🧬 RNA is far more than just a blueprint for proteins! Its shape is crucial to its function. But how do we study RNA's complex structure?
🔍 Find out at the 20th March RNA Club as we dive into groundbreaking techniques that are changing the game in RNA research!
#RNAstructure #RNA
🔍 Find out at the 20th March RNA Club as we dive into groundbreaking techniques that are changing the game in RNA research!
#RNAstructure #RNA
a black and white drawing of a clock that says 11:18
ALT: a black and white drawing of a clock that says 11:18
media.tenor.com
March 11, 2025 at 12:41 PM
🧬 RNA is far more than just a blueprint for proteins! Its shape is crucial to its function. But how do we study RNA's complex structure?
🔍 Find out at the 20th March RNA Club as we dive into groundbreaking techniques that are changing the game in RNA research!
#RNAstructure #RNA
🔍 Find out at the 20th March RNA Club as we dive into groundbreaking techniques that are changing the game in RNA research!
#RNAstructure #RNA
How do we connect RNA structure to function? This review highlights new approaches to probe RNA structure across dimensions, linking structural features to RNA activity, interactions, and regulation in complex cellular contexts #RNAbiology #RNAstructure #Genomics #ComputationalBiology bit.ly/4sthgOt
May 4, 2026 at 4:45 PM
How do we connect RNA structure to function? This review highlights new approaches to probe RNA structure across dimensions, linking structural features to RNA activity, interactions, and regulation in complex cellular contexts #RNAbiology #RNAstructure #Genomics #ComputationalBiology bit.ly/4sthgOt
Can we drug RNA? This review explores the landscape of RNA-targeting small molecules, highlighting strategies to identify binding sites, design ligands, and overcome challenges posed by RNA structural flexibility #RNAbiology #RNAstructure #ChemicalBiology #DrugDiscovery #Genomics
bit.ly/4sv5Dq1
bit.ly/4sv5Dq1
April 30, 2026 at 8:33 PM
Can we drug RNA? This review explores the landscape of RNA-targeting small molecules, highlighting strategies to identify binding sites, design ligands, and overcome challenges posed by RNA structural flexibility #RNAbiology #RNAstructure #ChemicalBiology #DrugDiscovery #Genomics
bit.ly/4sv5Dq1
bit.ly/4sv5Dq1
How well can machine learning predict RNA secondary structure? This review surveys current approaches highlighting both impressive gains and key limitations in generalizability and interpretability #RNAbiology #MachineLearning #RNAstructure #ComputationalBiology #Genomics bit.ly/4spSj6s
April 23, 2026 at 6:19 PM
How well can machine learning predict RNA secondary structure? This review surveys current approaches highlighting both impressive gains and key limitations in generalizability and interpretability #RNAbiology #MachineLearning #RNAstructure #ComputationalBiology #Genomics bit.ly/4spSj6s
Today I tested my own method for RNA analysis. This method can serve as an early indicator of RNA stability, even before detailed 3D modeling.
#Bioinformatics #ComputationalBiology #StructuralBiology #MolecularBiology #RNA #Biotechnology #LifeSciences #RNAresearch #RNAstructure #RNAfolding #LLM
#Bioinformatics #ComputationalBiology #StructuralBiology #MolecularBiology #RNA #Biotechnology #LifeSciences #RNAresearch #RNAstructure #RNAfolding #LLM
September 24, 2025 at 5:22 AM
Today I tested my own method for RNA analysis. This method can serve as an early indicator of RNA stability, even before detailed 3D modeling.
#Bioinformatics #ComputationalBiology #StructuralBiology #MolecularBiology #RNA #Biotechnology #LifeSciences #RNAresearch #RNAstructure #RNAfolding #LLM
#Bioinformatics #ComputationalBiology #StructuralBiology #MolecularBiology #RNA #Biotechnology #LifeSciences #RNAresearch #RNAstructure #RNAfolding #LLM
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 25, 2025 at 10:27 PM
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
🚀 DesiRNA, our new RNA design tool, solved all 100 puzzles in the Eterna100 benchmark within 24 hours, outperforming all existing RNA design programs! 🧬
🔗 Read about it in Nucleic Acids Research: doi.org/10.1093/nar/...
#Science #Bioinformatics #ComputationalBiology #RNA #RNAstructure
🔗 Read about it in Nucleic Acids Research: doi.org/10.1093/nar/...
