#ADAR1
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milofasken.bsky.social
#ADAR1 #RNA #Editing
March 18, 2025 at 1:08 PM
jackiheraudfarlow.bsky.social
Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.

If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X

www.science.org/doi/10.1126/...

#RNASky #ImmunoSky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
December 6, 2024 at 1:31 AM
brancolab.bsky.social
New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.
ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface
This study reveals that ADAR1, an RNA-editing enzyme, fine-tunes immune responses in the placenta by preventing the accumulation of immunogenic double-stranded RNAs (dsRNAs) from interferon-stimulate...
advanced.onlinelibrary.wiley.com
August 22, 2025 at 11:28 AM
johannajoyce.bsky.social
𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄: 𝐅𝐥𝐢𝐩𝐩𝐢𝐧𝐠 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐠𝐥𝐢𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚

#BrainTIME 🧠🦠🔬🧪

UNIL news 📰: www.unil.ch/news/1757312...
#OpenAccess article 🔗: www.sciencedirect.com/science/arti...

@alvarezprado.bsky.social @ahernandezb.bsky.social
@joycelab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
#adar1 #adar1 | Oncologie | UNIL-CHUV
𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄: 𝐅𝐥𝐢𝐩𝐩𝐢𝐧𝐠 𝐚𝐧𝐭𝐢𝐯𝐢𝐫𝐚𝐥 𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐠𝐥𝐢𝐨𝐛𝐥𝐚𝐬𝐭𝐨𝐦𝐚 🧠 Glioblastoma is one of the deadliest cancers. A new study in 𝑪𝒆𝒍𝒍 𝑹𝒆𝒑𝒐𝒓𝒕𝒔 by Ángel Álvarez-Prado and Johanna Joyce shows how reawakenin...
www.linkedin.com
September 8, 2025 at 5:33 PM
labwaggoner.bsky.social
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity @natgenet.nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...
December 3, 2025 at 8:47 PM
alvarezprado.bsky.social
Can we exploit anti-viral immunity to treat brain cancer? 🦠 🧠

Our last results suggest so, go ahead and check the paper if you’re curious! 🤓

www.cell.com/cell-reports...

#Brain_cancer #Glioblastoma #TumorMicroenvironment #RNAsensing #ADAR1
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Álvarez-Prado et al. report that targeting ADAR1 triggers cancer-cell-intrinsic anti-proliferative mechanisms and fosters anti-tumoral immune responses, blocking tumor growth and extending survival in...
www.cell.com
September 3, 2025 at 9:34 AM
morkoshenen.bsky.social
We uncover the first evidence that the long-mysterious Zβ domain of #ADAR1 binds G-quads, a surprising twist that reshapes how we think about ADAR targeting—opening new directions for understanding the links between innate immunity and splicing regulation. #NMR #RNA
www.biorxiv.org/content/10.1...
Zα and Zβ domains of ADAR1 and ZBP1 bind to G-quadruplexes with low micromolar affinity
While it is well established that the Zα domains of ADAR1 and ZBP1 proteins bind Z-form prone nucleic acid, it has also been shown that the Zα domain of ADAR1 binds DNA G-quadruplexes. However, no bin...
www.biorxiv.org
November 20, 2025 at 5:33 PM
jackiheraudfarlow.bsky.social
Thrilled to share our new paper out today in #ScienceImmunology!

It’s been a long time coming and I’m so excited to be able to share it.

Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!

#ImmunoSky #RNASky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 22, 2024 at 8:06 PM
haoyin.bsky.social
#RNAEditing #PulmonaryArterialHypertension

ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)

