#calorierestriction
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haoyin.bsky.social
#CalorieRestriction #VascularAging #Progeroid🐭

CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell

+Aortic bulk RNAseq

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...
April 27, 2025 at 11:40 AM
terrancegjohns.bsky.social
Two papers from a great collaboration. Our Epigenes–La Trobe partnership, working with colleagues worldwide, is revealing how intermittent fasting reshapes tissues from proteins to gene regulation. #calorierestriction
doi.org/10.7554/eLif...
doi.org/10.1093/pnas...
Client Challenge
doi.org
October 7, 2026 at 12:03 AM
terrancegjohns.bsky.social
After 4 years of groundwork, Epigenes has officially launched from our new labs at La Trobe University. Exciting times ahead as we advance new drugs that mimic the mental health benefits of calorie restriction #mentalhealth #calorierestriction #Epigenetics
April 29, 2025 at 2:28 AM
terrancegjohns.bsky.social
A striking result from this study is Figure 6. Male offspring of calorie-restricted mothers show increased sexual behaviour and reduced aggression despite being fed normally themselves.
biorxiv.org/content/10.6...
#Epigenetics #Transgenerational #CalorieRestriction #Neuroscience
biorxiv.org
March 6, 2026 at 12:26 AM
cu-kidney.bsky.social
We’re proud to spotlight the groundbreaking work of Drs. Kristen Nowak & Katharina Hopp, whose research is shaping the future of ADPKD care. Read the full story:
www.uchealth.org/today/explor...
🔬 #ADPKD #KidneyResearch #UCHealth #CalorieRestriction #MedicalInnovation #CUKidney
Exploring ADPKD treatments: Can reducing calories help control hereditary kidney disease?
A patient's experience with an ADPKD treatment trial focusing on calorie reduction to manage hereditary kidney disease.
www.uchealth.org
August 6, 2025 at 5:31 PM
lrampoldi.bsky.social
Support by grants from Fondazione Telethon, the Italian Ministry of Health, and the Italian Ministry of University and Research (Investment PE8 –Project Age-It: “Ageing Well in an Ageing Society”, National Recovery and Resilience Plan).

#ADTKD #UMOD #calorierestriction #RareKidneyDisease
February 5, 2026 at 7:44 PM
gmj-georgia.bsky.social
📊 NEW TRIAL: Intermittent fasting produces weight loss equivalent to calorie restriction—but with significantly lower psycholo…

#Calorierestriction #Clinicaltrial #Dietaryadherence #Intermittentfasting #Weightloss

#Calorierestriction #Clinicaltrial #Dietaryadherence #Intermittentfasting #Weight…
Intermittent fasting equals calorie restriction for weight loss
📊 NEW TRIAL: Intermittent fasting produces weight loss equivalent to calorie restriction—but with significantly lower psycholo… #Calorierestriction #Clinicaltrial #Dietaryadherence #Intermittentfasting #Weightloss
news.gmj.ge
September 30, 2026 at 1:26 PM
terrancegjohns.bsky.social
Planning the research for 2026 with myself, Jim Penman (CEO of Epigenes) and Garrie Arumugam, our major collaborator at La Trobe University. #calorierestriction #intermittentfasting
January 14, 2026 at 11:42 PM
muellerrom.bsky.social
Great collaborative effort — thanks to everyone involved!

www.nature.com/articles/s41...

#Aging #Longevity #KidneyTransplantation #Nephrology #CalorieRestriction

@cecad.bsky.social @uniklinikkoeln.bsky.social @hhu.de
An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation - npj Aging
npj Aging - An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation
www.nature.com
May 28, 2026 at 4:14 PM
isbnpa.bsky.social
📢 New in #IJBNPA! A recent publication examines whether energy expenditure from #PhysicalActivity can influence the benefits of #CalorieRestriction
🔗 Read more:
https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-025-01825-5
October 23, 2025 at 1:33 PM
newsmedical.bsky.social
Lithocholic acid enhances health and lifespan, mimicking calorie restriction ✨🧬💪 news-medical.net/news/2025010... #Longevity #AntiAging #CalorieRestriction #Health #AMPKActivation #Metabolomics #Muscle #LifeExtension #Science #LCA @natureportfolio.bsky.social
Lithocholic acid enhances health and lifespan, mimicking calorie restriction
Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose t...
news-medical.net
January 1, 2025 at 11:52 PM
newsmedical.bsky.social
Dietary interventions improve mitochondrial function and reduce inflammation in obesity 🥗🧬🔥 www.news-medical.net/news/2024072... #Diet #Mitochondria #Health #Obesity #GutMicrobiota #CalorieRestriction #IntermittentFasting #KetogenicDiet #Inflammation #Nutrition #Bioenergetics #Health
Dietary interventions improve mitochondrial function and reduce inflammation in obesity
Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by mo...
www.news-medical.net
July 24, 2024 at 2:49 AM
terrancegjohns.bsky.social
Calorie restriction enhances brain health and extends lifespan; it may also help alleviate anxiety and depression. Our review explores the science behind this idea and how we might harness it to create new treatments. #calorierestriction #MentalHealth www.frontiersin.org/journals/psy...
Frontiers | Less is more: calorie restriction as a therapeutic for mental health disorders
Anxiety, depression, and substance use disorders are prevalent mental health disorders that have debilitating health outcomes, and current treatment options ...
www.frontiersin.org
June 16, 2025 at 11:39 PM
cancereducation.bsky.social
Cells use signaling to respond to changes, like IGF-1 (growth), mTORC1 (protein synthesis), and AMPK (energy sensing). Calorie restriction reduces IGF-1 and mTORC1 while activating AMPK, limiting tumor growth. Learn more at www.cancereducation.net

