#EZH2
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cp-cellrepmed.bsky.social
Online now: Multipronged enhancement of CART cell activity against ROR1 neoantigen by inhibition of H3K27 methyltransferase EZH2
Multipronged enhancement of CART cell activity against ROR1 neoantigen by inhibition of H3K27 methyltransferase EZH2
Wang et al. report that inhibition of EZH2 and, to lesser degree, other epigenetic modifiers promotes expression of ROR1 neoantigen on malignant cells. CART cells targeting ROR1 are able to detect the neoantigen at very low concentration and, in combination with EZH2 inhibition, highly effectively eliminate the ROR1-expressing cells.
dlvr.it
September 27, 2026 at 7:19 PM
markey.senate.gov
Join live at the Capitol: We need universal care—Let’s pass the State Based Universal Health Care Act.

www.youtube.com/watch?v=ezH2...
Join live at Capitol: We need universal care—Let’s pass the State Based Universal Health Care Act.
YouTube video by Senator Markey
www.youtube.com
July 15, 2025 at 1:51 PM
oncodaily.bsky.social
Extreme and unexpected phenotypic plasticity by RMC during EZH2 inhibition - Pavlos Msaouel

@msaouel.bsky.social

oncodaily.com/science/pavl...

#Cancer #EZH2Inhibition #OncoDaily #Oncology #Health #Medicine
Pavlos Msaouel: Extreme and unexpected phenotypic plasticity by RMC during EZH2 inhibition - OncoDaily
Pavlos Msaouel: Extreme and unexpected phenotypic plasticity by RMC during EZH2 inhibition / cancer, EZH2 inhibition, Giannicola Genovese, Gleb Khegai, Ian E.
oncodaily.com
January 23, 2025 at 10:02 PM
jamesnolan.bsky.social
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma
AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. ...
www.biorxiv.org
October 17, 2025 at 7:11 AM
labwaggoner.bsky.social
EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function
www.cell.com/cancer-cell/...
December 6, 2024 at 3:47 AM
plosbiology.org
Epigenetic regulators like EZH2 are mutated in #Bcell #lymphoma, but what is their effect? This study reveals a role for mutant EZH2 in lymphomagenesis, using a new method for measuring #epigenetic heterogeneity & intra- #chromatin connectivity in #cancer @plosbiology.org 🧪 plos.io/4mZcS8n
EZH2-mutants exhibit two distinct epigenetic populations. Top: Joint UMAP of OCI-Ly7 WT cells and the isogenic EZH2 Y646N cells (Left) or dMUT cells (Right). Colors indicate the sample index. Bottom: Only mutant-EZH2 cells are plotted, to highlight the subpopulation of mutant cells that cluster with WT cells, referred to as ‘WT-like’. The subpopulation of cells that cluster separately from WT is referred to as EZH2 Y646N ‘extreme’ or dMUT ‘extreme’, respectively.
June 16, 2025 at 8:04 AM
plosbiology.org
Epigenetic regulators like EZH2 are mutated in #Bcell #lymphoma, but what is their effect? This study reveals a role for mutant EZH2 in lymphomagenesis, using a new method for measuring #epigenetic heterogeneity & intra- #chromatin connectivity in #cancer @plosbiology.org 🧪 plos.io/4mZcS8n
EZH2-mutants exhibit two distinct epigenetic populations. Top: Joint UMAP of OCI-Ly7 WT cells and the isogenic EZH2 Y646N cells (Left) or dMUT cells (Right). Colors indicate the sample index. Bottom: Only mutant-EZH2 cells are plotted, to highlight the subpopulation of mutant cells that cluster with WT cells, referred to as ‘WT-like’. The subpopulation of cells that cluster separately from WT is referred to as EZH2 Y646N ‘extreme’ or dMUT ‘extreme’, respectively.
June 13, 2025 at 5:34 PM
peterlewislab.bsky.social
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2
June 5, 2026 at 12:30 AM
mattmuscleguy.bsky.social
New @ScienceAdvances paper: Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy. #DMD #Myoblue tinyurl.com/3jbcw9fp
Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy
Genome-wide survey of human and mouse DMD tissues suggests EZH2’s role in satellite cells; its inhibition improves prognosis.
tinyurl.com
March 15, 2025 at 10:08 AM
cvasilescu.bsky.social
A new collection of papers summarizing the research published last week on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/...

➡️ A genetic switch involving EGR1 and EZH2 links aging and development [..]

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A genetic switch involving EGR1 and EZH2 links aging and development across human tissues
August 23, 2026 at 1:50 PM
genesdev.bsky.social
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full