#Science #Bioinformatics #ComputationalBiology #RNA #RNAstructure
DesiRNA: structure-based design of RNA sequences with a replica exchange Monte Carlo approach
Abstract. Designing RNA sequences that form a specific structure remains a challenge. Current computational methods often struggle with the complexity of R
doi.org
February 12, 2025 at 9:36 PM
🚀 DesiRNA, our new RNA design tool, solved all 100 puzzles in the Eterna100 benchmark within 24 hours, outperforming all existing RNA design programs! 🧬
🔗 Read about it in Nucleic Acids Research: doi.org/10.1093/nar/...
#Science #Bioinformatics #ComputationalBiology #RNA #RNAstructure
🔗 Read about it in Nucleic Acids Research: doi.org/10.1093/nar/...
#Science #Bioinformatics #ComputationalBiology #RNA #RNAstructure
We've thought really hard about using #NMR to look at #RNA dynamics at our RNA-binding interfaces but always figured it was too hard for our system. Really exciting to see the possibility moving a step closer! Super work, congratulations!! #RBPs #IDRs #RNAstructure
Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...
19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone
Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…
www.sciencedirect.com
April 23, 2026 at 6:07 AM
We've thought really hard about using #NMR to look at #RNA dynamics at our RNA-binding interfaces but always figured it was too hard for our system. Really exciting to see the possibility moving a step closer! Super work, congratulations!! #RBPs #IDRs #RNAstructure
Super new work from Chris and the team, including some cool #smFRET showing changes to n #RNAstructure- have a read!
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 20, 2025 at 9:48 AM
Super new work from Chris and the team, including some cool #smFRET showing changes to n #RNAstructure- have a read!
Super method linking GROseq/DMSMaPseq shedding light on co-transcriptional #RNA folding. Really enjoyed seeing this presented recently. #RNAStructure www.biorxiv.org/content/10.1...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
www.biorxiv.org
November 27, 2024 at 7:15 AM
Super method linking GROseq/DMSMaPseq shedding light on co-transcriptional #RNA folding. Really enjoyed seeing this presented recently. #RNAStructure www.biorxiv.org/content/10.1...
This looks useful- will give it a go #RNAstructure
A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...
Accurate RNA 3D structure prediction using a language model-based deep learning approach - Nature Methods
RhoFold+ is an end-to-end language model-based deep learning method to predict RNA three-dimensional structures of single-chain RNAs from sequences.
www.nature.com
November 22, 2024 at 8:13 AM
This looks useful- will give it a go #RNAstructure
SEISMICgraph: a web-based tool for RNA structure data visualization. #RNAstructure #WebTool #DataVisualization #Bioinformatics @narjournal.bsky.social
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
August 10, 2025 at 4:49 PM
SEISMICgraph: a web-based tool for RNA structure data visualization. #RNAstructure #WebTool #DataVisualization #Bioinformatics @narjournal.bsky.social
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Most of the predictions e.g. mfold, RNAfold, etc. allow you to set folding constraints so you can force the structure you wanna see. Otherwise I like the Structure Editor part of RNAstructure rna.urmc.rochester.edu/GUI/html/Str... you can reshape the molecule to your liking & calculate the energy
StructureEditor
rna.urmc.rochester.edu
November 22, 2024 at 8:40 PM
Most of the predictions e.g. mfold, RNAfold, etc. allow you to set folding constraints so you can force the structure you wanna see. Otherwise I like the Structure Editor part of RNAstructure rna.urmc.rochester.edu/GUI/html/Str... you can reshape the molecule to your liking & calculate the energy
🧬(1/2) Capturing RNA structure at the single-molecule level🔬NanoRAPID is a deep learning framework that directly analyzes raw nanopore DRS signals to accurately identify RNA structural probing sites.
#Nanopore #DirectRNASequencing #RNAStructure #DeepLearning
#Nanopore #DirectRNASequencing #RNAStructure #DeepLearning
July 13, 2026 at 2:10 PM
🧬(1/2) Capturing RNA structure at the single-molecule level🔬NanoRAPID is a deep learning framework that directly analyzes raw nanopore DRS signals to accurately identify RNA structural probing sites.
