#GenomicInstability
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sigtrans-sttt.bsky.social
#Micronuclei can actively fuel #GenomicInstability rather than simply mark it. This review in #STTT explores their origins, mechanisms, cellular fates, disease links, and emerging potential as #TherapeuticTargets.

#OpenAccess: doi.org/10.1038/s413...
August 19, 2026 at 1:01 PM
alicefrolov.bsky.social
New Visualization: Age-Dependent Slowing of Double-Strand Break Repair Foci Resolution

I am sharing a figure developed for pedagogical and hypothesis-framing purposes

#DNArepair #DoubleStrandBreaks #gammaH2AX #Radiobiology #AgingBiology #GenomicInstability #NHEJ
New Visualization: Age-Dependent Slowing of Double-Strand Break Repair Foci Resolution I am sharing a figure developed for pedagogical and hypothesis-framing purposes, titled "Age-Dependent Slowing of Double-Strand Break Repair Foci Resolution," with the subtitle "Simulated γH2AX foci clearance kinetics after 2 Gy ionizing radiation across donor age cohorts and repair pathways." Important caveat up front: the data plotted here are simulated. The curves do not derive from a single empirical dataset but are constructed to illustrate a well-established, literature-grounded trend regarding the attenuation of DSB repair capacity with advancing donor age. The multiline plot tracks residual γH2AX foci per nucleus as a function of post-irradiation time (0–48 h) following a 2 Gy dose. Cohorts are stratified by donor age (young, middle-aged, and aged), with parallel decompositions approximating the relative contributions of non-homologous end joining (NHEJ) and homologous recombination (HR). The simulated kinetics reproduce the canonical biphasic clearance profile: a rapid initial decline dominated by NHEJ-mediated rejoining within the first several hours, followed by a slower resolution phase reflecting HR processing of complex or clustered lesions. The salient qualitative feature is the progressive rightward shift and elevated residual foci plateau in older cohorts, consistent with reported declines in DNA-PKcs activity, chromatin remodeling efficiency, and 53BP1/BRCA1 pathway coordination during aging. The persistence of unresolved foci at 24–48 h in the aged cohort is intended to represent the accumulation of unrepaired or misrepaired breaks associated with senescence-associated genomic instability. I welcome methodological critique, particularly regarding parameterization of the HR/NHEJ balance and whether the assumed rate constants adequately capture reported interindividual variability.
August 7, 2026 at 5:00 PM
alicefrolov.bsky.social
LINE-1 Retrotransposon Derepression in Aging Tissues: Publication Trend Analysis (2015–2024)

#LINE1Retrotransposons #TransposableElements #EpigeneticAging #HeterchromatinErosion #cGASSTING #CellularSenescence #RepetitiveElementBiology #GenomicInstability
LINE-1 Retrotransposon Derepression in Aging Tissues: Publication Trend Analysis (2015–2024) The PubMed bibliometric data for LINE-1 retrotransposon derepression in aging tissues reveals a field that has undergone a discernible but restrained growth trajectory over the past decade, with an apparent plateau emerging after approximately 2021. Beginning at a low baseline of 3 publications in 2015, output remained modest and inconsistent through 2018, consistent with a pre-paradigmatic phase in which mechanistic frameworks—particularly those connecting heterochromatin erosion, loss of DNMT1/3a-mediated CpG methylation at L1 5' UTR promoters, and downstream innate immune activation via cGAS-STING—were still being consolidated from disparate lines of evidence. The notable inflection between 2018 and 2021, peaking at 8 publications, temporally correlates with several convergent developments: the demonstration that age-associated H3K9me3 depletion at L1 loci facilitates ORF1p and ORF2p expression in somatic tissues, the characterization of L1-derived reverse transcription intermediates as cGAS ligands, and the mechanistic linking of L1 reactivation to the sterile inflammatory phenotype characteristic of cellular senescence and the senescence-associated secretory phenotype (SASP). The stabilization at 6–8 publications annually from 2021 onward is analytically informative and warrants careful interpretation rather than dismissal. It does not straightforwardly indicate decline or saturation of scientific interest. Rather, it may reflect a field entering a phase of methodological and conceptual consolidation, wherein the primary mechanistic axes—epigenetic derepression via loss of repressive chromatin marks, retrotransposition-competent versus retrotransposition-incompetent L1 element activity, nucleic acid sensing pathway engagement, and tissue-specific permissiveness to L1 expression during aging.
June 2, 2026 at 5:03 PM
bionewscentral.com
New research shows that dialing down an overactive immune sensor can restore tissue health in severe #GeneticDisorders, reshaping how scientists think about #aging and #DNAdamage. 
#ImmuneSystem #GenomicInstability
A new view of aging: How the immune system rewrites rapid aging – BioNews Central
New research shows that dialing down an overactive immune sensor can restore tissue health in severe genetic disorders, reshaping how scientists think about aging and DNA damage. ...
sbee.link
April 19, 2026 at 4:47 PM
narjournal.bsky.social
⭐ Explore the NARCAN 5th Anniversary Symposium Collection!
🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more!
Read here: lnkd.in/ezznFh2f
#NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability
February 12, 2026 at 3:19 PM
ramiaqeilan.bsky.social
Our findings also point to transcriptional addiction as a cancer-specific vulnerability.

Huge congratulations to Osama for his perseverance and outstanding work, and to all co-authors for this collective achievement.

#ScienceAdvances #CancerResearch #GenomicInstability #DNARepair #SuperEnhancers
January 21, 2026 at 7:19 PM
arrosan.bsky.social
I remember presenting this paper from @hunterlab.bsky.social in our journal club a year ago, when it was still on bioRxiv. I’m delighted to see it now published in Nature!

www.nature.com/articles/s41...

#Cohesion #Development #Genomicinstability #Meiosis
Protecting double Holliday junctions ensures crossing over during meiosis - Nature
Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.
www.nature.com
September 25, 2025 at 10:48 PM
oncodaily.bsky.social
Aneuploidy in Cancer: Mechanisms, Consequences, and Therapeutic Implications

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Aneuploidy #TumorGenetics #GenomicInstability #CancerBiology
Aneuploidy in Cancer: Mechanisms, Consequences, and Therapeutic Implications - OncoDaily
Aneuploidy in cancer fuels genomic instability, tumor evolution, immune evasion, and therapy resistance. Learn its mechanisms, consequences, and clinical relevance.
oncodaily.com
June 12, 2025 at 1:18 PM
mortusewicz.bsky.social
🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"

👉 doi.org/10.1016/j.mo...

#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
Redirecting
doi.org
May 20, 2025 at 8:07 AM
mainzuniversity.bsky.social
Researchers find link between excessive R-loop levels and #DNA damage to be a potential cause of disease https://www.uni-mainz.de/presse/aktuell/15114_ENG_HTML.php #biology #LifeSciences #proteomics #cancer #leukemia #GenomicInstability #DDX41 #RLoops #research @imbmainz...
December 12, 2024 at 1:54 PM