Eric Conway
Adrian Bracken

#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover
November 10, 2025 at 4:05 PM
plosbiology.org
Epigenetic regulators like EZH2 are mutated in #Bcell #lymphoma, but what is their effect? This study reveals a role for mutant EZH2 in lymphomagenesis, using a new method for measuring #epigenetic heterogeneity & intra- #chromatin connectivity in #cancer @plosbiology.org 🧪 plos.io/4mZcS8n
EZH2-mutants exhibit two distinct epigenetic populations. Top: Joint UMAP of OCI-Ly7 WT cells and the isogenic EZH2 Y646N cells (Left) or dMUT cells (Right). Colors indicate the sample index. Bottom: Only mutant-EZH2 cells are plotted, to highlight the subpopulation of mutant cells that cluster with WT cells, referred to as ‘WT-like’. The subpopulation of cells that cluster separately from WT is referred to as EZH2 Y646N ‘extreme’ or dMUT ‘extreme’, respectively.
June 13, 2025 at 1:09 PM
cp-cancercell.bsky.social
Online now: Online Now: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
Porazzi et al. highlight how inhibiting the epigenetic regulators EZH2 and EZH1 enhances cancer cell immunogenicity, boosting the effectiveness of CAR- and TCR-engineered T cells across liquid and solid tumor models, which represents a promising strategy…
dlvr.it
February 20, 2025 at 7:51 PM
labwaggoner.bsky.social
EZH2 coordinates memory B-cell programming and recall responses @jimmunol.bsky.social
doi.org/10.1093/jimm...
March 13, 2025 at 2:48 AM
scinews.bsky.social
Anticancer drugs could make immunotherapies more effective #CancerCell

"EZH2 inhibition combined with T-cell based immunotherapy worked better at shrinking non-Hodgkin B-cell lymphomas than immunotherapy alone."

Paper:
www.cell.com/cancer-cell/...

News:
news.weill.cornell.edu/news/2024/12...
EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function
Isshiki et al. demonstrate that EZH2 inhibitors re-activate immune synapse functions between B cell lymphomas and T cells, sensitizing lymphomas to T cell immunotherapies. EZH2 inhibition enhances killing activity by promoting T cell recruitment, prolonging binding and increasing contact surface with lymphoma cells, and prevents T cell exhaustion. This strategy is currently under clinical evaluation.
www.cell.com
December 5, 2024 at 4:53 PM
elfangortheone.bsky.social
¡Y nuevo capítulo de #Death'sDoor ! ¡Con la inestimable
@lauriellemaven.bsky.social !

La más profunda oscuridad.

www.youtube.com/watch?v=ezH2...
October 30, 2025 at 7:42 PM
natcancer.nature.com
🚨New Article Alert from Nature Cancer !

'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer'
✏️ By Michael Karin and colleagues

🔗 www.nature.com/articles/s43...
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer - Nature Cancer
Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant trans...
www.nature.com
July 4, 2025 at 10:41 AM
labwaggoner.bsky.social
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @cp-cancercell.bsky.social @marcoruella.bsky.social
www.cell.com/cancer-cell/...
February 20, 2025 at 11:13 PM
epigenometech.bsky.social
Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity bit.ly/460jVa1

Agata L. Patriotis (Rockefeller University) reporting in Genes Dev

#Epigenetics #EZH2 #PRC2
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Perfect for cancer, immunology, and aging research; epigenometech.com
February 11, 2026 at 8:45 AM
epigenometech.bsky.social
Epigenetics Update - EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity bit.ly/4qOfmYw

William J Muller (McGill University) reporting in EMBO Rep

#Epigenetics #EZH2 #BreastCancer
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Perfect for cancer, immunology, and aging research; epigenometech.com
February 3, 2026 at 12:43 PM
evhealy.bsky.social
#CancerResearch #Chromatin #EZH2 #PRC1 #PRC2 #Quiescence #EZH2Inhibitors
January 14, 2025 at 10:57 PM
abelmartel.bsky.social
Just released our latest work in @jci-insight.bsky.social, @mdanderson.bsky.social - Inhibition of histone methyltransferase EZH2 for immune-interception of colorectal cancer in Lynch syndrome. insight.jci.org/articles/vie...
insight.jci.org
February 13, 2025 at 7:39 PM
jcellsci.bsky.social
Jessica Sacco, Esther Gomez and colleagues find that chemomechanical regulation of EZH2 localisation controls EMT.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Model showing how matrix stiffness and cell contractility regulate EZH2 subcellular localization, H3K27me3 levels and gene expression in response to TGFβ1. TGFβ1-treated cells cultured on stiff substrata exhibit higher nuclear localization of EZH2 and increased H3K27me3 levels than cells cultured on soft substrata. Inhibition or knockdown of EZH2 attenuates TGFβ1-induced changes in the expression of EMT-associated genes in cell cultured on stiff substrata. Furthermore, inhibition of ROCK1/2 or myosin II reduces stiffness- and TGFβ1-induced nuclear localization of EZH2, suggesting that matrix stiffness and TGFβ1 mediate EZH2 subcellular localization and the expression of EMT-associated genes via a contractility-dependent mechanism. For further detail, see Discussion.
November 28, 2024 at 10:30 AM
nimasharifimd.bsky.social
Provocative study from Michael Schweitzer @fredhutch.bsky.social suggesting the activity of EZH2 inhibition in combination with enzalutamide for mCRPC #GU25 @ascocancer.bsky.social @theaacr.bsky.social
February 14, 2025 at 1:36 AM
renesugar.bsky.social
Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/32855270/
Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2 - PubMed
Enhancer of zester homolog 2 (EZH2), a histone lysine methyltransferase and the catalytic component of polycomb repressive complex 2, has been extensively investigated as a chromatin regulator and a t...
pubmed.ncbi.nlm.nih.gov
January 24, 2025 at 4:53 AM