#Nanopore #DirectRNASequencing #RNAStructure #DeepLearning
#Nanopore #DirectRNASequencing #RNAStructure #DeepLearning
(2/8) Predicting full 3D #RNAstructure remains extremely hard — even with AI.
Recent benchmarks show deep-learning tools still struggle on novel RNAs (c.f. Bahai et al, 2024, PLoS Comp Bio)
And while AlphaFold 3 can model RNA, its accuracy lags far behind proteins: www.ebi.ac.uk/training/onl...
Recent benchmarks show deep-learning tools still struggle on novel RNAs (c.f. Bahai et al, 2024, PLoS Comp Bio)
And while AlphaFold 3 can model RNA, its accuracy lags far behind proteins: www.ebi.ac.uk/training/onl...
August 25, 2025 at 3:02 AM
(2/8) Predicting full 3D #RNAstructure remains extremely hard — even with AI.
Recent benchmarks show deep-learning tools still struggle on novel RNAs (c.f. Bahai et al, 2024, PLoS Comp Bio)
And while AlphaFold 3 can model RNA, its accuracy lags far behind proteins: www.ebi.ac.uk/training/onl...
Recent benchmarks show deep-learning tools still struggle on novel RNAs (c.f. Bahai et al, 2024, PLoS Comp Bio)
And while AlphaFold 3 can model RNA, its accuracy lags far behind proteins: www.ebi.ac.uk/training/onl...
.@AGbioDS from http://RNAfold.ai closing off this session of the @UNSWRNA annual symposium presenting his (and @oncogenie's) company, that leverages #AI to design new therapies targeting #RNAstructure and accessibility.
December 3, 2024 at 5:44 AM
.@AGbioDS from http://RNAfold.ai closing off this session of the @UNSWRNA annual symposium presenting his (and @oncogenie's) company, that leverages #AI to design new therapies targeting #RNAstructure and accessibility.
Missed our recent webinar on New Methods for RNA Modification Detection and Structure Probing?
Explore innovative techniques that are transforming our understanding of #RNAmods and #RNAstructure.
Watch here: bit.ly/3TULhbr
#RNA #RNASky #structuralRNA
Explore innovative techniques that are transforming our understanding of #RNAmods and #RNAstructure.
Watch here: bit.ly/3TULhbr
#RNA #RNASky #structuralRNA
New Methods for RNA Modification Detection and Structure Probing
In this webinar, you’ll hear from three experts in the field about their research into the structure, function, regulation and detection of RNA modifications.
bit.ly
February 6, 2025 at 7:28 PM
Missed our recent webinar on New Methods for RNA Modification Detection and Structure Probing?
Explore innovative techniques that are transforming our understanding of #RNAmods and #RNAstructure.
Watch here: bit.ly/3TULhbr
#RNA #RNASky #structuralRNA
Explore innovative techniques that are transforming our understanding of #RNAmods and #RNAstructure.
Watch here: bit.ly/3TULhbr
#RNA #RNASky #structuralRNA
Happy World RNA Day! 🧬
RNA is at the heart of everything we do in our lab.
There is still so much to discover, and we're excited to be part of that journey.
#WorldRNADay #RNA #RNAstructure
RNA is at the heart of everything we do in our lab.
There is still so much to discover, and we're excited to be part of that journey.
#WorldRNADay #RNA #RNAstructure
August 1, 2026 at 8:10 AM
Happy World RNA Day! 🧬
RNA is at the heart of everything we do in our lab.
There is still so much to discover, and we're excited to be part of that journey.
#WorldRNADay #RNA #RNAstructure
RNA is at the heart of everything we do in our lab.
There is still so much to discover, and we're excited to be part of that journey.
#WorldRNADay #RNA #RNAstructure
RNA is not just a messenger — structure matters.
In our review, we explore how RNA folding shapes translation, stability, protein binding and cellular function. #RNA #RNAstructure #mRNA #RNABiology
www.mdpi.com/1422-0067/21...
In our review, we explore how RNA folding shapes translation, stability, protein binding and cellular function. #RNA #RNAstructure #mRNA #RNABiology
www.mdpi.com/1422-0067/21...
March 22, 2026 at 7:43 AM
RNA is not just a messenger — structure matters.
In our review, we explore how RNA folding shapes translation, stability, protein binding and cellular function. #RNA #RNAstructure #mRNA #RNABiology
www.mdpi.com/1422-0067/21...
