#diabeticnephropathy
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kidneyint.bsky.social
Improving the Histologic Classification of Advanced Diabetic Nephropathy Based on the Transformative Research in #DiabeticNephropathy (TRIDENT) Findings

doi.org/10.1016/j.kint.2026.07.028

#NephSky #MedSky #OpenAccess @upenn.edu @cedarssinaihsu.bsky.social @yale.edu #DiabeticNephropathy #PathSky
September 3, 2026 at 4:29 PM
kidneyint.bsky.social
Commentary
Renal biopsy in patients with diabetes: still going strong after all these years

doi.org/10.1016/j.kint.2026.05.003

Original article: doi.org/10.1016/j.kint.2026.03.015

#MedSky #NephSky #PathSky #DiabeticNephropathy #KidneyBiopsy #NonDiabeticKidneyDisease #NDKD #RenalPath
August 12, 2026 at 3:49 PM
bio-integration.org
A rutin and glimepiride combination is explored as a potential strategy for diabetic nephropathy, connecting phytochemicals with established antidiabetic therapy. www.scienceopen.com/hosted-docum... #DiabeticNephropathy #Rutin #Glimepiride
May 26, 2026 at 12:45 PM
kidneyint.bsky.social
Reversal of advanced diabetic kidney disease in mice treated with a monoclonal anti-VEGFR1 antibody

doi.org/10.1016/j.kint.2026.03.016

#NephSky #MedSky #OpenAccess #diabeticnephropathy
@usc.edu
April 30, 2026 at 9:38 PM
kidneyint.bsky.social
Clinical and Histologic Predictors of Non-Diabetic Kidney Disease in Patients with Diabetes Mellitus

doi.org/10.1016/j.kint.2026.03.015

#NephSky #MedSky #OpenAccess #diabeticnephropathy
@arkanalabs.bsky.social @stanforddeptmed.bsky.social
@jhu.edu
April 30, 2026 at 9:25 PM
crijournal.bsky.social
Combined Ursolic Acid and Rosuvastatin Treatment Mitigates Inflammation and Oxidative Stress in Diabetic Nephropathy Model Cells

www.dl.begellhouse.com/journals/2ff...

#DiabeticNephropathy #CombinationTherapy #KidneyDisease
April 24, 2026 at 4:30 PM
currentmedscience.bsky.social
This study shows that Xiaoke decoction (XKD) protects #RenalFunction in #DiabeticNephropathy (DN) via the #COX 2–mediated #LDLr pathway, reducing #Inflammation & #LipidAccumulation, highlighting XKD as a potent #therapeutic approach for DN. #medsky
See: doi.org/10.1007/s115...
April 22, 2026 at 1:00 PM
haoyin.bsky.social
#DiabeticNephropathy

PAI1/SERPINE1 mediates Paracrine Senescence of renal tubular epithelial cells (TGFβ1 + high glucose)

Blocked by TM5441, PAI1 Inhibitor

#SciRep 2023
www.nature.com/articles/s41...
April 20, 2026 at 7:03 PM
kidneyint.bsky.social
Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes

doi.org/10.1016/j.kint.2026.02.020

#MedSky #NephSky #OpenAccess #diabetes #diabeticnephropathy
March 27, 2026 at 2:37 AM
currentmedscience.bsky.social
#USP19 promotes high glucose– and fatty acid–induced kidney cell dysfunction by stabilizing TAK1, driving #apoptosis, mitochondrial stress, and PINK1/Parkin pathway disruption, highlighting USP19–TAK1 signaling as a target for #DiabeticNephropathy.
Read: doi.org/10.1007/s115...
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
February 18, 2026 at 1:55 PM
currentmedscience.bsky.social
A cross-sectional study identified a 13.1% stroke prevalence among #Type2DiabetesMellitus Chinese patients, showing that age, #Hypertension, diabetic duration, and #DiabeticNephropathy are significant independent risk factors.
Read: doi.org/10.1007/s115...
Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China
February 18, 2026 at 2:55 AM
genesndiseases.bsky.social
The mTOR pathway plays a central role in diabetic nephropathy progression—highlighting promising therapeutic targets.
#mTOR #DiabeticNephropathy #RenalDisease #TherapeuticTargets #Nephrology
www.sciencedirect.com/science/arti...
January 19, 2026 at 11:08 AM
genesndiseases.bsky.social
Reviewing the pathological mechanisms associated with four distinct resident renal cell types & #ImmuneCells within the #Diabetic environment, highlighting recent research in #mTOR-targeted treatment of #DiabeticNephropathy.

