Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
February 19, 2026 at 7:09 PM
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
Many of you never had to painfully hand-annotate all the EcoRI sites on several printed pages of DNA sequence and it shows.
#PILife #molbio #AlwaysBeCloning
#PILife #molbio #AlwaysBeCloning
September 8, 2025 at 2:59 PM
Many of you never had to painfully hand-annotate all the EcoRI sites on several printed pages of DNA sequence and it shows.
#PILife #molbio #AlwaysBeCloning
#PILife #molbio #AlwaysBeCloning
Hello Bsky!
We are the Max Planck Research Group Biological Clocks.
#evolution #evobio #ecology #adaptation #biodiversity #behaviour #genetics #genomics #chronobiology #circadian #circalunar #biologicalclock #moon #tides #marine #molbio #biology #nature #research #science #scicomm #insect #clunio
We are the Max Planck Research Group Biological Clocks.
#evolution #evobio #ecology #adaptation #biodiversity #behaviour #genetics #genomics #chronobiology #circadian #circalunar #biologicalclock #moon #tides #marine #molbio #biology #nature #research #science #scicomm #insect #clunio
February 10, 2025 at 11:59 AM
Hello Bsky!
We are the Max Planck Research Group Biological Clocks.
#evolution #evobio #ecology #adaptation #biodiversity #behaviour #genetics #genomics #chronobiology #circadian #circalunar #biologicalclock #moon #tides #marine #molbio #biology #nature #research #science #scicomm #insect #clunio
We are the Max Planck Research Group Biological Clocks.
#evolution #evobio #ecology #adaptation #biodiversity #behaviour #genetics #genomics #chronobiology #circadian #circalunar #biologicalclock #moon #tides #marine #molbio #biology #nature #research #science #scicomm #insect #clunio
Merry Christmas 🎄🧪! Here's a video I made of the predicted structure for the protein MERRYCHRISTMAS. I used AlphaFold to predict the structure and then colored the backbone (green), amino acids by index (rainbow), and noncovalent interactions (dotted lines). #sciart #science #MolBio
December 25, 2025 at 5:59 PM
Every year, new graduate students in research labs are confronted by the Totem of Molbio that is "Captain Eppie".
Captain Eppie was a promotional item given away with the purchase of Eppendorf centrifuges, but his mismatched eyes, primal energy & faint supernatural aura have led many to ask:
WHY?
Captain Eppie was a promotional item given away with the purchase of Eppendorf centrifuges, but his mismatched eyes, primal energy & faint supernatural aura have led many to ask:
WHY?
September 29, 2026 at 1:31 AM
Every year, new graduate students in research labs are confronted by the Totem of Molbio that is "Captain Eppie".
Captain Eppie was a promotional item given away with the purchase of Eppendorf centrifuges, but his mismatched eyes, primal energy & faint supernatural aura have led many to ask:
WHY?
Captain Eppie was a promotional item given away with the purchase of Eppendorf centrifuges, but his mismatched eyes, primal energy & faint supernatural aura have led many to ask:
WHY?
I thought about making educational videos on microbiology and molbio but it's just narrated by my fursona in animalese
Something came to me in a dream and now I need to learn video editing
April 5, 2026 at 1:05 PM
I thought about making educational videos on microbiology and molbio but it's just narrated by my fursona in animalese
Any old school molbio people have a copy of the 1987 paper from BMBiochemica on using Bailey’s as a blocking agent for colony hybridization?
July 5, 2026 at 2:02 PM
Any old school molbio people have a copy of the 1987 paper from BMBiochemica on using Bailey’s as a blocking agent for colony hybridization?
Wong et al. present IQ-TREE version 3, with new features including mixture models, gene and site concordance factors, integration with phylogenomic divergence time estimation, and a fully featured sequence simulator.
🔗 doi.org/10.1093/molbev/msag117
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msag117
#evobio #molbio #compbio
May 25, 2026 at 11:30 AM
Wong et al. present IQ-TREE version 3, with new features including mixture models, gene and site concordance factors, integration with phylogenomic divergence time estimation, and a fully featured sequence simulator.
🔗 doi.org/10.1093/molbev/msag117
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msag117
#evobio #molbio #compbio
Fantastic collab with @jmtali.bsky.social and colleages, feat. Agnese Kocere and Seth Jacobson from our team @cuanschutz.bsky.social - OINC-seq!
...and my career's biggest omission that we didn't have #pIGLET transgenics yet for this collaboration...🐽
#collaborate #devbio #zebrafish #molbio #RNA
...and my career's biggest omission that we didn't have #pIGLET transgenics yet for this collaboration...🐽
#collaborate #devbio #zebrafish #molbio #RNA
Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...
November 13, 2024 at 5:09 PM
Fantastic collab with @jmtali.bsky.social and colleages, feat. Agnese Kocere and Seth Jacobson from our team @cuanschutz.bsky.social - OINC-seq!
