#CellularReprogramming
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cellreprolab.bsky.social
Can we move TLSs from biomarkers of response to active therapeutic tools? Harnessing cDC1 reprogramming to engineer immunogenic tertiary lymphoid structures within tumors may help answer that question. Exciting opportunities ahead!
#TLSs #CellularReprogramming #CancerImmunotherapy
November 13, 2026 at 12:41 PM
cellreprolab.bsky.social
The transformative concept of cellular reprogramming is now being applied for in vivo cancer immunotherapy. How might the next 20 years expand reprogramming approaches within the tumor microenvironment? Exciting times ahead!
#iPSC #CellularReprogramming #CancerImmunotherapy
October 30, 2026 at 12:13 PM
purescience.news
STAT+: Life Biosciences share glaucoma study updates for its cellular reprogramming drug #Science #HealthandMedicine #GeneticsandGenomics #lifebiosciences #glaucomastudy #cellularreprogramming #biotechnewsletter #readoutupdate

https://purescience.news/read?id=234356299200987136
Life Biosciences share glaucoma study updates for its cellular reprogramming drug
Life Biosciences said yesterday that three glaucoma patients have now received a single injection of its experimental cellular reprogramming drug, with no serious adverse events.
purescience.news
October 11, 2026 at 3:49 AM
robertlufkinmd.bsky.social
I'm Dr. Robert Lufkin, and that's how you live well, longer.

#Longevity #Epigenetics #CellularReprogramming #MetabolicHealth #HealthLongevitySecrets (5/5)
August 26, 2026 at 12:18 PM
robertlufkinmd.bsky.social
#Longevity #CellularReprogramming #ExponentialMedicine #MetabolicHealth #HealthLongevitySecrets

Source: www.nature.com/articles/d41... (6/6)
August 26, 2026 at 12:01 PM
longevitytech.bsky.social
Insilico Medicine’s VAC platform makes biological age a core variable as it attempts to model cellular change across six biological scales.

Link as first comment.

#longevity #geroscience #insilico #biologicalage #cellularreprogramming
Digital artwork with virtual cells and a large clock face.
August 17, 2026 at 8:52 AM
thelolgic.bsky.social
For the first time ever, ER-100, a cellular reprogramming gene therapy, was injected into a human eye.

Developed by Harvard's David Sinclair, the trial targets glaucoma and, eventually, aging.

#TheLolgic #antiaging #GeneTherapy #glaucoma #CellularReprogramming
August 9, 2026 at 5:42 PM
alicefrolov.bsky.social
Sharing a visualization from our ongoing methodological work on reprogramming factor dose-response modeling.

Figure: "OSKM factor stoichiometry shapes reprogramming trajectories"

#iPSC #CellularReprogramming #StemCellBiology #Yamanaka #Pluripotency #SystemsBiology
Sharing a visualization from our ongoing methodological work on reprogramming factor dose-response modeling. Figure: "OSKM factor stoichiometry shapes reprogramming trajectories" Subtitle: "Simulated fibroblast reprogramming outcomes across six OSKM cocktail formulations" The parallel coordinates plot traces six OSKM cocktail formulations (equimolar 1:1:1:1, high-Oct4, high-Klf4, high-cMyc, high-Sox2, and low-cMyc/high-Klf4) across a series of outcome axes: reprogramming efficiency (AP+ colony frequency), kinetic latency to TRA-1-60 acquisition, mesenchymal-to-epithelial transition completeness, residual somatic transcriptional memory, genomic instability index (CNV burden proxy), and endpoint pluripotency fidelity (naive vs primed scoring). The visualization is intended to make explicit a mechanistic trend consistently reported in the reprogramming literature: elevated Oct4 relative to the other factors biases trajectories toward trophectodermal and extraembryonic endoderm-like off-target states, while high-Klf4/low-cMyc stoichiometries improve fidelity at the expense of kinetics and yield. High cMyc dosage compresses latency and boosts colony counts but concurrently elevates the genomic instability axis, consistent with replication stress and apoptotic selection dynamics described for MYC-driven reprogramming intermediates. The Sox2-biased regime shows the expected suppression of mesendodermal derailment but incomplete MET closure. Important caveat: the underlying data are simulated. Values were generated to illustrate a literature-grounded qualitative trend synthesized from published observations (Carey et al., Papapetrou et al., Buganim et al., and subsequent stoichiometry studies), not from a specific experimental dataset. The figure is intended as a didactic and hypothesis-structuring device for discussions of factor dosage as a determinant of trajectory bifurcation, rather than as an empirical claim.
July 8, 2026 at 5:00 PM
thailandmedical.bsky.social
A Must Read For All Interested in Wellness & Longevity

How Epigenetics and Cellular Reprogramming Are Redefining Wellness and Longevity

thailandwellness.news/how-epigenet...

