Ob-Gyns Hematologists
🤝
Never order MTHFR
🤝
Never order MTHFR
How to make friends with a hematologist
Chapter 1
1. Order a peripheral smear before they ask
2. Never get a CBC without a diff
3. Stop the heparin before you call for a HIT consult
4. NEVER order MTHFR
5. Order a reticulocyte count before you consult for anemia
Chapter 1
1. Order a peripheral smear before they ask
2. Never get a CBC without a diff
3. Stop the heparin before you call for a HIT consult
4. NEVER order MTHFR
5. Order a reticulocyte count before you consult for anemia
a man in a striped shirt is talking to another man and says did we just become best friends ?
Alt: a man in a striped shirt is talking to another man and says did we just become best friends ?
media.tenor.com
November 22, 2024 at 4:51 PM
Ob-Gyns Hematologists
🤝
Never order MTHFR
🤝
Never order MTHFR
i know someone is selling snake oil when they start talking about the mthfr gene
I love it when people start talking about the mthfr mutation like it means anything at all. Half of humanity has a variant of the mthfr gene! Including me! Maybe including you and you'd never even know.
September 25, 2026 at 12:30 AM
i know someone is selling snake oil when they start talking about the mthfr gene
We are really living the movie Idiocracy. I went to Twitter to see all the comments complaining about California adding folic acid to tortillas, and wow. People have bought the MTHFR scam hook line and sinker.
December 27, 2025 at 7:47 PM
We are really living the movie Idiocracy. I went to Twitter to see all the comments complaining about California adding folic acid to tortillas, and wow. People have bought the MTHFR scam hook line and sinker.
A study of 1,035 people w/acute COVID shows a common genetic MTHFR variant (homozygous MTHFR C677T) has higher risk of severe COVID infections and Long COVID. buff.ly/Bevs5WN
Genetic testing for MTHFR gene may help stratify patients for treatments for COVID infection.
#medsky #IDsky #hemesky 😷
Genetic testing for MTHFR gene may help stratify patients for treatments for COVID infection.
#medsky #IDsky #hemesky 😷
March 4, 2025 at 9:46 PM
A study of 1,035 people w/acute COVID shows a common genetic MTHFR variant (homozygous MTHFR C677T) has higher risk of severe COVID infections and Long COVID. buff.ly/Bevs5WN
Genetic testing for MTHFR gene may help stratify patients for treatments for COVID infection.
#medsky #IDsky #hemesky 😷
Genetic testing for MTHFR gene may help stratify patients for treatments for COVID infection.
#medsky #IDsky #hemesky 😷
"This questionable statement reflects a widespread myth in the wellness community concerning an extremely common gene mutation called MTHFR, which can inhibit the ability of cells’ mitochondria to process folic acid."
Yep. I wrote about this in March 2019 and it won't die.
Yep. I wrote about this in March 2019 and it won't die.
September 23, 2025 at 4:54 PM
"This questionable statement reflects a widespread myth in the wellness community concerning an extremely common gene mutation called MTHFR, which can inhibit the ability of cells’ mitochondria to process folic acid."
Yep. I wrote about this in March 2019 and it won't die.
Yep. I wrote about this in March 2019 and it won't die.
The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
December 20, 2025 at 3:53 PM
The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
BTW, if you have an MTHFR variant or similar, it is true that you don't process folic acid as well.
✨SINCE YOU NEED FOLIC ACID TO LIVE, THAT MEANS YOU NEED MORE FOLIC ACID THAN OTHER PEOPLE.✨
✨SINCE YOU NEED FOLIC ACID TO LIVE, THAT MEANS YOU NEED MORE FOLIC ACID THAN OTHER PEOPLE.✨
December 27, 2025 at 7:43 PM
BTW, if you have an MTHFR variant or similar, it is true that you don't process folic acid as well.
