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Research priorities in epilepsy: a consensus position paper from the European Reference Network ERN EpiCARE.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Epilepsy #ERN #EpiCARE #EU4Health #HealthUnion #genetics #rareandcomplexepilepsies #researchfunding @stephane_auvin
January 16, 2026 at 7:25 PM
epilepsia-open.bsky.social
Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate
January 15, 2026 at 5:45 PM
epilepsia-open.bsky.social
This case shows the potential of SqEEG to guide treatment decisions in the perioperative setting.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #epilepsysurgery #epilepsytreatment #objectiveseizuredocumentation #subcutaneousEEG #ultralongtermEEGmonitoring
January 12, 2026 at 4:22 PM
epilepsia-open.bsky.social
URE patients had a median of six failed treatment strategies, including surgery or neurostimulation.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy
December 15, 2025 at 7:12 PM
epilepsia-open.bsky.social
In the cavernous sinus, eEEG detected IEDs with higher amplitude than scalp EEG, indicating its diagnostic potential.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #EP01 #focalonsetepilepsy #localizedepileptogenicity
December 12, 2025 at 4:56 PM
epilepsia-open.bsky.social
Introducing a systematic sample handling protocol to assess tissue epileptogenicity at structural, functional and molecular levels.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #electronmicroscopy #electrophysiology #histology #MRI #multiscale #omics
December 12, 2025 at 4:55 PM
epilepsia-open.bsky.social
The overall pooled prevalence of active cases of IESS was 3.33 per 100 000 population (95% CI, 1.46–5.82) in India.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #burden #infantilespasms #prevalence
December 11, 2025 at 5:15 PM
epilepsia-open.bsky.social
Dravet Syndrome is now diagnosed earlier but this has not led to earlier initiation of stiripentol treatment.⁠
doi.org/10.1002/epi4...
⁠
#epilepsy #ILAE #epilepsiaopen #efficacy #healthcareutilization #qualityoflife #statusepilepticus #stiripentol #DravetSyndrome⁠
December 10, 2025 at 4:21 PM
epilepsia-open.bsky.social
The ELUCID Study is a prospective, multi-site, longitudinal observational study on late-onset unexplained epilepsy (LoUE).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cognition #dementia #elderly #lateonset
December 9, 2025 at 3:44 PM
epilepsia-open.bsky.social
New in Epilepsia Open – December 7, 2025
mailchi.mp/ilae/epileps...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
December 8, 2025 at 8:37 PM
epilepsia-open.bsky.social
Martinique status epilepticus incidence: 25.2/100000—ourfold higher than mainland France.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mobileintensivecareunit #mortality #prehospitalcare #statusepilepticus #WestIndies
December 4, 2025 at 3:37 PM
epilepsia-open.bsky.social
We performed epilepsy surgery in experimental models of focal onset seizures to investigate the effectiveness of surgeries using neurophysiological and metabolic changes before and after the surgery.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #DBS #kainicacid #kindling
November 21, 2025 at 6:37 PM
epilepsia-open.bsky.social
RNS with neocortical depth leads achieved 66.7% seizure reduction at 1 year and 77.5% at long term follow up.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #depthelectrode #neocortex #networkremodeling #responsiveneurostimulation #RNS #seizure #sEEG
November 21, 2025 at 6:36 PM
epilepsia-open.bsky.social
This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel
November 20, 2025 at 5:18 PM
epilepsia-open.bsky.social
Epilepsy is associated with significantly increased long-term risk of cardiovascular disease.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cardiovasculardiseases #riskfactors #SouthKorea
November 19, 2025 at 7:04 PM
epilepsia-open.bsky.social
This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation
November 17, 2025 at 4:27 PM
epilepsia-open.bsky.social
We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure
November 17, 2025 at 4:26 PM
epilepsia-open.bsky.social
Combined multimodal imaging (82–100% sensitivity) outperforms single modalities for localizing epileptogenic foci in surgical candidates.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #multimodalimaging #neuroimaging #radiosurgery #stereotactic
November 13, 2025 at 6:51 PM
epilepsia-open.bsky.social
The study compared the effectiveness of 5 mg melatonin versus partial sleep deprivation in inducing sleep during nap-time EEG in children with epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #melatonin #napEEG #sleepinduction #sleeplatency
November 12, 2025 at 4:08 PM
epilepsia-open.bsky.social
This review provides a practical approach to assessing and selecting PROMs, and discusses how they may be incorporated into clinic workflows.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mooddisorders #patientreportedoutcome #qualityoflife #seizure
November 11, 2025 at 3:46 PM
epilepsia-open.bsky.social
New in Epilepsia Open – November 9, 2025
mailchi.mp/ilae/epileps...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 10, 2025 at 3:51 PM
epilepsia-open.bsky.social
Global adolescent epilepsy burden increased 1990–2021, with marked regional and SDI disparities.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #adolescenthealth #globalburdenofdisease #healthpolicy #publichealth
November 7, 2025 at 3:33 PM
epilepsia-open.bsky.social
Approximately, 26% patients with unexplained seizures or epilepsy deterioration tested positive for autoimmune or paraneoplastic antibodies.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antibodytesting #APEscore #autoimmuneencephalitis #EEG #paraneoplasticencephalitis
November 7, 2025 at 3:32 PM
epilepsia-open.bsky.social
After a median follow-up of 20 months, CBD was globally effective and safe in 107 patients with LGS, DS, TSC, and other DEEs.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #CBD #DEE #Dravetsyndrome #LennoxGastautsyndrome #realworld #cannabidiol
November 6, 2025 at 5:05 PM
epilepsia-open.bsky.social
This MR study assessed causal links between thousands of plasma proteins and epilepsy risk.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #causalinference #GWAS #MR #plasmaproteins
November 5, 2025 at 2:56 PM