January 25, 2025 at 6:48 PM
New preprint: In situ Architecture of #Plasmodesmata.
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
July 26, 2025 at 3:38 PM
New preprint: In situ Architecture of #Plasmodesmata.
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
#TeamTomo in Paris🗼
Great dinner with our cryoET friends from Basel! @sofie-dot-rec.bsky.social @computingcaitie.bsky.social @cellarchlab.com @jacky and Mohamad Harastani
May 19, 2025 at 9:41 PM
#TeamTomo in Paris🗼
Huntingtin protein bound to actin filaments. I didn’t know it could do that! Nice one @schurlab.bsky.social and friends! 🧪🧶🧬 #TeamTomo
Cryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
September 22, 2025 at 4:25 PM
Huntingtin protein bound to actin filaments. I didn’t know it could do that! Nice one @schurlab.bsky.social and friends! 🧪🧶🧬 #TeamTomo
MemBrain v2: streamlined analysis of membranes in cryo-ET with tools for membrane segmentation, protein localization and spatial analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
www.nature.com
September 24, 2026 at 12:15 PM
This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪
#PILife #TeamTomo 🧪
#PILife #TeamTomo 🧪
To supplement our cryo-ET and generate candidates for proteins that localize to different ciliary regions, we took a trip to the local butcher to pick up some cow trachea to build a mammalian multiciliated cell interactome using XL/MS (enjoy this vid of @cellarchlab.com shaking cilia off trachea)
April 8, 2026 at 10:23 AM
Tomo is the first runner to begin Loop 3. #BM100
March 19, 2025 at 4:36 PM
Go #TeamTomo! 🧪 @wilflinglab.bsky.social & @nanigrotjahn.bsky.social are on a roll! Beautiful in-cell visualization of lysosome rupture 🎈💥
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
January 20, 2026 at 8:36 PM
Go #TeamTomo! 🧪 @wilflinglab.bsky.social & @nanigrotjahn.bsky.social are on a roll! Beautiful in-cell visualization of lysosome rupture 🎈💥
Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
December 12, 2025 at 3:53 PM
Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet
December 17, 2024 at 4:23 PM
This large-scale open dataset and the continued community development around it exemplify the spirit of #TeamTomo 🧪 🔬 👨🔬👩💻
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
ter.li/of4cgh
January 18, 2026 at 8:40 AM
This large-scale open dataset and the continued community development around it exemplify the spirit of #TeamTomo 🧪 🔬 👨🔬👩💻
#TeamTomo 🧪🔬🧶🧬
First Bluesky post!
Our recent eLife paper is now an official version of record. This was my first project using #Cryo-ET and I'm definitely hooked - it's so fun to look at snapshots of synapses within brain tissue and see individual proteins. Excited to share more soon!
doi.org/10.7554/eLif...
Our recent eLife paper is now an official version of record. This was my first project using #Cryo-ET and I'm definitely hooked - it's so fun to look at snapshots of synapses within brain tissue and see individual proteins. Excited to share more soon!
doi.org/10.7554/eLif...
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse br...
doi.org
November 24, 2024 at 7:40 PM
#TeamTomo 🧪🔬🧶🧬
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications
Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...
www.nature.com
October 24, 2025 at 10:14 AM
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
#OpenSoftwareAcceleratesScience
March 18, 2026 at 11:52 AM
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
#OpenSoftwareAcceleratesScience
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
June 27, 2025 at 10:58 AM
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
November 12, 2024 at 12:54 PM
Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
March 24, 2026 at 2:46 PM
Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.
December 28, 2025 at 4:37 AM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
August 13, 2025 at 10:28 PM
This is super impressive and interesting #TeamTomo work by @carter-lab.bsky.social. Congrats everyone!! 🧪 🧶🧬
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
March 24, 2026 at 8:05 PM
This is super impressive and interesting #TeamTomo work by @carter-lab.bsky.social. Congrats everyone!! 🧪 🧶🧬
Stunning video installation by Isabell Bullerschen featuring our T. kivui #CryoET data 🧡
On view until April 19th at the HEK in #Basel!
hek.ch/en/program/e...
On view until April 19th at the HEK in #Basel!
hek.ch/en/program/e...
March 9, 2026 at 4:51 PM
Proudly present our new preprint on my first post here. We performed SPA on the ciliary tip and identify 7 proteins. Among them, we found the conserved protein SPEF1 at the microtubule seam. In vitro assays show that SPEF1 binds to the seam and stablizes microtubules.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 8, 2024 at 5:39 PM
Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
Congratulations to @florianwollweber.bsky.social, the recently appointed Group Leader at EMBL Grenoble, who received an ERC Starting Grant worth approximately €2 million to investigate the origins of eukaryotic cell complexity.
bit.ly/4gNwEBk
bit.ly/4gNwEBk
September 5, 2026 at 12:57 PM
Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
