Great week made better with great friends like these two 🥰 thanks Tahoe Dreamin’! @jeanvelonis.bsky.social @adam17.bsky.social
May 17, 2025 at 9:22 PM
Great week made better with great friends like these two 🥰 thanks Tahoe Dreamin’! @jeanvelonis.bsky.social @adam17.bsky.social
Read in #JEV NF1 Leucine Rich Domain-Derived Extracellular Vesicles Remodel the Glioblastoma Immune Microenvironment via an ADAM17-Associated Inflammatory Program #adam17 #extracellularvesicles #glioblastoma #microglia isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
September 23, 2026 at 2:33 PM
Read in #JEV NF1 Leucine Rich Domain-Derived Extracellular Vesicles Remodel the Glioblastoma Immune Microenvironment via an ADAM17-Associated Inflammatory Program #adam17 #extracellularvesicles #glioblastoma #microglia isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
January 18, 2026 at 1:44 PM
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation @natcomms.nature.com
www.nature.com/articles/s41... @stonybrooku.bsky.social
www.nature.com/articles/s41... @stonybrooku.bsky.social
March 17, 2026 at 6:23 PM
IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation @natcomms.nature.com
www.nature.com/articles/s41... @stonybrooku.bsky.social
www.nature.com/articles/s41... @stonybrooku.bsky.social
Function | New Article Alert! 🚨 #Endothelial #CD44 cleavage by #ADAM17 impairs shear stress #mechanotransduction. https://ow.ly/5lMX50Z83pg #T2D
June 10, 2026 at 1:30 PM
Function | New Article Alert! 🚨 #Endothelial #CD44 cleavage by #ADAM17 impairs shear stress #mechanotransduction. https://ow.ly/5lMX50Z83pg #T2D
Did you know that the cytoplasmic domain of the pseudoprotease iRhom2 mediates distinct signaling mechanisms to control activation of the cell surface protease ADAM17?
You do now
Brought to you mainly by the outstanding Dr Fangfang Lu
Open access, of course
www.jbc.org/article/S002...
You do now
Brought to you mainly by the outstanding Dr Fangfang Lu
Open access, of course
www.jbc.org/article/S002...
September 30, 2025 at 5:25 PM
Did you know that the cytoplasmic domain of the pseudoprotease iRhom2 mediates distinct signaling mechanisms to control activation of the cell surface protease ADAM17?
You do now
Brought to you mainly by the outstanding Dr Fangfang Lu
Open access, of course
www.jbc.org/article/S002...
You do now
Brought to you mainly by the outstanding Dr Fangfang Lu
Open access, of course
www.jbc.org/article/S002...
ADAM17 inhibitors show promise in blocking SARS-CoV-2 virus entry
www.thailandmedical.news/news/adam17-...
www.thailandmedical.news/news/adam17-...
ADAM17 inhibitors show promise in blocking SARS-CoV-2 virus entry - Thailand Medical News
www.thailandmedical.news
September 20, 2024 at 11:37 AM
ADAM17 inhibitors show promise in blocking SARS-CoV-2 virus entry
www.thailandmedical.news/news/adam17-...
www.thailandmedical.news/news/adam17-...
I know I will miss some but here is who I have on Bluesky to say thank you too....
@mehansen82.bsky.social @salesforcestacey.bsky.social @janeenm.bsky.social @adam17.bsky.social @sfdckokua.bsky.social @salesforcek8.bsky.social @proton-pat.bsky.social
@mehansen82.bsky.social @salesforcestacey.bsky.social @janeenm.bsky.social @adam17.bsky.social @sfdckokua.bsky.social @salesforcek8.bsky.social @proton-pat.bsky.social
March 5, 2025 at 11:46 PM
I know I will miss some but here is who I have on Bluesky to say thank you too....
@mehansen82.bsky.social @salesforcestacey.bsky.social @janeenm.bsky.social @adam17.bsky.social @sfdckokua.bsky.social @salesforcek8.bsky.social @proton-pat.bsky.social
@mehansen82.bsky.social @salesforcestacey.bsky.social @janeenm.bsky.social @adam17.bsky.social @sfdckokua.bsky.social @salesforcek8.bsky.social @proton-pat.bsky.social
😂😂 if I can teach you and @adam17.bsky.social something about LWCs I'll consider it a win!
September 30, 2025 at 7:51 PM
😂😂 if I can teach you and @adam17.bsky.social something about LWCs I'll consider it a win!
Leukocytic ADAM10 and ADAM17 modulate disease severity and systemic outcome in bacterial and viral pneumonia publications.ersnet.org/content/erj/...
November 18, 2025 at 3:12 PM
Leukocytic ADAM10 and ADAM17 modulate disease severity and systemic outcome in bacterial and viral pneumonia publications.ersnet.org/content/erj/...
Structural basis for ADAM17 activation by the iRhom1 pseudoprotease
Structural basis for ADAM17 activation by the iRhom1 pseudoprotease
Ungvary et al. present the cryo-EM structure of the iRhom1 pseudoprotease bound to the ADAM17 zymogen. Structural and functional studies reveal a conserved signaling axis spanning the iRhom cytoplasmic and membrane regions that transmits intracellular signals to control ADAM17 activation and substrate processing at the cell surface.
dlvr.it
May 15, 2026 at 12:36 PM
Structural basis for ADAM17 activation by the iRhom1 pseudoprotease
Now online! Cell-autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis
Cell-autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis
AIR, a minimal 15-amino acid motif, enables rapid, activation-dependent shedding of surface receptors through ADAM17, allowing T cells to autonomously tune receptor expression. AIR reduces tonic CAR signaling and exhaustion, limits activation-induced cell death, enables logic-gated antigen recognition, and improves tumor clearance when engineered into CARs or endogenous receptors.
dlvr.it
May 15, 2026 at 10:38 PM
Now online! Cell-autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis
Shoutout to Dr. @drnickiw.bsky.social and for sending so many essentials for our unhoused youth this holiday season.