#CancerEducation #CalorieRestriction #CellSignaling
January 23, 2025 at 3:14 PM
terrancegjohns.bsky.social
Please to share my first paper on calorie restriction (intermittent fasting; IF) with new collaborator Thirum Arumugam. We show that the metabolic benefits of IF can be inherited. www.ijbs.com/v21p1852.htm #calorierestriction #epigenetics #intermittentfasting
Impact of Parental Time-Restricted Feeding on Offspring Metabolic Phenotypic Traits
www.ijbs.com
February 11, 2025 at 4:39 AM
the-14.com
Can nutrients in our foods mimic calorie restriction and increase our healthspan?
#Health #Science #Diet #Nutrition
#Healthspan #HealthyAging #Longevity #CalorieRestriction #NutritionScience #AgingResearch #HealthyAgingResearch #The14Media
the-14.com/can-nutrient...
Can nutrients in our foods mimic calorie restriction and increase our healthspan? | The-14
Scientists are studying nutrients such as spermidine, resveratrol and urolithin A for their potential to mimic calorie restriction and support human healthspan.
the-14.com
September 25, 2026 at 4:41 PM
purescience.news
Long-term calorie restriction may slow biological aging in the brain #Science #HealthandMedicine #Nutrition #CalorieRestriction #AgingResearch #BrainHealth
Long-term calorie restriction may slow biological aging in the brain
A new study suggests that restricting calorie intake over a lifetime may slow the biological aging of support cells in the primate brain. The research provides evidence that a thirty percent reduction...
purescience.news
December 4, 2025 at 3:30 AM
endosocjournals.bsky.social
A Very-low-energy Fast Involves Increased Adipose Inflammatory Gene Expression: A 6-day Feeding Trial (FASTOMICS-6). Read more in #JCEM: https://bit.ly/49nhv6N #Fasting, #CalorieRestriction, #adiposetissue@endocrinesociety.bsky.social
A Very-low-energy Fast Involves Increased Adipose Inflammatory Gene Expression: A 6-day Feeding Trial (FASTOMICS-6)
AbstractBackground. Fasting and ketogenic diets may have health benefits, but we lack a deeper understanding of tissue mechanisms and associated metabolome
bit.ly
May 15, 2026 at 8:35 PM
autophagyfasting.bsky.social
Is intermittent fasting just another way to cut calories?

Not exactly. The time you spend without food can trigger changes in your body that eating fewer calories alone may not.

#IntermittentFasting #CalorieRestriction #MetabolicHealth
July 31, 2026 at 7:15 AM
drhowardsmith.bsky.social
STOP AGING WITHOUT CUTTING CALORIES? Yale researchers have found a protein that helps control the aging process. Blocking it could slow that process. #Aging #Longevity #CalorieRestriction #Inflammation #MedicalResearch
September 15, 2026 at 6:44 PM
martincid.com
The drug in Ozempic extended healthy mice’s lives by nearly 100 days — in a trial that had nothing to do with weight #CalorieRestriction #Glp #Aging
The drug in Ozempic extended healthy mice’s lives by nearly 100 days — in a trial that had nothing to do with weight
Researchers at UC Berkeley gave semaglutide — the compound that powers Ozempic — to healthy, non-obese female mice for three months, then followed them to the end of their lives; the treated mice live
www.martincid.com
September 3, 2026 at 7:00 PM
robertlufkinmd.bsky.social
Source: www.sciencedirect.com/science/arti...

#Longevity #SenescentCells #CalorieRestriction #MetabolicHealth #HealthLongevitySecrets (6/6)
August 25, 2026 at 12:57 PM
autophagyfasting.bsky.social
Intermittent fasting isn't just another way to eat less. It changes how your body responds to food and fasting beyond weight loss. In this article, I explore why these strategies differ physiologically and what that means for metabolic health.

#IntermittentFasting #CalorieRestriction
July 31, 2026 at 2:09 PM
orson-johnson.bsky.social
50% Healthspan Boost Through Longevity Science Fasting

https://longevitynotes.online/50-healthspan-boost-fasting/?utm_source=bluesky&utm_medium=social
#intermittentfasting #calorierestriction #longevityscience
June 5, 2026 at 12:26 AM
the-14.com
Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
the-14.com/anti-ageing-...
the-14.com
June 19, 2025 at 7:47 PM