Propagation of #neuronal micronuclei regulates #microglial characteristics.
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may a...
www.nature.com
January 17, 2025 at 4:35 PM
Propagation of #neuronal micronuclei regulates #microglial characteristics.
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
biology never ceases to amaze: www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may a...
www.nature.com
January 17, 2025 at 11:51 PM
biology never ceases to amaze: www.nature.com/articles/s41...
Neuronal micronuclei transfer to #microglia, altering microglial morphology and gene expression during the postnatal period in mice 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may act as mediators that control microglial characteristics.
www.nature.com
January 21, 2025 at 3:07 PM
Neuronal micronuclei transfer to #microglia, altering microglial morphology and gene expression during the postnatal period in mice 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
My choice this week in @science.org
RCC1 depletion drives protein transport defects and rupture in micronuclei
doi.org/10.1083/jcb....
RCC1 depletion drives protein transport defects and rupture in micronuclei
doi.org/10.1083/jcb....
April 17, 2026 at 10:19 AM
My choice this week in @science.org
RCC1 depletion drives protein transport defects and rupture in micronuclei
doi.org/10.1083/jcb....
RCC1 depletion drives protein transport defects and rupture in micronuclei
doi.org/10.1083/jcb....
New preprint from the lab led by Yanyang Chen identifies BAF as a key regulator of TREX1 activity at micronuclei.
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
April 16, 2025 at 11:39 AM
New preprint from the lab led by Yanyang Chen identifies BAF as a key regulator of TREX1 activity at micronuclei.
Great to see our latest work published in @natureportfolio.nature.com scientific reports on the effect of proton LET on micronuclei. @protonresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unravelling the impact of linear energy transfer on micronuclei induction from proton and photon irradiation - Scientific Reports
Scientific Reports - Unravelling the impact of linear energy transfer on micronuclei induction from proton and photon irradiation
www.nature.com
July 9, 2025 at 9:45 AM
Great to see our latest work published in @natureportfolio.nature.com scientific reports on the effect of proton LET on micronuclei. @protonresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧵 We are excited to share our new paper, showcasing micronuclAI, which leverages #AI and #ComputerVision to detect #chromosomal_instability #CIN #micronuclei
Congratulations to @miguelib.bsky.social and Lindsay Caprio for leading this project.
Congratulations to @miguelib.bsky.social and Lindsay Caprio for leading this project.
March 7, 2025 at 3:48 PM
🧵 We are excited to share our new paper, showcasing micronuclAI, which leverages #AI and #ComputerVision to detect #chromosomal_instability #CIN #micronuclei
Congratulations to @miguelib.bsky.social and Lindsay Caprio for leading this project.
Congratulations to @miguelib.bsky.social and Lindsay Caprio for leading this project.
The cGAS-STING DNA-sensing pathway in #Atherosclerosis
Exogenous: Pathogen/Plasmid DNA
Endogenous: mtDNA, cfDNA, micronuclei, chromatin bridge, retrotransposon transcript, DNA damage▶️cytosolic DNA
Table cGAS/STING inhibitors
#FrontCVMed 2025
www.frontiersin.org/journals/car...
Exogenous: Pathogen/Plasmid DNA
Endogenous: mtDNA, cfDNA, micronuclei, chromatin bridge, retrotransposon transcript, DNA damage▶️cytosolic DNA
Table cGAS/STING inhibitors
#FrontCVMed 2025
www.frontiersin.org/journals/car...
June 30, 2025 at 12:22 PM
The cGAS-STING DNA-sensing pathway in #Atherosclerosis
Exogenous: Pathogen/Plasmid DNA
Endogenous: mtDNA, cfDNA, micronuclei, chromatin bridge, retrotransposon transcript, DNA damage▶️cytosolic DNA
Table cGAS/STING inhibitors
#FrontCVMed 2025
www.frontiersin.org/journals/car...
Exogenous: Pathogen/Plasmid DNA
Endogenous: mtDNA, cfDNA, micronuclei, chromatin bridge, retrotransposon transcript, DNA damage▶️cytosolic DNA
Table cGAS/STING inhibitors
#FrontCVMed 2025
www.frontiersin.org/journals/car...
☕Lebrec, @zierlab.bsky.social & co present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chromatin bridges as potential cGAS activators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology
Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...
www.nature.com
August 26, 2026 at 7:46 AM
☕Lebrec, @zierlab.bsky.social & co present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chromatin bridges as potential cGAS activators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The beauty of neurobiology: a newly discovered form of neuron-microglia communication during brain development, based on the release of neuronal micronuclei.
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics
Sarasa Yano et al. 🧪 #Neuroscience
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics
Sarasa Yano et al. 🧪 #Neuroscience
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may a...
www.nature.com
March 12, 2025 at 11:06 AM
The beauty of neurobiology: a newly discovered form of neuron-microglia communication during brain development, based on the release of neuronal micronuclei.
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics
Sarasa Yano et al. 🧪 #Neuroscience
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics
Sarasa Yano et al. 🧪 #Neuroscience
Look up chromothripsis--this happens in some cancer cells when chromosome segregation goes awry and chromosomes end in micronuclei
June 18, 2025 at 6:34 PM
Look up chromothripsis--this happens in some cancer cells when chromosome segregation goes awry and chromosomes end in micronuclei
Long non-coding RNA and
Extra-chromosomal DNA/micronuclei and
Liquid-liquid phase separation/condensates
Oh my!