#WellnessNews #ThailandWellnessNews #Wellness #Longevity #CellularReprogramming #Epigenetics #Health #Thailand #News
How Epigenetics and Cellular Reprogramming Are Redefining Wellness and Longevity - thailandwellness.news
Wellness News: For centuries, humanity has searched for the secret to extending life without sacrificing vitality. From ancient herbal remedies and royal
thailandwellness.news
July 6, 2026 at 2:17 PM
alicefrolov.bsky.social
Sharing a visualization developed in the context of our ongoing work on somatic cell reprogramming trajectories.

Figure: Single-cell transcriptomic heterogeneity during OSKM reprogramming

#CellularReprogramming #iPSC #SingleCellTranscriptomics #Pluripotency #SystemsBiology
Sharing a visualization developed in the context of our ongoing work on somatic cell reprogramming trajectories. Figure: Single-cell transcriptomic heterogeneity during OSKM reprogramming Subtitle: Distribution of pluripotency score across reprogramming day in mouse embryonic fibroblasts The plot displays violin distributions of a composite pluripotency score (aggregated expression of canonical markers including Nanog, Sox2, Esrrb, Zfp42/Rex1, and Dppa3) computed at the single-cell level across discrete time points (day 0, 3, 6, 9, 12, 15) following doxycycline-induced expression of the Yamanaka cassette (Oct4, Sox2, Klf4, c-Myc) in mouse embryonic fibroblasts. Key features illustrated: 1. Day 0 MEFs display a tight, low-score distribution consistent with a stable somatic transcriptional ground state. 2. Intermediate time points (day 6–9) exhibit pronounced multimodality and increased variance, capturing the well-documented coexistence of partially reprogrammed intermediates, including cells transiting through mesenchymal-to-epithelial transition (MET) and stochastic activation phases preceding the deterministic late phase. 3. A subpopulation bifurcation emerges around day 9–12, separating cells progressing toward the pluripotent attractor from refractory or alternative-fate trajectories (e.g., trophoblast-like or stalled XEN-like states described by Polo, Hochedlinger, and colleagues). 4. By day 15, a bimodal structure persists, reflecting the characteristically low conversion efficiency of OSKM reprogramming and the stabilization of bona fide iPSCs at the upper mode. Important caveat: the data shown are simulated. The distributions were generated to recapitulate qualitative trends consistently reported in single-cell studies of OSKM reprogramming (e.g., Buganim et al. 2012, Polo et al. 2012, Schiebinger et al. 2019), and are intended as a didactic and conceptual illustration of intermediate-state heterogeneity rather than a quantitative representation.
July 2, 2026 at 5:00 PM
alicefrolov.bsky.social
Sharing a visualization developed for didactic and exploratory purposes, addressing the temporal dynamics of OSKM-mediated reprogramming in somatic cells.

