, which explores the function and regulation of #nucleicacids: go.tum.de/705241 🧬

#RNA #DNA
@lmumuenchen.bsky.social @uni-wuerzburg.de

📷A. Heddergott
“We are witnessing a revolution in nucleic acid research”
Stefan Engelhardt is one of three spokespeople of the new Cluster of Excellence NUCLEATE. In this interview he explains the importance of nucleic acid research.
go.tum.de
May 23, 2025 at 9:16 AM
genecenter-lmu.bsky.social
➡️RNA damage⬅️ was long dismissed as not that significant. In an interview, Julian Stingele explains why this view has changed:
www.lmu.de/en/newsroom/...
#RNA #NucleicAcids @lmumuenchen.bsky.social @jstingele.bsky.social
Overlooked alarm signal: RNA damage moves into the spotlight
Because RNA is relatively short lived, RNA damage was long dismissed as not that significant. In our interview, biochemist Julian Stingele explains why this view has changed.
www.lmu.de
February 21, 2025 at 8:57 AM
kathlab.bsky.social
Excited to host all members of @mechanism-network.bsky.social for a full week of science 🧬 and networking 🤝 in Cologne! Great kickoff with Fredrik Westerlund introducing the MeChaNiSM MSCA DN🎓 Looking forward to a week full of #nucleicacids ideas 💡
@unicologne.bsky.social @wilhelmssonlab.bsky.social
October 6, 2025 at 8:07 AM
danbose.bsky.social
Two fantastic talks from the #nucleicAcids world at today's @biochemsoc.bsky.social SM@SH seminar! Great to welcome Askash Basu from Durham to hear about bendability in #DNA sequences and beautiful cryoEM from Anamika Kumari Lahiri Lab in the ECR talk slot! 🧬🧬🧬👏@sheffielduni.bsky.social
July 17, 2025 at 12:32 PM
stephanhacker2.bsky.social
Very insightful review by the group of Alexander Deiters in @rscchembio.rsc.org. They give an overview of the development of covalent #aptamers for protein labeling and inhibition including an overview of the chemistries used. doi.org/10.1039/d5cb...
#ChemSky #ChemBio #NucleicAcids #RNA #DNA
Covalent aptamers: agents with promising therapeutic and diagnostic potential
Small molecule- and antibody-based approaches have shown tremendous success in both therapeutic and diagnostic applications. Aptamers, which are engineered nucleic acid ligands for proteins, have not found similar broad applicability, potentially due to their susceptibility to nuclease-mediated degradation and shor
doi.org
December 4, 2025 at 2:00 PM
stephanhacker2.bsky.social
She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. (2/2) www.nature.com/articles/s41...

#ChemSky #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids
Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry - Nature Communications
Mixtures of peptides and nucleic acids tend to demix and form coacervate droplets. Here, the authors show that even short peptides and oligonucleotides form droplets. DNA and RNA impart different prop...
www.nature.com
November 25, 2025 at 10:09 AM
plenty-of-room.bsky.social
New issue is out! 🎉 Creating artificial cells is synthetic biology's boldest goal, and today is a step closer, thanks to RNA origami! Amazing work from @zmbh.uni-heidelberg.de and @mpi-mr.bsky.social 😎🧪🖥️🧬 #biotech #RNA #synbio #nucleicacids Subscribe at 👉 plentyofroom.beehiiv.com/p/rna-skelet...
RNA Cytoskeletons & AI-Driven Synthetic Biology: New Frontiers!
Cutting-edge RNA research explores synthetic biology's frontier, unveiling groundbreaking strategies for constructing artificial cells and understanding cellular building blocks.
plentyofroom.beehiiv.com
March 27, 2025 at 3:09 PM
kathlab.bsky.social
JOB ALERT! 2 open PHD positions @kathlab.bsky.social in the framework of the MSCA doctoral network MeChaNiSM! Searching for organic chemists dedicated to nucleic acid chemistry.🧬⚗️🎉
More info: www.kathlab.uni-koeln.de
#organicchemistry #nucleicacids
December 18, 2024 at 2:11 PM
mmckeague.bsky.social
Thrilled to receive the 2026 Melanie O’Neill New Investigator Award in Biological Chemistry. Grateful for the phenomenal students, postdocs, collaborators and mentors who power every discovery in our lab! Onward with more nucleic acid chemistry, gene activation and biosensing!!! #NucleicAcids
ciccheminst.bsky.social Chemical Institute of Canada @ciccheminst.bsky.social · Nov 14
The Melanie O’Neill New Investigator Award is presented to a scientist residing in Canada who has made a distinguished contribution to biological chemistry or biophysical methods. Congratulations to Dr. Maureen McKeague of McGill University on being the recipient of this award. buff.ly/gqajBj4
November 14, 2025 at 11:46 PM
actacrystf.iucr.org
Shin Ando et al.: The first report of structural analysis of a nucleic acid using crystals grown in space ##XRayCrystallography##NucleicAcids##Microgravity... ##IUCrhttps://journals.iucr.org/paper?S2053230X25000810
The first report of structural analysis of a nucleic acid using crystals grown in space
The first structural analysis of a nucleic acid using crystals obtained under microgravity crystallization in space is reported. A DNA/RNA heteroduplex was successfully crystallized in a microgravity environment, improving the size and appearance of the crystals compared with crystals obtained on Earth.
journals.iucr.org
February 13, 2025 at 1:00 AM
tum.de
In the second episode of our new EXplained series, we highlight the #ClusterofExcellence NUCLEATE. At our #university, it is represented by Stefan Engelhardt, who shares insights into #nucleid-based #medicine: go.tum.de/139582