How they might contribute to cancer progression, drug resistance and metastasis. Possible Achille’s heel in new cancer treatments.
#Science 🧪
Extra-chromosomal DNA/micronuclei and
Liquid-liquid phase separation/condensates
Oh my!
How they might contribute to cancer progression, drug resistance and metastasis. Possible Achille’s heel in new cancer treatments.
#Science 🧪
Seeking bold new tactics in the war on cancer
Researchers in Japan are searching for novel approaches of treating cancer which could overcome the limitations of current therapies.
www.nature.com
April 25, 2026 at 11:46 AM
Long non-coding RNA and
Extra-chromosomal DNA/micronuclei and
Liquid-liquid phase separation/condensates
Oh my!
How they might contribute to cancer progression, drug resistance and metastasis. Possible Achille’s heel in new cancer treatments.
#Science 🧪
Extra-chromosomal DNA/micronuclei and
Liquid-liquid phase separation/condensates
Oh my!
How they might contribute to cancer progression, drug resistance and metastasis. Possible Achille’s heel in new cancer treatments.
#Science 🧪
Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity"
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
www.sciencedirect.com
January 20, 2025 at 9:57 PM
Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity"
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
Supremely excited to share our new paper in @natcellbio.nature.com
With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation.
www.nature.com/articles/s41...
With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation.
www.nature.com/articles/s41...
A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology
Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...
www.nature.com
August 21, 2026 at 10:26 AM
Supremely excited to share our new paper in @natcellbio.nature.com
With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation.
www.nature.com/articles/s41...
With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation.
www.nature.com/articles/s41...
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
April 16, 2025 at 4:18 AM
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
📝 Online now - the Feature Review "Transactions on micronuclear DNA and implications for immune signaling" from @johnmaciejowski.bsky.social and Roger Greenberg.
#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse
Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...
#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse
Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...
November 24, 2025 at 7:34 PM
📝 Online now - the Feature Review "Transactions on micronuclear DNA and implications for immune signaling" from @johnmaciejowski.bsky.social and Roger Greenberg.
#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse
Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...
#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse
Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...
RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
February 10, 2026 at 4:15 PM
RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/...
#disease #chromatin #epigenetics #cancer
#disease #chromatin #epigenetics #cancer
PS What is the name for the little bobbles formed by individual chromosomes before they merge into a joint nucleus? Micronuclei?!
December 19, 2025 at 7:00 PM
PS What is the name for the little bobbles formed by individual chromosomes before they merge into a joint nucleus? Micronuclei?!
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
April 16, 2025 at 4:18 AM
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei https://www.biorxiv.org/content/10.1101/2025.04.14.648782v1
RCC1 depletion drives protein transport defects and rupture in #micronuclei. From Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch: rupress.org/jcb/article/...
📕 From #Cancer Cell Biology 2026 👉 rupress.org/jcb/collecti...
📕 From #Cancer Cell Biology 2026 👉 rupress.org/jcb/collecti...
April 29, 2026 at 3:15 PM
RCC1 depletion drives protein transport defects and rupture in #micronuclei. From Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch: rupress.org/jcb/article/...
📕 From #Cancer Cell Biology 2026 👉 rupress.org/jcb/collecti...
📕 From #Cancer Cell Biology 2026 👉 rupress.org/jcb/collecti...
How and why micronuclei rupture?
The answer to this long-lasting conundrum is in my first author paper published, together with its back-to-back companion from @stesantaguida.bsky.social lab, on Science. (1/3)
The answer to this long-lasting conundrum is in my first author paper published, together with its back-to-back companion from @stesantaguida.bsky.social lab, on Science. (1/3)
November 21, 2024 at 12:01 AM
How and why micronuclei rupture?
The answer to this long-lasting conundrum is in my first author paper published, together with its back-to-back companion from @stesantaguida.bsky.social lab, on Science. (1/3)
The answer to this long-lasting conundrum is in my first author paper published, together with its back-to-back companion from @stesantaguida.bsky.social lab, on Science. (1/3)
MicronuclAI, a deep-learning based pipeline, enables automated and reliable quantification of micronuclei from nuclei-stained human and murine cancer cell lines for quantification of chromosomal instability.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
March 6, 2025 at 6:21 PM
MicronuclAI, a deep-learning based pipeline, enables automated and reliable quantification of micronuclei from nuclei-stained human and murine cancer cell lines for quantification of chromosomal instability.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes
Genome instability, including chromothripsis, is a hallmark of cancer. Cancer cells frequently contain micronuclei—small, nucleus-like structures formed by chromosome missegregation—that are susceptib...
www.science.org
December 12, 2025 at 10:07 PM
🧬🔬@science.org #Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes | Science www.science.org/doi/10.1126/...
While analyzing our Xenium data, we discovered that DAPI images, routinely taken for cell segmentation, can also be used to identify micronuclei in tumor sections. Super excited about this—now we can study micronuclei in the tumor microenvironment!
February 28, 2025 at 2:27 PM
While analyzing our Xenium data, we discovered that DAPI images, routinely taken for cell segmentation, can also be used to identify micronuclei in tumor sections. Super excited about this—now we can study micronuclei in the tumor microenvironment!