Appreciate you, @adam17.bsky.social for donating some $ too.
Handing out goodie bags on Saturday and this means so much.
Appreciate you, @adam17.bsky.social for donating some $ too.
Handing out goodie bags on Saturday and this means so much.
December 17, 2024 at 5:46 PM
Shoutout to Dr. @drnickiw.bsky.social and for sending so many essentials for our unhoused youth this holiday season.
Appreciate you, @adam17.bsky.social for donating some $ too.
Handing out goodie bags on Saturday and this means so much.
Appreciate you, @adam17.bsky.social for donating some $ too.
Handing out goodie bags on Saturday and this means so much.
T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0
No description available
www.cell.com
September 24, 2026 at 10:00 AM
ADAM17-Mediated Cleavage of CD44 Impairs Hyaluronan-Dependent Shear Stress Mechanotransduction
ADAM17-Mediated Cleavage of CD44 Impairs Hyaluronan-Dependent Shear Stress Mechanotransduction | Physiology | American Physiological Society
Type 2 diabetes (T2D) is associated with endothelial dysfunction and reduced flow-mediated dilation (FMD), suggesting impaired shear stress mechanotransduction. Loss of endothelial glycocalyx componen...
journals.physiology.org
May 16, 2026 at 7:52 AM
ADAM17-Mediated Cleavage of CD44 Impairs Hyaluronan-Dependent Shear Stress Mechanotransduction
Hint: human ADAM17:p functional domains.
September 11, 2026 at 12:34 PM
Hint: human ADAM17:p functional domains.
ADAM17 looks sketchy too
October 25, 2025 at 3:05 AM
ADAM17 looks sketchy too
quality programming today @utkan.com @adam17.bsky.social
June 16, 2025 at 7:09 PM
quality programming today @utkan.com @adam17.bsky.social
The cytoskeletal protein LASP promotes fibrosis in the diabetic kidney in response to high glucose by increasing expression and activation of the metalloprotease ADAM17 #DKD #Diabetes #DiabetesResearch
The cytoskeletal protein LASP promotes fibrosis in the diabetic kidney through increasing expression and activation of the metalloprotease ADAM17. LASP1 inhibition could protect against development of diabetic kidney disease link.springer.com/article/10.1...
LASP1 mediates ADAM17 upregulation in high glucose to promote fibrosis in diabetic kidneys - Diabetologia
Aims/hypothesis Diabetic kidney disease (DKD), a prevalent complication of diabetes, is the leading cause of chronic kidney disease globally. The current standard of care cannot halt disease progressi...
link.springer.com
February 13, 2026 at 11:17 AM
The cytoskeletal protein LASP promotes fibrosis in the diabetic kidney in response to high glucose by increasing expression and activation of the metalloprotease ADAM17 #DKD #Diabetes #DiabetesResearch
T cell activation triggers ADAM17-mediated cleavage of a designed 15-aa motif, enabling rapid CAR regulation. Embedding this AIR mechanism in CARs decreases basal expression, enhancing therapeutic precision! PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0
https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0
No description available
www.cell.com
September 22, 2026 at 5:00 AM
T cell activation triggers ADAM17-mediated cleavage of a designed 15-aa motif, enabling rapid CAR regulation. Embedding this AIR mechanism in CARs decreases basal expression, enhancing therapeutic precision! PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0
The cytoskeletal protein LASP promotes fibrosis in the diabetic kidney through increasing expression and activation of the metalloprotease ADAM17. LASP1 inhibition could protect against development of diabetic kidney disease link.springer.com/article/10.1...
LASP1 mediates ADAM17 upregulation in high glucose to promote fibrosis in diabetic kidneys - Diabetologia
Aims/hypothesis Diabetic kidney disease (DKD), a prevalent complication of diabetes, is the leading cause of chronic kidney disease globally. The current standard of care cannot halt disease progressi...
link.springer.com
February 13, 2026 at 10:30 AM
The cytoskeletal protein LASP promotes fibrosis in the diabetic kidney through increasing expression and activation of the metalloprotease ADAM17. LASP1 inhibition could protect against development of diabetic kidney disease link.springer.com/article/10.1...
The awesome @adam17.bsky.social will be presenting.
June 1, 2025 at 2:01 PM
The awesome @adam17.bsky.social will be presenting.
Returning to our goal to visualize ADAM17 activity, we found that eNRGies with a cleavage site of the EGFR ligand TGFa can reliably report on ADAM17 activity. Using this sensor we found that ADAM17 is transiently activated during mitosis in HEK293T. (8/10)
June 22, 2026 at 2:32 PM
Returning to our goal to visualize ADAM17 activity, we found that eNRGies with a cleavage site of the EGFR ligand TGFa can reliably report on ADAM17 activity. Using this sensor we found that ADAM17 is transiently activated during mitosis in HEK293T. (8/10)