✨SINCE YOU NEED FOLIC ACID TO LIVE, THAT MEANS YOU NEED MORE FOLIC ACID THAN OTHER PEOPLE.✨
✨SINCE YOU NEED FOLIC ACID TO LIVE, THAT MEANS YOU NEED MORE FOLIC ACID THAN OTHER PEOPLE.✨
Just in case anyone needs to hear it:
- Acetaminophen does not deplete glutathione unless you are taking toxic doses of it
- MTHFR variants don't prevent you from being able to use folic acid
- We don't know how folic acid works to prevent neural tube defects (NTDs); we simply know it does. (1/7)
- Acetaminophen does not deplete glutathione unless you are taking toxic doses of it
- MTHFR variants don't prevent you from being able to use folic acid
- We don't know how folic acid works to prevent neural tube defects (NTDs); we simply know it does. (1/7)
September 28, 2025 at 8:16 PM
Just in case anyone needs to hear it:
- Acetaminophen does not deplete glutathione unless you are taking toxic doses of it
- MTHFR variants don't prevent you from being able to use folic acid
- We don't know how folic acid works to prevent neural tube defects (NTDs); we simply know it does. (1/7)
- Acetaminophen does not deplete glutathione unless you are taking toxic doses of it
- MTHFR variants don't prevent you from being able to use folic acid
- We don't know how folic acid works to prevent neural tube defects (NTDs); we simply know it does. (1/7)
I think anytime I want to swear on this app I'll just use MTHFR because every time I see that acronym I think that's what it means.
MTHFR!!
MTHFR!!
April 24, 2026 at 10:56 PM
I think anytime I want to swear on this app I'll just use MTHFR because every time I see that acronym I think that's what it means.
MTHFR!!
MTHFR!!
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
September 28, 2025 at 12:25 AM
The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.
“This questionable statement reflects a widespread myth in the wellness community concerning an extremely common gene mutation called MTHFR”
MOTHERFUCKER! The mutation is called what?
MOTHERFUCKER! The mutation is called what?
NEW: With @kieraevebutler.bsky.social, we wrote about the pseudoscience underpinning yesterday's chaotic, bizarre, disturbing autism announcement at the White House www.motherjones.com/politics/202...
The Bonkers Wellness Myths That Fueled Trump’s Autism Announcement
Tylenol, folate deficiency, and other still-undetermined “environmental factors” were all to blame.
www.motherjones.com
September 23, 2025 at 11:38 AM
“This questionable statement reflects a widespread myth in the wellness community concerning an extremely common gene mutation called MTHFR”
MOTHERFUCKER! The mutation is called what?
MOTHERFUCKER! The mutation is called what?
I knew it! PNAS, MTHFR gene, just further proof of Everyone is 12!
February 10, 2026 at 3:41 PM
I knew it! PNAS, MTHFR gene, just further proof of Everyone is 12!
(Conflicts of interest aside, I don’t want this information to discourage people from taking supplemental or prescription folate in coordination with their doctors, especially if they have one of the MTHFR genetic mutations that interfere with folate metabolization, as many autistic people do.)
September 22, 2025 at 9:33 PM
(Conflicts of interest aside, I don’t want this information to discourage people from taking supplemental or prescription folate in coordination with their doctors, especially if they have one of the MTHFR genetic mutations that interfere with folate metabolization, as many autistic people do.)
I just learned a possible cause of chronic fatigue is called the "NO/ONOO cycle," which is the funniest name since MTHFR
April 23, 2026 at 1:16 PM
I just learned a possible cause of chronic fatigue is called the "NO/ONOO cycle," which is the funniest name since MTHFR
I see MTHFR and my brain reads as motherfucker
"This questionable statement reflects a widespread myth in the wellness community concerning an extremely common gene mutation called MTHFR, which can inhibit the ability of cells’ mitochondria to process folic acid."
Yep. I wrote about this in March 2019 and it won't die.
Yep. I wrote about this in March 2019 and it won't die.
September 23, 2025 at 5:26 PM
I see MTHFR and my brain reads as motherfucker
And, bc the internet: I'm on HRT, I have a chronic illness, I have regular bloodwork and know all the vitamins I need because the MTHFR gene mutation is a huge pain. I get enough sleep, I lift heavy, I walk every day. I STILL FEEL BAD SOMETIMES. LET A GAL WALLOW.