...and my career's biggest omission that we didn't have #pIGLET transgenics yet for this collaboration...🐽
#collaborate #devbio #zebrafish #molbio #RNA
...and my career's biggest omission that we didn't have #pIGLET transgenics yet for this collaboration...🐽
#collaborate #devbio #zebrafish #molbio #RNA
November 17, 2025 at 12:53 PM
@nurdankuru.bsky.social & Adebali present PHACE, a phylogeny-aware coevolution algorithm that maps amino acid substitutions onto a phylogenetic tree to detect molecular coevolution.
🔗 doi.org/10.1093/molbev/msaf150
#evobio #molbio #phylogenetics
🔗 doi.org/10.1093/molbev/msaf150
#evobio #molbio #phylogenetics
July 18, 2025 at 1:14 PM
@nurdankuru.bsky.social & Adebali present PHACE, a phylogeny-aware coevolution algorithm that maps amino acid substitutions onto a phylogenetic tree to detect molecular coevolution.
🔗 doi.org/10.1093/molbev/msaf150
#evobio #molbio #phylogenetics
🔗 doi.org/10.1093/molbev/msaf150
#evobio #molbio #phylogenetics
Haller, Ralph & Messer present SLiM 5, a major extension of the SLiM simulation framework for simulating multiple chromosomes, enabling a heightened level of realism for full-genome simulations.
🔗 doi.org/10.1093/molbev/msaf313
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msaf313
#evobio #molbio #compbio
January 5, 2026 at 8:53 AM
Haller, Ralph & Messer present SLiM 5, a major extension of the SLiM simulation framework for simulating multiple chromosomes, enabling a heightened level of realism for full-genome simulations.
🔗 doi.org/10.1093/molbev/msaf313
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msaf313
#evobio #molbio #compbio
Exciting news from my colleagues @sciencehistory.org! This archive documents the early history of #MolecularBiology & efforts to determine the structure of #DNA.
@matthewcobb.bsky.social provides an overview of its contents & significance in the thread below.
#histSTM #histsci #histbio #Molbio 🗃️📜🧬
@matthewcobb.bsky.social provides an overview of its contents & significance in the thread below.
#histSTM #histsci #histbio #Molbio 🗃️📜🧬
News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n
History of Molecular Biology Collection
This unparalleled collection includes Rosalind Franklin's historic 'Photo 51,' which revealed the double-helix structure of DNA.
www.sciencehistory.org
September 8, 2025 at 12:58 PM
Exciting news from my colleagues @sciencehistory.org! This archive documents the early history of #MolecularBiology & efforts to determine the structure of #DNA.
@matthewcobb.bsky.social provides an overview of its contents & significance in the thread below.
#histSTM #histsci #histbio #Molbio 🗃️📜🧬
@matthewcobb.bsky.social provides an overview of its contents & significance in the thread below.
#histSTM #histsci #histbio #Molbio 🗃️📜🧬
#StockInFocus : Molbio Diagnostics jumped 15% on Thursday after HDFC Mutual Fund bought a stake Motilal Oswal sold. Here’s the full picture. ✍️S. JHA
#stockMarket #Equity #diagnostics
theraisinahills.com/molbio-diagn...
#stockMarket #Equity #diagnostics
theraisinahills.com/molbio-diagn...
theraisinahills.com
October 2, 2026 at 6:35 AM
#StockInFocus : Molbio Diagnostics jumped 15% on Thursday after HDFC Mutual Fund bought a stake Motilal Oswal sold. Here’s the full picture. ✍️S. JHA
#stockMarket #Equity #diagnostics
theraisinahills.com/molbio-diagn...
#stockMarket #Equity #diagnostics
theraisinahills.com/molbio-diagn...
Hello world! Moving from x to (sk)y, learning the ropes and hoping to build my #academicsky 🧬 🖥️ 👩🏻🔬#MolBio #SciPol network in a positive and inclusive environment 🙏
November 4, 2023 at 11:05 AM
Hello world! Moving from x to (sk)y, learning the ropes and hoping to build my #academicsky 🧬 🖥️ 👩🏻🔬#MolBio #SciPol network in a positive and inclusive environment 🙏
#quotes #books #booksky #excerpts #citations #behave #sapolsky #behavior #brain #neurobiology #genes #genome #politics #molbio #polymorphic #freewill #heritability
July 22, 2026 at 2:50 PM
@jomcinerney.bsky.social proposes that genomes do not encode fixed functions but rather “probability distributions” over functional and phenotypic outcomes, and introduces “genomic perplexity” as a measure of gene-context incompatibility.
🔗 doi.org/10.1093/molbev/msag041
#evobio #molbio
🔗 doi.org/10.1093/molbev/msag041
#evobio #molbio
March 4, 2026 at 3:59 PM
@jomcinerney.bsky.social proposes that genomes do not encode fixed functions but rather “probability distributions” over functional and phenotypic outcomes, and introduces “genomic perplexity” as a measure of gene-context incompatibility.