SMC ADAR1 KO🐭 excerbates PAH

SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation

@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
November 23, 2025 at 12:37 PM
immunoeditor.bsky.social
This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 22, 2024 at 8:36 PM
cp-cellreports.bsky.social
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Álvarez-Prado et al. report that targeting ADAR1 triggers cancer-cell-intrinsic anti-proliferative mechanisms and fosters anti-tumoral immune responses, blocking tumor growth and extending survival in preclinical mouse models of glioblastoma.
dlvr.it
September 8, 2025 at 2:38 PM
chadweldy.bsky.social
Hard to understate how wonderful it is to see our manuscript in print today @natcardiovascres.nature.com. We discover ADAR1 to control dsRNA sensor MDA5 in atherosclerosis, creating a new paradigm of endogenous dsRNA sensing as a causal mechanism of disease. Let's get into it 👇 #RNAsky rdcu.be/eGEyu
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Nature Cardiovascular Research - Weldy et al. show that smooth muscle expression of the RNA editing enzyme ADAR1 regulates activation of the double-stranded RNA sensor MDA5 in a novel mechanism of...
rdcu.be
September 16, 2025 at 12:48 PM
labwaggoner.bsky.social
dsRNAs regulated by ADAR1 go beyond A-to-I edited transcripts and that ADAR1 can control mitochondrial dsRNAs @cp-cellreports.bsky.social @columbiauniversity.bsky.social
www.cell.com/cell-reports...
March 8, 2026 at 2:57 AM
cp-cellreports.bsky.social
ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms
ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms
We report that the RNA-editing enzyme ADAR1 downregulates nuclear- and mitochondria-encoded double-stranded RNAs (dsRNAs) to maintain immune homeostasis. ADAR1 employs RNA-editing-dependent and -independent mechanisms to keep dsRNA levels low in cells. Notably, upon ADAR1 loss, mitochondrial dsRNA levels increase and can cause enhanced inflammation upon mitochondrial stress.
dlvr.it
March 21, 2026 at 11:23 PM
cp-molcell.bsky.social
Biochemical profiling and structural basis of ADAR1-mediated RNA editing
Biochemical profiling and structural basis of ADAR1-mediated RNA editing
Deng et al. reveal mechanisms of ADAR1-mediated RNA editing through biochemical profiling and cryo-EM structure determination. They show how disease-related mutations disrupt short RNA editing and highlight key RNA-binding domains, providing insights into immune regulation by ADAR1 and rational targeting of ADAR1 for therapeutic applications.
dlvr.it
April 6, 2025 at 3:20 PM
dsrna.bsky.social
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting
April 15, 2025 at 1:45 AM
jalees.bsky.social
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

www.science.org/doi/10.1126/...
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 26, 2024 at 9:24 PM
jmannion1.bsky.social
#paperoftheweek @jackiheraudfarlow.bsky.social & Co report that GGNBP2-CNOT10/11 complex formation promotes MDA5 sensing of immunogenic self dsRNAs, upon ADAR1 mutation. Congrats to all involved! 👏🏻

www.science.org/doi/10.1126/...
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 24, 2024 at 12:32 PM
natrevgenet.nature.com
New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Nature Reviews Genetics, Published online: 14 April 2025; doi:10.1038/s41576-025-00830-5ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-mediated RNA editing, which are now providing insights for the development of potential therapies that target these mechanisms.
www.nature.com
April 14, 2025 at 1:54 PM
labwaggoner.bsky.social
Review @naturerevgenet.bsky.social
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
www.nature.com/articles/s41...
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease - Nature Reviews Genetics
ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-me...
www.nature.com
April 14, 2025 at 6:26 PM
drnatsampaio.bsky.social
Great to see this super exciting work published by @jackiheraudfarlow.bsky.social and Carl Walkley’s team, where they reveal new players in the ADAR1-MDA5 axis. 👏 team #innateimmunity #immunosky
jackiheraudfarlow.bsky.social Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Nov 22
Thrilled to share our new paper out today in #ScienceImmunology!

It’s been a long time coming and I’m so excited to be able to share it.

Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!

#ImmunoSky #RNASky
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 23, 2024 at 7:18 AM
natrevgenet.nature.com
Our August 2025 issue is now live: go.nature.com/4kIXzOI
Topics include: systems biology in the single-cell era; ADAR1-mediated RNA editing; retrotransposable element reactivation and its biological impact; transcriptional condensates as temporal signal integrators; X-linked competition
July 18, 2025 at 8:05 AM
biorxivpreprint.bsky.social
Biochemical Profiling and Structural Basis of ADAR1-Mediated RNA Editing https://www.biorxiv.org/content/10.1101/2025.01.02.631069v1
January 3, 2025 at 3:45 AM
labwaggoner.bsky.social
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA
www.science.org/doi/10.1126/...
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
November 22, 2024 at 8:55 PM
cyrilpedia.bsky.social
'Using genetically distinct mouse models of glioblastoma, we found that deletion of Adar1 consistently reduced tumor growth and extended survival, suggesting that disrupting ADAR1 activity could overcome the genetic heterogeneity of glioblastomas.'
Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival
Álvarez-Prado et al. report that targeting ADAR1 triggers cancer-cell-intrinsic anti-proliferative mechanisms and fosters anti-tumoral immune responses, blocking tumor growth and extending survival in...
www.cell.com
September 7, 2025 at 10:56 AM