In our review, we explore how RNA folding shapes translation, stability, protein binding and cellular function. #RNA #RNAstructure #mRNA #RNABiology
www.mdpi.com/1422-0067/21...
NCN @ncn.gov.pl project spotlight 🔬
We investigate how mRNA folds in vivo, how its structure changes across the cell, and how RNA structure regulates gene expression in yeast. #RNA #mRNA #RNAstructure #GeneExpression #Yeast
We investigate how mRNA folds in vivo, how its structure changes across the cell, and how RNA structure regulates gene expression in yeast. #RNA #mRNA #RNAstructure #GeneExpression #Yeast
March 11, 2026 at 9:59 AM
NCN @ncn.gov.pl project spotlight 🔬
We investigate how mRNA folds in vivo, how its structure changes across the cell, and how RNA structure regulates gene expression in yeast. #RNA #mRNA #RNAstructure #GeneExpression #Yeast
We investigate how mRNA folds in vivo, how its structure changes across the cell, and how RNA structure regulates gene expression in yeast. #RNA #mRNA #RNAstructure #GeneExpression #Yeast
Hi Bluesky — welcome to KPW Lab!
We are interested in how #RNAstructure influences function, stability, and interactions in the cell.
Our work connects experimental #RNA structure probing with structural modeling and #bioinformatics. We’re excited to share our science, publications, and tools here.
We are interested in how #RNAstructure influences function, stability, and interactions in the cell.
Our work connects experimental #RNA structure probing with structural modeling and #bioinformatics. We’re excited to share our science, publications, and tools here.
March 10, 2026 at 8:28 AM
Hi Bluesky — welcome to KPW Lab!
We are interested in how #RNAstructure influences function, stability, and interactions in the cell.
Our work connects experimental #RNA structure probing with structural modeling and #bioinformatics. We’re excited to share our science, publications, and tools here.
We are interested in how #RNAstructure influences function, stability, and interactions in the cell.
Our work connects experimental #RNA structure probing with structural modeling and #bioinformatics. We’re excited to share our science, publications, and tools here.
Please join us for our next seminar, featuring Danny IncaRNAto, PhD: “Discovery of RNA regulatory structural switches via ensemble mapping”
@incarnatolab.bsky.social #rna #casprnasig #rnastructure
@incarnatolab.bsky.social #rna #casprnasig #rnastructure
October 10, 2025 at 5:34 PM
Please join us for our next seminar, featuring Danny IncaRNAto, PhD: “Discovery of RNA regulatory structural switches via ensemble mapping”
@incarnatolab.bsky.social #rna #casprnasig #rnastructure
@incarnatolab.bsky.social #rna #casprnasig #rnastructure
#RNABenasque RL: many constrained folding programs are now available: UNAfold, RNAstructure, Vienna 2.2+ has generalized ones now!
November 17, 2024 at 4:56 AM
#RNABenasque RL: many constrained folding programs are now available: UNAfold, RNAstructure, Vienna 2.2+ has generalized ones now!
Calling #RNA & #Virology researchers! 🧬🦠
Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing.
📝 Original research & reviews welcome!
🗓️ Deadline: Feb 28, 2026
michaelwolfinger.com/blog/2025/bl...
#FunctionalRNA #RNAstructure
Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing.
📝 Original research & reviews welcome!
🗓️ Deadline: Feb 28, 2026
michaelwolfinger.com/blog/2025/bl...
#FunctionalRNA #RNAstructure
Functional RNAs in Virology Special Issue
MDPI Viruses has launched a new open-access Special Issue on “Functional RNAs in Virology” to highlight recent advances in understanding how RNAs act as regulatory molecule in viral infection
michaelwolfinger.com
July 30, 2025 at 11:20 AM
Calling #RNA & #Virology researchers! 🧬🦠
Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing.
📝 Original research & reviews welcome!
🗓️ Deadline: Feb 28, 2026
michaelwolfinger.com/blog/2025/bl...
#FunctionalRNA #RNAstructure
Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing.
📝 Original research & reviews welcome!
🗓️ Deadline: Feb 28, 2026
michaelwolfinger.com/blog/2025/bl...
#FunctionalRNA #RNAstructure
Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including:
#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)
#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n
#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)
#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n
January 18, 2025 at 9:33 PM
Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including:
#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)
#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n
#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)
#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n