#nucleicacids
@lmumuenchen.bsky.social @uni-wuerzburg.de

📷 ProLehre
Nucleic acids as key to a new class of drugs
In our "EXplained" video series, we present the seven Clusters of Excellence with which our university is entering the next funding phase of the Excellence Strategy. In the second episode, we get to k...
go.tum.de
September 26, 2025 at 2:37 PM
actacrystf.iucr.org
This structure of a tRNA acceptor-stem mimic demonstrates the use of bromine and phosphorus anomalous scattering for RNA structure determination #Crystallography #AnomalousScattering #NucleicAcids doi.org/10.1107/S205...
February 19, 2026 at 4:20 PM
actacrystf.iucr.org
Ziwei Liu et al.: Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution ##Crystallography##AnomalousScattering##NucleicAcids@Cambridge_Uni...##IUCrhttps://journals.iucr.org/paper?S2053230X26000658
Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution
This paper reports the structure solution of an RNA complex using anomalous scattering.
journals.iucr.org
January 30, 2026 at 1:01 AM
iocbprague.bsky.social
🧬 A new paper from the group of Ed Curtis at IOCB Prague in collab with the @pluskal-lab.org introduces a structure-guided way to explore nucleic acid sequence space that goes beyond traditional random mutagenesis.

#research #machinelearning #nucleicacids #chemistry
1/3
January 6, 2026 at 2:53 PM
ei-science.bsky.social
🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...

Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite
doi.org
September 22, 2025 at 7:00 AM
csbj.org
🔗Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csb...

📚CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

#StructuralBiology #DNA #MolecularBiology #Biosensors #NucleicAcids
🔗 Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0127 📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
June 9, 2026 at 9:07 PM
actacrystf.iucr.org
Shin Ando et al.: The first report of structural analysis of a nucleic acid using crystals grown in space. Corrigendum ##XRayCrystallography##NucleicAcids##Microgravity... ##IUCrhttps://journals.iucr.org/paper?S2053230X25002766
The first report of structural analysis of a nucleic acid using crystals grown in space. Corrigendum
The article by Ando et al. [(2025), Acta Cryst. F81, 95–100] is corrected.
journals.iucr.org
March 31, 2025 at 12:00 AM
moleculore.bsky.social
Nucleic Acid "Assembly"

DNA & RNA are vital for life, carrying genetic info. DNA, as a double helix, stores it, while RNA translates it to proteins. DNA's stability ensures accurate replication, RNA's versatility aids gene expression.

Made in Blender.

#molecules #nucleicacids #blender #molbio
March 4, 2025 at 2:17 PM
healthdivine.bsky.social
CDMO für Nukleinsäuretherapeutika
🧬🏭 CDMO-Markt steigt auf $25.49 Mrd. bis 2034 📈 +12.27% CAGR 🚀
#PharmaManufacturing #NucleicAcids #BioTech

ekz-crosstour.ch/2025/07/17/d...
Der CDMO-Markt für Nukleinsäuretherapeutika soll bis 2034 ein Volumen von 25,49 Milliarden US-Dollar erreichen und eine gesunde jährliche Wachstumsrate von 12,27 % aufweisen. - ekz-crosstour
Marktübersicht für Nukleinsäure‑Therapeutika-CDMOs:Marktforschungsbericht zum Markt für CDMO-Dienstleistungen rund um Nukleinsäure-Therapeutika nach Molekültyp (mRNA, siRNA, ASO, CRISPR/Cas, Plasmid-D...
ekz-crosstour.ch
August 12, 2025 at 9:46 AM
moltherapy.bsky.social
#MolecularTherapy Nucleic Acids is the top journal for research and cutting-edge reviews focused on #NucleicAcids, #GeneEditing, #Biotechnology, and more. Learn more about MTNA and submit your research today: bit.ly/4lj850B
April 4, 2025 at 10:23 PM
debashisdhara.bsky.social
Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages
Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.
academic.oup.com
November 29, 2025 at 8:37 PM
kathlab.bsky.social
Back from an exciting visit to Chalmers University Gothenburg discussing projects with Marcus Wilhelmsson and Fredrik Westerlund. Stay tuned for our PhD position offers in the MSCA doctoral network MeChaNiSM! 🎉🧬
chalmers.se/en/projects/me…#nucleicacidsd#chemicalbiologygy
November 21, 2024 at 8:04 PM
narjournal.bsky.social
What’s the most exciting or influential nucleic acids research you’ve come across? Share it with us! 👇 #NationalDNADay #NucleicAcids #Genomics #DNAday2025 #MolecularBiology #Research #DNA #RNA #Epigenetics
April 25, 2025 at 8:02 AM
iocbprague.bsky.social
#research #machinelearning #nucleicacids

Using structured libraries, selection, and machine learning to rapidly explore the sequence space of a fluorescent deoxyribozyme
(Kurfürst, Volek, Samusevich, Pluskal, Curtis)–NAR: doi.org/10.1093/nar/...

@iocbprague.bsky.social @czechacademy.bsky.social
Using structured libraries, selection, and machine learning to rapidly explore the sequence space of a fluorescent deoxyribozyme
Abstract. Finding ways to more comprehensively explore the sequence space of complex functional motifs is an important and unresolved question in nucleic a
doi.org
January 6, 2026 at 2:53 PM