#aortaed
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jmills55.bsky.social
Interesting study #VascularSky #SurgSky #AortaEd
haoyin.bsky.social Hao Yin @haoyin.bsky.social · Nov 28
Depth of dissection planes of type A (n=119)/B (n=5) #AorticDissection

"In 95% of patients with aortic dissection.... the dissection depth index (0.782 [0.695, 0.842]) is greater than 0.503"

Dissection propagates in outer media

#AortaEd
#CardiovascPathol 2024
www.sciencedirect.com/science/arti...
November 28, 2024 at 5:34 PM
jmills55.bsky.social
#aortaEd. Marfan syndrome Ehlers-Danlos syndrome and Loeys-Dietz syndrome #VascularSky #SurgSky
December 15, 2024 at 11:20 PM
mattsmeds.bsky.social
Need more #vascular surgery posts on here to train my discovery feed…. Where’s the #AortaEd at?
December 3, 2024 at 5:18 PM
haoyin.bsky.social
Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField

Their transcript profiles by scRNAseq + snATACseq👇

#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
January 26, 2025 at 1:39 PM
aortadad.bsky.social
This is your aorta on drugs.

#dissection
#aortaed
October 22, 2023 at 10:41 PM
haoyin.bsky.social
Real-time visualization of the propagation of #AorticDissection induced by intimal tear + elevated pressure >200 mmHg & the formation of #FalseLumen in healthy rabbit #Aorta ex vivo

#AortaEd
#ActaBio 2023
www.sciencedirect.com/science/arti...
November 16, 2024 at 8:54 PM
haoyin.bsky.social
Single-cell Proteomics🔥 #MarfanSyndrome
Aortic Root
Fbn1 C1041G/+🐭

2.4k proteins
3.5k cells
487 proteins/cell👈

7 Smooth Muscle Cell subtypes
Prss2, Lrp1 as modulated SMC markers

vs scRNAseq

+SeqIF (21 Ab)

#AortaEd
Sarah Parker lab #MolCellProteomics 2026
www.mcponline.org/article/S153...
March 16, 2026 at 12:44 PM
haoyin.bsky.social
Evidence for an active role of #EndothalialCell in #Aortopathy

EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide

#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...
November 28, 2024 at 8:57 PM
haoyin.bsky.social
Amazing - Human Aortas can be cryopreserved at -80 °C with 10% DMSO for 12 months with histological (elastin, SMC, EC) & mechanical (subfailure stress, max stress, low/high stretch moduli) integrity largely retained

#AortaEd
#JTissEng 2025
journals.sagepub.com/doi/10.1177/...
December 21, 2025 at 8:26 PM
flareyre.bsky.social
How Artificial can enhance future clinical trials in Vascular Surgery ? #AortaEd @mattsmeds.bsky.social @jmills55.bsky.social @jsmhoughton.bsky.social @drpenwa.bsky.social @tlforbes.bsky.social
👇👇👇
www.annalsofvascularsurgery.com/article/S089...
December 4, 2024 at 8:16 AM
haoyin.bsky.social
Regionalized & Sex-dependent scRNAseq of 🐭Aorta

Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell

Arch
#SecondHeartField vs #NeuralCrest SMC

339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS

#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...
September 30, 2025 at 10:48 AM
haoyin.bsky.social
⏬Mechanosensing & ⏫inflammation of aortic #EndothelialCell as a potential disease driver in #MarfanSyndrome 😎

A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk

⏬pSMAD2 ↔️pERK1/2

#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...
May 17, 2025 at 11:15 AM
haoyin.bsky.social
#AortaEd #OpenScience
June 19, 2025 at 12:50 PM
haoyin.bsky.social
CT Imaging determinants for Ascending aortic growth rate in #BicuspidAorticValve Aortopathy
N=121
5.4 y f/up

Neg➖
Ascending Aortic Angle
I want BAV🐭 to study aortic angles!🤔

Pos➕
Diameter Length Calcium

#AortaEd
@markelindsay.bsky.social #ClinImaging 2026
www.sciencedirect.com/science/arti...
April 6, 2026 at 7:01 PM
haoyin.bsky.social
Depth of dissection planes of type A (n=119)/B (n=5) #AorticDissection

"In 95% of patients with aortic dissection.... the dissection depth index (0.782 [0.695, 0.842]) is greater than 0.503"

Dissection propagates in outer media

#AortaEd
#CardiovascPathol 2024
www.sciencedirect.com/science/arti...
November 28, 2024 at 12:53 PM
aortadad.bsky.social
This is the first #aortaed post in Bluesky!
haoyin.bsky.social Hao Yin @haoyin.bsky.social · Sep 6
#AORTAGene😎

#AORTAScore (clinical covariates)+aortic #PolygenicScore

Explaining 35%~42% variance in #AscendingAorticDiameter
Identify👤ɸ≥4cm in 4 cohorts
UK Biobank
MGB
FHS
All of Us
#AortaEd

@jpirruccello @MarkELindsay @patrick_ellinor bioRxiv 2023
www.medrxiv.org/content/10.1...
October 22, 2023 at 9:50 PM
jsmhoughton.bsky.social
This also picks up #AortaEd posts. Please suggest any other labels I should include!