#OpenAccess: doi.org/10.1016/j.ge...
December 25, 2025 at 4:34 PM
haoyin.bsky.social
#DiabeticNephropathy

Endothelial Cell FGF13 (a non-secreted FGF) as a Parkin-#Mitophagy inhibitor▶️Mitochondrial dysfunction▶️
⏫Glomerular EC Apoptosis
⏬Glomerular endothelial fenestration
⏫Glomerular Fibrosis
⏫Renal injury
in Diabetic🐭

#Diabetes_ADA 2023
diabetesjournals.org/diabetes/art...
December 16, 2025 at 12:53 PM
haoyin.bsky.social
Interesting evidence that FGF9 protects high glucose-induced EMT in vitro

FGF9⏬in human #DiabeticNephropathy

A possible Exosomal circRNA-miRNA-FGF9 regulatory axis (in silico only, needs experimental validation)

@plosone.org 2025
journals.plos.org/plosone/arti...
November 28, 2025 at 8:00 PM
genesndiseases.bsky.social
This review outlines recent progress in treating #DiabeticNephropathy via drugs and molecules targeting the #mTORpathway, offering insights for improved prevention and therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
November 10, 2025 at 4:15 PM
haoyin.bsky.social
#FGF9 renal mRNA (2 RNAseq datasets), renal (glomerular + tubular) protein (IHC), serum level (49 case vs 51 ctrl)⬇️in👤#DiabeticNephropathy

FGF9 protein⬇️in kidney glomeruli & tubule (IHC) in STZ diabetic🐭

FGF9⏬hi glucose-induced #EMT

#JCellMolMed 2025
onlinelibrary.wiley.com/doi/10.1111/...
October 28, 2025 at 7:11 PM
kidneyint.bsky.social
Heterogeneity in the relationships between #albuminuria and glomerular structure in type 1 and type 2 #diabetes.

doi.org/10.1016/j.kint.2025.08.034

#NephySky #MedSky #diabetes #diabeticnephropathy
@uwdeptmedicine.bsky.social
October 9, 2025 at 3:54 PM
currentmedscience.bsky.social
This study identifies the role of USP19 in promoting HK-2 cell dysfunction induced by combined #HighGlucose and #FreeFattyAcid stimulation by stabilizing #TAK1, providing a potential therapeutic strategy for combating #DiabeticNephropathy. #medsky
Read more:
link.springer.com/article/10.1...
September 10, 2025 at 12:45 PM
kidneyint.bsky.social
Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates #diabeticnephropathy

doi.org/10.1016/j.kint.2025.07.023

#MedSky #NephSky #OpenAccess
September 3, 2025 at 2:39 PM
sigtrans-sttt.bsky.social
This #STTT review summarizes the complex mechanisms underlying the #pathophysiology of #DiabeticNephropathy (DN), outlining recent advances in diagnostic & therapeutic strategies and future directions for managing DN. #medsky

#OpenAccess: doi.org/10.1038/s413...
August 23, 2025 at 4:30 AM
kidneyint.bsky.social
Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study

Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011

Original article: doi.org/10.1016/j.kint.2025.04.017

#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
August 19, 2025 at 4:30 PM
febsopenbio.bsky.social
ℹ️ New Review out!

Current trends in single-cell RNA sequencing applications in diabetes mellitus

👉 buff.ly/1R29Yi1

#DiabetesMellitus #scRNAseq #DiabeticNephropathy
July 2, 2025 at 9:33 AM
jmirpub.bsky.social
Amir Abdipour from #LomaLindaUniversityMedicalCenter discusses his study on the alignment of AI models with nephrologists when answering patient questions about #diabeticnephropathy.

Watch now: www.youtube.com/watch?v=yqDP...

Read the full article: diabetes.jmir.org/2025/1/e65846/

#AI #LLU
AI vs. Nephrologists: Diabetic Nephropathy Q&A
This video reviews a cross-sectional study comparing how artificial intelligence models like ChatGPT and Google Gemini align with nephrologists when answerin...
www.youtube.com
June 23, 2025 at 2:04 PM
kidneyint.bsky.social
Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney- #metabolicsyndrome models

doi.org/10.1016/j.kint.2025.04.025

#OpenAccess #Nephsky #MedSky #chronickidneydisease #CKD #diabeticnephropathy #cardiovasculardisease #CVD #kidney
May 22, 2025 at 2:31 PM