#CellularReprogramming #YamanakaFactors #iPSC #Pluripotency #Epigenetics #Senescence #PartialReprogramming #SystemsBiology
Sharing a visualization developed for didactic and exploratory purposes, addressing the temporal dynamics of OSKM-mediated reprogramming in somatic cells. Figure: "Partial reprogramming progressively erodes somatic identity" Subtitle: "Transcriptional trajectories of fibroblast, pluripotency, and senescence markers during OSKM induction" The multiline plot tracks normalized expression trajectories of three marker classes across a continuous induction window (0–20 days of doxycycline-driven OSKM expression): 1. Somatic/fibroblast identity markers (Col1a1, Thy1, S100a4, Fsp1) exhibit monotonic downregulation, with inflection between days 4–8 consistent with the loss of mesenchymal transcriptional programs that precedes MET. 2. Pluripotency-associated loci (Nanog, Esrrb, endogenous Oct4, Sox2) display the canonical biphasic trajectory: a latent phase (days 0–6), followed by stochastic activation and, in a subset of trajectories, deterministic stabilization beyond day 12, recapitulating the late hierarchical activation described by Polo, Buganim, and Hochedlinger and colleagues. 3. Senescence/stress markers (Cdkn2a/p16, Cdkn1a/p21, IL6) show a transient peak between days 3–9, mirroring the OSKM-induced senescence barrier and its paracrine reinforcement. The figure is intended to make explicit the inverse coupling between somatic dedifferentiation kinetics and the senescence-associated barrier, and to delineate the partial reprogramming window (approximately days 4–8) in which somatic identity is substantially eroded before robust pluripotency network activation — the regime exploited in transient OSKM rejuvenation paradigms (Ocampo et al., 2016; Browder et al., 2022). The data plotted are simulated. Trajectories were parameterized to reflect qualitative trends consolidated in the reprogramming literature (MEF→iPSC transitions, secondary reprogramming systems, single-cell lineage tracing studies) and do not correspond to any specific experimental dataset.
June 28, 2026 at 5:03 PM
longevitytech.bsky.social
The longevity biotech is accelerating toward the clinic after uncovering a promising age-reprogramming therapy years sooner than expected.

Link as first comment.

#longevity #geroscience #biotech #cellularreprogramming #aging
A promotional image for NewLimit announcing $435 million funding ahead of human trials. The image features a laboratory setting with a logo and slogan overlay.
June 5, 2026 at 7:47 AM
longevitytech.bsky.social
Korean pharma company targets regenerative medicine market with partial cellular reprogramming platform.

Link as first comment.

#longevity #regenerativemedicine #cellularreprogramming #mrna #geroscience
Graphic announcing Daewoong Pharmaceutical's acquisition of Turn Bio's age-reversal assets. Features company logos on a blue gradient background.
May 27, 2026 at 3:33 PM
aldesinaga.bsky.social
moving the world one step closer to systemic, whole-body age reversal.

#AgeReversal #Longevity #ReverseAging #AntiAgingBreakthrough
#YouthExtension #EpigeneticReprogramming #CellularReprogramming #GeneTherapy #YamanakaFactors #Biotech #LifeBiosciences #DavidSinclair #FDAApprova
May 17, 2026 at 2:59 PM
longevitytech.bsky.social
Fresh funding backs the first human trial of a therapy designed to make older, damaged cells act younger again.

Link as first comment.

#longevity #geroscience #epigenetics #cellularreprogramming #biotech

@LifeBiosciences
April 9, 2026 at 10:21 AM
robertlufkinmd.bsky.social
FDA Clears First Age Reversal Trial (Nature Biotechnology / Life Biosciences)

The FDA just cleared the first-ever human trial of cellular age reversal. This is not scien... https://www.nature.com/articles/s41587-026-03037-z