🔗 doi.org/10.1093/molbev/msag041
#evobio #molbio
🔗 doi.org/10.1093/molbev/msag041
#evobio #molbio
Resources that never grow old, like:
#AlwaysBeCloning #MakeMoreTransgenics #molbio #RestrictionEnzymesStillMatter 🧪🧫🧬
#AlwaysBeCloning #MakeMoreTransgenics #molbio #RestrictionEnzymesStillMatter 🧪🧫🧬
August 20, 2025 at 7:29 PM
Resources that never grow old, like:
#AlwaysBeCloning #MakeMoreTransgenics #molbio #RestrictionEnzymesStillMatter 🧪🧫🧬
#AlwaysBeCloning #MakeMoreTransgenics #molbio #RestrictionEnzymesStillMatter 🧪🧫🧬
👋🏼 Glad you’re here! Dropping your post into some relevant feeds
#neuroskyence #molbio #WomeninSTEM 🧪
#neuroskyence #molbio #WomeninSTEM 🧪
Hey there Neuro 🦋 . My name’s Joy and I love ion channels.
November 27, 2024 at 12:16 AM
👋🏼 Glad you’re here! Dropping your post into some relevant feeds
#neuroskyence #molbio #WomeninSTEM 🧪
#neuroskyence #molbio #WomeninSTEM 🧪
🧬🔬🧪 We are seeking a Scientist to push the limits of spatial transcriptomics in zebrafish! Come join us!
#MolBio #SpatialTranscriptomics #DevelopmentalBiology #ScienceJobs 🧫🐟🔍
job-boards.greenhouse.io/chanzuckerbe...
#MolBio #SpatialTranscriptomics #DevelopmentalBiology #ScienceJobs 🧫🐟🔍
job-boards.greenhouse.io/chanzuckerbe...
Scientist, Spatial Molecular Cartography (Jacobo/Royer Group - Biohub SF)
San Francisco, California, United States
job-boards.greenhouse.io
April 15, 2025 at 6:27 PM
🧬🔬🧪 We are seeking a Scientist to push the limits of spatial transcriptomics in zebrafish! Come join us!
#MolBio #SpatialTranscriptomics #DevelopmentalBiology #ScienceJobs 🧫🐟🔍
job-boards.greenhouse.io/chanzuckerbe...
#MolBio #SpatialTranscriptomics #DevelopmentalBiology #ScienceJobs 🧫🐟🔍
job-boards.greenhouse.io/chanzuckerbe...
Pinheiro de Castro et al. trace the evolution of cyanogenic glucosides biosynthesis in Heliconiini butterflies, providing evidence for the genetic basis of this phenotype and empirical evidence for plasticity-first evolution.
🔗 academic.oup.com/mbe/article/...
#societyjournal #evobio #molbio
🔗 academic.oup.com/mbe/article/...
#societyjournal #evobio #molbio
August 24, 2026 at 11:24 AM
Pinheiro de Castro et al. trace the evolution of cyanogenic glucosides biosynthesis in Heliconiini butterflies, providing evidence for the genetic basis of this phenotype and empirical evidence for plasticity-first evolution.
🔗 academic.oup.com/mbe/article/...
#societyjournal #evobio #molbio
🔗 academic.oup.com/mbe/article/...
#societyjournal #evobio #molbio
Asgari & @annttate.bsky.social uncover the evolutionary forces shaping the multilayered regulation of signaling pathways by negative feedback loops.
🔗 doi.org/10.1093/molbev/msaf104
#evobio #molbio #regulation
🔗 doi.org/10.1093/molbev/msaf104
#evobio #molbio #regulation
May 22, 2025 at 5:26 AM
Asgari & @annttate.bsky.social uncover the evolutionary forces shaping the multilayered regulation of signaling pathways by negative feedback loops.
🔗 doi.org/10.1093/molbev/msaf104
#evobio #molbio #regulation
🔗 doi.org/10.1093/molbev/msaf104
#evobio #molbio #regulation
Ancestral sequence reconstruction often assumes unrealistic homogeneous substitution models; however @rmuniztrejo.bsky.social et al. find that reconstruction accuracy is determined by phylogenetic signal, not model choice.
🔗 doi.org/10.1093/molb...
#evobio #molbio
🔗 doi.org/10.1093/molb...
#evobio #molbio
Robustness of Ancestral Sequence Reconstruction to Among-site and Among-lineage Evolutionary Heterogeneity
Abstract. Ancestral sequence reconstruction is typically performed using homogeneous evolutionary models, which assume that the same substitution propensit
doi.org
April 30, 2025 at 11:29 PM
Ancestral sequence reconstruction often assumes unrealistic homogeneous substitution models; however @rmuniztrejo.bsky.social et al. find that reconstruction accuracy is determined by phylogenetic signal, not model choice.
🔗 doi.org/10.1093/molb...
#evobio #molbio
🔗 doi.org/10.1093/molb...
#evobio #molbio
a guy in my molbio class drank a 15mL tube of e.coli
July 31, 2026 at 2:53 AM
a guy in my molbio class drank a 15mL tube of e.coli