April 16, 2026 at 9:30 PM
And, bc the internet: I'm on HRT, I have a chronic illness, I have regular bloodwork and know all the vitamins I need because the MTHFR gene mutation is a huge pain. I get enough sleep, I lift heavy, I walk every day. I STILL FEEL BAD SOMETIMES. LET A GAL WALLOW.
It’s a good question - it turns out there is no clinical utility. If there is an MTHFR variant, there is no benefit to giving supplements to lower homocysteine. The American College of Medical Genetics issued a guideline that discourages testing for the two common polymorphisms in the MTHFR gene.
November 21, 2024 at 2:12 PM
It’s a good question - it turns out there is no clinical utility. If there is an MTHFR variant, there is no benefit to giving supplements to lower homocysteine. The American College of Medical Genetics issued a guideline that discourages testing for the two common polymorphisms in the MTHFR gene.
There is a reason MTHFR looks like an abbreviation of motherfucker. It’s because it’s the dumbest motherfucker of all the labs that exist
November 22, 2024 at 4:51 PM
There is a reason MTHFR looks like an abbreviation of motherfucker. It’s because it’s the dumbest motherfucker of all the labs that exist
Learned there’s a gene called “MTHFR” and all I can think of is “MOTHERFUCKER”
(It stands for 'methylenetetrahydrofolate')
(It stands for 'methylenetetrahydrofolate')
January 18, 2024 at 10:41 AM
Learned there’s a gene called “MTHFR” and all I can think of is “MOTHERFUCKER”
(It stands for 'methylenetetrahydrofolate')
(It stands for 'methylenetetrahydrofolate')
They’re quick to label us as psychiatric. Ignoring that dysautonomia creates the physiological effects of anxiety w/out anxious thoughts. The psychiatrist figured out I had high histamine, MTHFR mutations and high prostaglandins. It’s mast cell disease, not a psych thing, meds have helped so much.
September 25, 2026 at 8:26 PM
They’re quick to label us as psychiatric. Ignoring that dysautonomia creates the physiological effects of anxiety w/out anxious thoughts. The psychiatrist figured out I had high histamine, MTHFR mutations and high prostaglandins. It’s mast cell disease, not a psych thing, meds have helped so much.
I think it's probably not, but every time I see the gene symbol MTHFR, I always wonder whether someone was making a joke.
October 4, 2024 at 5:03 PM
I think it's probably not, but every time I see the gene symbol MTHFR, I always wonder whether someone was making a joke.
If you are (or suspect you are) autistic, it’s worth getting tested to see if you have an MTHFR gene mutation. It’s just a simple blood test.
The inability to metabolize folate puts one at risk for developing a number of physical and mental health conditions.
www.sciencedirect.com/science/arti...
The inability to metabolize folate puts one at risk for developing a number of physical and mental health conditions.
www.sciencedirect.com/science/arti...
Association between MTHFR gene polymorphism and susceptibility to autism spectrum disorders: Systematic review and meta-analysis
A growing number of studies have highlighted the potential link between MTHFR gene polymorphisms and autism spectrum disorder (ASD), however, the resu…
www.sciencedirect.com
September 5, 2025 at 7:09 PM
If you are (or suspect you are) autistic, it’s worth getting tested to see if you have an MTHFR gene mutation. It’s just a simple blood test.
The inability to metabolize folate puts one at risk for developing a number of physical and mental health conditions.
www.sciencedirect.com/science/arti...
The inability to metabolize folate puts one at risk for developing a number of physical and mental health conditions.
www.sciencedirect.com/science/arti...
Where my MTHFR tribe at?
February 27, 2025 at 3:20 AM
Where my MTHFR tribe at?
More things should have protein structures on them. A great gift of the structure of MTHFR on a tea towel from Linnea Blomgren. #structuralbiology
March 3, 2025 at 9:34 AM
More things should have protein structures on them. A great gift of the structure of MTHFR on a tea towel from Linnea Blomgren. #structuralbiology