#AgingReversal #Longevity #CellularReprogramming #MetabolicHealth #Biotech
March 20, 2026 at 12:46 PM
byteandpieces.bsky.social
📣 New Podcast! "AI vs. Aging: The End of the Human Expiration Date?" on @Spreaker #aidrugdiscovery #altoslabs #antiaging #aubreydegrey #biointelligence #biotech #cellularreprogramming #digitaltwins #epigenetics #futureofhealth #generativebiology #healthtech #immortality #lifeextension
AI vs. Aging: The End of the Human Expiration Date?
🧬 The Death of Death: Is Aging Just a Software Bug? 🛠️ What if I told you that you might be part of the last generation of humans destined to die from old age? In this mind-bending episode, we dive deep into the radical frontier of biotechnology where the world’s elite are no longer looking for a 'fountain of youth'—they are building it with code. We explore the controversial shift from viewing aging as an inevitable tragedy to treating it as a reparable software bug that can be patched, updated, and optimized. 🚀 The Race to Longevity Escape Velocity Driven by massive investments from Silicon Valley billionaires and the predictive power of Generative AI, we are rapidly approaching Longevity Escape Velocity. This is the tipping point where science extends your life expectancy by more than a year for every year you stay alive. In this episode, we break down: - 🧪 Cellular Reprogramming: How scientists are resetting biological clocks to 'factory settings.' - 🤖 Generative AI in BioScience: How AI is compressing 50 years of drug discovery into just a few months. - 💰 The Immortal Billionaires: Why the tech elite are obsessed with 'curing' death and what it means for the rest of us. - ⚖️ The Stagnation Paradox: If nobody dies, does human progress stop? We tackle the chilling philosophical warning about a world without new generations. 🧠 Why This Matters Now This isn't science fiction anymore; it’s a tangible reality. From AI-driven medicine to the ethics of immortality, the convergence of tech and biology is rewriting the human script. Whether you find it thrilling or terrifying, the anti-aging revolution is here, and it’s changing what it means to be human. Is a world without death a utopia or a biological prison? Join us as we pull back the curtain on the most significant scientific shift in human history. 🔗 Stay Ahead of the Future If you enjoyed this deep dive into the future of humanity, hit that Subscribe button and leave us a 5-star review! 🌟 Share this episode with the one person you want to live forever with. Let’s keep the conversation going—are you ready to live for 200 years? #BioTech #Longevity #AI #Immortality #FutureTech #AntiAging #GenerativeAI #SciencePodcast #LongevityEscapeVelocity  
www.spreaker.com
March 9, 2026 at 10:35 AM
arxivlens.bsky.social
Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging models
Ergul, O. C. et al.
Paper
Details
#CellularReprogramming #AgingResearch #GeneticOptimization
December 18, 2025 at 9:01 AM
efapostolou29.bsky.social
Honored to be part of the "Reprogramming Stars" interview series by @cellreprolab.bsky.social @CellularReprogramming. Humbling title but very fun discussion about past and ongoing research, future directions, advice to new trainees and more. Check it out! www.liebertpub.com/doi/10.1177/...
Reprogramming Stars #23: Charting Cell Fate Crossroads from the Interplay Between Epigenetics, Transcription, and 3D Chromatin Architecture—An Interview with Dr. Effie Apostolou | Cellular Reprogrammi...
Cellular Reprogramming
www.liebertpub.com
August 26, 2025 at 9:24 AM
cellreprolab.bsky.social
Welcome aboard @DrouinOuellet @Dan_Li123 @YuanchengLu @camivaze! #CellularReprogramming
August 3, 2025 at 1:30 PM
cellreprolab.bsky.social
Reprogramming Stars #1 is now published! Read the first chapter of our interview series with the leaders in Cellular Reprogramming: Genome Programming Through the Cell Cycle, featuring @TsubouchiTomomi
#CellularReprogramming #CellCycle
August 3, 2025 at 1:29 PM
katie-hb.bsky.social
Groundbreaking news‼️🔬🤯 Scientists at the #BabrahamInstitute have successfully rejuvenated 53-year-old #skincells to function like 23-year-old #cells using an innovative technique called #cellularreprogramming. This #breakthrough could potentially revolutionize skin #health & wound #healing! ❤️‍🩹
June 24, 2025 at 10:33 AM
screamdump.bsky.social
This is how it goes down from birthday zero
#healthyaging #CellReprogramming, #AgingPrevention, #ImmortalitySeekers, #NextGenAntiAging #AntiAging #AgingResearch #Longevity #LifeExtension #BioTechnology #CellularReprogramming #StemCells #Telomeres #Senolytics

youtube.com/shorts/xvaN3...
🛏️Nobody Told Me 30 Means 9PM is Late
YouTube video by ScreamDump
youtube.com
November 7, 2024 at 12:12 PM
cellreprolab.bsky.social
Discover the latest in stem cell and cellular reprogramming through this fascinating thread by @CellRepJrnl! Don't miss out on the exciting meetings—spread the word, save, and share to keep the conversation going!
#StemCellResearch #CellularReprogramming #ScienceMeetings
August 3, 2025 at 1:41 PM
cellreprolab.bsky.social
It was an exciting kick-off meeting with the consortium partners of the Eurostars REPRINT project. We are paving the way for an entirely new cancer immunotherapy platform based on cellular reprogramming!

#REPRINT #cellularreprogramming #cancerimmunotherapy
August 3, 2025 at 1:31 PM