@scullingmonkey.bsky.social @shipraaryamd.bsky.social @zieglermd.bsky.social @pacuhold.bsky.social @ginnyab.bsky.social @dukevascular.bsky.social @drpenwa.bsky.social @tristanlane.bsky.social
November 15, 2024 at 9:55 PM
haoyin.bsky.social
Partial aortic endothelial detachment from disorganized internal elastic lamina, + #EndothelialCell α5⏫ β1⏬ integrin, in a🐭#MarfanSyndrome model mgΔlpn/+ 6-mo♂️ (Already #AorticAneurysm...)

#AortaEd
#SciReports 2025
www.nature.com/articles/s41...
July 24, 2025 at 11:57 AM
haoyin.bsky.social
Incidence & Prevalence of #ThoracicAorticAneurysms
Meta-analysis of 22 Studies

TAA
Incidence🟰5.3/100,000 person-year
Prevalence🟰0.16%

Thoracic #AorticRupture
Incidence🟰1.6/100,000 ps-yr

#AortaEd
#SeminThoracCardiovascSurg 2022
www.sciencedirect.com/science/arti...
January 11, 2025 at 8:19 PM
haoyin.bsky.social
#SingleCellProteomics 🐭 #Aorta #MarfanSyndrome

6X ea ♀️♂️ WT Fbn1C1049G/+
24 Aortic roots▶️4996 cells, 2746 proteins, 487 proteins/cell

7 #SmoothMuscleCell subtypes!🤩
poorly overlapped with scRNAseq SMC subtype

#EndMT in Marfan #EndothelialCell

#AortaEd
bioRxiv 2025
www.biorxiv.org/content/10.1...
April 26, 2025 at 11:55 AM
haoyin.bsky.social
3D #VascularDeformationMapping for thoracic aortic pulsatile motion, distensibility & growth rate (4.6 yr f/up)

Dilated subjects (vs Non-dilated)
⏬Axial & in-plane motion
⏬Distensibility

Less stiff aortas (or just larger?🧐)➡️⬆️risks of growth

#AortaEd
#EHJIMP 2024
academic.oup.com/ehjimp/advan...
February 3, 2025 at 7:55 PM
haoyin.bsky.social
Transcript signature of lineage-specific mouse proximal thoracic aortic #SmoothMuscleCell

Wnt1-Cre cardiac neural crest (inner media)-derived SMC
vs
Mef2c-Cre second heart field (outer media)-derived SMC

#AortaEd
David Dichek lab #ATVB 2025
www.ahajournals.org/doi/10.1161/...
February 22, 2026 at 8:18 PM
haoyin.bsky.social
Arterial vs Aortic Events in #HeritableThoracicAorticDisease
N=1790
#VascularEhlersDanlosSyndrome
#LoeysDietzSyndrome
#MarfanSyndrome

Risk by 40 y/o
Arterial
♂️vEDS>LDS~MFS
♀️vEDS~LDS>MFS

Aortic
TGFBR2>FBN1>TGFBR1~TGFB2>COL3A1~SMAD3

#AortaEd
#JACC 2025
www.sciencedirect.com/science/arti...
June 25, 2025 at 7:23 PM
jsmhoughton.bsky.social
I can’t crochet but I made a #Lego FEVAR once… #vascsky #aortaed #medsky
Photograph of a Lego fenestrated stent graft for repairing a complex abdominal aortic aneurysm
November 16, 2024 at 7:55 PM
haoyin.bsky.social
#MarfanSyndrome #AorticRupture

Fbn1 G234D/G234D🐭
👉Early death by 5-wk of age◀️ #AorticRupture
👉⏬binding to LTBP1/2/4➡️⏬aortic TGFβ signal

Endothelial mechanosensing failure as an early event in Marfan Aortopathy!😎

#AortaEd
Hiromi Yanagisawa lab bioRxiv 2024
www.biorxiv.org/content/10.1...
April 20, 2025 at 11:29 AM