LightNews — News, ranked by scholars

Prof John Gordon

@profcelentyx.bsky.social

#ImmunoSky

#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers

#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged

#Bcells #Antibodies #TertiaryLymphoidStructures

Breaking Open Access Study @jci-insight.bsky.social

insight.jci.org/articles/vie...

April 9, 2025 at 8:28 AM

Abhishek Garg LAB

@abhishekgarglab.bsky.social

We discuss how #tumour's #spatialweb supports T cells or causes #dysfunction/#exclusion e.g., supportive #perivascular or pro-#immunogenic/#antigenic niches & #tertiarylymphoidstructures vs. #hypoxic cores, #wound #healing & #myeloid, #stromal or #fibroblastic #barriers. 4/6🧵

April 11, 2025 at 5:31 PM

Jean de Lima

@jeandelima.bsky.social

Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1α in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10).

www.cell.com/immunity/ful...

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...

www.cell.com

March 7, 2026 at 9:11 AM

The Innovation

@theinnovation.bsky.social

In this review, Zheng et al. synthesize key pathways governing #tertiarylymphoidstructures induction, formation, and maturation, emphasizing vascular and stromal scaffold requirements that enable lymphocyte recruitment and compartmentalization.
doi.org/10.59717/j.x...
#TumorMicroenvironment

May 8, 2026 at 5:54 AM

Researhcer Plus

@researcherplus.bsky.social

Paper of the Day ! 📄

One kind of immune messenger cell builds then keeps tumor immune hubs alive. Would you want treatments that boost these cells in tumors?

Paper: doi.org/10.1158/2159-8290.cd-rw2026-075

#dendriticcells #tertiarylymphoidstructures #cancerimmunotherapy #paperoftheday

Dendritic Cells Establish and Maintain Tertiary Lymphoid Structure and Function

Tertiary lymphoid structures (TLS), which are organized aggregates of T cells, B cells, and stromal elements that arise within tumors, are associated with improved outcomes and stronger responses to i...

doi.org

August 25, 2026 at 5:37 PM

Prof John Gordon

@profcelentyx.bsky.social

#cancersky #immunosky #antibodysky

Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social

First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer

Fantastic work 👏

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...

www.cell.com

August 14, 2025 at 4:00 PM

BioNews Central

@bionewscentral.com

New research shows that peripheral #HelperTCells (Tph cells) in #RheumatoidArthritis include stem-like Tph cells that reside in joint #TertiaryLymphoidStructures and give rise to effector Tph cells that drive #inflammation—suggesting that targeting stem-like Tph cells could improve treatment.